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Congophilic fibrils in the glomeruli with polyclonal immunoglobulin gamma staining-another cause for diagnostic overlap:A case report

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World Journal of Clinical Cases 2024年第17期12卷 3200-3205页

作者： Maria Bernadette Che-Ying Chow Lucas Bushrow Irmeen Siddiqui April chiu Mirza Hamirani Anjali A Satoskar Department of Pathology The Ohio State University Medical CenterColumbusOH 43210United States Department of Pathology North District HospitalSheung ShuiHong KongChina Department of Laboratory Medicine and Pathology Mayo ClinicRochesterMN 55905United States Department of Internal Medicine S.Joseph's HospitalParkersburgWV 26101United States

BACKGROUND Glomerulopathy with fibrillary deposits is not uncommon in routine nephropathology practice,with amyloidosis and fibrillary glomerulonephritis being the two most frequently encountered *** amyloid heavy and light chain(AHL)is relatively uncommon and its biopsy diagnosis is usually limited to cases that show strong equivalent staining for a single immunoglobulin(Ig)heavy chain and a single light chain,further supported by mass spectrometry(MS)and serum studies for monoclonal *** polyclonal light chain staining can pose a *** SUMMARY Herein we present a challenging case of renal AHL with polyclonal and polytypic Ig gamma(IgG)staining pattern by *** patient is a 62-yearold Caucasian male who presented to an outside institution with a serum creatinine of up to 8.1 mg/dL and nephrotic range *** the finding of a polyclonal and polytypic staining pattern on immunofluorescence,ultrastructural study of the renal biopsy demonstrated the presence of fibrils with a mean diameter of 10 *** red was positive while DNAJB9 was *** suggested a diagnosis of amyloid AHL type with IgG and lambda,but kappa light chains were also present supporting the immunofluorescence staining *** immunofixation studies demonstrated IgG lambda monoclonal *** patient was started on *** chronic renal injury however was quite advanced and he ended up needing dialysis shortly *** Tissue diagnosis of AHL amyloid can be *** confirmation using other available diagnostic techniques is recommended in such cases.

关键词： Heavy and light chain amyloid Fibrillary glomerulonephritis DNAJB9 Serum immunofixation Protein electrophoresis Mass spectrometry Congo red Case report

敦煌临摹《朱衣大士》领衔，张大千三幅力作苏富比拍卖斩获1.26亿港币

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艺术品鉴 2024年第13期 154-159页

作者：赵志瀚 Ryan chiu

近现代书画的拍卖市场，张大千向来是中流砥柱，是每季都不可能缺席的名字。2024年香港春拍，苏富比带来大师的三幅力作，囊括血战古人的青绿山水、敦煌临摹的佛教肖像、晚年工笔仕女，分别出自刘汉堃家族、“乐山堂”蔡一鸣、张葆萝（...

近现代书画的拍卖市场，张大千向来是中流砥柱，是每季都不可能缺席的名字。2024年香港春拍，苏富比带来大师的三幅力作，囊括血战古人的青绿山水、敦煌临摹的佛教肖像、晚年工笔仕女，分别出自刘汉堃家族、“乐山堂”蔡一鸣、张葆萝（大千儿子）家族雅蓄，先后于三个专场领衔上阵并悉数售出，共斩获逾1.26亿港币。其中，敦煌临摹的《朱衣大士》以1600万港币起拍，最终以估价三倍的6500万港币落槌，含佣金7757万港币成交。

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敦煌临掌《朱衣大士》领衔,张大千三幅力作苏富比拍卖斩获1.26亿港币

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艺术品鉴 2024年第5期 154-159页

作者：赵志瀚 Ryan chiu 不详

近现代书画的拍卖市场,张大千向来是中流砥柱,是每季都不可能缺席的名字。2024年香港地区春拍,苏富比带来大师的三幅力作,囊括血战古人的青绿山水、敦煌临摹的佛教肖像、晚年工笔仕女,分别出自刘汉堃家族、“乐山堂”蔡一鸣、张葆萝(大... 详细信息

近现代书画的拍卖市场,张大千向来是中流砥柱,是每季都不可能缺席的名字。2024年香港地区春拍,苏富比带来大师的三幅力作,囊括血战古人的青绿山水、敦煌临摹的佛教肖像、晚年工笔仕女,分别出自刘汉堃家族、“乐山堂”蔡一鸣、张葆萝(大千儿子)家族雅蓄,先后于三个专场领衔上阵并悉数售出,共斩获逾1.26亿港币。

关键词：苏富比近现代书画青绿山水张大千拍卖市场临摹敦煌

Extracellular Disintegration of Viral Proteins as an Innovative Strategy for Developing Broad-Spectrum Antivirals Against Coronavirus

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CCS Chemistry 2024年第2期6卷 487-496页

作者： Ke Sun Zhe Ding Xiaoying Jia Haonan Cheng Yingwen Li Yan Wu Zhuoyu Li Xiaohua Huang Fangxu Pu entao Li Guiyou Wang Wei Wang Yun Ding Gary Wong Sandra chiu Jiaming Lan Aiguo Hu Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237 CAS Key Laboratory of Molecular Virology&Immunology Chinese Academy of SciencesShanghai 200031 University of the Chinese Academy of Sciences Beijing 100049 State Key Laboratory of Virology Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071 Division of Life Sciences and Medicine University of Science and Technology of ChinaHefeiAnhui 230027 Department of Clinical Laboratory The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001

The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has claimedmillions of lives and caused innumerable economic losses ***,state-of-the-art treatments still lag behind the continual emergence of new *** to resolving this issue is developing antivirals to deactivate coronaviruses regardless of their structural ***,we report an innovative antiviral strategy involving extracellular disintegration of viral proteins with hyperanion-grafted enediyne(EDY)*** core EDY generates reactive radical species and causes significant damage to the spike protein of coronavirus,while the hyperanion groups ensure negligible cytotoxicity of the *** EDYs exhibit antiviral activity down to nanomolar concentrations,and the selectivity index of up to 20,000 against four kinds of human coronavirus,including the SARS-CoV-2 Omicron variant,suggesting the high potential of this new strategy in combating the COVID-19 pandemic and a future“disease X.”

关键词： enediyne broad spectrum antiviral protein disintegration coronavirus polyanions

白藜芦醇治疗多囊卵巢综合征作用机制研究进展

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中国中西医结合杂志 2024年

作者：王俐榕马呈呈万天恩 Chi chiu Wang 韩延华吴效科常惠黑龙江中医药大学第一临床医学院黑龙江中医药大学附属第一医院妇一科香港中文大学妇产科学系

多囊卵巢综合征（polycystic ovary syndrome,PCOS）是一种常见的女性内分泌疾病，影响着全球5%～20%的育龄妇女，其临床表现为高雄激素血症、稀发排卵或无排卵和卵巢多囊样改变[1]。根据临床症状可归于中医“月经后期”“不孕”“闭经...

多囊卵巢综合征（polycystic ovary syndrome,PCOS）是一种常见的女性内分泌疾病，影响着全球5%～20%的育龄妇女，其临床表现为高雄激素血症、稀发排卵或无排卵和卵巢多囊样改变[1]。根据临床症状可归于中医“月经后期”“不孕”“闭经”等范畴。目前PCOS的一线治疗为生活方式干预，其次为药物治疗，但其作用效果有限[2]。白藜芦醇（resveratrol,Res）是一种来源于葡萄和浆果的天然多酚有机化合物，近年研究发现，Res对PCOS具有改善胰岛素抵抗（insulin resistance,IR），调节血脂异常，

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电刺激治疗骨骼肌肉疾病的应用研究进展

中华解剖与临床杂志 2024年第6期29卷 421-426页

作者：吴泽霖陈紫航艾斯玛尔古丽·艾斯克尔郑小飞 Kin chiu 王华军暨南大学附属第一医院运动医学科/广州市精准骨科与再生医学重点实验室/广东省速度能力研究重点实验室广州510630 香港大学李嘉诚医学院心理系/脑与认知科学国家重点实验室(香港大学) 中国香港999077

目的总结电刺激(EStim)技术治疗骨骼肌肉系统疾病的临床效果及其作用机制方面的研究进展。方法在中国知网、万方数据、Springer Link、PubMed等中、英文数据库中,检索自2000年1月以后公开发表的有关EStim与骨骼肌肉系统的文章共2778篇,... 详细信息

目的总结电刺激(EStim)技术治疗骨骼肌肉系统疾病的临床效果及其作用机制方面的研究进展。方法在中国知网、万方数据、Springer Link、PubMed等中、英文数据库中,检索自2000年1月以后公开发表的有关EStim与骨骼肌肉系统的文章共2778篇,最终纳入57篇文献进行系统复习及归纳总结。结果EStim技术对骨骼、肌肉、肌腱、韧带、关节软骨等骨骼肌肉系统各组成部分的疾病,如骨折、骨质疏松、肌肉萎缩,以及肌腱、韧带、关节软骨和周围神经损伤等,均有积极的治疗效果,且具备经济性、安全性、便捷性与有效性等优势。EStim对骨骼肌肉系统疾病的作用机制是通过物理、分子生物学等途径,对骨骼肌肉系统的血液循环、细胞分化、机械运动、蛋白质代谢等产生影响,甚至有可能促进软骨细胞增殖、加速神经轴突再生。结论采用EStim技术治疗骨骼肌肉系统疾病,其方法可行、疗效肯定;其作用机制是通过物理和生化两个方面的途径来实现的。

关键词：骨骼肌肉系统电刺激骨骼肌肉肌腱韧带软骨

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Vonoprazan 10 mg or 20 mg *** 15 mg as maintenance therapy in Asian patients with healed erosive esophagitis:A randomized controlled trial

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Chinese Medical Journal 2024年第8期137卷 962-971页

作者： Yinglian Xiao Jiaming Qian Shutian Zhang Ning Dai Hoon Jai Chun Chengtang chiu Chui Fung Chong Nobuo Funao Yuuichi Sakurai Jessica D.Eisner Li Xie Minhu Chen Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510062China Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100006China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Gastroenterology Sir Run Run Shaw HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310020China Department of Internal Medicine Korea University Anam HospitalKorea University College of Medicine73 Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Department of Gastroenterology&Hepatology Linkou Medical CenterChang Gung Memorial HospitalTaoyuanTaiwan 33353China College of Medicine Chang Gung UniversityTaoyuanTaiwan 33353China Takeda Development Center Asia Singapore 018981Singapore Takeda Pharmaceutical Company Chuo-kuOsaka 540-8645Japan Takeda Pharmaceuticals International Company CambridgeMA02142 USA China Medical Team Takeda ChinaBeijing 100027China Hoffmann-La Roche Basel4070 Switzerland Abbott Laboratories Lake ForestIL 60045USA

Background:Erosive esophagitis(EE)is a gastroesophageal reflux disease characterized by mucosal breaks in the *** pump inhibitors are widely used as maintenance therapy for EE,but many patients still *** this trial,we evaluated the noninferiority of vonoprazan *** as maintenance therapy in patients with healed ***:We performed a double-blind,double-dummy,multicenter,phase 3 clinical trial among non-Japanese Asian adults with endoscopically confirmed healed EE from April 2015 to February *** from China,South Korea,and Malaysia were randomized to vonoprazan 10 mg or 20 mg once daily or lansoprazole 15 mg once daily for 24 *** primary endpoint was endoscopically confirmed EE recurrence rate over 24 weeks with a noninferiority margin of 10%using a two-sided 95%confidence interval(CI).Treatment-emergent adverse events(TEAEs)were ***:Among 703 patients,EE recurrence was observed in 24/181(13.3%)and 21/171(12.3%)patients receiving vonoprazan 10 mg or 20 mg,respectively,and 47/184(25.5%)patients receiving lansoprazole(differences:-12.3%[95%CI,-20.3%to-4.3%]and-13.3%[95%CI,-21.3%to-5.3%],respectively),meeting the primary endpoint of noninferiority to lansoprazole in preventing EE recurrence at 24 *** of superiority(upper bound of 95%CIendoscopically confirmed EE recurrence was observed in 5/18,2/20,and 7/20 of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** were experienced by 66.8%(157/235),69.0%(156/226),and 65.3%(158/242)of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** most common TEAE was upper respiratory tract infection in 12.8%(30/235)and 12.8%(29/226)patients in vonoprazan 10 mg and 20 mg groups,respectively and 8.7%(21/242)patients in lansoprazole ***:Vonoprazan maintenance therapy was well-tolerated and noninferior to lansoprazole for preventing EE recurrence i

关键词： Erosive esophagitis Lansoprazole Maintenance therapy Potassium-competitive acid blockers Vonoprazan

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论唐代题画诗题材、体裁创制的多样性特征

肇庆学院学报 2024年第3期45卷 93-98页

作者：赵婵媛惠州学院文学与传媒学院广东惠州516007

一般认为,宋代是中国传统题画诗发展的高峰,历来研究者众多,实际上唐代题画诗已多有创制。立足于唐代题画诗创作文本,着力于从题材、体裁两方面探讨唐人在唐诗繁荣基础上的题画诗开创之功,题材方面涉及山水、人物、花鸟、鞍马、鳞虫等... 详细信息

一般认为,宋代是中国传统题画诗发展的高峰,历来研究者众多,实际上唐代题画诗已多有创制。立足于唐代题画诗创作文本,着力于从题材、体裁两方面探讨唐人在唐诗繁荣基础上的题画诗开创之功,题材方面涉及山水、人物、花鸟、鞍马、鳞虫等诸多类别,体裁方面呈现四言、五绝、五律、七绝、七律、杂言、歌行、组诗等多种形式。宋人继承了唐人衣钵,范式大体无出其外。唐代题画诗为即将到来的宋代题画诗的繁荣奠定了重要基础,其成就值得进一步重视与探讨。

关键词：唐代题画诗题材体裁特征

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Learning of medical pharmacology via innovation:a personal experience at McMaster and in Asia

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Acta Pharmacologica Sinica 2004年第9期25卷 84-92页

作者： chiu-yin KWAN Canada Department of Medicine HSC-4N40 Faculty of Health Sciences Hamilton L8N 3Z5 McMaster University Ontario

Pharmacology in the traditional medical curriculum has been treated as a discrete "preclinical" discipline identifying itself distinctly different from the other preclinical sciences or clinical subjects in knowledge base as well as learning/teaching instructions. It is usually run in series with other pre-clinical courses (eg, anatomy, biochemistry, physiology etc), but in parallel with other paraclinical courses such as pathology, microbiology and community medicine. Clinical pharmacology was only introduced relatively recently designed to overcome the perceived deficiency in "preclinical" pharmacology regarding its therapeutic relevance and application to medicine. In many universities, both preclinical and clinical pharmacology courses co-exist, usually independently offered by two separate, sometimes non-interacting Departments of Pharmacology and Clinical Pharmacology. In this model, pharmacology is generally taught in a teacher-centered, discipline-oriented, and knowledge-based curriculum. Further

关键词： problem-based learning pharmacology medical education self-directed learning small group tutorial