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用杂交基因探针检测埃希氏大肠杆菌分离株的肠毒素,志…

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国外兽医学（畜禽传染病） 1995年第3期15卷 46-48页

作者： shin.,sj 谢占玲

用单克隆杂交技术检测了纽约州６６６头牛及５７头猪分离的埃希氏大肠杆菌的肠毒素（ＳＴａＰ，ＳＴｂ，ＬＴ，ＳＬＴ－１及ＳＬＴ－Ⅱ）和粘着素（Ｋ８８，Ｋ９９，Ｆ４１，９８７Ｐ）。有３６７株牛源分离株（４５．２％）至少能与一... 详细信息

用单克隆杂交技术检测了纽约州６６６头牛及５７头猪分离的埃希氏大肠杆菌的肠毒素（ＳＴａＰ，ＳＴｂ，ＬＴ，ＳＬＴ－１及ＳＬＴ－Ⅱ）和粘着素（Ｋ８８，Ｋ９９，Ｆ４１，９８７Ｐ）。有３６７株牛源分离株（４５．２％）至少能与一个基因探针杂交，其中２２３株（３３．２％）与Ｆ４１、１１２株（１６．７％）与Ｋ９９、８２株（１２．２％）与９８７Ｐ，９６株（１４．３％）与ＳＴａＰ，７株（１．１％）与ＳＴｂ杂交。

关键词：兽医埃希氏大肠杆菌肠毒素杂交基因探针检测

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肩袖修复术后肩峰下类固醇注射

中国康复 2017年第1期32卷 5-5页

作者： shin sj Do NH Lee J 何成奇四川大学华西医院

肩袖修复术后患者经常在出现严重的术后疼痛,控制患者在康复期间持续的疼痛方法的研究较少。本研究旨在确定肩胛下类固醇注射对肩袖修复术后疼痛控制的有效性和安全性。这项回顾性研究纳入了458例接受过关节镜下肩袖修复术且进行最少两... 详细信息

肩袖修复术后患者经常在出现严重的术后疼痛,控制患者在康复期间持续的疼痛方法的研究较少。本研究旨在确定肩胛下类固醇注射对肩袖修复术后疼痛控制的有效性和安全性。这项回顾性研究纳入了458例接受过关节镜下肩袖修复术且进行最少两年随访的患者。手术后,患者每天一次接受口服非甾体抗炎药,持续两周,并参与标准康复计划。用American Shoulder and Elbow Surgeons（ASES）评分和Constant评分评定肩关节功能。此外,术后采用VAS评分,并对患者满意度进行评价。

关键词：肩袖修复修复术后类固醇注射肩峰下术后疼痛控制 VAS评分术后患者

Repeated head trauma and thalamic volumes

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中华物理医学与康复杂志 2015年第8期37卷 630-630页

作者： Bernick C Banks sj shin W

BACKGROUND AND OBJECTIVE Previous studies of boxers have reported that the frequency and duration of fighting seems to be associated with cognitive or neurologic *** study included data from the Professional Fighters Brain Health Study(PFBHS),a longitudinal cohort of boxers and mixed martial arts fighters designed to understand the effects of repeated blows over *** Participants were at least 1 8 years of age and were licensed to fight professionally in either boxing or mixed martial arts.A

关键词：体积丘脑外伤头部持续时间神经系统脑健康拳击

Curcumin based combination therapy for anti-breast cancer： from in vitro drug screening to in vivo efficacy evaluation

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Frontiers of Chemical Science and Engineering 2016年第3期10卷 383-388页

作者： Sunhui Chen Qiuling Liang Shuping Xie Ergang Liu Zhili Yu Lu Sun Meong Cheol shin Seung Jin Lee Huining He Victor C. Yang Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics) School of Pharmacy Tianjin Medical University Tianjin 300070 China Collaborative Irmovation Center of Chemical Science and Chemical Engineering School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China College of Pharmacy and Research Institute of Pharmaceutical Sciences Gyeongsang National University Jinjudaero Jinju Gyeongnam 660-751 Republic of Korea Department of Pharmacy Ewha Womans University 11-1 Daehyun-dong Seodaemun-gu Seoul 120-750 Republic of Korea Department of Pharmaceutical Sciences College of Pharmacy University of Michigan Ann Arbor 48109-1065 MI USA Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science and Technology and College of Medicine or College of Pharmacy Seoul National University Seoul Republic of Korea

While drug resistance appears to be an inevitable problem of an increasing number of anticancer drugs in monotherapy, combination drug therapy has become a prosperous method to reduce the administered total drug dosages as well as overcome the drug resistance of carcinoma cells. Curcumin, considered to possess multi- faceted roles in cancer treatment according to its multiple anti-neoplastic mechanisms as a depressor of chemo- resistance, can significantly facilitate its anti-cancer functions and improve therapeutic effects via combination usage with a variety of other drugs with different reaction mechanisms. To explore this possibility, four anti-cancer chemotherapeutic agents that all possess a certain degree of drug resistance problems, including three tyrosine kinase inhibitors （erlotinib, sunitinib and sorafenib） that are acting on different cell pathways and a typical anticancer drug doxorubicin, were combined with curcumin individually to examine the synergistic anti-tumor effect both in vitro and in vivo. Results revealed that sunitinib combined with curcumin at the molar ratio of 0.46 yielded the most potent synergistic effect in vitro, and was therefore chosen for further animal evaluation. To further enhance the anti- cancer effect, bovine serum albumin （BSA） nanoparticles were utilized as a carrier to deliver the selected drug combination in situ. Preliminary in vivo findings confirmed our hypothesis of being able to maintain a similar injected drug ratio for prolonged time periods in tested animals by our approach, thereby maximizing the therapeutic potency yet minimizing the toxicity of these drugs. This work could open up a new avenue on combination drug therapy and realization the clinical utility of such drugs.

关键词： curcumin sunitinib synergistic effect bovine serum albumin (BSA) nano-carriers