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Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

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World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seungmee lee Yu-Ra Jeon Changmin shin Sun-Young Kwon Sojin shin Department of Obstetrics and Gynecology Keimyung University School of MedicineDaegu 42601South Korea Department of Pathology and Institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTRK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TRK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRK-fusion *** SUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK ***,subsequent next generation sequencing revealed no NTRK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTRK gene fusion lies in potential treatment with TRK inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report

Water hammer in the pump-rising pipeline system with an air chamber

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Journal of Hydrodynamics 2014年第6期26卷 960-964页

作者： KIM Sang-Gyun lee Kye-Bock KIM Kyung-yup Korea Water Resources Corporation School of Mechanical Engineering Chungbuk National University School of Mechanical Engineering Korea Polytechnic University

Water hammer following the tripping of pumps can lead to overpressure and negative pressure. Reduction in overpressure and negative pressure may be necessary to avoid failure, to improve the efficiency of operation and to avoid fatigue of system components. The field tests on the water hammer have been conducted on the pump rising pipeline system with an air chamber. The hydraulic transient was simulated using the method of characteristics. Minimizing the least squares problem representing the difference between the measured and predicted transient response in the system performs the calibration of the simulation program. Among the input variables used in the water hammer analysis, the polytropic exponent, the discharge coefficient and the wave speed were calibrated. The computer program developed in this study will be useful in designing the optimum parameters of an air chamber for the real pump pipeline system. The correct selection of air chamber size and the effect of the inner diameter of the orifice to minimize water hammer have been investigated by both field measurements and numerical modeling.

关键词： air chamber design parameter field test pump pipeline system water hammer

Effects of structure and electronic properties of D-π-A organic dyes on photovoltaic performance of dye-sensitized solar cells

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Journal of Energy Chemistry 2021年第3期30卷 208-216页

作者： Min-Woo lee Jae-yup Kim Hyung-Geun lee Hyun Gil Cha Duck-Hyung lee Min Jae Ko Bio-Based Chemistry Research Center Advanced Convergent Chemistry DivisionKorea Research Institute of Chemical Technology(KRICT)Ulsan 44429Republic of Korea Department of Chemical Engineering Dankook UniversityYongin 16890Republic of Korea Department of Chemistry Sogang UniversitySeoul 04107Republic of Korea Department of Chemical Engineering Hanyang UniversitySeoul 04763Republic of Korea Institute of Nano Science and Technology Hanyang UniversitySeoul 04763Republic of Korea

Herein,we examine the performance of dye-sensitized solar cells containing five D-π-A organic dyes designed by systematic modification of π-bridge size and geometric *** dye has a simple push-pull structure with a triarylamino group as an electron donor,bithiophene-4,4-dimethyl-4 H-cyclopenta 1,2-b:5,4-b’]dithiophene(M11),4,4-dimethyl-4 H-cyclopenta[1,2-b:5,4-b’]dithiophenethiophene(M12),thiophene-4,4-dimethyl-4 H-cyclopenta[1,2-b:5,4-b’]dithiophene(M13),4,4-dimethyl-4 H-cyclopenta[1,2-b:5,4-b’]dithiophene-benzene(M14),and 4,4-dimethyl-4 H-cyclopenta[1,2-b:5,4-b’]dithiophene(M15)units asπ-bridges,and cyanoacrylic acid as an electron acceptor/*** extension of theπ-bridge linkage favors wide-range absorption but,because of the concomitant molecular volume increase,hinders the efficient adsorption of dyes on the TiO_(2) film ***,higher loadings are achieved for smaller dye molecules,resulting in(i)a shift of the TiO_(2) conduction band edge to more negative values,(ii)a greater photocurrent,and(iii)suppressed charge recombination between the photoanode and the redox couple in the ***,under one-sun equivalent illumination(AM 1.5 G,100 mW/cm^(2)),the highest photovoltage,photocurrent,and conversion efficiency(η=7.19%)are observed for M15,which has the smallest molecular volume among M series dyes.

关键词： Dye-sensitized solar cells Donor-acceptor dyes Electron-rich unit Wide-range absorption Impedance spectroscopy

Revealing the influence of in-situ formed LiCl on garnet/Li interface for dendrite-free solid-state batteries

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Journal of Energy Chemistry 2024年第5期92卷 394-403页

作者： Seoyoon shin Jinuk lee Tae Ho shin Seokhee lee Hydrogen Energy Materials Center Korea Institute of Ceramic Engineering&TechnologyJinju-siGyeongsangnam-do 52851Republic of Korea Department of Materials Science and Engineering Yonsei UniversitySeoul 03722Republic of Korea

Inadequate interfacial contact between lithium and solid-state electrolytes(SSEs)leads to elevated impedance and the growth of lithium dendrites,presenting significant obstacles to the practical viability of solid-state batteries(SSBs).To ameliorate interfacial contact,optimizing the surface treatment of SSEs has been widely ***,the formation of LiCl through acid treatment,an equally crucial factor impacting SSB performance,has received limited attention,leaving its underlying mechanism *** study aims to shed light on SSE characteristics following LiCl formation and the removal of Li_(2)CO_(3) through acid *** seek to establish quantifiable links between SSE surface structure and SSB performance,focusing on interfacial resistance,current distribution,critical current density(CCD),and lithium *** formation of LiCl,occurring as Li_(2)CO_(3) is removed through acid treatment,effectively mitigates lithium dendrite formation on SSE *** action inhibits electron injection and reduces the diffusion rate of Li ***,acid treatment transforms the SSE surface into a lithiophilic state by eliminating surface Li_(2)CO_(3).Consequently,the interfacial resistance between lithium and SSEs substantially decreases from 487.67 to 35.99Ωcm^(2) at 25°*** leads to a notably high CCD of 1.3 mA cm^(-2) and a significantly extended cycle life of 1,000 ***,in full SSBs incorporating LiCoO_(2)cathodes and acid-treated garnet SSEs,we observe exceptional cyclability and rate *** findings highlight that acid treatment not only establishes a fundamental relationship between SSE surfaces and battery performance but also offers an effective strategy for addressing interfacial challenges in SSBs.

关键词： Solid-statebatteries Acidtreatment Interfacial stability LiCl Surface modification

Delayed-onset micrococcus luteus-induced postoperative endophthalmitis several months after cataract surgery:A case report

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World Journal of Clinical Cases 2023年第27期11卷 6592-6596页

作者： Ki-yup Nam Hong-Won lee Department of Ophthalmology Chungnam National UniversityCollege of MedicineDaejeon 35015South Korea Department of Ophthalmology Chungnam National University HospitalDaejeon 35015South Korea

BACKGROUND Micrococcus luteus(***)-induced endophthalmitis is very rare and and may present as either acute or chronic postoperative *** aim of this study was to report a case of delayed-onset ***-induced endophthalmitis that occurred several months after cataract *** SUMMARY A 78-year-old man presented with decreased vision,pain and redness in the right eye that had begun 3 days *** had undergone cataract surgery 4 mo *** acuity was counting fingers;slit-lamp examination revealed conjunctival injection,posterior corneal precipitates,anterior chamber inflammation(cell 4+),and *** examination revealed moderate vitreous *** vitrectomy was performed for suspected infectious endophthalmitis,followed by vitreous irrigation with injections of *** the postoperative day 1,anterior chamber cell decreased to 2+and hypopyon was not observed on slit lamp *** days postoperatively,the patient had recurrent eye pain,and the anterior chamber cell grade increased to 4+;hypopyon recurred in the anterior chamber,and whitish plaque was observed in the lens ***,the patient underwent intraocular lens(IOL)and lens capsule removal,followed by vitreous irrigation,antibiotics injection,and *** was identified from a lens capsule *** In cases of delayed-onset ***-induced endophthalmitis,early vitrectomy and removal of the IOL and lens capsule may be necessary.

关键词： Micrococcus luteus Chronic endophthalmitis Postoperative endophthalmitis Case report

CRISPy-web: An online resource to design sgRNAs for CRISPR applications

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Synthetic and Systems Biotechnology 2016年第2期1卷 118-121页

作者： Kai Blin Lasse Ebdrup Pedersen TilmannWeber Sang yup lee The Novo Nordisk Foundation Center for Biosustainability Technical University of DenmarkKogle Alle 62970 HosholmDenmark Metabolic and Biomolecular Engineering National Research Laboratory Department of Chemical and Biomolecular Engineering(BK21 Plus Program)Center for Systems and Synthetic BiotechnologyInstitute for the BioCenturyKorea Advanced Institute of Science and Technology(KAIST)Daejeon 305-701Republic of Korea

CRISPR/Cas9-based genome editing has been one of the major achievements of molecular biology,allowing the targeted engineering of a wide range of *** system originally evolved in prokaryotes as an adaptive immune system against bacteriophage *** now sees widespread application in genome engineering workflows,especially using the Streptococcus pyogenes endonuclease *** utilize Cas9,so-called single guide RNAs(sgRNAs)need to be designed for each target *** there are many tools available to design sgRNAs for the popular model organisms,only few tools that allow designing sgRNAs for non-model organisms ***,we present CRISPy-web(http://***/),an easy to use web tool based on CRISPy to design sgRNAs for any userprovided microbial ***-web allows researchers to interactively select a region of their genome of interest to scan for possible *** checks for potential off-target matches,the resulting sgRNA sequences are displayed graphically and can be exported to text *** steps and information are accessible from a web browser without the requirement to install and use command line scripts.

关键词： CRISPR Cas9 sgRNA Guide RNA Genome editing Genome engineering

Delayed-onset endophthalmitis associated with Achromobacter species developed in acute form several months after cataract surgery:Three case reports

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World Journal of Clinical Cases 2022年第19期10卷 6496-6500页

作者： Tae-Hoon Kim Sang-Joon lee Ki-yup Nam Department of Ophthalmology Kosin University HospitalBusan 49267South Korea Department of Ophthalmology Kosin UniversityCollege of MedicineBusan 49267South Korea Department of Ophthalmology Chungnam National UniveristyCollege of MedicineDaejeon 35015South Korea Department of Ophthalmology Chungnam National University Sejong HospitalSejong 30099South Korea

BACKGROUND Achromobacter species-associated endophthalmitis is rare and may present as either acute or chronic postoperative ***-onset Achromobacter species endophthalmitis appearing in acute presentation that develops more than several months after cataract surgery is very *** lens(IOL)removal is commonly recommended to treat Achromobacter species endophthalmitis,which is based on previous ***,we report the results of surgery without IOL removal when treating patients with delayed-onset postoperative Achromobacter species endophthalmitis that developed in an acute *** SUMMARY Three patients visited our ophthalmology clinic due to visual impairment that began 2-3 d *** had undergone cataract surgery 5-18 mo *** visual acuity of the diseased eye was between counting fingers at 30 cm to non-light *** showed conjunctival injection,inflammation in the anterior chamber(cell reaction 4+)and hypopyon *** patients were diagnosed with infectious endophthalmitis and immediately underwent pars plana vitrectomy,anterior chamber irrigation and intravitreal injection of ceftazidime and *** fluid infusion,a vitreous specimen was obtained. In all cases, the IOLs were not removed. Achromobacter species was detected on vitreousspecimen culture. After surgery, the vitreous opacity decreased gradually and there was littleretinal damage. At 1 mo after treatment, the best-corrected visual acuity had improved to 20/50and 20/*** onset postoperative endophthalmitis caused by Achromobacter species can appear in anacute form. All patients responded well to early vitrectomy and administration of empiricalantibiotics including ceftazidime. There was no need for IOL removal during surgery.

关键词： Achromobacter species Chronic endophthalmitis Postoperative endophthalmitis Case report

Delivery of nitric oxide-releasing silica nanoparticles for in vivo revascularization and functional recovery after acute peripheral nerve crush injury

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Neural Regeneration Research 2022年第9期17卷 2043-2049页

作者： Jung Il lee Ji Hun Park Yeong-Rim Kim Kihak Gwon Hae Won Hwang Gayoung Jung Joo-yup lee Jeong-Yun Sun Jong Woong Park Jae Ho shin Myoung-Ryul Ok Department of Orthopedic Surgery College of MedicineKorea UniversitySeoulRepublic of Korea Medical Sensor Biomaterial Research Institute Kwangwoon UniversitySeoulRepublic of Korea Center for Biomaterials Korea Institute of Science&TechnologySeoulRepublic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea Department of Orthopedic Surgery College of MedicineCatholic UniversitySeoulRepublic of Korea Department of Chemistry Kwangwoon UniversitySeoulRepublic of Korea

Nitric oxide(NO)has been shown to promote revascularization and nerve regeneration after peripheral nerve ***,in vivo application of NO remains challenging due to the lack of stable carrier materials capable of storing large amounts of NO molecules and releasing them on a clinically meaningful time ***,a silica nanoparticle system capable of reversible NO storage and release at a controlled and sustained rate was *** this study,NO-releasing silica nanoparticles(NO-SNs)were delivered to the peripheral nerves in rats after acute crush injury,mixed with natural hydrogel,to ensure the effective application of NO to the *** using a polymer dye and immunohistochemical staining for the detection of CD34(a marker for revascularization)results showed that NO-releasing silica nanoparticles increased revascularization at the crush site of the sciatic *** sciatic functional index revealed that there was a significant improvement in sciatic nerve function in NO-treated *** and anatomical analyses showed that the number of myelinated axons in the crushed sciatic nerve and wet muscle weight excised from NO-treated rats were ***,muscle function recovery was improved in rats treated with *** together,our results suggest that NO delivered to the injured sciatic nerve triggers enhanced revascularization at the lesion in the early phase after crushing injury,thereby promoting axonal regeneration and improving functional recovery.

关键词： crush injury nerve injury,nerve regeneration nitric oxide peripheral nerve revascularization silica nanoparticles

Properties of multilayer gallium and aluminum doped ZnO(GZO/AZO) transparent thin films deposited by pulsed laser deposition process

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 96-99页

作者： Jin-Hyun shin Dong-Kyun shin Hee-Young lee Jai-Yeoul lee Department of Materials Engineering Yeungnam University

Multilayer gallium and aluminum doped ZnO （GZO/AZO） films were fabricated by alternative deposition of Ga-doped zinc oxide（GZO） and Al-doped zinc oxide（AZO） thin film by using pulsed laser deposition（PLD） process. The electrical and optical properties of these GZO/AZO thin films were investigated and compared with those of GZO and AZO thin films. The GZO/AZO （1：1） thin film deposited at 400 ~C shows the electrical resistivity of 4.18 x 10 4 ~.cm, an electron concentration of 7.5 x 1020/cm3, and carrier mobility of 25.4 cm2/（V.s）. The optical transmittances of GZO/AZO thin films are over 85%. The optical band gap energy of GZO/AZO thin films linearly decreases with increasing the AI ratio.

关键词： multilayer thin films Ga-doped zinc oxide Al-doped zinc oxide pulsed laser deposition