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Development of an analytical method for multi-residue quantification of 18 anthelmintics in various animal-based food products using liquid chromatography-tandem mass spectrometry

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Journal of Pharmaceutical Analysis 2021年第1期11卷 68-76页

作者： Kyung-Hee Yoo Da-Hee Park A.M.Abd El-Aty Seong-Kwan Kim Hae-Ni Jung Da-Hye Jeong Hee-Jung Cho Ahmet Hacimuftuoglu Jae-Han Shim Ji Hoon Jeong Ho-Chul shin Department of Veterinary Pharmacology and Toxicology College of Veterinary MedicineKonkuk UniversitySeoul143-701Republic of Korea State Key Laboratory of Biobased Material and Green Papermaking College of Food Science and EngineeringQilu University of TechnologyShandong Academy of ScienceJinan250353China Department of Pharmacology Faculty of Veterinary MedicineCairo University12211GizaEgypt Department of Medical Pharmacology Medical FacultyAtaturk UniversityErzurum25240Turkey Department of Veterinary Physiology College of Veterinary MedicineKonkuk UniversitySeoul143-701Republic of Korea Natural Products Chemistry Laboratory College of Agriculture and Life SciencesChonnam National UniversityGwangju500-757Republic of Korea Department of Pharmacology College of MedicineChung-Ang UniversitySeoul156-756Republic of Korea

In this study,we developed a simple screening procedure for the determination of 18 anthelmintics(including benzimidazoles,macrocyclic lactones,salicylanilides,substituted phenols,tetrahydropyrimidines,and imidazothiazoles)in five animal-derived food matrices(chicken muscle,pork,beef,milk,and egg)using liquid chromatography-tandem mass *** were extracted using acetonitrile/1% acetic acid(milk and egg)and acetonitrile/1% acetic acid with 0.5 mL of distilled water(chicken muscle,pork,and beef),and purified using saturated n-hexane/acetonitrile.A reversed-phase analytical column and a mobile phase consisting of(A)10 mM ammonium formate in distilled water and(B)methanol were used to achieve optimal chromatographic ***-matched standard calibration curves(R^(2)≥0.9752)were obtained for concentration equivalent to ×1/2,×1,×2,×3,×4,and×5 fold the maximum residue limit(MRL)stipulated by the Korean Ministry of Food and Drug *** of 61.2e118.4%,with relative standard deviations(RSDs)of ≤19.9%(intraday and interday),were obtained for each sample at three spiking concentrations(×1/2,×1,and ×2 the MRL values).Limits of detection,limits of quantification,and matrix effects were 0.02e5.5 mg/kg,0.06e10 mg/kg,and -98.8 to 13.9%(at 20 μg/kg),*** five samples of each food matrix(chicken muscle,pork,beef,milk,and egg)purchased from large retailers in Seoul that were tested,none of the target analytes were *** has therefore been shown that this protocol is adaptable,accurate,and precise for the quantification of anthelmintic residues in foods of animal origin.

关键词： Anthelmintics Tandem mass spectrometry Animal-based food products Residue analysis Method validation

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Clinical significance of the leptin and leptin receptor expressions in prostate tissues

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Asian Journal of Andrology 2008年第6期10卷 923-928页

作者： Jung Hoon Kim shin Young Lee Soon Chul Myung Young Sun Kim Tae-Hyoung Kim Mi Kyung Kim Departments of Urology College of Medicine Chung-Ang University Seoul 140-757 Korea Departments of Pathology College of Medicine Chung-Ang University Seoul 140-757 Korea

Aim： To evaluate the expression of leptin and leptin receptor in benign prostatic hyperplasia （BPH） and prostate cancer （PCa）, and to investigate whether they are associated with the development and progression of PCa. Methods： hnmunohistochemical staining was performed to examine the expression of leptin and leptin receptor in BPH and PCa. PCa was divided into three groups： localized PCa, locally advanced PCa and metastatic PCa. The positive staining was identified and the percentage of the positive staining was graded. We also assessed the relationship between both the Gleason score and body mass index （BMI） and PCa. Results： The percentage of the leptin expression in PCa was significantly higher than that in BPH （P 〈 0.01）. For the PCa group, the expressed levels of leptin showed a considerable correlation with localized PCa and metastatic PCa （P 〈 0.05）. Leptin receptor, however, did not reveal a definite difference between BPH and PCa. The expression of leptin indicated a significant difference between well-differentiated PCa （Gleason score ≤6） and poorly differentiated PCa （Gleason score 8-10）（P 〈 0.05）. The relation between the leptin expression level in PCa and the BMI was not remarkable （P = 0.447）. Conclusion： Our results suggest that leptin might have a promoting effect on the carcinogenesis and progression of PCa.

关键词： leptin leptin receptor prostatic neoplasms

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IL-1β activates p44/42 and p38 mitogen-activated protein kinases via different pathways in cat esophageal smooth muscle cells

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World Journal of Gastroenterology 2006年第5期12卷 716-722页

作者： Tai Sang Lee Hyun Ju Song Ji Hoon Jeong Young Sil Min Chang Yell shin Uy Dong Sohn Department of Pharmacology College of PharmacyChung-Ang UniversitySeoul 156-756Republic of Korea Research Laboratory Dong-A Pharmaceuticals Co.LtdKyunggidoRepublic of Korea

AIM： To examine the pathway related to the IL-1β induced activation of mitogen-activated protein （MAP） kinases in cat esophageal smooth muscle cells. METHODS： Culture of the esophageal smooth muscle cells from cat was prepared. Specific inhibitors were treated before applying the IL-β3. Western blot analysis was performed to detect the expressions of COX, iNOS and MAP kinases. RESULTS： In the primary cultured cells, although IL-β3 failed to upregulate the COX and iNOS levels, the levels of the phosphorylated forms of 1344142 HAP kinase and p38 MAP kinase increased in both concentration- and time-dependent manner, of which the level of activation reached a maximum within 3 and 18 h, respectively. The pertussis toxin reduced the level of p44/42 MAP kinase phosphorylation. Tyrphostin 51 and genistein also inhibited this activation. Neomycin decreased the density of the p44/42 HAP kinase band to the basal level. Phosphokinase C （PKC） was found to play a mediating role in the IL-1β-induced p44/42 MAP kinase activity. In contrast, the activation of p38 MAP kinase was inhibited only by a pretreatment with forskolin, and was unaffected by the other compounds. CONCLUSION： Based on these results, IL-1β-induced p44/42 MAP kinase activation is mediated by the Gi protein, tyrosine kinase, phospholipase C （PLC） and PKC. The pathway for p38 MAP kinase phosphorylation is different from that of p44/42 MAP kinase, suggesting that it plays a different role in the cellular response to IL- 1β.

关键词： IL-1β MAP kinase Esophageal smoothmuscle cells

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Real-world outcomes of ibrutinib therapy in Korean patients with relapsed or refractory mantle cell lymphoma:amulticenter,retrospective analysis

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Cancer Communications 2021年第3期41卷 275-278页

作者： Jun Ho Yi Seok Jin Kim Dok Hyun Yoon Cheolwon Suh Myung Hee Chang Deok Hwan Yang Jae-Cheol Jo shin Young Hyun Hyeon-Seok Eom Jeong-Ok Lee Ji Hyun Kwon Sang Hoon Han Seung-shin Lee Jae-Yong Kwak Se Hyung Kim Dae Sik Kim Ji Hyun Lee Sung Yong Oh Hun Mo Ryoo Hyo Jung Kim Won Seog Kim Division of Hematology-Oncology Department of MedicineChung-Ang UniversityDongjak-guSeoul 06973Korea Division of Hematology and Oncology Department of MedicineSamsung Medical Center Sungkyunkwan University School of MedicineGangnam-guSeoul 06351Korea Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSongpa-guSeoul 05505Korea National Health Insurance Corporation Ilsan Hospital Ilsandong-guGoyang 10444Korea Department of Hemato-Oncology Chonnam National University Hwasun HospitalChonnam National University Medical SchoolHwasunGwangju 58128Korea Department of Hematology and Oncology Ulsan University HospitalUniversity of Ulsan College of MedicineDong-guUlsan 44033Korea Department of Internal Medicine Yonsei University Wonju College of MedicineGangwon-DoWonju 26426Korea Department of Internal Medicine National Cancer CenterGoyang-si Gyeonggi-doGoyang 10408Korea Department of Internal Medicine Seoul National University Bundang HospitalBundang-guSeongnam 13620Korea Department of Internal Medicine ChungBuk National University HospitalChungbukCheongju 28644Korea Department of Internal Medicine Jeju National University HospitalJeju National University School of MedicineJeju 63241Korea Department of Hematology-Oncology Wonkwang University HospitalIksan-daeroIksan 54538Korea Department of Internal Medicine Jeonbuk National University Medical SchoolJeollabuk-doJeonju 54907Korea Division of Hematology-Oncology Department of Internal MedicineSoonchunhyang University College of MedicineBucheon HospitalWonmi-guBucheon 14584Korea Division of Hematology-Oncology Department of Internal MedicineKorea University Guro HospitalGuro-guSeoul 08308Korea Division of Hematology-Oncology Department of Internal MedicineDong-A University College of MedicineSeo-guBusan 49201Korea Department of Internal Medicine Division of Hematology-Oncology Catholic University of DaeguDaegu 42472Korea Division of Hematology-Oncology Department of Internal MedicineHallym U

Dear Editor,Despite the introduction of novel front-line therapies including rituximab plus high-dose cytarabine followed by consolidative autologous stem cell transplantation(ASCT)and salvage therapy with bendamustine,lenalidomide or bortezomib,mantle cell lymphoma(MCL)is still considered incurable and most patients experience relapse or refractory(RR)disease.

关键词： patients relapse lymphoma

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The effects ofα-defensin 1 on the contraction and relaxation of rat bladder

The effects ofα-defensin 1 on the contraction and relaxatio...

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第十七届全国泌尿外科学术会议

作者： Tae-Hyoung Kim shin Young Lee Soon-Chul Myung Bongsuk Shim Department of Urology Chung-Ang University HospitalSeoulKorea Department of Urology Ewha Womans University School of MedicineSeoulKorea

Introduction Defensins,cysteine-rich cationic polypeptides released from neutrophils,have powerful antimicrobial *** have been recently shown to affect the contractility of smooth *** the present study,we investigated...

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Transanal excision of a malignant fibrous histiocytoma of anal canal:A case report and literature review

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World Journal of Gastroenterology 2008年第9期14卷 1459-1462页

作者： Beom Gyu Kim In Taik Chang Jun Seok Park Yoo shin Choi Gi Hyeon Kim Eon Sub Park Chang Hwan Choi Department of Surgery College of MedicineChung-Ang University Seoul 156-755Korea Department of Radiology College of MedicineChung-Ang University Seoul 156-755Korea Department of Pathology College of MedicineChung-Ang University Seoul 156-755 Korea Department of Internal Medicine College of Medicine Chung-Ang UniversitySeoul 156-755Korea

Malignant fibrous histiocytoma, which is composed of spindle-shaped cells arranged in a pleomorphic and storiform pattern, is rarely found in the colorectum. Although complete surgical excision remains the main stem of therapy, an optimal treatment strategy according to the stage has not been elucidated. We report a case of a 63-year-old woman with an ulcerative lesion in the anorectal junction and a final diagnosis of malignant fibrous histiocytoma. We introduced an access for transanal local excision and adjuvant radiotherapy because the patient refused abdominoperineal resection. No local recurrences or distant metastases were observed 15 mo after the operation. To our knowledge, this is the first case reported in the English literature of a malignant fibrous histiocytoma treated with the transana local excision and adjuvant radiotherapy. This report showed that this approach is selectively reserved for early-stage malignant fibrous histiocytoma and for those patients who refuse radical surgery because of the risk in a permanent colostomy.

关键词： Malignant fibrous histiocytoma Anorectal junction Transanal local excision

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Retrospective analysis of extra-gastrointestinal stromal tumors

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World Journal of Gastroenterology 2015年第6期21卷 1845-1850页

作者： Jun Ho Yi Byeong-Bae Park Jung Hun Kang In Gyu Hwang Dong Bok shin Sun Jin Sym Hee Kyung Ahn Soon Il Lee Do Hyoung Lim Keon Woo Park Young-Woong Won Sung Hee Lim Se Hoon Park Division of Hematology-Oncology Department of Internal Medicine Hanyang University Seoul Hospital Division of Hematology-Oncology Department of Internal Medicine Gyeongsang National University School of Medicine Division of Hematology-Oncology Department of Internal Medicine Chung-Ang University Hospital ChungAng University College of Medicine Division of Hematology-Oncology Department of Internal MedicineGachon University Gil Hospital Department of Hematology-Oncology Dankook University School of Medicine Division of Hematology and Oncology Department of Internal Medicine Hanyang University Guri Hospital Hanyang University College of Medicine Division of HematologyOncology Department of Medicine Sungkyunkwan University Samsung Medical Center Cancer hospital

AIM:To investigate the clinicopathologic features of patients with extra-gastrointestinal stromal tumors(EGISTs)in South ***:A total of 51 patients with an EGIST were *** clinicopathologic features,including sex,age,location,tumor size,histology,mitotic rate,immunohistochemical features,genetic status and survival data,were ***:The median age was 55 years(range:29-80years),and male:female ratio was 1:*** most common site was in the mesentery(n=15)followed by the retroperitoneum(n=13)and omentum(n=8).The median tumor size was 9.0 cm(range:2.6-30.0cm)and the median mitotic rate was 5.0/50HPF.(1/50-185/50).KIT was analyzed in 16,which revealed 10cases with wild-type KIT and 6 cases with an exon *** 51 patients,31 patients had undergone surgery,and 10 had unresectable disease and had taken palliative imatinib,which resulted in 22.7 mo of progression-free *** the patients who had undergone surgery,18 did not take adjuvant imatinib,and 8 of these were categorized as"high risk"according to the risk ***,the relapse-free survival was not different(P=0.157)between two ***:Because the biologic behaviors of GISTs differ according to the location of the tumor,a more stratified strategy is required for managing EGISTs including incorporation of molecular features.

关键词： Gastrointestinal stromal tumor Survival Imatinib R

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Comparison of Depth Dose Distributions Using Cerenkov Fiber-Optic Dosimeter and Monte Carlo Simulation for HDR Brachytherapy

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Journal of Applied Mathematics and Physics 2016年第8期4卷 1499-1502页

作者： Sang Hun shin Young Beom Song Mingeon Kim Hye Jin Kim Wook Jae Yoo Kyoung Won Jang Bongsoo Lee School of Biomedical Engineering BK21 Plus Research Institute of Biomedical Engineering Konkuk University Chungju-si Korea School of Energy Systems Engineering Chung-Ang University Seoul Korea

In this study, we fabricated a Cerenkov fiber-optic dosimeter (CFOD) without any scintillator to measure Cerenkov radiation signals owing to gamma-rays. The relative depth dose (RDD) distributions of Ir-192 HDR brachytherapy source were obtained by using the CFOD based on a subtraction method and the RDD curve was compared with the simulation result of Monte Carlo N-particle extended transport code (MCNPX). Finally, we demonstrated that the CFOD can be used to measure real-time dose information for HDR brachytherapy.

关键词： Cerenkov Fiber-Optic Dosimeter Cerenkov Radiation Gamma-Ray Relative Depth Dose HDR Brachytherapy

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叙事技术在交互媒体中的应用

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设计 2005年第5期21卷 80-81页

作者： Kwang-Pil Ko Yong-tae shin Graduate School of Chung-ang Univ Graduate School of Advanced Imaging Science Multimedia ＆ Film Chung-Ang Univ

各种形式的互动媒体逐渐取代鼠标、键盘等输入设备。从这方面来讲，这个研究主要的目的是叙事技术的可用性，这种技术将是一种有效的信息交流工具，可以解决很多问题，例如利用互动媒体“如何是信息更好地在消费者和生产者间进行交流”... 详细信息

各种形式的互动媒体逐渐取代鼠标、键盘等输入设备。从这方面来讲，这个研究主要的目的是叙事技术的可用性，这种技术将是一种有效的信息交流工具，可以解决很多问题，例如利用互动媒体“如何是信息更好地在消费者和生产者间进行交流”。是一种新的交流媒体。

关键词：流媒体技术应用交互信息交流输入设备可用性生产者消费者

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Brassiere wearing and breast cancer risk:A systematic review and meta-analysis

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World Journal of Meta-Analysis 2015年第4期3卷 193-205页

作者： Winnie KW So Dorothy NS Chan Yan Lou Kai-Chow Choi Carmen WH Chan Kristina shin Ava Kwong Diana TF Lee The Nethersole School of Nursing The Chinese University of Hong KongNew Territories Nursing Department School of MedicineHangzhou Normal University Institute of Textiles and Clothing the Hong Kong Polytechnic University Breast Surgery Division Department of SurgeryQueen Mary Hospital

AIM： To evaluate existing evidence for the association between different type of brassiere exposures and the risk of breast ***： Ovid Medline, CINAHL, Cochrane Data Base of Systematic Reviews, Pubmed, Scopus, Proquest, Sciencedirect, Wiley Online Library, WanFang Data, Hong Kong Index to Chinese Periodicals, China Journal Net, Chinese Medical Current Contents, Chinese Biomedical Literature Database, China Academic Journals Full-Text database, Taiwan Electronic Periodical Services and HyRead; reference lists of published studies; origi-nal research studies published in English or Chinese examining the association between type and duration of brassiere-wearing and breast cancer risk. Data were abstracted by a frst reviewer and verifed by a second. Study quality was rated according to predefned criteria. “Fair” or “good” quality studies were included. Results were summarised by meta-analysis whenever adequate material was ***： Twelve case-control studies were included in the review. Meta-analysis showed brassiere wearing during sleep was associated with a two times ofincreased odds. CONCLUSION： The present review demonstrates insuffcient evidence to establish a positive association between the duration and type of brassiere wearing and breast cancer. Further research is essential; specifcally, a large-scale epidemiological study of a better design is needed to examine the association between various forms of brassiere exposure in detail and breast cancer risk, with adequate control of confounding variables.

关键词： Breast cancer Brassiere Risk factors Systematic review Meta-analysis

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