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中国药理学会第八次全国代表大会暨全国药理学术会议

作者： Liu Edgar Shiu-Lam shin vivian-yvonne CHO Chi-Hin Department of Pharmacology The University of Hong Kong Hong Kong China

AIM: 5-lipoxygenase (5-LOX) is an enzyme that converts arachidonic acid to 5-s-HETE, andseveral studies have suggested a link between 5-s-HETE formation and carcinogenesis in variousorgans. Our previous study shows that passive cigarette smoking promotedinflammation-associated adenoma formation in colon. The purpose of the present study was toinvestigate the possible involvement of 5-LOX in the tumorigenesis enhanced by cigarette ***: In vivo study, male balb/c mice were allocated into 4 groups: control, cigarettesmoke (CS), dextran sulfate sodium (DSS) and DSS+CS. They were given water or 3% DSS indrinking water for 7 days to induce colitis, with or without 1-hour daily exposure to 2% CS. They

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New actions for nicotine in the gastrointestinal tract

New actions for nicotine in the gastrointestinal tract

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中国药理学会第八次全国代表大会

作者：曹之宪 shin vivian - yvonne YE Grace Yi - Ni LIU Edgar Shiu - Lam Department of Pharmacology The University of Hong Kong Hong Kong China

AIM:Previous studies showed that cigarette smoking was associated with gastric *** is one of-the most representative compounds in cigarette smoke, which has long been considered to exhibit many of the tobacco effects including those in the gastrointestinal *** study reports the new actions of nicotine on wound repair and also on the tumorigenesis in the gastrointestinal tract,which could have signifcant clinical implications in ***:*** of cell

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Involvement of polyamine in the delay of wound healing induced by cigarette smoke

Involvement of polyamine in the delay of wound healing induc...

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中国药理学会第八次全国代表大会

作者： shin vivian - yvonne LIU Edgar Shiu - Lam KOO Marcel Wing - Leung CHO Chi - Hin Department of Pharmacology The University of Hong Kong Hong Kong China

AIM: Strong association of cigarette smoking and peptic ulcer diseases has been well established. However, the mechanistic adverse action of cigarette smoke on wound healing is still unclear. Cell proliferation and cell migration are important factors for maintaining the gastrointestinal integrity during wound repair. Ornithine decarboxylase (ODC), a rate-limiting enzyme for polyamine biosynthesis, is crucial for cell growth and differentiation. This study was designed to delineate the involvement of polyamines on the delay of wound healing induced by cigarette smoke. METHODS: Cigarette smoke extracts (CSE) were prepared from the burning cigarettes, and differentiated into chloroform extract (CE) and

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The role of 5 -lipoxygenase in the tumorigenesis promoted by cigarette smoke

The role of 5 -lipoxygenase in the tumorigenesis promoted by...

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第六届全国药理学教学学术会议

作者： YE Yi - Ni, Liu Edgar Shiu - Lam, shin vivian - yvonne, CHO Chi - Hin Department of Pharmacology, The University of Hong Kong, Hong Kong, China

AIM: 5-lipoxygenase (5-LOX) is an enzyme that converts arachidonic acid to 5-s-HETE, and several studies have suggested a link between 5 - s - HETE formation and carcinogenesis in various organ. Our previous study shows that passive cigarettesmoking promoted inflammation - associated adenoma formation in colon. The purpose of the present study was to investigate the possible involvement of 5 - LOX in the tumorigenesis enhanced by cigarette smoke. METHODS: In vivo study, male balb/c mice were allocated into 4 groups: control, cigarette smoke (CS), dextran sulfate sodium (DSS)

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MiRNA as potential biomarkers and therapeutic targets for gastric cancer

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World Journal of Gastroenterology 2014年第30期20卷 10432-10439页

作者： vivian yvonne shin Kent-Man Chu Department of Surgery The University of Hong KongQueen Mary Hospital

Gastric cancer is one of the leading causes of cancer mortality in the world. Aberrant expression of microRNAs (miRNAs) is the hallmark of this disease. MiRNAs are endogenous non-coding RNAs that are involved in many biological processes (e.g., cell proliferation, differentiation, apoptosis, invasion and development) through gene repression. Deregulation of miRNA expression in gastric tumors and cancer cell lines have been documented to contribute in tumorigenesis, and the expression signature may correlate with different cancer types and clinicopathological features. Here, we summarized the updated gastric cancer-associated miRNAs and the downstream targets in the process of tumorigenesis. Recently, many researchers make use of the miRNA microarray platform to profile miRNA expression in gastric cancer and correlated with different clinical parameters. Its application on cancer diagnosis, prognosis and predicting treatment response rate are still underway and needs further investigation. Emerging roles of miRNAs with oncogenic or tumor suppressive properties in gastric tumorigenesis were discussed. Epigenetic silencing of miRNA by hypermethylation of promoter CpG island was also observed in gastric cancer. However, detailed mechanisms of how miRNAs regulate gene expression in gastric cancer has not been well studied. In this review, we highlight the up-to-date findings on the deregulated miRNAs in gastric cancer, and the potential use of miRNA in the clinical settings, such as diagnostic/prognostic markers and chemotherapeutic tools.

关键词： MicroRNA Gastric cancer Biomarker Diagnosis Prognosis Clinical application

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沐浴阳光肌肤依然白皙无瑕

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国际服装动态 2006年第7期 110-112页

作者： vivian

清洁皮肤去油脂夏季,皮脂腺与汗腺的分泌大大增加,因此,夏季皮肤的保养重在清洁。每天早晚两次的皮肤清洁,可使皮肤保持清新。如果在旅行结束后,再进行一次彻底的大清洗,那么,皮肤会格外清爽宜人。

关键词：防晒清爽宜人大清洗精华油晒伤彩妆孔宜修护防御机能于洁

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