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Improving Method of Anomaly Detection Performance for Industrial IoT Environment

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Computers, Materials & Continua 2022年第9期72卷 5377-5394页

作者： Junwon Kim Jiho shin Ki-Woong Park Jung Taek Seo Department of Information Security Engineering Gachon UniversitySeongnam13120Korea Police Science Institute Korea National Police UniversityAsan31539Korea SysCore Lab. Sejong UniversitySeoul05006Korea Department of Computer Engineering Gachon UniversitySeongnam13120Korea

Industrial Control System(ICS),which is based on Industrial IoT(IIoT),has an intelligent mobile environment that supports various mobility,but there is a limit to relying only on the physical security of the ICS *** to various threat factors that can disrupt the workflow of the IIoT,machine learning-based anomaly detection technologies are being presented;it is also essential to study for increasing detection performance to minimize model errors for promoting stable ICS *** this paper,we established the requirements for improving the anomaly detection performance in the IIoT-based ICS environment by analyzing the related *** that,we presented an improving method of the performance of a machine learning model specialized for IIoT-based ICS,which increases the detection rate by applying correlation coefficients and clustering;it provides a mechanism to predict thresholds on a ***,we adopted the HAI dataset environment that actively reflected the characteristics of IIoT-based ICS and demonstrated that performance could be improved through comparative experiments with the traditional method and our proposed *** presented method can further improve the performance of commonly applied error-based detection techniques and includes a primary method that can be enhanced over existing detection techniques by analyzing correlation coefficients between features to consider feedback between ICS *** can contribute to improving the performance of several detection models applied in ICS and other areas.

关键词： Industrial IoT industrial control system anomaly detection clustering algorithm correlation coefficient

A Blockchain-Based Trust Model for Supporting Collaborative Healthcare Data Management

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Computer Systems Science & Engineering 2023年第9期46卷 3403-3421页

作者： Jiwon Jeon Junho Kim Mincheol shin Mucheol Kim Department of Computer Science and Engineering Chung-Ang UniversitySeoul06911Korea

The development of information technology allows the collaborative business process to be run across multiple enterprises in a larger market ***,while collaborative business expands the realm of businesses,it also causes various hazards in collaborative Interaction,such as data falsification,inconstancy,*** solve these issues,a blockchainbased collaborative business modeling approach was proposed and ***,the existing studies lack the blockchain risk problem-solving specification,and there is no verification technique to examine the ***,it is difficult to confirm the appropriateness of the ***,here,we propose and build a blockchain-based trust model to strengthen and verify the integrity and security of the collaborative business process;Integrity and security address the validity of collaborative interactions in terms of a trust,and we construct a blockchain pattern based on trust elements to meet the required the ***,a trust model can be applied to the healthcare data-sharing process,and then the achievement of the trustbased safe data-sharing process can be *** model can be used as a trust-building guidance tool or for integrity and security verification with the collaborative business process in a distributed environment with blockchain.

关键词： Blockchain business process trustmodel healthcare data-sharing data science

Corticosteroid-induced bradycardia in multiple sclerosis and maturity-onset diabetes of the young due to hepatocyte nuclear factor 4-alpha mutation:A case report

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World Journal of Clinical Cases 2022年第21期10卷 7415-7421页

作者： Sung-Yeon Sohn shin Yeop Kim In Soo Joo Department of Neurology Ajou University School of MedicineAjou University Medical CenterSuwon 16499South Korea

BACKGROUND Intravenous steroid pulse therapy is the treatment of choice for acute exacerbation of multiple sclerosis(MS).Although steroid administration is generally welltolerated,cases of cardiac arrhythmia have been ***,we describe a young woman who developed marked sinus bradycardia and T-wave abnormalities after corticosteroid *** also present plausible explanations for the abnormalities observed in this *** SUMMARY An 18-year-old woman experienced vertiginous dizziness and binocular diplopia 1 wk prior to *** examination revealed left internuclear ophthalmoplegia with left peripheral-type facial *** initial laboratory results were consistent with those of type 2 *** magnetic resonance imaging revealed multifocal,non-enhancing,symptomatic lesions and multiple enhancing *** was diagnosed with MS and maturity-onset diabetes of the *** methylprednisolone was *** day 5 after methylprednisolone infusion,marked bradycardia with T-wave abnormalities were *** evaluation to elucidate the underlying conditions revealed a hepatocyte nuclear factor 4-alpha(HNF4A)gene *** treatment was discontinued under suspicion of corticosteroid-induced *** electrocardiogram changes returned to normal without complications two days after steroid *** Corticosteroid-induced bradycardia may have a significant clinical impact,especially in patients with comorbidities,such as HNF4A mutations.

关键词： Steroids Bradycardia Multiple sclerosis Maturity-onset diabetes of the young Hepatocyte nuclear factor 4-alpha Case report

Flexoelectric-effect-based light waveguide liquid crystal display for transparent display

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Photonics Research 2022年第2期10卷 407-414页

作者： Yunho shin Yingfei Jiang Qian Wang Ziyuan Zhou Guangkui Qin Deng-Ke Yang Materials Science Program Advanced Materials and Liquid Crystal InstituteKent State UniversityKentOhio 44242USA BOE Technology Group Co. BeijingChina Department of Physics Kent State UniversityKentOhio 44242USA

We report a light waveguide liquid crystal display(LCD) based on the flexoelectric effect. The display consists of two parallel flat substrates with a layer of flexoelectric liquid crystal sandwiched between them. A light-emitting diode(LED) is installed on the edge of the display and the produced light is coupled into the display. When no voltage is applied, the liquid crystal is uniformly aligned and is transparent. The incident light propagates through the display by total internal reflection at the interface between the substrate and air, and no light comes out of the viewing side of the display. The display appears transparent. When a voltage is applied, the liquid crystal is switched to a micrometer-sized polydomain state due to flexoelectric interaction and becomes scattering. The incident light is deflected from the waveguide mode and comes out of the viewing side of the display. We achieved thin-film-transistor active matrix compatible driving voltage by doping liquid crystal dimers with large flexoelectric coefficients. The light waveguide LCD does not use polarizers as in conventional LCDs. It has an ultrahigh transmittance near 90% in the voltage-off state. It is very suitable for transparent display, which can be used for head-up display and augmented reality display.

关键词： waveguide switched transparent

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A unique and well-designed 2D graphitic carbon nitride with sponge-like architecture for enhanced visible-light photocatalytic activity

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Journal of Materials Science & Technology 2023年第28期159卷 99-111页

作者： Mahdieh Razi Asrami Milad Jourshabani Min Hee Park Daiha shin Byeong-Kyu Lee Department of Civil and Environment Engineering University of UlsanDaehakro 93NamguUlsan 680-749Republic of Korea Western Seoul Center Korea Basic Science InstituteSeoul 03759Republic of Korea

A unique and well-designed 2D graphitic carbon nitride(g-CN)with sponge-like architecture has been successfully synthesized by engineering supramolecular self-assembly and well-organized SiO 2 *** resulting material showed great optical and textural characteristics with plenty of open and uni-form pores,which are very helpful whether for multiple light scattering or mass *** formation of boosted delocalizedπ-conjugated electrons at the molecular level and condensed heptazine building blocks result in enhanced carrier density and charge transfer *** emission spectroscopy and time-resolved fluorescence lifetime(TRPL)strongly confirmed the enhancement of light harvesting and prolonged charge carrier *** optimized sample exhibited a degradation performance of 95%of bisphenol A(BPA,10 mg L-1)after 60 min under visible-light irradiation at pH=*** the scavenging experiments,probing experiments as well as electron paramagnetic resonance(EPR)confirm that•O 2-is the dominant reactive species that fragments bisphenol ***,density functional theory(DFT)calculations unveil that the BPA interaction with a modified g-CN containing porous structure is energeti-cally more favorable than non-porous pure ***,the toxicity assessment showed that the final degradation products were placed in the non-harmful category based on acute and chronic *** study presents a promising strategy to modify the g-CN properties and provides an efficient technique for boosting its visible-light photocatalytic activity.

关键词： Sponge-like Carbon nitride Photocatalysis Visible-light

A new flame-retardant polymer electrolyte with enhanced Li-ion conductivity for safe lithium-sulfur batteries

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Journal of Energy Chemistry 2022年第2期31卷 616-622页

作者： Hongping Li Yixi Kuai Jun Yang shin-ichi Hirano Yanna Nuli Jiulin Wang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Hirano Institute for Materials Innovation Shanghai Jiao Tong UniversityShanghai 200240China c College of Chemistry Zhengzhou UniversityZhengzhou 450001HenanChina

Flame-retardant polymer electrolytes(FRSPEs)are attractive due to their potential for fundamentally settling the safety issues of liquid ***,the current FRSPEs have introduced large quantity of flame-retardant composition which cannot conduct lithium ions,thus decreasing the Li-ion ***,we synthesize a novel liquid monomer 2-((bis((2-oxo-1,3-dioxolan-4-yl)methoxy)phosphoryl)oxy)ethyl acrylate(BDPA)for preparing FRSPE by in-situ polymerization,in which PBDPA polymer can not only conduct lithium ions,but also prevent *** prepared FRSPE demonstrated outstanding flame-retardant property,favorable lithium-ion conductivity of 5.65×10^(-4) S cm^(-1) at ambient temperature,and a wide electrochemical window up to 4.5 ***,the Li/in-situ FRSPE/S@pPAN cell exhibited favorable electrochemical *** believe that this work provides an effective strategy for establishing high-performance fireproof quasi-solid-state battery system.

关键词： Polymer electrolyte Flame-retardance Lithium-ion conductivity Lithium-sulfur battery

维普期刊数据库

Nusinersen for spinal muscular atrophy types Ⅱ and Ⅲ:a retrospective single-center study in South Korea

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World Journal of Pediatrics 2023年第5期19卷 450-459页

作者： Hui Jin shin Ji-Hoon Na Hyunjoo Lee Young-Mock Lee Department of Pediatrics Gangnam Severance HospitalYonsei University College of Medicine211 Eonju-RoGangnam-GuSeoul135-720Korea

Background This study investigated the efficacy and safety of nusinersen,an antisense oligonucleotide,in patients with spinal muscular atrophy(SMA)types II(OMIM:253,550)or III(OMIM:253,400),including those with severe scoliosis or requiring respiratory support via mechanical *** Data from 40 patients with genetically confirmed SMA who were treated with nusinersen at our institute from March 2019 to April 2022 were retrospectively *** these,30 patients with an age of onset<3 years and not on permanent ventilation were *** and genetic characteristics were investigated,and motor function was evaluated based on the Hammersmith Functional Motor Scale-Expanded(HFMSE)*** The mean age of symptom onset was 1.2 *** patients were diagnosed with SMA type II(27/30,90%).Nusinersen was administered via computed tomography-guided or direct intrathecal injection in 87%(26/30)and 13%(4/30)of the patients,*** the 6-,14-,22-,and 26-month follow-ups,72%,71%,88%,and 86%of patients showed motor improvement,respectively,with mean changes in HFMSE scores of 2.10,2.88,4.21,and 5.29,*** analysis showed that the use of noninvasive ventilation was associated with poorer outcomes of motor *** Patients with SMA type II or III who received nusinersen treatment showed significant improvement in motor function.A longer treatment duration led to a higher number of patients with improved motor *** significant side effects of nusinersen were *** with SMA,even those with severe scoliosis or on respiratory support,can be safely treated using nusinersen.

关键词： Hammersmith Functional Motor Scale Expanded Motor function Nusinersen South Korea Spinal muscular atrophy

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COEDA咖啡厅

城市环境设计 2024年第1期147卷 162-167页

作者：大庭晋小松克仁川澄·小林研二写真事务所

我们随机堆叠8厘米正方形的桧木棒，制作了一个巨大的树状结构。用碳纤维棒加固（抗拉强度是铁的7倍），就有了一个带有巨大枝杈的“树干”，同时能保证在地震期间减少晃动。项目用地位于可以俯瞰太平洋的悬崖上，通过利用树木状的外观...

我们随机堆叠8厘米正方形的桧木棒，制作了一个巨大的树状结构。用碳纤维棒加固（抗拉强度是铁的7倍），就有了一个带有巨大枝杈的“树干”，同时能保证在地震期间减少晃动。项目用地位于可以俯瞰太平洋的悬崖上，通过利用树木状的外观造型，可以避免使用遮挡景观的外围柱子。

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Pyrimidine nucleotide starvation induces a decrease in the number of effector T cells but not memory T cells

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Cellular & Molecular Immunology 2023年第8期20卷 859-860页

作者： Gwanghun Kim Hyun Mu shin Hang-Rae Kim Department of Biomedical Sciences Seoul National University College of MedicineSeoul03080Republic of Korea Department of Anatomy&Cell Biology Seoul National University College of MedicineSeoul03080Republic of Korea BK21 FOUR Biomedical Science Project Department of Anatomy&Cell BiologySeoul National University College of MedicineSeoul03080Republic of Korea Medical Research Institute Seoul National University College of MedicineSeoul03080Republic of Korea Wide River Institute of Immunology Seoul National UniversityHongcheon25159Republic of Korea

Scherer et *** the influence of de novo pyrimidine nucleotide synthesis on T-cell responses after antigen stimulation,particularly on effector and memory T-cell development[1].Their work focused on the effect of leflunomide(trade name Avara®),which is a direct inhibitor of dihydroorotate dehydrogenase(DHODH;a key enzyme in the de novo pyrimidine nucleotide pathway and located on the inner mitochondrial membrane).In this pathway,DHODH converts dihydroorotate to orotate and has been implicated in the reduction of ubiquinol to ubiquinone mediated by Complex III in the electron transport *** metabolic effects of DHODH inhibition are unclear[2,3].However,it is known to block S-phase progression by activating *** was originally approved for the treatment of rheumatoid arthritis(RA)in 1998;the mechanism involves the induction of S-phase cell cycle arrest and apoptosis,inhibiting cell proliferation and *** studies have demonstrated the therapeutic potential of leflunomide for cancer[4].Despite the efficacy of leflunomide,the mechanism by which it targets immune cells in the treatment of RA was unknown;however,the work of Scherer and colleagues has shed new light on this mechanism.

关键词： mechanism rotate convert