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An association between Helicobacter pylori and upper respiratory tract disease: Fact or fiction?

World Journal of Gastroenterology 2014年第6期20卷 1470-1484页

作者： shin kariya Mitsuhiro Okano Kazunori Nishizaki Department of Otolaryngology-Head and Neck Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Helicobacter pylori(H. pylori) is a major cause of chronic gastritis and gastric ulcers and considerable evidence supports the notion that infection with this bacterium is also associated with gastric malignancy in addition to various other conditions including pulmonary, vascular and autoimmune disorders. Gastric juice infected with H. pylori might play an important role in upper respiratory tract infection. Although direct and/or indirect mechanisms might be involved in the association between H. pylori and upper respiratory tract diseases, the etiological role of H. pylori in upper respiratory tract disorders has not yet been fully elucidated. Although various studies over the past two decades have suggested a relationship between H. pylori and upper respiratory tract diseases, the findings are inconsistent. The present overview describes the outcomes of recent investigations into the impact of H. pylori on upper respiratory tract and adjacent lesions.

关键词： Paranasal sinus Ear Adenoid Oral cavity Pharynx Larynx Upper respiratory tract Cancer

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Relationship between chronic rhinosinusitis and lower airway diseases: An extensive review

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World Journal of Otorhinolaryngology 2015年第2期5卷 44-52页

作者： shin kariya Mitsuhiro Okano Kazunori Nishizaki Department of Otolaryngology-Head and Neck Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Signifcant links between allergic rhinitis and asthma have been reported, and the united airway disease hypothesis is supported by numerous findings in epidemiologic, physiologic, pathologic, and immunologic studies. The impact of allergic rhinitis on asthma has been esta-blished. On the other hand, the relationship between chronic rhinosinusitis and lung diseases has been under investigation. Chronic rhinosinusitis is a common disease, and the high prevalence of chronic rhinosinusitis in some kinds of lung diseases has been reported. Recent studies suggest that the treatment of chronic rhinosinusitis has beneficial effects in the management of asthma. Here, we present an overview of the current research on the relationship between chronic rhinosinusitis and lower airway diseases including asthma, chronic obstructive pul-monary disease, cystic fibrosis, diffuse panbronchiolitis, primary ciliary dyskinesia, idiopathic bronchiectasis, and allergic bronchopulmonary aspergillosis.

关键词： Chronic rhinosinusitis Sinusitis Asthma Chronic obstructive pulmonary disease Cystic fbrosis Diffuse panbronchiolitis Primary ciliary dyskinesia Idiopathic bronchiectasis Allergic bronchopulmonary aspergillosis

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