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Recent progress on the hydrogen storage properties of ZrCo-based alloys applied in International Thermonuclear Experimental Reactor(ITER)

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Progress in Natural Science:Materials International 2017年第1期27卷 58-65页

作者： Feng Wang Rongfeng Li Cuiping Ding Wukui Tang Yibo Wang shimeng Xu Ronghai yu Ying Wu School of Materials Science and Engineering Beihang University China Iron & Steel Research Institute Group Advanced Technology & Materials Co. Ltd

Under the development of International Thermonuclear Experimental Reactor（ITER） system aimed at realizing the controllable fusion reaction to solve the energy crisis fundamentally, there is an urgent need to find an appropriate material for tritium handling. ZrCo alloy is considered to be a promising candidate for the storage and delivery of hydrogen isotopes due to the favorable characteristics such as low plateau pressure for absorption, high dissociation pressure at moderate temperature and better ability of trapping;He. However, the hydrogen induced disproportionation and the slower recovery/deliverty rate of ZrCo-based alloys have limited their further application in ITER system. This review summarizes the efforts towards enhancing the hydrogen storage properties of ZrCo-based alloys including element substitution, surface modification, disproportionation mechanism investigation and the isotope effect study. Element substitution and surface modification play positive role to improve the anti-disproportionation ability and kinetic property of the alloys. However, the ZrCo-based alloys require to be further modified by more attempts such as new composition, novelty modification method or catalyst addition in order to better satisfy the application demands for tritium handling. Moreover, new insight for further understanding the inner disproportionation mechanisms of this material is needed by combining the advance characterization and theoretical analysis, which is in favor of addressing the disproportionation problem of the ZrCo-based alloys essentially.

关键词： ZrCo-based alloy Hydrogen storage properties Disproportionation reaction Element substitution Surface modification

Hierarchical carbon nanosheet confined defective MoS_(x) cathode towards long-cycling zinc-ion-battery

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Nano Research 2023年第7期16卷 9364-9370页

作者： Xiaoqi Wang shimeng Zhang Rui Yang Shengchi Bai Jianbo Li yu Wu Bowen Jin Xu Jin Mingfei Shao Bo Wang School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Research Center of New Energy PetroChina Research Institute of Petroleum Exploration&DevelopmentBeijing 100083China

Aqueous zinc-ion batteries(ZIBs)have attracted increasing attention due to their low cost and high ***_(2) is a promising cathode material for aqueous ZIBs due to its favorable Zn^(2+)accommodation ***,the structural strain and large volume changes during intercalation/deintercalation lead to exfoliation of active materials from substrate and cause irreversible capacity *** this work,a highly stable cathode was developed by designing a hierarchical carbon nanosheet-confined defective MoS_(x)material(CNS@MoS_(x)).This cathode material exhibits an excellent cycling stability with high capacity retention of 88.3%and~100%Coulombic efficiency after 400 cycles at 1.2 A·g^(-1),much superior compared to bare MoS_(2).Density functional theory(DFT)calculations combined with experiments illustrate that the promising electrochemical properties of CNS@MoS_(x)are due to the unique porous conductive structure of CNS with abundant active sites to anchor MoS_(x)via strong chemical bonding,enabling MoS_(x)to be firmly confined on the ***,this unique hierarchical complex structure ensures the fast migration of Zn^(2+)within MoS_(x)interlayer.

关键词： aqueous zinc-ion batteries MoS_(x)cathode porous carbon nanosheets long-cycling hierarchical structure

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禽流感病毒M基因的重组慢病毒构建

畜牧与兽医 2024年第8期56卷 85-90页

作者：潘俊慧王素春禹兰平周凯钰太魏世萌祁倩李超隋金钰康京丽王楷宬中国动物卫生与流行病学中心山东青岛266032 农业农村部动物生物安全风险预警及防控重点实验室(南方) 山东青岛266032

旨在建立针对禽流感病毒(AIV)的实验室快速分子检测方法。构建重组慢病毒作为分子检测方法中的阳性对照品,采用PCR扩增技术获得AIV M基因的保守区片段,并构建pLVX-M-IRES-ZsGreen1重组慢病毒穿梭载体;将鉴定成功的重组穿梭质粒与骨架质... 详细信息

旨在建立针对禽流感病毒(AIV)的实验室快速分子检测方法。构建重组慢病毒作为分子检测方法中的阳性对照品,采用PCR扩增技术获得AIV M基因的保守区片段,并构建pLVX-M-IRES-ZsGreen1重组慢病毒穿梭载体;将鉴定成功的重组穿梭质粒与骨架质粒pMD2.G和psPAX2共转染293T细胞,获得携带AIV M基因保守区的重组慢病毒;将重组慢病毒感染293T细胞,观察其荧光表达情况,收集、浓缩病毒液并测定其滴度;用AIV实时荧光定量PCR(RT-qPCR)检测方法检测M基因。结果表明:携带AIV M基因的重组慢病毒成功拯救,且其病毒滴度高、安全性强,可作为分子检测方法的阳性对照标准品。综上,本研究成功构建了AIV M基因的重组慢病毒,可高效包装出含有M基因保守区的慢病毒颗粒,为后续AIV分子检测试剂盒的研制提供参考。

关键词：禽流感病毒 M基因 293T细胞重组慢病毒

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肝动脉灌注化疗联合仑伐替尼治疗巴塞罗那临床肝癌B或C期肝细胞癌

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中国介入影像与治疗学 2024年第2期21卷 70-74页

作者：于海东郭应兴雷振武杨海明孙世蒙马存凯青海大学附属医院介入诊疗科青海西宁810000

目的观察肝动脉灌注化疗(HAIC)联合仑伐替尼治疗巴塞罗那临床肝癌(BCLC)B或C期肝细胞癌(HCC)效果,分析影响患者生存时间的因素。方法回顾性分析104例BCLC B或C期HCC患者资料,根据治疗方案将其归入观察组(46例,接受HAIC联合仑伐替尼治疗... 详细信息

目的观察肝动脉灌注化疗(HAIC)联合仑伐替尼治疗巴塞罗那临床肝癌(BCLC)B或C期肝细胞癌(HCC)效果,分析影响患者生存时间的因素。方法回顾性分析104例BCLC B或C期HCC患者资料,根据治疗方案将其归入观察组(46例,接受HAIC联合仑伐替尼治疗)及对照组(58例,仅接受HAIC);比较2组疗效、不良反应及患者总生存期(OS)和无进展生存期(PFS),以Cox回归分析评估OS影响因素。结果治疗后3、6个月,观察组改良实体瘤疗效评价标准(mRECIST)评估结果均优于对照组(P均0.05)。观察组患者总生存率高于对照组(P0.05)。观察组皮疹发生率高于对照组(P<0.05)。多因素Cox回归分析结果显示,相比单一HAIC,HAIC联合仑伐替尼[风险比(HR)=0.425,95%CI(0.255,0.791)]可延长患者OS;相比治疗前美国东部肿瘤协作组(ECOG)评分1、AFP≥400μg/ml、瘤灶数目≥3及BCLC C期,治疗前ECOG评分0、AFP<400μg/ml、瘤灶数目≤2及BCLC B期均为HCC患者OS独立保护因素(P均<0.05)。结论 HAIC联合仑伐替尼治疗BCLC B期或C期HCC安全、有效;治疗前ECOG评分、血清AFP水平、瘤灶数目及BCLC分期均为OS影响因素。

关键词：癌,肝细胞化学疗法癌症局部灌注预后

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Least Time Path Planning under Urban Timetabled Public Transport Using A* Algorithm

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Least Time Path Planning under Urban Timetabled Public Trans...

Phosphorylation and function of DGAT1 in skeletal muscle cells

第25届中国控制与决策会议

作者： yu ZHANG Jiafu TANG shimeng LV Dept. of Systems Engineering State Key Lab of Synthetic Automation of Process Industries Northeastern University

ISBN: (纸本)9781467355339

This paper proposes an ad hoc A* algorithm to find a least time path under urban timetabled public transport network. Vehicles are assumed to run punctually associated with timetables. This work first formulate complex urban timetabled public transport network considering scheduled lines serving over it and walk between two nodes for transfer purpose. Then, multi-label arc, shorte for m-arc, is defined to represent detailed travel process, and timing of each m-arc is expounded, too. Path is composed of a sequence of m-arcs. To find a least travel time path from an origin with pre-specified initial time to a destination under urban timetabled public transport among a large number of candidates, an ad hoc A* algorithm is developed, which propose a strategy for estimating elapsed time of partial paths that ended at destination, to be a tight lower bound of associated real elapsed time for the purpose of trying to reduce searching scope. The proposed algorithm is proved to guarantee an optimal solution in theory and demonstrated with an application for its high efficiency.

关键词： Least Time Path Urban Timetabled Public Transport Multi-label Arc A* Algorithm

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Biophysics Reports 2015年第1期1卷 41-50页

作者： Jinhai yu Yiran Li Fei Zou shimeng Xu Pingsheng Liu National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of Sciences University of Chinese Academy of Sciences Department of Biological Science and Biotechnology School of Biological Science and Medical EngineeringBeihang University Graduate School of Anhui Medical University General Hospital of Air Force

Aberrant intramuscular triacylglycerol(TAG) storage in human skeletal muscle is closely related to insulin insensitivity. Excessive lipid storage can induce insulin resistance of skeletal muscle, and under severe conditions, lead to type 2 diabetes. The balance of interconversion between diacylglycerol and TAG greatly influences lipid storage and utilization. Diacylglycerol O-acyltransferase 1(DGAT1) plays a key role in this process, but its activation and phosphorylation requires further dissection. In this study,12 putative conserved phosphorylation sites of DGAT1 were identified by examining amino acid conservation of DGAT1 in different species. Another 12 putative phosphorylation sites were also found based on bioinformatics predictions and previous reports. Meanwhile, several phosphorylation sites of DGAT1 were verified by phosphorylation mass spectrometry analysis of purified DGAT1 from mouse myoblast C2 C12 cells. Using single point mutations, a regulatory role of 3 putative phosphorylation sites was dissected. Finally, using truncation mutations, a potential domain of DGAT1 that was involved in the regulation of enzymatic activity was revealed. This study provides useful information for further understanding DGAT1 activity regulation.

关键词： DGAT1 Enzymatic activity Phosphorylation Single point mutation

Nutritional Value Evaluation of Saccharum spontaneum L. Germplasm Resources

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Agricultural Science & Technology 2014年第11期15卷 1981-1986,2002页

作者： Jianle LIU Changjun BAI Linling YAN shimeng CHEN yu ZHANG Hubiao YANG College of Agronomy Hainan University Ministry of Agriculture's Key Laboratory of Tropical Crops Germplasm Utilization Tropical Crops Genetic Resources InstituteChinese Academy of Tropical Agriculture Sciences

The contents of dry matter, crude fat, crude protein, neutral detergent fiber, acid detergent fiber, crude ash, Ca and P in 43 Saccharum spontaneum *** during the vegetative period were determined. Among them, the crude protein, crude fat, neutral detergent fiber, acid detergent fiber, P and Ca contents were treated as the judging indicators. The nutritional value evaluation was carried out with the analytic hierarchy process(AHP). The results showed A49(Guangxi)had the highest nutritional value. Its dry matter, crude protein, crude fat, crude ash,neutral detergent fiber, acid detergent fiber, Ca and P contents were 32.35%,7.20%, 4.06%, 8.07%, 75.81%, 50.72%, 0.23% and 0.16% respectively. While A3(Guangdong) had the lowest nutritional value. Its dry matter, crude protein, crude fat, crude ash, neutral detergent fiber, acid detergent fiber, Ca and P contents were32.24%, 4.62%, 0.51%, 6.38%, 46.40%, 40.02%, 0.15% and 0.09% *** crude protein content differed significantly among different germplasms. A48 had the highest crude protein content(9.11%), and A14 had the lowest crude protein content(3.72%). Based on the evaluation results, the 43 Saccharum spontaneum *** were divided into 3 groups: high-nutritional value type, moderate-nutritional value type and low-nutritional value type. We hoped to provide a theoretical reference for the application of Saccharum spontaneum L. as a forage grass.

关键词： Saccharum spontaneum L. Neutral detergent fiber Nutritional value Evaluation

青藏高原地表非绝热加热模态及其与中国北方环流异常的联系

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高原气象 2019年第2期38卷 237-252页

作者：于涵张杰刘诗梦气象灾害预报预警与评估协同创新中心/气象灾害省部共建教育部重点实验室南京信息工程大学江苏南京210044 辽阳市气象局辽宁辽阳111000 内蒙古自治区气候中心内蒙古呼和浩特010000

利用青藏高原非均匀下垫面热力输送系数及地表有效辐射的EOF分析结果,计算了2000年以来的高原地表非绝热加热资料,并将1958—2013年地表非绝热加热资料进行重建得到高原地表非绝热加热指数,以表征高原不同气候分区的地表热力状况。根据... 详细信息

利用青藏高原非均匀下垫面热力输送系数及地表有效辐射的EOF分析结果,计算了2000年以来的高原地表非绝热加热资料,并将1958—2013年地表非绝热加热资料进行重建得到高原地表非绝热加热指数,以表征高原不同气候分区的地表热力状况。根据EOF分析结果将高原分为4个气候区,并从波能传播的角度分析其对中国北方环流异常的影响。结果表明,高原地表非绝热加热指数在西部边缘(气候Ⅰ区),除了冬季为微弱下降趋势以外,其他季节都为微弱的上升趋势;在高原中西部腹地(气候Ⅱ区),四季均为下降趋势;在高原东北部(气候Ⅲ区),除了冬季表现为微弱的下降趋势外,其他季节均为微弱的上升趋势;而在高原东南部(气候Ⅳ区),四季均表现为下降趋势。高原西部边缘地表非绝热加热异常增强时,高原200 h Pa上空为波能辐散区,并向东传播,初夏在北方辐合加强,有利于降水,干旱减弱;盛夏在北方地区处于辐散区,加剧干旱。在高原东北部地表非绝热加热异常增强时,该区200 h Pa上空为波能辐散区,并向东传播,无论是在初夏还是盛夏,除了东北地区北部,北方其他地区辐合加强,有助于干旱减弱。

关键词：青藏高原地表非绝热加热指数北方环流异常波列

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从动物防疫角度浅谈实验动物运输的法律规定

中国动物检疫 2024年第8期41卷 39-43页

作者：徐太辉于晓云郑世磊李萍刘玉荣冯阳魏世萌祁倩王楷宬李金积青岛易邦生物工程有限公司山东青岛266114 烟台市农业综合执法支队山东烟台264009 青岛市城阳区农业农村局山东青岛266109 中国动物卫生与流行病学中心山东青岛266032

实验动物运输活动应按照相关法律规定做好动物防疫工作,以防止实验动物疫病远距离跨地区传播。本文从动物防疫的角度概括了国内机构通过道路运输实验动物,尤其是向无规定动物疫病区运输实验动物,在运输前、中、后不同环节应遵循的法律... 详细信息

实验动物运输活动应按照相关法律规定做好动物防疫工作,以防止实验动物疫病远距离跨地区传播。本文从动物防疫的角度概括了国内机构通过道路运输实验动物,尤其是向无规定动物疫病区运输实验动物,在运输前、中、后不同环节应遵循的法律规定及相关要求,并指出运输环节易出现的违规问题及处罚规定,提出了动物防疫部门应加强运输实验动物的动物卫生监管及相关法律法规宣传,实验动物运输机构应加强动物防疫相关法规的学习,做到依法运输实验动物。本文为相关单位及人员做好实验动物卫生防疫工作提供参考。

关键词：实验动物道路运输法律法规无规定动物疫病区