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Bacillus CotA laccase improved the intestinal health,amino acid metabolism and hepatic metabolic capacity of Pekin ducks fed naturally contaminated AFB_(1)diet

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Journal of Animal Science and Biotechnology 2025年第1期16卷 331-344页

作者： Mingxin Ma Qianqian Wang Yanrong Liu Guiming Li Limeng Liu Gaigai Wang Yongpeng Guo shimeng huang Qiugang Ma Cheng Ji Lihong Zhao State Key Laboratory of Animal Nutrition and Feeding Poultry Nutrition and Feed Technology Innovation TeamCollege of Animal Science and TechnologyChina Agricultural UniversityNo.2.Yuanmingyuan West RoadBeijing 100193People’s Republic of China Poultry Institute Shandong Academy of Agricultural SciencesJinan 250100China College of Animal Science and Technology Henan Agricultural UniversityZhengzhou 450046China

Background AflatoxinB1(AFB_(1))is a prevalent contaminant in agricultural products,presenting significant risks to animal *** laccase from Bacillus licheniformis has shown significant efficacy in degrading mycotoxins in vitro *** efficacy of Bacillus CotA laccase in animals,however,remains to be confirmed.A 2×2 factorial design was used to investigate the effects of Bacillus CotA laccase level(0 or 1 U/kg),AFB_(1) challenge(challenged or unchal-lenged)and their interactions on *** purpose of this study was to evaluate the efficacy of Bacillus CotA laccase in alleviatingAFB_(1) toxicosis of *** Bacillus CotA laccase alleviatedAFB_(1)-induced declines in growth performance of ducks accompanied by improved average daily gain(ADG)and lower feed/gain ratio(F/G).Bacillus CotA laccase amelioratedAFB_(1)-induced gut barrier dysfunctions and inflammation testified by increasing the jejunal villi height/crypt depth ratio(VH/CD)and the mRNA expression of tight junction protein 1(TJP1)and zonula occluden-1(ZO-1)as well as decreasing the expression of inflammation-related genes in the jejunum of *** acid metabolome showed that Bacillus CotA laccase amelioratedAFB_(1)-induced amino acid metabolism disorders evidenced by increasing the level of glu-tamic acid in serum and upregulating the expression of amino acid transport related genes in jejunum of ***-lus CotA laccase amelioratedAFB_(1)-induced liver injury testified by suppressing oxidative stress,inhibiting apoptosis,and downregulating the expression of hepatic metabolic enzyme related genes of ***,Bacillus CotA laccase degradedAFB_(1) in digestive tract of ducks,resulting in the reduced absorption level ofAFB_(1) across intestinal epithelium testified by the decreased level ofAFB_(1)-DNA adduct in the liver,and the reduced content ofAFB_(1) residues in liver and feces of *** Bacillus CotA laccase effectively improved the growth performance,inte

关键词： AFB_(1)residue Aflatoxin Bacillus CotA laccase Duck Intestinal barrier function Liver metabolic enzyme

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Exposure to zearalenone exacerbates the decrease in calcium transport via selective regulation to estrogen receptor α/β in estrogenic deficient model

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Science China Life Sciences 2025年

作者： Qingxiu Liu Leli Wang Yafei Liu shimeng huang Lihong Zhao Yulong Yin Qiugang Ma State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and Technology China Agricultural University Centre of Healthy Animal Husbandry Institute of Subtropical Agriculture Chinese Academy of Sciences

Dear Editor,Postmenopausal estrogen deficiency in humans is thought to be the main cause of osteoporosis and diminished calcium absorption in older women. Estrogen supplementation may alleviate the problem of osteoporosis in estrogen-deficient women by promoting calcium ***, clinical estrogen supplementation increases the risk of breast cancer,and the search for other estrogen replacement is becoming of increased interest.

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Dietary supplementation of porcine bile acids improves laying performance,serum lipid metabolism and cecal microbiota in latephase laying hens

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Animal Nutrition 2022年第4期11卷 283-292页

作者： Bowen Yang shimeng huang Guoxian Zhao Qiugang Ma State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijingChina College of Animal Science and Technology Hebei Agricultural UniversityBaodingChina

Due to the exceptional laying performance of hens,the demand on lipid metabolism and oxidation in vivo is vigorous,resulting in excessive lipid accumulation in late-phase hens,which lowers the production *** acids regulate lipid metabolism and gut microbiota in humans and ***,the effect of porcine bile acids on lipid metabolism and cecal microbiota in laying hens in the late phase is still unclear.A total of 360 healthy 45-week-old laying hens were chosen for a 24-week feeding trial,where 0,30,60 and 90 mg/kg porcine bile acids were added to a basal diet,*** results showed that dietary supplementation of 60 mg/kg bile acids increased egg production and feed conversion(P<0.05).Also,60 and 90 mg/kg porcine bile acids reduced abdominal fat percentage and body weight(P<0.05).The levels of serum total cholesterol,triglyceride,and low-density lipoprotein cholesterol of hens decreased(P<0.05)in bile acids supplement *** for cecal microbiota,bile acids supplementation did not affect the alpha diversity of cecal microbiota at the genus ***,dietary supplementation of 90 mg/kg bile acids resulted in an increase in the abundance of beneficial bacteria in the cecum,such as Lactobacillus,Bifidobacterium and *** changes in the cecal microbiota caused by bile acids supplementation correlated with serum lipid *** to KEGG pathway analysis,dietary supplementation of 60 and 90 mg/kg bile acids promoted structural transformation of the cecal microbiota to down-regulate steroid biosynthesis,up-regulate fatty acid degradation and up-regulate unsaturated fatty acid ***,bile acids bioisomerization function of cecal microbiota was enhanced in 60 and 90 mg/kg bile acids treatment,and the short-chain fatty acid metabolism was also *** conclusion,the present study revealed dietary supplementation of porcine bile acids enriched probiotics in the gut and improved serum lipid metabolism of

关键词： Porcine bile acids Lipid metabolism Gut microbiota Laying hens 16S rRNA

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色氨酸及其细菌代谢产物对畜禽肠道屏障及生产性能影响的研究进展

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中国畜牧兽医 2025年第2期52卷 636-644页

作者：杨鑫硕常丹翼续丹丹张海华马秋刚黄世猛中国农业大学动物科学技术学院畜禽营养与饲养全国重点实验室北京100193 北京工商大学轻工技术与工程学院京100048 河北科技师范学院动物科技学院河北省特色动物种质资源挖掘与创新重点实验室秦皇岛066004

色氨酸(tryptophan, Trp)是功能性必需氨基酸之一。色氨酸及其细菌代谢产物对维持宿主肠道稳态,促进机体生长性能和代谢极为重要。色氨酸通过吲哚途径、犬尿氨酸途径和5-羟色胺途径等代谢过程,产生多种具有益生功能的细菌代谢产物。色... 详细信息

色氨酸(tryptophan, Trp)是功能性必需氨基酸之一。色氨酸及其细菌代谢产物对维持宿主肠道稳态,促进机体生长性能和代谢极为重要。色氨酸通过吲哚途径、犬尿氨酸途径和5-羟色胺途径等代谢过程,产生多种具有益生功能的细菌代谢产物。色氨酸及其代谢产物能够促进肠道上皮细胞的紧密连接蛋白表达,增加肠道黏膜屏障中黏蛋白的合成与分泌,此外,色氨酸及其代谢产物通过促进肠道微生物中一些有益菌的定植,抑制致病菌的增殖,维持菌群稳定性和多样性。色氨酸及其细菌代谢产物对畜禽生长性能的积极影响,包括提高采食量、日增重,缓解生长阻碍及提高畜禽产品品质等。然而,目前对色氨酸细菌代谢产物在畜禽肠道健康、营养代谢和生长性能中的作用机制尚缺乏系统性研究。未来的研究可探讨色氨酸细菌代谢产物如何影响畜禽肠道微生物定植,如何介导不同信号通路调控肠道屏障功能。作者综述了近些年色氨酸及其细菌代谢产物对畜禽肠道黏膜屏障及其在调节畜禽生长性能和免疫反应中的作用,旨在为色氨酸细菌代谢产物应用于畜禽生产提供新思路、新方法。

关键词：色氨酸细菌代谢产物肠道黏膜屏障生长性能畜禽

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Zearalenone toxicosis on reproduction as estrogen receptor selective modulator and alleviation of zearalenone biodegradative agent in pregnant sows

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Journal of Animal Science and Biotechnology 2022年第4期13卷 1222-1232页

作者： Jianchuan Zhou Lihong Zhao shimeng huang Qingxiu Liu Xiang Ao Yuanpei Lei Cheng Ji Qiugang Ma State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Sichuan tieqilishi Food Co. LtdMianyang 610000Sichuan provinceChina.

Background:Zearalenone(ZEA)is a resorcylic acid lactone derivative derived from various Fusarium species that are widely found in food and *** molecular structure of ZEA resembles that of the mammalian hormone 17β-oestradiol,thus zearalenone and its metabolites are known to compete with endogenous hormones for estrogen receptors binding sites and to activate transcription of oestrogen-responsive ***,the effect of long-term low-dose ZEA exposure on the reproductive response to Bacillus subtilis ANSB01G culture for first-parity gilts has not yet been *** study was conducted to investigate the toxic effects of ZEA as an estrogen receptor selective modulator and the alleviating effects of Bacillus subtilis ANSB01G cultures as ZEA biodegraders in pregnant sows during their first ***:A total of 80 first-parity gilts(Yorkshire×Landrace)were randomly assigned to four dietary treatments during gestation:CO(positive control);MO(negative control,246μg ZEA/kg diet);COA(CO+*** ANSB01G culture with 2×10^(9)CFU/kg diet);MOA(MO+*** ANSB01G culture with 2×10^(9)CFU/kg diet).There were 20 replications per treatment with one gilt per *** low-dose ZEA naturally contaminated diets disordered most of reproductive hormones secretion and affected estrogen receptor-αand estrogen receptor-βconcentrations in serum and specific organs and led to moderate histopathological changes of gilts,but did not cause significant detrimental effects on reproductive *** addition of Bacillus subtilis ANSB01G culture to the diet can effectively relieve the competence of ZEA to estrogen receptor and the disturbance of reproductive hormones secretion,and then ameliorate toxicosis of ZEA in ***:Collectively,our study investigated the effects of feeding low-dose ZEA on reproduction in pregnant sows during their first *** low-dose ZEA could modulate estrogen receptor-αand-βconcentrations in specific organs,ca

关键词： Bacillus subtilis ANSB01G Estrogen receptor Mycotoxin biodegradation Pregnant sows Reproductive performance ZEA

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Dynamic changes of postprandial plasma metabolites after intake of corn-soybean meal or casein-starch diets in growing pigs

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Journal of Animal Science and Biotechnology 2019年第4期10卷 1049-1058页

作者： Tiantian Li shimeng huang Juntao Li Hu Liu Wei Wang Na Li Meng Shi Shiyu Tao Shuai Zhang Zhen Li Junjun Wang State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China

Background: Postprandial nutrients utilization and metabolism of a certain diet is a complicated process. The metabolic feature of pigs after intake of corn-soybean meal or casein-starch diets are largely unknown. Therefore,this study was conducted to investigate the dynamic postprandial changes of plasma metabolic profile using growing pigs using ***: Twenty-four growing pigs with average initial body weight(BW) about 30 kg were placed in metabolic cages and then fitted with precaval vein catheters. Pigs were fed daily 4% of initial body weight. Two experimental diets were included:(i) a starch-casein based purified diet(PD) and(ii) a common corn-soybean meal diet(CD).Plasma was collected before feeding and 0.5 h, 1 h, 2 h, 4 h, 8 h after ***: In both diets, compared to prior to feeding, the concentrations of glucose, most amino acids, metabolites such as 5-aminopentanoic acid, pipecolic acid, ornithine and 5-hydroxy-L-tryptophan were significantly increased in plasma during the first hour, whereas the concentrations of plasma triglycerides, glutamate, glycine, palmitelaidic acid, 13-HODE and oleic acid were decreased in the first hour. Compared with PD group, concentration of plasma leucine and isoleucine declined at 30 min in CD group. Plasma linoleic acid, sphingosine and many dipeptides were significantly higher in pigs fed ***: Most significant metabolic changes occurred during the first hour after feeding and then became relatively stable after 2 h in both diets. These results show a broad scope picture of postprandial changes in plasma metabolites after intake of PD and CD and could be a reference for further nutrition intervention as well as the design of nutritional studies.

关键词： Diet Metabolomics Plasma metabolites Pig Postprandial

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不同驴皮转化效率德州驴的皮肤及粪便微生物群落定植规律研究

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中国畜牧兽医 2025年第1期52卷 94-106页

作者：李诗诺胡彤杨定乾单娴婷鲁智然涂亦然周谦梁凯宣曲洪磊马秋刚黄世猛中国农业大学动物科学技术学院畜禽营养与饲养全国重点实验室北京100193

[目的]分析不同驴皮转化效率德州公驴的背部和颈部皮肤、粪便微生物群落的差异定植规律。[方法]基于3 000头驴皮厚度均一的德州黑毛驴(公)群体,饲喂相同基础饲粮,对背部和颈部皮肤厚度进行连续监测,筛选出驴皮(背部和颈部)厚度增量高、... 详细信息

[目的]分析不同驴皮转化效率德州公驴的背部和颈部皮肤、粪便微生物群落的差异定植规律。[方法]基于3 000头驴皮厚度均一的德州黑毛驴(公)群体,饲喂相同基础饲粮,对背部和颈部皮肤厚度进行连续监测,筛选出驴皮(背部和颈部)厚度增量高、低组各7头,通过测定16S rRNA扩增所获序列,进行背部和颈部皮肤、粪便微生物群落的组成和功能分析。[结果]驴皮厚度增量高、低组间驴皮厚度变化存在显著差异(P0.05),而主坐标分析(principal co-ordinates analysis, PCoA)显示两组间的微生物群落聚类有不同程度的差异(P<0.05),韦恩图显示两组驴皮背部和颈部皮肤、粪便微生物均存在共有扩增子序列变异(amplicon sequence variant, ASV)或特有ASV。门水平显示,两组的不同部位以厚壁菌门、放线菌门、绿弯菌门、变形菌门、拟杆菌门等为主要优势菌;属水平显示,两组的不同部位以狭义梭菌属1、棒状杆菌属、链球菌属、鸟氨酸微菌属为优势菌属,其中链球菌属为粪便的优势菌属,鸟氨酸微菌属为颈部和背部皮肤的优势菌属。通过差异物种分析,与颈部驴皮厚度增量低组相比,23个属水平菌富集于颈部驴皮厚度增量高组;与背部驴皮厚度增量低组相比,7个属水平菌富集于颈部驴皮厚度增量高组;与驴皮厚度增量低组的粪便相比,13个属水平菌富集于驴皮厚度增量高组的粪便。[结论]驴皮厚度增量不同的德州驴皮肤微生物群落结构、功能存在差异,相比粪便,皮肤组织的微生物多样性具有更高的趋势。本研究结果为解析德州驴微生物定植规律、驴皮转化效率潜在调控机制提供了理论依据。

关键词：德州驴肠道微生物皮肤微生物驴皮厚度定植规律

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Intrauterine growth restriction alters nutrient metabolism in the intestine of porcine offspring

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Journal of Animal Science and Biotechnology 2021年第2期12卷 649-660页

作者： Tiantian Li shimeng huang Long Lei Shiyu Tao Yi Xiong Guoyao Wu Jie Hu Xiongkun Yuan Shengjun Zhao Bin Zuo Hongjian Yang Yingping Xiao Gang Lin Junjun Wang State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193People’s Republic of China Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety Hubei Key Laboratory of Animal Nutrition and Feed ScienceWuhan Polytechnic UniversityWuhan 430023People’s Republic of China Department of Animal Science Texas A&M UniversityCollege StationTX 77843USA State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Institute of Quality and Standard for Agro-productsZhejiang Academy of Agricultural SciencesHangzhou 310021People’s Republic of China Key Laboratory of Agrifood Safety and Quality Institute of Quality Standards and Testing Technology for Agricultural ProductsChinese Academy of Agricultural SciencesMinistry of Agriculture and Rural AffairsBeijing 100081People’s Republic of China

Background:Intrauterine growth restriction(IUGR)has negative impacts on the postnatal survival,growth and development of humans and animals,with not only on newborns but also ***,the characteristics for nutrient digestion and absorption in IUGR offspring are still largely ***,the normal birth weight(NBW)and IUGR growing pigs were used in this study to investigate their differences in nutrient utilization,with an expectition for further nutritional optimization of the IUGR offspring during their later ***:Twelve IUGR and 12 NBW growing pigs were fitted with catheters in their portal vein to measure blood flow rate as well as nutrients and metabolites in *** digestibilities of nutrients in different intestinal segments,and bacterial fermentation in the large intestine were examined to reveal the characteristics of nutrients utilization in IUGR versus NBW ***:The rate of portal venous blood flow did not differ beween IUGR and NBW *** concentrations of total cholesterol,triglycerides and glucose were much lower but those of urea were higher in the portal vein of IUGR pigs,compared with the NBW *** ileal digestibility of dry matter,gross energy and starch were lower in IUGR pigs than in NBW *** increased hindgut microbial diversity and bacterial fermentation activity in the *** vitro cross-fermentation of ileal digesta by caecal microbes of NBW and IUGR pigs showed that gas production was much higher for IUGR ileal digesta regardless of the source of caecal ***:IUGR impairs the nutrient digestion and absorption in small intestine,reduces caecal microbial diversity and promotes bacterial fermentation in the large intestine during the growing *** findings aid in our understanding of nutrient metabolism in IUGR pigs and provide the basis for future nutritional interventions.

关键词： Absorption Digestion Fermentation IUGR pigs Portal vein

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梅花鹿角盘胶原蛋白的鉴定及其理化性质

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食品工业科技 2024年第3期45卷 284-292页

作者：黄诗萌王景琦皮钰珍邵俊花沈阳农业大学食品学院辽宁沈阳110866 沈阳奉鹿堂生物科技有限公司辽宁沈阳110180

本研究以梅花鹿角盘为原料,利用酸法和酶法提取梅花鹿角盘酸溶性胶原蛋白(ASC)和酶溶性胶原蛋白(PSC),研究其结构和理化性质,为开发胶原蛋白新资源,提高鹿产品附加值提供理论依据。结果表明,梅花鹿角盘ASC和PSC符合Ⅰ型胶原蛋白氨基酸... 详细信息

本研究以梅花鹿角盘为原料,利用酸法和酶法提取梅花鹿角盘酸溶性胶原蛋白(ASC)和酶溶性胶原蛋白(PSC),研究其结构和理化性质,为开发胶原蛋白新资源,提高鹿产品附加值提供理论依据。结果表明,梅花鹿角盘ASC和PSC符合Ⅰ型胶原蛋白氨基酸的特征分布。其中蛋氨酸含量最低,羟基化程度较高,分别为45.69%和46.30%。ASC和PSC至少由两条α链(α1和α2)组成,β链含量较高,并含有少量的γ链。ASC和PSC二级结构相似,均出现酰胺A、B、Ⅰ、Ⅱ和Ⅲ的特征吸收峰,保存着三螺旋结构。ASC和PSC在280 nm处基本无吸收,其最大吸收峰位于219.0 nm和224.0 nm处。ASC和PSC溶液的pH越接近pI值,其溶解性、乳化能力和乳化稳定性越小。当NaCl浓度为0~2 mol/L时,增加盐量可以增大ASC和PSC的溶解性、起泡性;盐浓度在0~0.4 mol/L范围内,能提高ASC和PSC乳化性和乳化稳定性。蛋白浓度0.5%时,两者的乳化稳定性最大,蛋白浓度4%时,两者的乳化稳定性最小。

关键词：梅花鹿角盘胶原蛋白鉴定理化性质

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微生物群落定植规律及其对产蛋鸡内分泌和生殖健康的影响

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动物营养学报 2023年第7期35卷 4148-4158页

作者：王庆凤米金秋马秋刚黄世猛中国农业大学动物科学技术学院动物营养学国家重点实验室北京100193

消化道和生殖道微生物群落对饲粮营养物质的消化和代谢过程、动物生长发育、免疫功能成熟以及内分泌和生殖系统健康等具有重要作用。蛋鸡消化道和生殖道内寄居着数量庞大且种类丰富的微生物,这些微生物参与了维持宿主内环境的稳态。微... 详细信息

消化道和生殖道微生物群落对饲粮营养物质的消化和代谢过程、动物生长发育、免疫功能成熟以及内分泌和生殖系统健康等具有重要作用。蛋鸡消化道和生殖道内寄居着数量庞大且种类丰富的微生物,这些微生物参与了维持宿主内环境的稳态。微生物群落演替集合了随机性过程和确定性过程的平衡,当前对产蛋鸡消化道和生殖道微生物群落稳态及其在宿主内分泌和生殖系统中的作用认识仍不够全面和深入。本文综述了产蛋鸡消化道和生殖道微生物群落的组成和功能,及其对宿主内分泌和生殖系统的影响,旨在为寻找应用精准营养干预调控微生物群落共生网络,实现蛋鸡内分泌和生殖系统的健康以及营养物质的高效利用提供参考。

关键词：蛋鸡微生物群落消化道生殖道内分泌生殖健康

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