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A Case of Secretory Carcinoma That Occurred in the Buccal Submucosa

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International Journal of Otolaryngology and Head & Neck Surgery 2019年第6期8卷 191-197页

作者： Saito Yoshiro Kurasawa Yuya Moriya Takashi Ikeda Kenitiro Kushihashi Yukiomi Egawa Shunya Katsuta Hideyuki shimane Toshikazu Head and Neck Oncology Center Showa UniversityTokyoJapan Department of Oral and Maxillofacial Surgery Division of Oral OncologyShowa UniversitySchool of DentistryTokyoJapan Department of Otorhinolaryngology Showa University School of MedicineTokyoJapan

Secretory carcinoma (SC) is a malignant salivary gland tumor that has been first reported by Skalova et al. in 2010. Histologically, it shows solidity infiltrated with very small cystic cavities and cribriform and papillary features and includes periodic acid-Schiff stain-positive, acid-fast secretions. The cells have oval nuclei, and vacuolated cytoplasm and foamy secretions are seen. Anaplasia is not strong and mitotic figures are rarely seen. These features closely resemble AciCC. Immunohistologically, it is thought to be positive for S-100 protein, vimentin, and mammaglobin and negative for DOG1. The presence of the ETV6-NTRK3 fusion gene is essential in diagnosing secretory carcinoma. In this report, we describe a case of SC in a 52-year-old woman. She was referred to our center because of a mass in left buccal mucosa. A soft and elastic submucosal mass measuring approximately 10 mm × 10 mm in size with a smooth surface was seen in the buccal mucosa in an area corresponding to the left mandibular canine to premolars. The imaging findings revealed that a high-intensity lesion was seen on T2-weighted images. Immunohistochemicalstaing for S-100 protein and vimentin were positive. Furthermore, genetic examination detected the presence of the ETV6-NTRK3 fusion gene. Based on these findings, the definitive diagnosis was secretory carcinoma.

关键词： Secretory Carcinoma ETV6-NTRK3 Fusion Gene Buccal Mucosa

A Case of Bilateral Secondary Pneumothorax Shortly after the Completion of Concurrent Chemoradiotherapy for Tongue Cancer

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International Journal of Otolaryngology and Head & Neck Surgery 2020年第3期9卷 93-100页

作者： Yoshiro Saito Hideyuki Katsuta Takashi Moriya Yuya Kurasawa Hitoshi Sato Shunya Egawa Yukiomi Kushihashi Kenichiro Ikeda Toshikazu shimane Head and Neck Oncology Center Showa University Tokyo Japan Department of Oral and Maxillofacial Surgery Division of Oral Oncology Showa University School of Dentistry Tokyo Japan Department of Otorhinolaryngology Showa University School of Medicine Tokyo Japan

Metastatic lung tumours rarely lead to development of pneumothorax, and no case of bilateral secondary pneumothorax due to lung metastases arising from tongue cancer has been reported. Here, we report a case of a patient with tongue cancer with lung metastases complicated by bilateral secondary pneumothorax soon after the completion of concurrent chemoradiotherapy. A 39-year-old man with cervical lymph node metastases originating from pT2N0M0 tongue cancer underwent neck dissection and postoperative concurrent chemoradiotherapy. Shortly after the completion of chemoradiotherapy, he developed bilateral secondary pneumothorax. Subsequently, he underwent partial lung resection for the pulmonary fistulae for diagnostic and therapeutic purposes;nodular lesions found in both the lungs. The diagnosis of secondary pneumothorax was based on histopathological findings. Although all pulmonary fistulae disappeared after partial lung resection, he died of the primary disease despite our best efforts to control the metastatic pulmonary lesions.

关键词： Tongue Cancer Metastatic Lung Tumour Pneumothorax Concurrent Chemoradiotherapy

Computer-Assisted Surgery for Mandibular Reconstruction Using a Patient-Specific Titanium Mesh Tray and Particulate Cancellous Bone and Marrow

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Case Reports in Clinical Medicine 2015年第3期4卷 85-92页

作者： Seiji Kondo Hideyuki Katsuta Ayako Akizuki Yuji Kurihara Takaaki Kamatani Atsushi Yaso Masahiro Nagasaki Toshikazu shimane Tatsuo Shirota Division of Craniomaxillofacial Surgery Department of Oral and Maxillofacial Surgery School of Dentistry Showa University Tokyo Japan Division of Oral Oncology Department of Oral and Maxillofacial Surgery School of Dentistry Showa University Tokyo Japan

Craniomaxillofacial surgery is difficult due to the complexity of the regional anatomy. Computer-assisted surgery is a promising tool aiming to improve the safety and precision of such surgery. A computer-assisted surgical navigation approach for reconstruction of mandibular defects using a patient-specific titanium mesh tray and particulate cancellous bone and marrow (PCBM) harvested from bilateral anterior ilia is proposed. This case report involves a large multicystic ameloblastoma affecting the right mandible of a 31-year-old male patient. Following detailed clinical examination, radiological interpretation, and histopathological diagnosis, computer-assisted surgical simulation with a virtual 3-dimensional (3-D) model was designed using surgical planning software based on the pre-operative computed tomography data. Long-span segmental resection of the mandible was planned, and the defect was analyzed for reconstruction using a patient-specific reconstruction titanium mesh tray mediated with computer-aided design and manufacturing (CAD/CAM) techniques. During the actual surgery, the ultrasonic bone cutting instrument in the surgeon’s hand was connected to the navigation system to touch an anatomical position on the patient. Therefore, osteotomies were performed finely and smoothly according to the navigation images of the cutting bone line by sequentially moving the instrument. Finally, a CAD/CAM-mediated titanium mesh tray condensed by PCBM was adapted to the remaining mandibular fragments. Six months postoperatively, the patient had a good mandibular configuration and facial contour. Integration of different technologies, such as software planning and 3-D surgical simulation, combined with intraoperative navigation and CAD/CAM techniques, provides safe and precise mandibular reconstruction surgery.

关键词： Patient-Specific Titanium Mesh Tray Computer-Assisted Surgery Mandibular Reconstruction Particulate Cancellous Bone and Marrow Surgical Navigation

A Study of 100 Cases of Cervical Schwannoma Treated with Inter-Capsular Resection

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International Journal of Otolaryngology and Head & Neck Surgery 2020年第2期9卷 61-67页

作者： Toshikazu shimane Shunya Egawa Yukiomi Kushihashi Hitoshi Sato Yoshiro Saito Yuya Kurasawa Takashi Moriya Hirano Koujiro Hideyuki Katsuta Kenichiro Ikeda Showa University Head and Neck Oncology Center Tokyo Japan Department of Otorhinolaryngology Showa University School of Medicine Tokyo Japan Department of Oral and Maxillofacial Surgery Division of Oral Oncology Showa University School of Dentistry Tokyo Japan

Background: Cervical schwannoma is a relatively rare disease, and it is difficult to experience many surgical cases because it may be followed up without surgery. We examined 100 patients who underwent inter-capsular resection for cervical schwannomas at our center and classified the patients according to the nerve of origin. Methods: We retrospectively reviewed 100 patients who underwent inter-capsular resection for cervical schwannoma at our center from April 2005 to September 2019. We examined the patient’s characteristics including age, sex, tumor size (maximum diameter), origin nerve, preoperative symptoms, and postoperative neurological deficits for all cases. We classified the cases according to the nerve of origin and the occurrence of postoperative neurological deficits. Results: The occurrence of postoperative neurological deficit for all cases was as follows: “none” was 73%, “temporary paralysis” was 21%, and “permanent paralysis” was 6%. In the case of vagus nerve: “none” was 65.4%, “temporary paralysis” was 23.1%, “permanent paralysis” was 11.5%. In the case of sympathetic nerve: “none” was 64.7%, “temporary paralysis” was 29.4%, “permanent paralysis” was 5.9%. In the case of brachial plexus: “none” was 87.0%, “temporary paralysis” was 13.0%, “permanent paralysis” was 0%. In the case of cervical and accessory nerves: “none” was 86.4%, “temporary paralysis” was 13.6%, “permanent paralysis” was 0%. In the case of facial nerve: “none” was 0%, “temporary paralysis” was 80.0%, “permanent paralysis” was 20%. In the case of lingual nerve: “none” was 80.0%, “temporary paralysis” was 20.0%, “permanent paralysis” was 0%. Conclusions: Inter-capsular resection is useful for the treatment of cervical schwannoma and a simple comparison is difficult, but probably with good results. This study provides information that will be useful for the treatment of cervical schwannoma.

关键词： Cervical Schwannoma Inter-Capsular Resection Origin Nerve Neurologi-cal Deficit Complication

Case Report of a Clear-Cell Variant of Follicular Thyroid Carcinoma

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International Journal of Otolaryngology and Head & Neck Surgery 2020年第2期9卷 68-77页

作者： Yukiomi Kushihashi Kenichiro Ikeda Syunya Egawa Yoshiro Saito Yuya Kurasaa Takashi Moriya Sawa Arai Takefumi Yui Hideyuki Katsuta Toshikazu shimane Head and Neck Oncology Center Showa UniversityTokyoJapan Department of Otorhinolaryngology Showa University School of MedicineTokyoJapan Department of Oral and Maxillofacial Surgery Division of Oral OncologyShowa UniversitySchool of DentistryTokyoJapan

Clear-cell variants of follicular carcinoma are rare subtypes of thyroid cancer. There is no unified view of the histopathological features of clear cell variants, but follicular carcinomas composed predominantly of clear cells are distinguished from clear cell variants. In clinical practice, it is important to determine whether clear cell variants arise primarily from the thyroid gland or are thyroid metastases of other clear cell carcinomas, such as renal cell carcinoma. We present a case in which a patient with initially suspected anaplastic thyroid carcinoma due to a rapidly progressive anterior neck mass was diagnosed with a clear cell variant of follicular carcinoma after a tissue biopsy. The patient was treated with lenvatinib, then his performance status improved, and he was discharged from the hospital. On day 188 after discharge, a contrast-enhanced computed tomography (CECT) scan of the neck showed further shrinkage of the tumor. However, a CECT scan of the chest revealed multiple lung metastases. On day 233 after discharge, the patient developed severe pneumonia resulting from tracheal rupture due to intratumoral necrosis. It was difficult to decide whether lenvatinib should have been discontinued or reduced when lung metastasis appeared. It is necessary to accumulate additional cases to make informed decisions about continuing lenvatinib therapy.

关键词： Clear Cell Variant Follicular Carcinoma Thyroid Carcinoma Lenvatinib

Screening and Phylogenetic Analysis of Deep-Sea Bacteria Capable of Metabolizing Lignin-Derived Aromatic Compounds

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Open Journal of Marine Science 2012年第4期2卷 177-187页

作者： Y. Ohta S. Nishi T. Haga T. Tsubouchi R. Hasegawa M. Konishi Y. Nagano Y. Tsuruwaka Y. shimane K. Mori K. Usui E. Suda K. Tsutsui A. Nishimoto Y. Fujiwara T. Maruyama Y. Hatada Institute of Biogeosciences Japan Agency of Marine-Earth Science and Technology (JAMSTEC) Yokosuka Japan

Lignin is one of the most abundant biomasses in nature. It is composed of aromatic moieties and has great potential for use in the production of chemical alternatives to petroleum products. Because of increasing interest in biocatalysis, the potential for industrial application of microbial metabolism of lignin-derived compounds has gained considerable recent attention. Functional screenings of culturable bacteria isolated from sediments and sunken wood collected from the deep sea revealed the existence of a number of previously unidentified bacteria capable of metabolizing lignin-related aromatic compounds. Of the 510 isolates obtained in the present study, 208 completely or partially metabolized these compounds. The 208 isolates were classified into diverse phyla, including Firmicutes, Actinobacteria, Bacteroidetes, and Proteobacteria. Among the 208 isolates, 61 unique 16S rRNA gene sequences were detected including previously unidentified marine lineage isolates. The metabolites of the isolates were analysed using liquid chromatography/mass spectrometry (LC/MS) or gas chromatography/mass spectrometry (GC/MS). Most of the representative 61 isolates non-oxidatively decarboxylated the substrates to produce the corresponding aromatic vinyl monomers, which are used as feed stocks for bio-based plastics production. Oxidative metabolism of the lignin-related compounds for assimilation was frequently observed. Our study showed that the deep-sea environment contains an abundance of microorganisms capable of both non-oxidative and oxidative bioconversion of lignin-derived aromatic compounds. The ability for bio-conversion of aromatic compounds found in this study will facilitate the development of future biotechnological applications.

关键词： Aromatic Compound Bacteria Deep Sea Lignin

至猫肠系膜Pacini小体的传出神经通路的电镜研究

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解剖学报 1995年第1期26卷 49-52页

作者：张文斌 Domoto Tokio Oki Mitsuru 李继硕李惠民第四军医大学解剖学教研室日本岛根医科大学第二解剖

电镜下观察了猫肠系膜正常Ｐａｃｉｎｉ小体的结构及双侧切断内脏大神经后其中央轴突和邻近结构的变性改变。位于猫肠系膜Ｐａｃｉｎｉ小体内的主轴突由近侧包有髓鞘的终末前纤维及远侧的无髓终末部构成。含有较多囊泡、少囊泡或无囊泡... 详细信息

电镜下观察了猫肠系膜正常Ｐａｃｉｎｉ小体的结构及双侧切断内脏大神经后其中央轴突和邻近结构的变性改变。位于猫肠系膜Ｐａｃｉｎｉ小体内的主轴突由近侧包有髓鞘的终末前纤维及远侧的无髓终末部构成。含有较多囊泡、少囊泡或无囊泡的小型终末和轴突样结构包绕中央主轴突的无髓部及其突起的周围。双侧切断内脏大神经３～５ｄ后，中央主轴突发生明显的变性。与此同时，周围的含较多囊泡、少囊泡或无囊泡的小结构亦由于变性而消失。根据上述结果及以往的研究可以认为，这些小型终末和轴突样结构是随内脏大神经走行的交感节后传出成分，它们可能对猫肠系膜Ｐａｃｉｎｉ小体的感受性产生影响。

关键词： Pacini小体传出神经内脏大神经变性猫

成纤维细胞体外培养结合串联质谱酰基肉碱谱诊断极长链酰基辅酶A脱氢酶缺陷症

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实用儿科临床杂志 2009年第20期24卷 1560-1562页

作者：李红马立燕马金海福田诚司长谷川有纪小林弘典山口清次宁夏医科大学附属医院儿科银川750004 日本岛根大学医学部小儿科日本岛根6938501

目的研究成纤维细胞体外培养结合串联质谱酰基肉碱谱分析对极长链酰基辅酶A脱氢酶(VLCAD)缺陷症的诊断价值。方法取健康对照标本6例,VLCAD缺陷症患儿标本9例(包括临床严重型2例,中间型3例及肌病型4例。男5例,女4例)。以棕榈酸(C16酸)为... 详细信息

目的研究成纤维细胞体外培养结合串联质谱酰基肉碱谱分析对极长链酰基辅酶A脱氢酶(VLCAD)缺陷症的诊断价值。方法取健康对照标本6例,VLCAD缺陷症患儿标本9例(包括临床严重型2例,中间型3例及肌病型4例。男5例,女4例)。以棕榈酸(C16酸)为培养溶媒底物在37℃培养箱中培养成纤维细胞株96h,应用串联质谱分析相应培养液中的酰基肉碱谱。结果与健康对照组比较,VLCAD缺陷症患儿乙酰肉碱(C2)明显降低,相应长链酰基肉碱异常增高,其中肉豆寇烯酰肉碱(C14)-酰基肉碱在临床严重型患儿中增高明显,月桂酰肉碱(C12)-酰基肉碱在临床轻型病例(包括中间型和肌病型)中增高更显著。长链酰基肉碱之和(ΣLC)及其与乙酰肉碱之比值(ΣLC/C2),VLCAD缺陷症患儿均明显高于健康对照。结论成纤维细胞体外特定条件培养结合串联质谱酰基肉碱谱分析,可诊断和鉴别VLCAD缺陷症及其临床分型,C12-酰基肉碱和C14-酰基肉碱可作为诊断标记。

关键词：极长链酰基辅酶A脱氢酶缺陷症串联质谱酰基肉碱成纤维细胞

INHIBITION OF THE MYD88 PATHWAY BY CURCUMIN, THE ACTIVE CONSTITUENT OF TURMERIC(CURCUMA LONGA L.), CAUSES APOPTOSIS IN HEPATIC STELLATE CELLS(HSCS)

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World Journal of Traditional Chinese Medicine 2015年第4期1卷 93-94页

作者： Shu J Kuchta K He Y Deng Y Lin Y Ye G Lv X Liu X Kobayashi Y Department of Gastroenterology Guangzhou Red Cross Hospital Jinan University National Institute of Health Sciences Division of Pharmacognosy Medical Corporation Soujikai Faculty of Medicine Shimane University

HSCs were divided into four groups,namely control group(A),MyD88 siRNA group(B),curcumin group(C),and curcumin+MyD88 siRNA group(D).Groups B and D were subjected to transient transfection with siRNA for *** C and D were incubated with curcumin(25μmol/L)for ***88 protein expression was observed by Western Blot,apoptosis was detected by flow cytometry,

关键词： siRNA