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In vitro and in vivo evaluation of cerium oxide nanoparticles in respiratory syncytial virus infection

Bioactive Materials 2023年第6期24卷 124-135页

作者： Akhil Patel Jessica Kosanovich Sameera Sansare Sricharani Balmuri Vinayak sant Kerry M.Empey shilpa sant Department of Pharmaceutical Sciences School of PharmacyUniversity of PittsburghPittsburghPA15261USA Center for Clinical Pharmaceutical Sciences Department of Pharmacy and TherapeuticsSchool of PharmacyClinical and Translational Science InstituteDepartment of ImmunologySchool of MedicineUniversity of PittsburghPittsburghPA15261USA Department of Bioengineering Swanson School of EngineeringMcGowan Institute for Regenerative MedicineUPMC Hillman Cancer CenterUniversity of PittsburghPittsburghPA15261USA

Respiratory syncytial virus(RSV)is the most common cause of viral bronchiolitis among children worldwide,yet there is no vaccine for RSV *** study investigates the potential of cube and sphere-shaped cerium oxide nanoparticles(CNP)to modulate reactive oxygen(ROS)and nitrogen(RNS)species and immune cell phenotypes in the presence of RSV infection in vitro and in *** and sphere-shaped CNP were synthesized by hydrothermal and ultrasonication methods,***-chemical characterization confirmed the shape of sphere and cube CNP and effect of various parameters on their particle size distribution and zeta *** vitro results revealed that sphere and cube CNP differentially modulated ROS and RNS levels in J774 ***,cube CNP significantly reduced RSV-induced ROS levels without affecting RNS levels while sphere CNP increased RSV-induced RNS levels with minimal effect on ROS *** CNP drove an M1 phenotype in RSV-infected macrophages in vitro by increasing macrophage surface expression of CD80 and CD86 with a concomitant increase in TNFαand IL-12p70,while simultaneously decreasing M2 CD206 *** administration of sphere and cube-CNP were well-tolerated with no observed toxicity in BALB/c ***,cube CNP preferentially accumulated in murine alveolar macrophages and induced their activation,avoiding enhanced uptake and activation of other inflammatory cells such as neutrophils,which are associated with RSV-mediated *** conclusion,we report that sphere and cube CNP modulate macrophage polarization and innate cellular responses during RSV infection.

关键词： Cerium oxide nanoparticles Reactive oxygen species Respiratory syncytial virus Macrophage phenotypes Immunomodulation Nanoparticle shape Bioactive nanoparticles

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