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Mortality characteristics during the two waves of COVID-19 in India:A retrospective observational study

Journal of Acute Disease 2022年第2期11卷 77-84页

作者： Nalini Ramesh Humaney shilpa sachin kuthe Shamim Akhtar Vivek K Pande Department of Medicine Nkpsims and Lata Mangeshkar HospitalNagpurIndia

Objective:To evaluate patient demographic characteristics and risk factors for mortality during the first and the second wave among COVID-19 patients in a tertiary care hospital of ***:Data were taken from the hospital’s electronic system for COVID-19 patients from August 2020 to December 2020,and the second from January 2021 to May *** mortality rate,demographic and clinical characteristics,laboratory profile,and reasons for the death of the two waves were retrieved and compared,and the risk factors of the two waves were ***:In the first wave,1177 COVID-19 cases visited the hospital and 96(8.2%)*** comparison,the death rate in the second wave was significantly higher(244/2038,12.0%)(P<0.001).No significant difference in age[60(50-69)vs.60.5(53-70),P=0.11]or gender(P=0.34)was observed between the two *** to the first *** were significantly more cases with fever,cough,weakness,loss of taste and smell,and sore throat during the second wave(P<0.05),but significantly fewer cases with kidney disease(6.6%vs.13.5%,P=0.038)and diabetes mellitus(35.7%vs.50.0%,P=0.015).Besides,during the second wave,more patients had abnormal X-ray findings,higher levels of lymphocytes and serum ferritin(P<0.05).In addition,there were significant differences in the rate of death cases with acidosis,septic shock,acute kidney injury,diabetes mellitus,cardiovascular events,hypothyroidism(P<0.05).Multivariate regression showed that during the first wave,age(OR:1.10;95%CI:1.02-1.21),diabetes mellitus(OR:3.16;95%CI:2.08-3.53),and abnormal X-ray(2.67;95%CI:2.32-2.87)were significant independent risk factors of mortality;while in the second wave,age(OR:1.13;95%CI:1.12-1.28),diabetes mellitus(OR:8.98;95%CI:1.79-45.67),abnormal X-ray(OR:12.83;95%CI:2.32-54.76),high D-dimer(OR:10.89;95%CI:1.56-134.53),and high IL-6(OR:7.89;95%CI:1.18-47.82)were significant independent risk factors of ***:Overall mortality and incidence of severe diseas

关键词： SARS-COV-2 COVID-19 Second wave First wave Pandemic

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