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脓毒症大鼠肝脏Toll样受体4水平及还原型谷胱甘肽的干预研究

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中国临床医学 2010年第5期17卷 667-670页

作者：陈斌杜施霖童朝阳施东伟闵珉黄培志复旦大学附属中山医院急诊科上海200032

目的:观察脓毒症大鼠急性肝损伤时肝脏Toll样受体4(TLR4)和肿瘤坏死因子α(TNF-α)水平的变化,探讨还原型谷胱甘肽(GSH)对脓毒症大鼠急性肝损伤的保护作用及其机制。方法:采用盲肠结扎穿孔术(CLP)制备SD大鼠脓毒症肝损伤模型。实验大鼠... 详细信息

目的:观察脓毒症大鼠急性肝损伤时肝脏Toll样受体4(TLR4)和肿瘤坏死因子α(TNF-α)水平的变化,探讨还原型谷胱甘肽(GSH)对脓毒症大鼠急性肝损伤的保护作用及其机制。方法:采用盲肠结扎穿孔术(CLP)制备SD大鼠脓毒症肝损伤模型。实验大鼠随机分成假手术组、模型组、GSH干预组(每组各24只),每组大鼠再按按0h、2h、6h、24h分为4个亚组(每组各6只)。GSH干预组在造模后立即经尾静脉给予GSH(***-1)共0.1mL,假手术组和模型组则给予等量0.9%氯化钠溶液。每组大鼠在4个时间点(CLP术后0h、2h、6h、24h)采集血标本和肝组织标本。HE染色观察肝组织病理改变;检测血清肝功能和肝组织TLR4和TNF-α水平的变化。结果:与假手术组相比,模型组大鼠血清肝功能水平在术后6h起开始升高,术后24h仍持续升高;肝组织TLR4和TNF-α水平均在术后2h显著升高,术后6h达到高峰,术后24h有所回落;术后24h肝组织HE染色显示肝细胞肿胀、大量炎性细胞浸润、细胞变性等损伤性改变。与模型组相比,GSH干预组在术后6h和24h血清肝功能损伤指标显著降低(P<0.05),而肝组织TLR4和TNF-α水平在术后2h、6h、24h均显著降低(P<0.05),肝组织的病理学损伤性改变也明显减轻。结论:在脓毒症早期肝组织TLR4及其调控的炎性因子TNF-α水平增高在脓毒症急性肝损伤中起重要作用;脓毒症早期应用GSH治疗可能通过降低TLR4水平,减少肝组织TNF-α浓度,对脓毒症急性肝损伤有保护作用。

关键词：还原型谷胱甘肽脓毒症肝损伤 Toll样受体4 肿瘤坏死因子α

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建筑碳排放软件对比分析及计算研究

建筑施工 2024年第1期46卷 48-51页

作者：孙建伟蒋世龙马义奎姜张张杜石林中建三局第一建设工程有限责任公司江苏南京210019 南京工业大学土木工程学院江苏南京211816

为更好地控制建筑碳排放量,建筑碳排放的测算与管理至关重要。基于此,对PKPM-CES建筑碳排放计算软件V3、东禾建筑碳排放软件、绿建斯维尔建筑碳排放CEEB 2023等3款建筑施工领域常用的碳排放软件进行了对比研究,分析其适用范围和计算过程... 详细信息

为更好地控制建筑碳排放量,建筑碳排放的测算与管理至关重要。基于此,对PKPM-CES建筑碳排放计算软件V3、东禾建筑碳排放软件、绿建斯维尔建筑碳排放CEEB 2023等3款建筑施工领域常用的碳排放软件进行了对比研究,分析其适用范围和计算过程,通过实际案例对其计算结果进行对比分析并总结各自的优缺点,以期为技术人员选择软件提供参考,并为新软件的开发提供建议。

关键词：碳排放计算软件对比功能分析计算分析

CFD-PBM coupled modeling of the liquid-liquid dispersion characteristics and structure optimization for Kenics static mixer

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Chinese Journal of Chemical Engineering 2024年第6期70卷 173-188页

作者： Junhai Deng shilin Lan Juchang Wu Shenghua du Weidong Liu Luchang Han Yefeng Zhou National&Local United Engineering Research Centre for Chemical Process Simulation and Intensification Chemical Process Simulation and Optimization Engineering Research Center of Ministry of EducationXiangtan UniversityXiangtan 411105China Hunan Haili Chemical Industry Company Limited Changsha 410000China

Kenics static mixers(KSM)are extensively used in industrial mixing-reaction processes by virtue of high mixing efficiency,low power homogenization and easy continuous *** liquid droplet size and its distribution and thus revealing the dispersion characteristics are of great significance for structural optimization and process intensification in the *** this work,a computational fluid dynamics-population balance model(CFD-PBM)coupled method is employed to systematically investigate the effects of operating conditions and structural parameters of KSM on droplet size and its distribution,to further reveal the liquid-liquid dispersion *** indicate that higher Reynolds numbers or higher dispersed phase volume fractions increase energy dissipation,reducing Sauter mean diameter(SMD)of dispersed phase droplets and with a shift in droplet size distribution(DSD)towards smaller *** aspect ratios,greater blade twist and assembly angles amplify shear rate,leading to smaller droplet size and a narrower DSD in the smaller *** degree of impact exerted by the aspect ratio is notably ***,mixing elements with different spin enhance shear and stretching *** to the same spin,SMD becomes 3.7-5.8 times smaller in the smaller size range with a significantly narrower *** into account the pressure drop and efficiency in a comprehensive manner,optimized structural parameters for the mixing element encompass an aspect ratio of 1-1.5,a blade twist angle of 180°,an assembly angle of 90°,and interlaced assembly of adjacent elements with different *** work provides vital theoretical underpinning and future reference for enhancing KSM performance.

关键词： CFD Population balance Liquid-liquid dispersion Kenics static mixer

基于文献计量学的流域生态健康评价研究热点及趋势分析

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环境保护科学 2023年第1期49卷 32-38页

作者：曹家乐张亚辉张瑾黄子晏杜士林孙福红安徽建筑大学环境与能源工程学院合肥230601 中国环境科学研究院环境基准与风险评估国家重点实验室北京100012 中国环境科学研究院环境检测与实验中心北京100012

流域生态健康评价是流域水生态功能分区和生态管理的基础,以Web of Science(WOS)和中国知网(CNKI)论文数据库为数据源,通过科学知识图谱工具CiteSpace对国内外流域生态健康评价研究领域进行文献计量分析。结果表明:2个数据库的流域生态... 详细信息

流域生态健康评价是流域水生态功能分区和生态管理的基础,以Web of Science(WOS)和中国知网(CNKI)论文数据库为数据源,通过科学知识图谱工具CiteSpace对国内外流域生态健康评价研究领域进行文献计量分析。结果表明:2个数据库的流域生态健康评价领域发文量呈波动式增长趋势,2005年后CNKI发文量高于WOS发文量;WOS发文量位居前列的国家有澳大利亚、中国、美国和法国等;该领域多学科交叉融合,包含生态学、动物学和植物学等;德国、英国和美国在该领域影响力表现突出,我国影响力较小,且与国际的研究合作较少;研究内容方面,国外集中在评价方法的研究,包括预测模型法、生物完整性法等;且注重流域的生境与栖息地评价,更强调流域生物多样性的保护及生态修复,关注流域生态的永续发展;国内则注重学习国外的评价体系与技术方法,构建适合本土的流域生态健康评价体系,同时3S技术在该领域成为较新的热点,可能在未来成为重要工具。

关键词：文献计量分析流域生态健康评价图谱分析 Web of Science CNKI

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Composition regulates dissolved organic matter adsorption onto iron (oxy)hydroxides and its competition with phosphate: Implications for organic carbon and phosphorus immobilization in lakes

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Journal of Environmental Sciences 2024年第10期144卷 159-171页

作者： ShuaiLong Wen JingJing Liu YueHan Lu JiaRu Dai XiuLin Huang shilin An Erik Jeppesen ZhengWen Liu YingXun du State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Molecular Eco-Geochemistry(MEG)Laboratory Department of Geological SciencesThe University of Alabama2017th AveTuscaloosaAL 35485USA School of Environmental Science and Engineering Nanjing Tech UniversityNanjing 210008China School of Environmental and Chemical Engineering Chongqing Three Gorges UniversityChongqing 404020China Department of Ecoscience Aarhus UniversitySilkeborg 8600Denmark Sino-Danish Centre for Education and Research University of Chinese Academy of SciencesBeijing 101408China Limnology Laboratory Department of Biological Sciences and Centre for Ecosystem Research and ImplementationMiddle East Technical UniversityAnkara 06800Turkey

Dissolved organicmatter(DOM)is a heterogeneous pool of compounds and exhibits diverse adsorption characteristics with or without phosphorous(P)*** impacts of these factors on the burial and mobilization of organic carbon and P in aquatic ecosystems remain *** this study,an algae-derived DOM(ADOM)and a commercially available humic acid(HA)with distinct compositions were assessed for their adsorption behaviors onto iron(oxy)hydroxides(FeOx),both in the absence and presence of *** contained less aromatics but more protein-like and highly unsaturated structures with oxygen compounds(HUSO)than *** adsorption capacity of FeOx was significantly greater for ADOM than for ***-like and HUSO compounds in ADOM and humic-like compounds and macromolecular aromatics in HA were preferentially adsorbed by ***,ADOM demonstrated a stronger inhibitory effect on phosphate adsorption than *** observation suggests that the substantial release of autochthonous ADOM by algae could elevate internal P loading and pose challenges for the restoration of restore eutrophic *** presence of phosphate suppressed the adsorption of protein-like compounds in ADOM onto FeOx,resulting in an increase in the relative abundance of protein-like compounds and a decrease in the relative abundance of humic-like compounds in post-adsorption *** contrast,phosphate exhibited no discernible impact on the compositional fractionation of ***,our results show the source-composition characters of DOM influence the immobilization of both DOM and P in aquatic ecosystems through adsorption *** preferential adsorption of proteinaceous compounds within ADOM and aromatics within HA highlights the potential for the attachment with FeOx to diminish the original source-specific signatures of DOM,thereby contributing to the shared DOM characteristics observed across diverse aquatic environments.

关键词： Algal dissolved organic matter Humic acid Adsorption Phosphate Fractionation FT-ICR MS

龙芽楤木皂甙对急性乙醇性肝损伤小鼠的保护作用

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中国临床医学 2010年第6期17卷 847-848页

作者：杜施霖张亚平姚晨玲薛渊栾骁樊帆童朝阳复旦大学附属中山医院上海200032

目的:探讨龙芽楤木皂苷(As)对乙醇所致小鼠急性肝损伤的保护作用及其机制。方法:采用乙醇灌胃法制备小鼠急性乙醇性肝损伤模型。50只雄性昆明小鼠随机分为对照组、急性乙醇性肝损伤模型组、As低剂量干预组(***-1)和As高剂量干预组(***-1... 详细信息

目的:探讨龙芽楤木皂苷(As)对乙醇所致小鼠急性肝损伤的保护作用及其机制。方法:采用乙醇灌胃法制备小鼠急性乙醇性肝损伤模型。50只雄性昆明小鼠随机分为对照组、急性乙醇性肝损伤模型组、As低剂量干预组(***-1)和As高剂量干预组(***-1)。比较各组小鼠肝脏指数、血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)活性及肝组织中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)含量及肝组织病理形态变化。结果:10d时急性乙醇性肝损伤小鼠肝组织SOD、GSH-Px活性降低(P<0.01),血清ALT、AST活性、肝脏脂质及肝组织MDA含量增加(P<0.05),与对照组比较有显著差异。给予不同剂量As后,急性乙醇性肝损伤小鼠肝组织SOD、GSH-Px活性均升高(P<0.01),血清ALT、AST活性和肝组织MDA含量降低(P<0.05),肝脏组织病理损伤不同程度地改善。结论:As能有效地改善肝功能、减轻脂质过氧化反应,对乙醇所致大鼠急性肝损伤具有预防作用。

关键词：龙芽楤木皂甙乙醇急性肝损伤脂质过氧化作用预防和控制小鼠

基于FLUENT的90°弯管内水环流动特性研究

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油气田地面工程 2019年第11期38卷 26-32页

作者：吴君强蒋文明杨娜张倩杜仕林刘杨陈义美来兴宇山东省油气储运安全省级重点实验室中国石油大学(华东)储运与建筑工程学院长庆油田公司生产运行处中国石油管道局工程有限公司

稠油由于其黏度过高,直接管输的难度较大,因此水环输送高黏原油作为一项高效节能的输油技术越来越受到关注.在高黏原油实际输送的过程中,水环会经过弯管部件,而在此过程中水环容易污染壁面,降低输送效率.运用CFD软件针对水环在90°弯管... 详细信息

稠油由于其黏度过高,直接管输的难度较大,因此水环输送高黏原油作为一项高效节能的输油技术越来越受到关注.在高黏原油实际输送的过程中,水环会经过弯管部件,而在此过程中水环容易污染壁面,降低输送效率.运用CFD软件针对水环在90°弯管内的流动进行分析,通过不同流动参数的对比研究其维稳特性.结果表明:在模拟条件下,当流速增加至0.9 m/s时水环在离心力的作用下偏心严重;当油水密度比较小时,水环在浮力的作用下偏心严重,甚至可能污染壁面;在一定范围内改变黏度比对弯管中的环状流影响较小.该研究结果可为水环在90°弯管内流动参数优化提供理论参考.

关键词：稠油输送弯管水环模型离心力浮力

Two-parameter Quantum Superalgebras and PBW Theorem

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Algebra Colloquium 2016年第2期23卷 303-324页

作者： Chunrui Ai shilin Yang College of Applied Sciences Beijing University of Technology Beijing 100124 China School of Mathematics and Statistics Zhengzhou University Zhengzhou 450001 China

A class of two-parameter quantum algebras Ur,s（s[（m｜n）） is constructed. It is shown that Ur,s（s[（m｜n）） is a Hopf superalgebra. Then the PBW basis of Ur,s（s[（m｜n）） is described. For this purpose, some co... 详细信息

关键词： Hopf superalgebra quantum group PBW basis

Coupling electro-mechanical behaviors in the interdigital electrode device of ferroelectrics

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Acta Mechanica Sinica 2021年第4期37卷 649-661,I0003页

作者： Suxin Pan shilin Xie Qun Li State Key Laboratory for Strength and Vibration of Mechanical Structures Xi’an Jiaotong UniversityXi’an 710049China

The electro-mechanical coupling behaviors of ferroelectric devices with interdigital electrodes may become complicated due to the material inhomogeneity and local field concentration under the complex working *** this paper,a ferroelectric model,drawn from the typical interdigital electrode structure of a ferroelectric sensor,is established based on phase field theory,to study the polarization evolution and explore the evolution laws in *** results show that there appears ferroelectric creep even under an applied electric field below the coercive field ***,the configurational force theory is introduced to investigate the mechanical behaviors related to polarization switching in the ferroelectric samples with interdigital *** is found that configurational force and polarization have similar evolution laws in both time evolving and space *** considering the configurational force as the driving force,it is possible to predict the potential direction of polarization evolution and explore its evolution mechanism in ferroelectrics,demonstrating the configurational force as a useful parameter for describing mechanical behavior during the polarization evolution and a powerful tool for investigating the evolution mechanism of microstructure with coupling effects in ferroelectric materials.

关键词： Phase field modeling Configurational force Polarization evolution Domain switching Interdigital electrode