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Whole-genome and genome-wide association studies improve key agricultural traits of safflower for industrial and medicinal use

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Horticulture Research 2023年第11期10卷 59-70页

作者： Jiang chen Shuai Guo Xueli Hu Rui Wang Donghai Jia Qiang Li Xianmei Yin Xuejiao Liao Zunhong Hu Peiqi Wang Chaoxiang Ren Shuai Dong Chao chen shilin chen Jiang Xu Jin Pei State Key Laboratory of Southwestern Chinese Medicine Resources College of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Industrial Crops Research Institute Yunnan Academy of Agricultural SciencesKunming 650205China Institute of Economic Crops Xinjiang Academy of Agricultural SciencesUrumchi 830091China

Safflower(Carthamus tinctorius)is widely cultivated around the world for its seeds and *** presence of linoleic acid(LA)in its seeds and hydroxysafflor yellow A(HSYA)in its flowers are the crucial traits that enable safflower to be used for industrial and medicinal *** the genetic control of these traits is essential for optimizing the quality of safflower and its *** further this research,we present a chromosome-scale assembly of the genome of the safflower variety‘Chuanhonghua 1’,which was achieved using an integrated strategy combining Illumina,Oxford Nanopore,and Hi-C *** obtained a 1.17-Gb assembly with a contig N50 of 1.08 Mb,and all assembled sequences were assigned to 12 ***’s evolution involved the core eudicotγ-triplication event and a whole-genome duplication event,which led to large-scale genomic *** genomic shuffling has occurred since the divergence of the ancestor of *** conducted metabolite and transcriptome profiles with time-and part-dependent changes and screened candidate genes that significantly contribute to seed lipid *** also analyzed key gene families that participate in LA and HSYA ***,we re-sequenced 220 safflower lines and carried out a genome-wide association study using high-quality SNP data for eight agronomic *** identified SNPs related to important traits in ***,the candidate gene HH_034464(CtCGT1)was shown to be involved in the biosynthesis of ***,we provide a high-quality reference genome and elucidate the genetic basis of LA and HSYA biosynthesis in *** vast amount of data will benefit further research for functional gene mining and breeding in safflower.

关键词： flowers Whole breeding

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50th anniversary of artemisinin:From the discovery to allele-aware genome assembly of Artemisia annua

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Molecular Plant 2022年第8期15卷 1243-1246页

作者： Jiang Xu Baosheng Liao Ling Yuan Xiaofeng Shen Xuejiao Liao Jigang Wang Haoyu Hu Zhihai Huang Li Xiang shilin chen Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Quality Evaluation of Chinese Medicine of the Guangdong Provincial Medical Products Administration the Second Clinical CollegeGuangzhou University of Chinese MedicineGuangzhou 510006China Kentucky Tobacco Research and Development Center and Department of Plant and Soil SciencesUniversity of KentuckyLexingtonKY 40546USA institute of Medicinal Plant Development Chinese Academy of Medical SciencesBeijing 100193China Artemisinin Research Center China Academy of Chinese Medical SciencesBeijing 100700China chengdu University of Traditional Chinese Medicine ChengduChina

Over the past half century,the fight against malaria has been a resounding success mainlydue to thediscoveryof *** to the World Health Organization(WHO),morbidity and mortality due to malaria have been cut by half sin... 详细信息

关键词： mortality malaria allele

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The Chrysanthemum nankingense Genome Provides Insights into the Evolution and Diversification of Chrysanthemum Flowers and Medicinal Traits

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Molecular Plant 2018年第12期11卷 1482-1491页

作者： Chi Song Yifei Liu Aiping Song Gangqiang Dong Hongbo Zhao Wei Sun Shyam Ramakrishnan Ying Wang Shuaibin Wang Tingzhao Li Yan Niu Jiafu Jiang Bin Dong Ye Xia Sumei chen Zhigang Hu Fadi chen shilin chen Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China College of Pharmacy Hubei University of Chinese Medicine Wuhan 430065 China College of Horticulture Nanjing Agricultural University Key Laboratory of Landscape Agriculture Ministry of Agriculture Nanjing 210095 China Amway (China) Botanical R&D Center Wuxi 214115 China Department of Ornamental Horticulture School of Landscape Architecture Zhejiang Agriculture and Forestry University Hangzhou 311300 China Amway Corporation Buena Park CA 90622-5940 USA Wuhan Benagen Tech Solutions Company Limited Wuhan 430070 China Key Laboratory of Plant Resources Conservation and Sustainable Utilization South China Botanical Garden The Chinese Academy of Sciences Guangzhou 510650 China These authors contributed equally to this article

The Asteraceae (Compositae),a large plant family of approximately 24 000-35 000 species,accounts for^10% of all angiosperm species and contributes a lot to plant *** most representative members of the Asteraceae are the economically important chrysanthemums (Chrysanthemum L.)that diversified through reticulate *** is typically created by multiple evolutionary mechanisms such as wholegenome duplication 0NGD)or polyploidization and locally repetitive genome ***,the lack of genomic data from chrysanthemum species has prevented an in-depth analysis of the evolutionary mechanisms involved in their ***,we used Oxford Nanopore long-read technologyto sequence the diploid Chrysanthemum nankingense genome,which represents one of the progenitor genomes of domesticated *** analysis revealed that the evolution of the *** genome was driven by bursts of repetitive element expansion and WGD events including a recentWGD that distinguishes chrysanthemum from sunflower,which diverged from chrysanthemum approximately 38.8 million years *** of ornamental and medicinal traits in chrysanthemums are linked to the expansion of candidate gene families by duplication events including paralogous gene ***,our study of the assembled reference genome offers new knowledge and resources to dissect the history and pattern of evolution and diversification of chrysanthemum plants,and also to accelerate their breeding and improvement.

关键词： Chrysanthemum genome evolution whole-genome duplication nanopore sequencing flower evolution medicinal plant

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Promoter variations in DBR2-like affect artemisinin production in different chemotypes of Artemisia annua

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Horticulture Research 2023年第9期10卷 220-232页

作者： Xingwen Wang Lan Wu Li Xiang Ranran Gao Qinggang Yin Mengyue Wang Zhaoyu Liu Liang Leng Yanyan Su Huihua Wan Tingyu Ma shilin chen Yuhua Shi Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine Artemisinin Research CenterInstitute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Institute of Herbgenomics Chengdu University of Traditional Chinese MedicineChengdu 611137China Amway(China)Botanical R&D Center Wuxi 214115China Key Lab of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People’s Republic of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China

Artemisia annua is the only known plant source of the potent antimalarial artemisinin,which occurs as the low-and high-artemisinin producing(LAP and HAP)***,the different mechanisms of artemisinin producing between these two chemotypes were still not fully ***,we performed a comprehensive analysis of genome resequencing,metabolome,and transcriptome data to systematically compare the difference in the LAP chemotype JL and HAP chemotype *** analysis revealed that 72.18%of sesquiterpenes was highly accumulated in HAN compared to *** omics analysis found a DBR2-Like(DBR2L)gene may be involved in artemisinin ***2L was highly homologous with DBR2,belonged to ORR3 family,and had the DBR2 activity of catalyzing artemisinic aldehyde to dihydroartemisinic *** resequencing and promoter cloning revealed that complicated variations existed in DBR2L promoters among different varieties of *** and were clustered into three variation *** promoter activity of diverse variant types showed obvious ***,the core region(-625 to 0)of the DBR2L promoter was identified and candidate transcription factors involved in DBR2L regulation were ***,the result indicates that DBR2L is another key enzyme involved in artemisinin *** promoter variation in DBR2L affects its expression level,and thereby may result in the different yield of artemisinin in varieties of *** provides a novel insight into the mechanism of artemisinin-producing difference in LAP and HAP chemotypes of ***,and will assist in a high yield of artemisinin in ***.

关键词： thereby insight homologous

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人与自然的矛盾及其化解——评福斯特的生态危机论

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国外社会科学 2007年第2期 15-20页

作者：陈食霖中南财经政法大学人文学院哲学系

针对当代西方日益严重的生态问题,北美著名的生态马克思主义理论家福斯特认为,生态危机产生的根源主要在于资本主义制度的非正义及其生产方式,解决生态环境问题的关键在于实现社会制度的变革和生态道德革命。福斯特的生态学马克思主义... 详细信息

针对当代西方日益严重的生态问题,北美著名的生态马克思主义理论家福斯特认为,生态危机产生的根源主要在于资本主义制度的非正义及其生产方式,解决生态环境问题的关键在于实现社会制度的变革和生态道德革命。福斯特的生态学马克思主义理论对于解决我国现代化进程中的生态环境问题,构建社会主义和谐社会具有启迪意义。

关键词：福斯特生态学马克思主义生态道德生态危机

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Strategies on biosynthesis and production of bioactive compounds in medicinal plants

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Chinese Herbal Medicines 2024年第1期16卷 13-26页

作者： Miaoxian Guo Haizhou Lv Hongyu chen Shuting Dong Jianhong Zhang Wanjing Liu Liu He Yimian Ma Hua Yu shilin chen Hongmei Luo Key Lab of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Engineering Research Center of Chinese Medicine Resource Ministry of EducationBeijing 100193China Key Laboratory of Hangzhou City for Ecosystem Protection and Restoration College of Life and Environmental SciencesHangzhou Normal UniversityHangzhou 311121China chengdu University of Traditional Chinese Medicine Chengdu 611137China

Medicinal plants are a valuable source of essential medicines and herbal products for healthcare and disease *** with chemical synthesis and extraction,the biosynthesis of natural products is a very promising alternative for the successful conservation of medicinal plants,and its rapid development will greatly facilitate the conservation and sustainable utilization of medicinal ***,we summarize the advances in strategies and methods concerning the biosynthesis and production of natural products of medicinal *** strategies and methods mainly include genetic engineering,plant cell culture engineering,metabolic engineering,and synthetic biology based on multiple“OMICS”technologies,with paradigms for the biosynthesis of terpenoids and *** also highlight the biosynthetic approaches and discuss progress in the production of some valuable natural products,exemplifying compounds such as vindoline(alkaloid),artemisinin and paclitaxel(terpenoids),to illustrate the power of biotechnology in medicinal plants.

关键词： biosynthetic strategies biotechnology natural products medicinal plants synthetic biology

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当代西方生态学马克思主义生态危机理论评析

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武汉大学学报（人文科学版） 2008年第6期61卷 685-690页

作者：陈食霖中南财经政法大学人文学院教授湖北武汉430073

当代西方生态学马克思主义继承和发展了经典马克思主义的资本主义危机理论,认为生态危机的主要根源在于资本主义制度及其生产方式;解决全球性生态危机、化解人与自然之间矛盾的根本途径是变革资本主义制度、实施生态转化战略,走向生态... 详细信息

当代西方生态学马克思主义继承和发展了经典马克思主义的资本主义危机理论,认为生态危机的主要根源在于资本主义制度及其生产方式;解决全球性生态危机、化解人与自然之间矛盾的根本途径是变革资本主义制度、实施生态转化战略,走向生态社会主义。客观评析生态学马克思主义的生态危机理论,对于我们解决中国社会主义现代化建设中生态环境问题,具有一定的现实意义。

关键词：生态危机生态学马克思主义生态社会主义

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生态批判与历史唯物主义的重构——评詹姆斯·奥康纳的生态学马克思主义思想

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武汉大学学报（人文科学版） 2006年第2期59卷 140-145页

作者：陈食霖中南财经政法大学人文学院湖北武汉430064

詹姆斯.奥康纳的《自然的理由》比较系统地反映了奥康纳的“重构”历史唯物主义,建构生态学马克思主义的基本思路和理论旨趣,奥康纳通过对包括历史唯物主义在内的整个马克思主义的种种责难进行了建构生态学马克思主义的理论探索;奥康纳... 详细信息

詹姆斯.奥康纳的《自然的理由》比较系统地反映了奥康纳的“重构”历史唯物主义,建构生态学马克思主义的基本思路和理论旨趣,奥康纳通过对包括历史唯物主义在内的整个马克思主义的种种责难进行了建构生态学马克思主义的理论探索;奥康纳对当代资本主义的批判是一种内涵制度批判和价值批判的生态批判,他试图建构在实践层面上的生态社会主义理论。

关键词：詹姆斯·奥康纳生态学马克思主义历史唯物主义生态批判生态社会主义

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Genome-wide pan-GPCR cell libraries accelerate drug discovery

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Acta Pharmaceutica Sinica B 2024年第10期14卷 4296-4311页

作者： Hanting Yang Yongfu Wang Wei Liu Taiping He Jiayu Liao Zhongzhi Qian Jinghao Zhao Zhaotong Cong Dan Sun Zhixiang Liu Can Wang Lingping Zhu shilin chen School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China Institute of Herbgenomics Chengdu University of Traditional Chinese MedicineChengdu 611137China School of Basic Medical Science Chengdu University of Traditional Chinese MedicineChengdu 611137China Department of Bioengineering University of CaliforniaRiversideCA 92521USA The Huaxi-Cal Research Center for Predictive Intervention Medicine West China HospitalSichuan UniversityChengdu 610041China Chinese Pharmacopoeia Commission Beijing 100061China

G protein-coupled receptors(GPCRs)are pivotal in mediating diverse physiological and pathological processes,rendering them promising targets for drug *** account for about 40%of FDA-approved drugs,representing the most successful drug ***,only approximately 15%of the 800 human GPCRs are targeted by market drugs,leaving numerous opportunities for drug discovery among the remaining *** expression systems play crucial roles in the GPCR drug discovery field,including novel target identification,structural and functional characterization,potential ligand screening,signal pathway elucidation,and drug safety ***,we discuss the principles,applications,and limitations of widely used cell expression systems in GPCR-targeted drug discovery,GPCR function investigation,signal pathway characterization,and pharmacological property *** also propose three strategies for constructing genome-wide pan-GPCR cell libraries,which will provide a powerful platform for GPCR ligand screening,and facilitate the study of GPCR mechanisms and drug safety evaluation,ultimately accelerating the process of GPCR-targeted drug discovery.

关键词： G-protein coupled receptors Genome-wide pan-GPCR Transgenic cell library High-throughput screening Drug discovery

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苏联哲学教科书与马克思主义哲学中国化

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山东社会科学 2011年第6期 25-29页

作者：陈食霖中南财经政法大学哲学院湖北武汉430060

"苏联哲学教科书"是苏联哲学家建构的一种马克思主义哲学解释体系。评价"苏联哲学教科书",必须坚持历史主义的态度,应立足于马克思主义哲学发展史和马克思主义哲学中国化的视角来评价,既要认识到它的历史局限性,也要承认它在马克思主义... 详细信息

"苏联哲学教科书"是苏联哲学家建构的一种马克思主义哲学解释体系。评价"苏联哲学教科书",必须坚持历史主义的态度,应立足于马克思主义哲学发展史和马克思主义哲学中国化的视角来评价,既要认识到它的历史局限性,也要承认它在马克思主义哲学发展史上特别是在马克思主义哲学中国化进程中发挥的积极作用。超越"苏联哲学教科书",建立中国特色的马克思主义哲学解释体系,仍将是中国马克思主义者必须直面的重大理论任务。

关键词：马克思主义哲学中国化苏联哲学教科书

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