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长寿与短命:十字花科植物中MADS-box基因的长袖善舞

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植物学报 2024年第3期59卷 351-354页

作者：廉小平 Getachew Melaku 张石来胡凤益云南大学农学院新基石科学实验室昆明650405

开花基因决定植物的一年生或多年生开花习性。已在不同植物中鉴定到多个开花基因,然而关于开花基因如何驱动十字花科植物一年生与多年生生活史策略转变的进化机制仍不清楚。最近一项研究聚焦十字花科不同属的自然变异,发现3个亲缘关系... 详细信息

开花基因决定植物的一年生或多年生开花习性。已在不同植物中鉴定到多个开花基因,然而关于开花基因如何驱动十字花科植物一年生与多年生生活史策略转变的进化机制仍不清楚。最近一项研究聚焦十字花科不同属的自然变异,发现3个亲缘关系密切的MADS-box类转录因子编码基因(即FLC、FLM和MAF)与其一年生/多年生习性转变相关,并解析了其分子机制,提出十字花科植物生活史策略(即多年生/二年生/一年生之间的转换)是由FLC类MADS-box基因剂量叠加所决定的连续过程。研究结果初步明确了十字花科植物一年生与多年生生活史策略转换的进化机制和轨迹,为培育多年生油菜品种奠定了理论基础,也为其它十字花科作物的多年生化遗传改良提供借鉴。

关键词：十字花科生活史策略 MADS-box 多年生一年生转换

The C_ν for calculating the shock temperatures of water below 80 GPa

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Science China(Physics,Mechanics & Astronomy) 2011年第8期54卷 1443-1446页

作者： PENG XiaoJuan LIU FuSheng zhang shilai zhang MingJian JING FuQian Institute of High Temperature and High Pressure Physics Southwest Jiaotong University Chengdu 610031 China

The shock temperatures of water under 35-50 GPa are firstly measured by the optical pyrometry technique. Cν is a constant below 51 GPa (Cν=7.07R), and increases with the temperature above 51 GPa (Cν=(5.76+3.84×10-4T)R). From our calculation, the dissociation has little effect on Cν. But the electron is essential to the Cν calculation.

关键词： shock temperature water Cν

Developing superior alleles of yield genes in rice by artificial mutagenesis using the CRISPR/Cas9 system

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The Crop Journal 2018年第5期6卷 475-481页

作者： Liyu Huang Ru zhang Guangfu Huang Yanxia Li Getachew Melaku shilai zhang Haitao Chen Yanjuan Zhao Jing zhang Yesheng zhang Fengyi Hu State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan/Research Center for Perennial Rice Engineering and Technology of Yunnan/School of Agriculture Yunnan University State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences BGI-Baoshan

Rice yield is an important and complex agronomic trait controlled by multiple *** recent decades,dozens of yield-associated genes in rice have been cloned,many of which can increase production in the form of loss or degeneration of ***,mutations occurring randomly under natural conditions have provided very limited genetic resources for yield *** this study,potentially yield-increasing alleles of two genes closely associated with yield were edited *** recently developed CRISPR/Cas9system was used to edit two yield genes:Grain number 1a(Gn1a)and DENSE AND ERECT PANICLE1(DEP1).Several mutants were identified by a target sequence *** analysis confirmed one mutant allele of Gn1a and three of DEP1 conferring yield superior to that conferred by other natural high-yield *** results demonstrate that favorable alleles of the Gnla and DEP1 genes,which are considered key factors in rice yield increases,could be developed by artificial mutagenesis using genome editing technology.

关键词： Rice CRISPR/Cas9 Gn1a DEP1 Gene editing

Ferroptosis in early brain injury after subarachnoid hemorrhage: review of literature

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中华神经外科杂志(英文) 2024年第2期10卷 1-16页

作者： Kang Junlin Tian shilai zhang Lei Yang Gang The First Hospital of Lanzhou University Lanzhou City Gansu Province China Gansu Provincial Hospital Lanzhou City Gansu Province China

Spontaneous subarachnoid hemorrhage (SAH), mainly caused by ruptured intracranial aneurysms, is a serious acute cerebrovascular disease. Early brain injury (EBI) is all brain injury occurring within 72 h after SAH, mainly including increased intracranial pressure, decreased cerebral blood flow, disruption of the blood-brain barrier, brain edema, oxidative stress, and neuroinflammation. It activates cell death pathways, leading to neuronal and glial cell death, and is significantly associated with poor prognosis. Ferroptosis is characterized by iron-dependent accumulation of lipid peroxides and is involved in the process of neuron and glial cell death in early brain injury. This paper reviews the research progress of ferroptosis in early brain injury after subarachnoid hemorrhage and provides new ideas for future research.

关键词： Subarachnoid hemorrhage Early brain injury Ferroptosis Intracranial aneurysm

Identification of Key Genes for the Ultrahigh Yield of Rice Using Dynamic Cross-tissue Network Analysis

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Genomics, Proteomics & Bioinformatics 2020年第3期18卷 256-270页

作者： Jihong Hu Tao Zeng Qiongmei Xia Liyu Huang Yesheng zhang Chuanchao zhang Yan Zeng Hui Liu shilai zhang Guangfu Huang Wenting Wan Yi Ding Fengyi Hu Congdang Yang Luonan Chen Wen Wang State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China State Key Laboratory of Hybrid Rice College of Life SciencesWuhan UniversityWuhan 430072China CAS Key Laboratory of Systems Biology Center for Excellence in Molecular Cell ScienceInstitute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Institute of Brain-Intelligence Technology Zhangjiang LaboratoryShanghai 201210China Institute of Food Crop of Yunnan Academy of Agricultural Sciences Kunming 650205China School of Agriculture Yunnan UniversityKunming 650500China BGI-Baoshan Baoshan 678004China Center for Ecological and Environmental Sciences Northwestern Polytechnical UniversityXi’an 710072China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

Significantly increasing crop yield is a major and worldwide challenge for food supply and *** is well-known that rice cultivated at Taoyuan in Yunnan of China can produce the highest yield ***,the gene regulatory mechanism underpinning this ultrahigh yield has been a ***,we systematically collected the transcriptome data for seven key tissues at different developmental stages using rice cultivated both at Taoyuan as the case group and at another regular rice planting place Jinghong as the control *** identified the top 24 candidate high-yield genes with their network modules from these well-designed datasets by developing a novel computational systems biology method,i.e.,dynamic cross-tissue(DCT)network *** used one of the candidate genes,Os SPL4,whose function was previously unknown,for gene editing experimental validation of the high yield,and confirmed that Os SPL4 significantly affects panicle branching and increases the rice *** study,which included extensive field phenotyping,cross-tissue systems biology analyses,and functional validation,uncovered the key genes and gene regulatory networks underpinning the ultrahigh yield of *** DCT method could be applied to other plant or animal systems if different phenotypes under various environments with the common genome sequences of the examined *** can be downloaded from https://***/ztpub/DCT.

关键词： Dynamic cross-tissue(DCT) Systems biology RNA-seq Ultrahigh yield Rice

Perennial rice improves farmer livelihood and ecosystem security

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Perennial rice improves farmer livelihood and ecosystem secu...

^(18)F-FDG-(OAc)_(4)的合成及其在小鼠体内的生物分布

第二十届中国作物学会学术年会

作者： zhang shilai Yunnan University

To tackle food insecurity faced by an ever-growing population, there is an urgent need to develop new forms of highly productive and ecologically-secure agricultural systems. Perennial Rice（PR） is now a reality from theory and practice with the release of three PR cultivars, which are perennial rice 23（PR23）, Yunda 25（PR25） and Yunda107（PR107） to farmers in the Yunnan Province of China and also testing over the world where rice is staple food. Selected from interspecific hybridization between the cultivated rice Oryza sativa and the wild perennial rice Oryza longistaminata, these PR cultivars have regularly produced grain yields(6.8 t ha) comparable with those of seasonally-replanted annual counterparts(6.7 t ha) under paddy conditions, with excellent agronomic type combining robust regrowth and acceptable grain quality. Farmer preference is strong, due to reduced labour requirements for land preparation and transplanting, also saved seeds input and seeding nursery preparing, which reduces costs, increases profitability, and reduces drudgery. In combination with no tillage, stubble retention and enhanced surface cover, PR cultivar possessed the benefit of reducing soil deterioration, with potential longer-term benefits to soil fertility(increase rate 0.95 and 0.11 Mg ha year for SOC and TN according to our permilinary result), farming-system flexibility and farmer livelihood compared to annual rice. This is the milestone of release of a hybridized perennial grain crop. This report will outline the breeding schedule and performance of perennial rice, summarized the social-economic, ecological and soil benefits of perennial rice-no tillage cropping system, zoning optimal application area for perennial rice production over the world. This innovation would help maintain food security and ecological integrity, and also inspire research on other perennial grains. This research was RunnerUp for Breakthrough of the Year 2022, according to Science, published by American Acad

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中国医疗设备 2024年第5期39卷 26-30页

作者：何正中庞丁华李宁张实来杨洪蒙小飞杨志肖国有广西医科大学附属肿瘤医院核医学科(广西临床重点建设专科) 广西南宁530021

目的分析正电子药物合成器合成基氟-18标记的四乙酰脱氧葡糖[1,3,4,6-四乙酰基-O-2-^(18)F-2-脱氧-β-D葡萄糖,简称^(18)F-FDG-(OAc)_(4)]的稳定性和实用性。方法基于合成器及其合成工艺流程,进行^(18)F-FDG-(OAc)4合成产量和质量控制... 详细信息

目的分析正电子药物合成器合成基氟-18标记的四乙酰脱氧葡糖[1,3,4,6-四乙酰基-O-2-^(18)F-2-脱氧-β-D葡萄糖,简称^(18)F-FDG-(OAc)_(4)]的稳定性和实用性。方法基于合成器及其合成工艺流程,进行^(18)F-FDG-(OAc)4合成产量和质量控制及其与氟-18标记的脱氧葡萄糖(2-[18F]-氟-2-脱氧-D-葡萄糖,简称18F-FDG)在小鼠体内的生物分布异同分析。结果连续3批合成^(18)F-FDG-(OAc)4的成功率为100%,产率分别为59.64%、60.61%、59.72%,产品溶液为无色透明溶液,放射性化学纯度≥96%(Rf值为0.8~0.9),放射性核纯度为100%。^(18)F-FDG-(OAc)_(4)与18F-FDG注入小鼠,后各个脏器的放射性摄取均无差别,差异无统计学意义(P>0.05)。结论正电子药物合成器合成^(18)F-FDG-(OAc)4的流程简单、便捷,合成成功率和合成产率较高,具有较强的稳定性和实用性。

关键词： ^(18)F-FDG-(OAc)_(4) 18F-FDG 显像剂制备生物分布

个性化护理干预对肿瘤患者^(18)F-FDG PET/CT检查质量及图像质量的影响研究

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中国医药科学 2024年第2期14卷 114-117页

作者：陆静佳张实来韦红娇杨志李宁柴华刘子雅杨彩娟方建芸肖国有广西医科大学附属肿瘤医院核医学科(广西临床重点建设专科) 广西南宁530021

目的探讨个性化护理干预对肿瘤患者^(18)F-FDG PET/CT检查质量及图像质量的影响。方法选取2020年1月至2022年12月在广西医科大学附属肿瘤医院行^(18)F-FDG PET/CT检查的100例肿瘤患者作为研究对象,随机分为观察组和对照组,每组各50例。... 详细信息

目的探讨个性化护理干预对肿瘤患者^(18)F-FDG PET/CT检查质量及图像质量的影响。方法选取2020年1月至2022年12月在广西医科大学附属肿瘤医院行^(18)F-FDG PET/CT检查的100例肿瘤患者作为研究对象,随机分为观察组和对照组,每组各50例。对照组实施常规护理干预,观察组实施个性化护理干预,比较两组患者的检查质量及图像质量。结果观察组在显像剂外漏(P=0.017)、注射次数(P=0.042)、肠道摄取增高(P=0.046)、声带摄取增高(P=0.037)、眼肌摄取增高(P=0.027)、全身肌肉摄取增高(P=0.037)发生率均低于对照组,差异有统计学意义(P<0.05)。结论对肿瘤患者在^(18)F-FDG PET/CT显像检查过程中实施个性化护理干预,有利于提高检查质量和图像质量,使患者和医护人员共同获益,值得推广。

关键词：个性化护理肿瘤患者 ^(18)F-FDG PET/CT检查检查质量图像质量

个性化护理干预对非小细胞肺癌根治术后患者行PET/CT检查的体会

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微创医学 2024年第1期19卷 90-92页

作者：陆静佳韦红娇潘海辉杨志张实来李宁杨彩娟方建芸肖国有劳永聪广西医科大学附属肿瘤医院核医学科(广西临床重点建设专科) 广西南宁市530021

目的探究个性化护理干预对非小细胞肺癌根治术后患者PET/CT检查的影响。方法选择在我院核医学科行PET/CT检查的100例非小细胞肺癌根治术后患者为研究对象,按照随机数字表法将其分为观察组与对照组,每组50例。比较两组患者的检查时间、PE... 详细信息

目的探究个性化护理干预对非小细胞肺癌根治术后患者PET/CT检查的影响。方法选择在我院核医学科行PET/CT检查的100例非小细胞肺癌根治术后患者为研究对象,按照随机数字表法将其分为观察组与对照组,每组50例。比较两组患者的检查时间、PET/CT图像质量、图像合格率、检查配合度、检查满意度。结果观察组检查时间短于对照组,图像质量评分、图像合格率、检查配合度、检查满意度均明显高于对照组,差异均有统计学意义(均P<0.05)。结论对非小细胞肺癌根治术后行PET/CT检查患者给予个性化护理干预,可以缩短患者检查时间,提升PET/CT图像质量,提高检查配合度和满意度,值得临床应用推广。

关键词：非小细胞肺癌个体化护理 PET/CT检查