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恒功率充放电条件下的锂离子电容器循环性能

广东电力 2021年第6期34卷 89-97页

作者：王超伍世嘉谢杭璇董家华徐凯琪钟国彬苏伟广东电网有限责任公司电力科学研究院广东广州510080 南方电网电力科技股份有限公司广东广州510080 中电投珠海横琴热电有限公司广东珠海519031

锂离子电容器循环寿命长,现场应用数据积累少,掌握其在恒功率充放电条件下的循环性能对于有效评估其健康状态、推动其在电力储能中的应用至关重要。为此,开展不同充放电功率(90~270 W)、工作温度(25~45℃)和充放电深度(25%~100%)下锂离... 详细信息

锂离子电容器循环寿命长,现场应用数据积累少,掌握其在恒功率充放电条件下的循环性能对于有效评估其健康状态、推动其在电力储能中的应用至关重要。为此,开展不同充放电功率(90~270 W)、工作温度(25~45℃)和充放电深度(25%~100%)下锂离子电容器循环性能的测试,以研究三者对锂离子电容器循环性能的影响。测试发现,在恒功率充放电条件下,锂离子电容器循环性能衰减呈现近似线性的变化规律,在适宜的工作条件下(额定充放电功率范围内、温度不高于45℃、充放电深度不高于50%)恒功率充放电时,充放电深度是最主要的影响因素,充放电深度越大,放电能量衰减越快;当超出适宜工作条件时,充放电功率、温度和充放电深度均会造成锂离子电容器加速老化,充放电功率越大,工作温度越高,其性能衰减越快。为实现锂离子电容器寿命的快速评估,建议在100%充放电深度、2~3倍额定功率、适当的高温(45℃)条件下开展锂离子电容器加速老化寿命测试。

关键词：锂离子电容器循环性能恒功率充放电充放电深度

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机械振动粘土砂旧砂再生实验

热加工工艺 1988年第2期 30-33页

作者：孟宪嘉杨越宁张桂芳房勇奇吴世甲王志臣沈阳工业学院熊岳铸造机械厂

本文探讨了机械振动粘土砂旧砂再生的效果和影响因素。大量试验证明,机械振动粘土砂旧砂再生是一种有效的再生方法,解决了许多生产和设计上的理论和实践问题,为振动再生机的设计提供了依据。

关键词：旧砂再生含泥量再生砂粘土砂型砂机械振动

基于ARCS动机模型的“中药鉴定实习”实践教学设计与应用

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中国医学教育技术 2024年第2期38卷 217-221页

作者：段世佳王晓琴薛焱夏慧敏杜晓鹂武世奎邢煜舒张慧文田景民内蒙古医科大学药学院呼和浩特010110

ARCS动机模型在实践教学中被广泛应用,对激发和维持学生学习动机起着重要的作用。文章以ARCS动机模型为基础对“中药鉴定实习”进行课堂教学设计,进而提升学生的学习动力。同时,该课程依托内蒙古医科大学位于河北安国的实习基地进行为... 详细信息

ARCS动机模型在实践教学中被广泛应用,对激发和维持学生学习动机起着重要的作用。文章以ARCS动机模型为基础对“中药鉴定实习”进行课堂教学设计,进而提升学生的学习动力。同时,该课程依托内蒙古医科大学位于河北安国的实习基地进行为期一周的实践教学,以期让学生对中药学专业有一个全新的认识,深入了解中药学相关工作。该课程的实践教学设计与应用,不仅有效地激发了学生的学习兴趣,调动了学生的学习热情,而且为其今后的学习深造和工作奠定了良好的基础,同时也为学生的职业生涯规划提供了良好的帮助。

关键词： ARCS动机中药鉴定学实践教学教学设计

SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer

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Protein & Cell 2020年第7期11卷 483-504页

作者： shijia Bi Zunpeng Liu Zeming wu Zehua Wang Xiaoqian Liu Si Wang Jie Ren Yan Yao Weiqi Zhang Moshi Song Guang-Hui Liu Jing Qu State Key Laboratory of Stem Cell and Reproductive Biology Instiute of ZoologyChinese Academy of SciencesBejing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBejing 100101China Beiing Institute for Brain Disorders Advanced Innovation Center for Human Brain ProtectionNational Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China CAS Key Laboratory of Genomic and Precision Medicine Beiing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Bejing 100101China Institute for Stem cell and Regeneration Chinese Academy of SciencesBeiing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Cardiology Bejing Anzhen HospitalCapital Medical UniversityBeijing 100029China

SIRT7,a sirtuin family member implicated in aging and disease,is a regulator of metabolism and stress responses.It remains elusive how human somatic stem cell populations might be impacted by SIRT7.Here,we found that SIRT7 expression declines during human mesenchymal stem cell(hMSC)aging and that SIRT7 deficiency accelerates senescence.Mechanistically,SIRT7 forms a complex with nuclear lamina proteins and heterochromatin proteins,thus maintaining the repressive state of heterochromatin at nuclear periphery.Accordingly,deficiency of SIRT7 results in loss of heterochromatin,derepression of the LINE1 retrotransposon(LINE1),and activation of innate immune signaling via the cGAS-STING pathway.These agingassociated cellular defects were reversed by overexpression of heterochromatin proteins or treatment with a LINE1 targeted reverse-transcriptase inhibitor.Together,these findings highlight how SIRT7 safeguards chromatin architecture to control innate immune regulation and ensure geroprotection during stem cell aging.

关键词： SIRT7 stem cell aging LINE1 cGAS STING

Natural compounds modulate the autophagy with potential implication of stroke

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Acta Pharmaceutica Sinica B 2021年第7期11卷 1708-1720页

作者： Anil Ahsan Mengru Liu Yanrong Zheng Wenping Yan Ling Pan Yue Li shijia Ma Xingxian Zhang Ming Cao Zhanxun wu Weiwei Hu Zhong Chen Xiangnan Zhang Institute of Pharmacology&Toxicology College of Pharmaceutical SciencesKey Laboratory of Medical Neurobiology of the Ministry of Health of ChinaZhejiang UniversityHangzhou 310058China

Stroke is considered a leading cause of mortality and neurological disability,which puts a huge burden on individuals and the community.To date,effective therapy for stroke has been limited by its complex pathological mechanisms.Autophagy refers to an intracellular degrading process with the involvement of lysosomes.Autophagy plays a critical role in maintaining the homeostasis and survival of cells by eliminating damaged or non-essential cellular constituents.Increasing evidence support that autophagy protects neuronal cells from ischemic injury.However,under certain circumstances,autophagy activation induces cell death and aggravates ischemic brain injury.Diverse naturally derived compounds have been found to modulate autophagy and exert neuroprotection against stroke.In the present work,we have reviewed recent advances in naturally derived compounds that regulate autophagy and discussed their potential application in stroke treatment.

关键词： Autophagy Cerebral ischemia Neuroprotection Mitochondria Lysosomal activation Mitophagy Natural compounds Neurological disorders

菱角壳基多孔炭的制备及其电化学电容特性研究

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功能材料 2019年第12期50卷 12080-12084页

作者：肖祥王超赵亚彬钟国彬王佩伍世嘉曾杰魏增福时志强广东电网有限责任公司电力科学研究院广州510080 天津工业大学材料科学与工程学院天津市先进纤维与储能技术重点实验室天津300387

以菱角壳为前驱体,采用KOH化学活化法制备超级电容器用多孔炭,研究了不同碱炭比对多孔炭结构和电化学性能的影响。采用SEM、XRD、Raman、N2吸脱附测试对多孔炭的微观结构进行表征,并利用循环伏安、恒流充放电、长循环、交流阻抗等方法... 详细信息

以菱角壳为前驱体,采用KOH化学活化法制备超级电容器用多孔炭,研究了不同碱炭比对多孔炭结构和电化学性能的影响。采用SEM、XRD、Raman、N2吸脱附测试对多孔炭的微观结构进行表征,并利用循环伏安、恒流充放电、长循环、交流阻抗等方法考察其电容性能。结果表明,碱炭比为4时,多孔炭具有最高的比表面积(2046.74 m^2/g)和最丰富的孔结构,以TEABF4/PC为电解液组装成超级电容器,在0.1 A/g电流密度下,其比电容高达126.1 F/g,以0.5 A/g电流密度循环10000次,其比电容仍保持92.6 F/g,展现出良好的电容性能。

关键词：菱角壳活化多孔炭超级电容器电化学性能

基于等值梁法的斜撑安装角度对基坑变形影响分析

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建筑结构 2023年第S1期53卷 2853-2859页

作者：王时佳吴世超郭子文中建海峡建设发展有限公司福州350015 东南大学土木工程学院南京211189

在城市密集区域,由于工程拟建地点周边存在大量地下结构或设施,不便于进行锚索施工,故采用钢管斜撑进行代替支护。在不合理地安装角度下,不但结构施工效果较差且抵抗主动土压力能力较弱。故采用二维等值梁法反向求解有利安装角度,并对... 详细信息

在城市密集区域,由于工程拟建地点周边存在大量地下结构或设施,不便于进行锚索施工,故采用钢管斜撑进行代替支护。在不合理地安装角度下,不但结构施工效果较差且抵抗主动土压力能力较弱。故采用二维等值梁法反向求解有利安装角度,并对永临结合部位施工进行工艺改良。斜撑安装完毕后对基坑变形动态监测数据,通过对监测点位的地表沉降、桩顶位移、桩顶沉降的变化累积量统计,在排除受到场地客观因素干扰的个别特殊点位后,通过对钢撑不同安装角度所对应变形量进行再次统计,分析安装角度对基坑变形的影响。发现在本案例工程中,实际最优角度区间与等值梁法计算所得的31.5°~33.2°区间近似,在此范围中地表沉降、桩顶位移、桩顶沉降均具有较好控制效果。

关键词：等值梁法最优角度永临结合变形监测

Identification of a Stable Quantitative Trait Locus for Percentage Grains with White Chalkiness in Rice (Oryza sativa)

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Journal of Integrative Plant Biology 2011年第8期53卷 598-607页

作者： Tao Guo Xiaolu Liu Xiangyuan Wan Jianfeng Weng shijia Liu Xi Liu Mingjiang Chen Jingjing Li Ning Su Fuqing wu Zhijun Cheng Xiuping Guo Cailin Lei Jiulin Wang Ling jiang Jianmin Wan Key-Laborato'ry of Crop Genetics and Germplasm Enhancement/Jiangsu Plant Gene Engineering Research Center Nanjing Agricultural University Nanjing 210095 China Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 China

High chalkiness is a major problem in many rice-producing areas of the world, especially in hybrid rice （Oryza sativa L.） in China. We previously showed a major quantitative trait locus for the percentage of grains with white chalkiness （QTLqPGWC-8） in the interval G1149-R727 on chromosome 8 using a chromosome segment substitution line （CSSL）. Here, we selected the line-CSSL50 harboring the QTLqPGWC-8 allele from the CSSLs derived from a cross between Asominori （as a recurrent parent） and IR24 （as a donor parent）, which had higher percentage chalkiness, markedly different from that of Asominori. There were also significant differences in starch granules, appearance of amylose content （AAC） and milling qualities between Asominori and CSSL50, but not in grain size or thousand grain weight （TGW）. The BC4F2 and BC4F3 populations from a cross between CSSL50 and Asominori were used for fine mapping of qPGWC-8. We narrowed down the location of this QTL to a 142 kb region between Indel markers 8G-7 and 8G-9. QTLqPGWC-8 accounted for 50.9% of the difference in PGWC between the parents. The markers tightly linked to qPGWC-8 should facilitate cloning of the gene underlying this QTL and will be of value for marker-assisted selection in breeding rice varieties with better grain quality.

关键词： fine mapping marker-assisted selection percentage grains with white chalkiness QTL rice.

PA1426 regulates Pseudomonas aeruginosa quorum sensing and virulence:an in vitro study

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Journal of Bio-X Research 2021年第1期4卷 18-28页

作者： Fang Tan Pengfei She Linying Zhou shijia Li Xianghai Zeng Lanlan Xu Yaqian Liu Zubair Hussain Yong wu Department of Clinical Laboratory The Third Xiangya Hospital of Central South UniversityChangshaChina

Objective:Pseudomonas aeruginosa(P.aeruginosa)contains a hierarchy of quorum sensing(QS)network,consisting of the las,rhl and pqs systems,which play a key role in coordinating the expression of virulence factors.PA2146 was found to be associated with P.aeruginosa pathogenicity in macrophage and host Immune response.The aim of this study was to investigate the effects of PA2146 on the virulence of P.aeruginosa and explore its mechanism.Methods:PA2146 gene knockout strain and complement strain of P.aeruginosa PAO1 were constructed.The biomass of biofilm was detected by crystal violet staining;the virulence factors were measured,including pyocyanin,rhamnolipid,LasA elastase,LasB elastase and hemolytic activity;RNA-seq and label-free relative quantitative proteomics analyses were carried out to test the influence of PA2146 on transcriptomics and proteomics.This study was approved by the Institutional Review Board of the Third Xiangya Hospital,Central South University,China(approval No.2019-S021).Results:PA2146-deficient strains showed reduced biofilm formation and increased pyocyanin,rhamnolipid,LasA elastase,LasB elastase,and hemolytic activity,as well as increased motility,compared with the wild-type strain.RNA-seq and label-free relative quantitative proteomics analyses revealed that PA2146 repressed the transcription of several genes that are integral to the pqs system and to pyocyanin biosynthesis,and increased the expression of MexEF-OprN efflux pump components at the gene and protein level.Conclusion:PA2146 gene was found to inhibit the pqs system.PA2146 may affect quorum sensing by directly inhibiting the pqs system or by enhancing the expression of MexEF-OprN efflux pump components,thereby promoting efflux of 2-heptyl-4(1H)-quinolone,a Pseudomonas quinolone signal precursor,and thus affecting P.aeruginosa virulence.

关键词： bacterial virulence PA2146 Pseudomonas aeruginosa QS quorum sensing