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Quantitative Evaluation of Pseudo Strain Signals Caused by Yarn Structural Deformation

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Advanced Fiber Materials 2022年第2期4卷 214-225页

作者： shihui lin Leitao Cao Zhuochen Lv Jing Ren Shengjie ling School of Physical Science and Technology ShanghaiTech University393 Middle Huaxia RoadShanghai 201210China

Yarn-based strain sensors(YSSs)have shown great promising in the fabrication of wearable devices for their good comfortability and fexible designability.However,the false signals generated by the changes in the yarn structure of the YSSs are usually ignored.In this study,the generation,the characteristic,and the prediction of these signals were investigated.We recognized that these signals are composed of two negative pseudo peaks and a spurious resistance response plateau.These responses are found to have nothing in common with a true tensile strain,but be attributed to plastic deformation of the fbers.This is due to the fact that the deformation of YSSs exceeds the linear elastic range of the fbers.Although the use of pure elastic fbers can eliminate the spurious resistance response plateau,it will lead to an increase in the pseudo peak to the value compared with a true strain signal peak.Hence,a theoretical model was established to decouple the real signals from the false responses,ensuring the high sensing accuracy of YSSs for applications in wearable devices and artifcial intelligence interfaces.This work provides an in-depth understanding of the response of the YSSs,which might provide inspiration and guidance in the design of high-accuracy fber-based strain sensors.

关键词： Textile strain sensor Pseudo-signal Structure-property relationship Contact resistance

Reproduction strategy of nocturnal marine molluscs:running for love

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Integrative Zoology 2023年第5期18卷 906-923页

作者： Xiaolong GAO Mo ZHANG shihui lin Mingxin LYU Xuan LUO Weiwei YOU Caihuan KE State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamenChina Fujian Key Laboratory of Genetics and Breeding of Marine Organisms Xiamen UniversityXiamenChina

The cost of reproduction is the core driver of life history evolution in animals.This paper demonstrates that the cumulative distance moved and the duration of movement of sexually immature abalones,Haliotis discus hannai,kept in various male and female groups,were significantly higher than those of sexually mature individuals,except when kept in mixed cultures of mature males and females.After mixed-culture,sexually mature males moved significantly further and for a longer duration than mature female abalones,and even more so than mature male abalones of any other group.Examination of the LC-MS metabolomics of mature males cultured with sexually mature females(AM)and those cultured with sexually immature females(JM)showed that cyclic adenosine monophosphate(cAMP)acted as a differential metabolic biomarker.After 24-h uninterrupted sampling,the concentration of 5-HT and the expression levels of the 5-HT2 and 5-HT6 receptors in AM were significantly higher than those in JM.After further injection of 5-HT2 and 5-HT6 receptor antagonists,the concentrations of cAMP and PKA rose again,but the cumulative movement duration and distance of male abalones decreased significantly,showing that 5-HT was involved in the regulation of movement behavior of male abalones through the 5-HT2 and 5-HT6 receptor-activated cAMP-PKA pathways.The results demonstrated a significant increase in the movement endurance of mature male abalones cultured with mature females,providing a theoretical basis for understanding the adaptive life history strategies of abalones and suggesting ways to protect diverse benthic resources for abalones during the reproductive stage.

关键词： 5-HT receptor behavior Haliotis discus hannai metabolism reproduction cost

颗粒蛋白前体对脓毒症急性肺损伤小鼠肺组织核转录因子-κB的表达的影响

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重庆医科大学学报 2024年第4期49卷 395-400页

作者：彭乔治徐昉林时辉重庆医科大学附属第一医院重症医学科重庆400016

目的:探讨颗粒蛋白前体(progranulin,PGRN)对脓毒症急性肺损伤(acute lung injury,ALI)的影响及可能机制。方法:将C57BL/6小鼠随机分为对照组(Control组)、急性肺损伤组(CLP组)、颗粒蛋白前体治疗组(CLP+PGRN组)。采用盲肠结扎穿刺术(ce... 详细信息

目的:探讨颗粒蛋白前体(progranulin,PGRN)对脓毒症急性肺损伤(acute lung injury,ALI)的影响及可能机制。方法:将C57BL/6小鼠随机分为对照组(Control组)、急性肺损伤组(CLP组)、颗粒蛋白前体治疗组(CLP+PGRN组)。采用盲肠结扎穿刺术(cecal ligation and puncture,CLP)构建小鼠脓毒症ALI模型,CLP+PGRN组在CLP处理半小时后使用PGRN腹腔注射。24 h后麻醉并处死小鼠,取小鼠肺HE染色观察肺组织病理损伤;TUNEL法检测肺部细胞凋亡情况;免疫荧光染色检测肺组织中核转录因子-κB(nuclear factor kappa B,NF-κB)水平;Western blot法检测NF-κB、总p65和磷酸化p65表达水平;RT-qPCR检测NF-κB和炎症细胞因子水平。结果:和Control组相比,CLP组和CLP+PGRN组肺损伤加重,促炎细胞因子升高,肺组织中细胞凋亡增加,NF-κB、p65和p-p65的表达水平明显增加;与CLP组相比,CLP+PGRN组肺组织损伤和凋亡减轻,促炎细胞因子降低,抑炎细胞因子升高,NF-κB、p65和p-p65的表达明显减少。结论:PGRN可以减轻脓毒症小鼠急性肺损伤,其机制可能与抑制NF-κB、p65表达和p65磷酸化有关。

关键词：急性肺损伤颗粒蛋白前体组织核转录因子-κB p65

Nanofibril Organization in Silk Fiber as Inspiration for Ductile and Damage-Tolerant Fiber Design

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Advanced Fiber Materials 2019年第3期1卷 231-240页

作者： shihui lin Chao Ye Wenwen Zhang Anchang Xu Shixian Chen Jing Ren Shengjie ling School of Physical Science and Technology ShanghaiTech University393 Middle Huaxia RoadShanghai 201210China Jiangsu Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources Jiangsu Key Lab of Biomass‑Based Green Fuel and ChemicalsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China State Key Laboratory of New Textile Materials and Advanced Processing Technology School of Textile Science and EngineeringWuhan Textile UniversityWuhan 430200China

Ductile and damage-tolerant fibers(DDTFs)are desired in aerospace engineering,mechanical engineering,and biomedical engineering because of their ability to prevent the catastrophic sudden structural/mechanical failure.However,in practice,design and fabrication of DDTFs remain a major challenge due to finite fiber size and limited processing techniques.In this regard,animal silks can provide inspirations.They are hierarchically structured protein fibers with an elegant trade-off of mechanical strength,extensibility and damage tolerance,making them one of the toughest materials known.In this article,we confirmed that nanofibril organization could improve the ductility and damage-tolerance of silk fibers through restricted fibril shearing,controlled slippage and cleavage.Inspired by these strategies,we further established a rational strategy to produce polyamide DDTFs by combining electrospinning and yarn-spinning techniques.The resultant polymeric DDTFs show a silk-like fracture resistance behavior,indicating potential applications in smart textile,biomedicine,and mechanical engineering.

关键词： Fiber Silk Mechanical property Damage tolerance Bioinspired materials

Light amplified oxidative stress in tumor microenvironment by carbonized hemin nanoparticles for boosting photodynamic anticancer therapy

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Light(Science & Applications) 2022年第3期11卷 52-67页

作者： Liyun lin Wen Pang Xinyan Jiang shihui Ding Xunbin Wei Bobo Gu Med-X Research Institute and School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai200030China Biomedical Engineering Department Peking UniversityBeijing100081China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Peking University Cancer Hospital&InstituteBeijing100142China

Photodynamic therapy(PDT),which utilizes light excite photosensitizers(PSs)to generate reactive oxygen species(ROS)and consequently ablate cancer cells or diseased tissue,has attracted a great deal of attention in the last decades due to its unique advantages.However,the advancement of PDT is restricted by the inherent characteristics of PS and tumor microenvironment(TME).It is urgent to explore high-performance PSs with TME regulation capability and subsequently improve the therapeutic outcomes.Herein,we reported a newly engineered PS of polymer encapsulated carbonized hemin nanoparticles(P-CHNPs)via a facile synthesis procedure for boosting photodynamic anticancer therapy.Solvothermal treatment of hemin enabled the synthesized P-CHNPs to enhance oxidative stress in TME,which could be further amplified under light irradiation.Excellent in vitro and in vivo PDT effects were achieved due to the improved ROS(hydroxyl radicals and singlet oxygen)generation efficiency,hypoxia relief,and glutathione depletion.Moreover,the superior in vitro and in vivo biocompatibility and boosted PDT effect make the P-CHNPs a potential therapeutic agent for future translational research.

关键词： boosting oxidative stress

“互联网+”背景下重症医学研究生《急危重症医学》课程思政建设研究

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中国继续医学教育 2024年第11期16卷 32-37页

作者：叶林徐昉张皑频吴婧张苜林时辉重庆医科大学附属第一医院重症医学科重庆400016 重庆医科大学附属第一医院研究生管理处重庆400016 重庆医科大学附属第一医院研究生院重庆400016

基于“互联网+”背景下,医学高校为深入学习贯彻落实全国高校思想政治工作会议精神,进一步深化学校管理和教学改革,提高医学院校思想政治工作的实效性,提升医学高端人才培养质量,学校了提出以“课程思政”为目标的教学改革。“互联网+... 详细信息

基于“互联网+”背景下,医学高校为深入学习贯彻落实全国高校思想政治工作会议精神,进一步深化学校管理和教学改革,提高医学院校思想政治工作的实效性,提升医学高端人才培养质量,学校了提出以“课程思政”为目标的教学改革。“互联网+课程思政”教学具有传统课堂教学无法比拟的优势,其优化了课程设置及教学模式,加入了思政元素,完善了教学设计,有效地做到了每门课程在立德树人过程中的重要作用,是新时代高等医学院校教育发展的要求与趋势。《急危重症医学》是医学院校重症医学专业研究生重要的专业课,为充分发挥此门专业课程的育人功能,文章从重症医学《急危重症医学》课程思政建设的重要性、课程思政构建存在的问题以及课程思政建设路径探索等方面,对重症医学研究生专业课程融入课程思政进行了探索,旨在提高《急危重症医学》课堂教学效果及课程思政建设,最终实现教书与育人的有机结合。

关键词：互联网+ 重症医学研究生教育课程思政急危重症医学医学研究生

鸦胆因D通过影响胰岛素信号通路和诱导中肠细胞凋亡抑制黑腹果蝇生长

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江西农业大学学报 2024年第3期46卷 648-655页

作者：陈冬平李康龙诗慧田永清林菲徐汉虹华南农业大学植物保护学院广东广州510642 华南师范大学生命科学学院广东广州510631

【目的】鸦胆因D(BD)是从中药鸦胆子(Brucea javanica)中提取的植物源农药,具有良好的杀虫活性,能有效抑制包括黑腹果蝇在内的多种害虫的生长发育,但是关于BD的毒性机制研究较少,研究旨在探索BD抑制黑腹果蝇生长的毒性机制。【方法】以... 详细信息

【目的】鸦胆因D(BD)是从中药鸦胆子(Brucea javanica)中提取的植物源农药,具有良好的杀虫活性,能有效抑制包括黑腹果蝇在内的多种害虫的生长发育,但是关于BD的毒性机制研究较少,研究旨在探索BD抑制黑腹果蝇生长的毒性机制。【方法】以黑腹果蝇为研究对象,给2龄末黑腹果蝇喂食含20μg/g BD的人工饲料后,测定用药处理24 h和48 h时,BD对黑腹果蝇体质量、中肠和脂肪体的影响,通过免疫组化、蛋白质免疫印迹和实时荧光定量PCR试验,研究BD是否诱导果蝇中肠细胞凋亡、影响脂肪体细胞生长和影响营养信号通路。【结果】20μg/g BD能显著抑制黑腹果蝇的生长,体现在抑制其体质量增加和脂肪体细胞生长,同时,20μg/g BD处理48 h后,会导致果蝇脂肪体细胞核皱缩和中肠细胞凋亡。实时荧光定量PCR和蛋白质免疫印迹试验发现,BD显著上调胰岛素信号通路负调控基因4EBP和InR的转录水平,同时下调脂肪体4EBP的磷酸化水平,抑制细胞生长。【结论】BD主要通过诱导细胞凋亡和影响胰岛素信号,进而影响营养物质的消化和吸收,最终抑制黑腹果蝇的生长发育。

关键词：鸦胆因D 抑制生长凋亡 4EBP InR

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肾素-血管紧张素系统与中枢神经系统疾病的关联及中医药的干预调控作用

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上海中医药杂志 2024年第6期58卷 88-94页

作者：夏师慧李红霞张起越林建华张岩上海中医药大学附属龙华医院上海200032 深圳市坪山区中医院广东深圳518118

肾素-血管紧张素系统(RAS)在水、电解质和血压动态调控中发挥重要作用。RAS组分也广泛分布在脑组织,参与多种中枢神经系统疾病的病理过程。从血管紧张素转化酶(ACE)-血管紧张素Ⅱ(AngⅡ)-血管紧张素1型受体(AT1R)、ACE2-Ang-(1-7)-Mas受... 详细信息

肾素-血管紧张素系统(RAS)在水、电解质和血压动态调控中发挥重要作用。RAS组分也广泛分布在脑组织,参与多种中枢神经系统疾病的病理过程。从血管紧张素转化酶(ACE)-血管紧张素Ⅱ(AngⅡ)-血管紧张素1型受体(AT1R)、ACE2-Ang-(1-7)-Mas受体(MasR)双轴,探讨RAS与中枢神经系统疾病(阿尔茨海默病、帕金森病、抑郁症、缺血性脑卒中等)的病理机制关联,并总结分析中药及中医非药物疗法基于RAS的靶向干预途径及防治中枢神经系统疾病的效应与作用机制,为中西医结合防治中枢神经系统疾病、中药新药研发提供参考。

关键词：阿尔茨海默病帕金森病脑卒中抑郁症肾素-血管紧张素系统中医药疗法作用机制

Screening of Brown Planthopper Resistant miRNAs in Rice and Their Roles in Regulation of Brown Planthopper Fecundity

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Rice science 2022年第6期29卷 559-568,I0031-I0033页

作者： LÜJun LIU Jinhui CHEN lin SUN Jiawei SU Qin LI shihui YANG Jianhua ZHANG Wenqing State Key Laboratory of Biocontrol School of Life SciencesSun Yat-sen UniversityGuangzhou 510275China

MicroRNAs(miRNAs)can participate in plant-insect interactions,which regulate plant defense networks.In this study,we analyzed the miRNA expression profiles of six rice varieties before and after brown planthopper(BPH)-feeding.We identified 45 differentially expressed miRNAs between BPH-susceptible and BPH-resistant rice varieties and 144 miRNAs that responded to BPH-feeding.Thus,miRNAs may be involved in multiple pathways regulating rice defense response against BPH.In addition,we found that the genetic history of rice varieties determined the regulation mode of the miRNA and affected the amounts,types,changing trends and response periods of miRNAs in response to BPH-feeding.To conclude,we scanned seven potential cross-kingdom miRNAs,of which miR5795 may target the vitellogenin gene in BPH,causing a 16.07%reduction in BPH oviposition.The results provide new miRNA information of rice-BPH interactions and BPH-resistant rice variety breeding.

关键词： Nilaparvata lugens insect-resistant rice miR5795 fecundity