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The antitumor effect of tanshinone IIA on antiproliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line

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Acta Pharmaceutica Sinica B 2015年第6期5卷 554-563页

作者： Jun Xie Jiahui Liu Heng Liu shihui liang Meigui Lin Yueyu Gu Taoli Liu Dongmei Wang Hui Gee Sui-lin Mo Department of Traditional Chinese Medicine The First Affiliated HospitalSun Yat-sen University Huanghuagang Street Community Health Service Center Liwan District Shiweitang Street Community Health Service Center School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou Higher Education Mega Center Health Care and Physical Examination Center The First Affiliated HospitalSun Yat-sen University

The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell line A549 and its possible mechanism on the VEGF/VEGFR signal pathway were investigated.The exploration of the interaction between tanshinone IIA and its target proteins provides a feasible platform for studying the anticancer mechanism of active components of herbs.The CCK-8 assay was used to evaluate the proliferative activity of A549 cells treated with tanshinone IIA(2.5 80 μmol/L) for 24,48 and 72 h,respectively.Flow cytometry was used for the detection of cell apoptosis and cell cycle perturbation.VEGF and VEGFR2 expression were studied by Western blotting.The binding mode of tanshinone IIA within thecrystal structure of the VEGFR2 protein was evaluated with molecular docking analysis by use of the CDOCKER algorithm in Discovery Studio 2.1.The CCK-8 results showed that tanshinone IIA can significantly inhibit A549 cell proliferation in a dose-and time-dependent manner.Flow cytometry results showed that the apoptosis rate of tested group was higher than the vehicle control,and tanshinone IIAtreated cells accumulated at the S phase,which was higher than the vehicle control.Furthermore,the expression of VEGF and VEGFR2 was decreased in Western blot.Finally,molecular docking analysis revealed that tanshinone IIA could be stably docked into the kinase domain of VEGFR2 protein with its unique modes to form H-bonds with Cys917 and π–π stacking interactions with Val848.In conclusion,tanshinone IIA may suppress A549 proliferation,induce apoptosis and cell cycle arrest at the S phase.This drug may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.

关键词： Non-small cell lung cancer Tanshinone IIA VEGF/VEGFR signal pathway Molecular docking

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基于FPGA的水下单程声径跟踪测速系统设计与实现

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传感技术学报 2024年第5期37卷 807-817页

作者：赵冬冬徐荣宝陈朋梁荣华梁世慧吕成财浙江工业大学计算机科学与技术学院浙江杭州310023 中国科学院深海科学与工程研究所海南三亚572000

针对现有水下航行体的导航存在时延大和无法同时满足跟踪测速一体化问题,提出了一种基于单程声径的水下定位测速方法。相比传统长基线的双程声径定位测距,该方法基于高精度原子钟的同步系统,实现单程声径的目标测距测速。该水下定位测... 详细信息

针对现有水下航行体的导航存在时延大和无法同时满足跟踪测速一体化问题,提出了一种基于单程声径的水下定位测速方法。相比传统长基线的双程声径定位测距,该方法基于高精度原子钟的同步系统,实现单程声径的目标测距测速。该水下定位测速一体化系统是基于具有快速并行计算能力的FPGA实现,解算结果可在微秒内完成,时延有效降低。针对目标跟踪测速一体化问题,水下航行体在系统同步时刻周期性发射线性调频信号,水下信标接收基阵设计基于短时傅里叶变换/逆变换算法对信号进行时频域转换分析,能够准确地提取信号的到达时刻和多普勒频偏。水下信标基阵进而可在系统同步周期内解算每个接收信标单元相对于水下航行体的径向速度和径向距离,实现目标的跟踪测速。仿真实验表明,该方法的跟踪相对误差控制在0.2%,测速相对误差控制在0.8 m/s。湖试试验结果表明,该方法跟踪相对误差控制在5%,测速相对误差控制在0.3 m/s。

关键词：水下通信 FPGA 单程声径短时傅里叶变换多普勒频偏到达时刻

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Efficient Pd-Catalyzed C-H Oxidative Bromination of Arenes with Dimethyl Sulfoxide and Hydrobromic Acid

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Chinese Journal of Chemistry 2020年第11期38卷 1245-1251页

作者： Yizhi Yuan Yujie liang shihui Shi Yu-Feng liang Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityXue Yuan Rd.38Beijing 100191China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200062China

of main observation and conclusion We have developed an efficient Pd-catalyzed directed C-H bromination protocol,in which dimethyl sulfoxide(DMSO)is employed as oxidant with hydrobromic add aqueous solution(HBr(aq))as bromide source.The DMSO/HBr(aq)system,which is novelly and efficiently utilized in transition-metal catalyzed C-H activation,illustrates its practicability by the operational simplicity,inexpensive and readily available starting materials,and high bromide-atom economy.

关键词： catalyzed bromide simplicity

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清肝化湿活血汤加减联合茵栀黄颗粒治疗酒精性肝病临床观察

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中国药业 2024年第3期33卷 105-109页

作者：张会玲张文静梁友云裴士会姚志山河北省丰润区第二人民医院河北唐山064000

目的探讨清肝化湿活血汤加减联合茵栀黄颗粒治疗酒精性肝病的临床疗效。方法选取医院2021年3月至2023年3月收治的酒精性肝病患者200例,按随机数字表法分为观察组和对照组,各100例。两组患者均予酒精性肝病的基础治疗,对照组患者加用茵... 详细信息

目的探讨清肝化湿活血汤加减联合茵栀黄颗粒治疗酒精性肝病的临床疗效。方法选取医院2021年3月至2023年3月收治的酒精性肝病患者200例,按随机数字表法分为观察组和对照组,各100例。两组患者均予酒精性肝病的基础治疗,对照组患者加用茵栀黄颗粒,观察组患者在对照组治疗基础上加用清肝化湿活血汤加减。两组患者均治疗12周。结果观察组总有效率为91.00%,显著高于对照组的79.00%(P0.05)。结论清肝化湿活血汤加减联合茵栀黄颗粒治疗酒精性肝病的临床疗效良好,可改善患者的中医证候积分和肝功能、肝门静脉血流动力学指标,降低炎性因子水平,且安全性良好。

关键词：酒精性肝病茵栀黄颗粒清肝化湿活血汤临床疗效中医证候肝功能肝门静脉血流动力学炎性因子

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A Comparative Study of the Flow Field of High Viscosity Media in Conventional/Rotary Hydrocyclones

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Petroleum Science 2007年第1期4卷 81-85页

作者： Ren Liancheng liang Zheng Zhong Gongxiang Wu shihui School of Mechanical and Electronic Engineering Southwest Petroleum University Chengdu Sichuan 610500 China Machinery Manufacturing Works of Henan Oilfield Nanyang Henan 473132 China

The flow fields inside conventional and rotary hydrocyclones were simulated respectively. In these simulations, water only and oil-water mixture, with distinctly different viscosities, were used as continuous phases. Simulation results agreed well with the experimental measurements. Simulation results showed that the conventional hydrocyclone could effectively separate sand from water, but could not separate sand from high viscosity water/oil emulsion. This showed that the viscosity of continuous phases influenced greatly both the separation efficiency and the flow field distribution in the conventional hydrocyclone. For high viscosity oil/water sand dispersion （mixture）, the rotary hydrocyclone has better separation performance than the conventional one, with a more favorable flow field distribution.

关键词： Rotary hydrocyclone high viscosity mixture computational fluid dynamics numerical simulation

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Late Mesozoic rifting and its deep dynamic mechanisms in the central Sulu orogenic belt: Records from Lingshan Island

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Science China Earth Sciences 2022年第9期65卷 1751-1771页

作者： Tengfei ZHOU Yaoqi ZHOU Nina SФAGER Paul Martin HOLM Zhenkai ZHANG Jun WANG Zhao liang Hongyu MU Yanjun CHENG Feifei LIU Miao WANG Yue ZHANG Hui ZHANG Yangjian GU shihui DONG Hanjie ZHAO Manjie LI Yang CHEN Yanzi LIU School of Geosciences China University of Petroleum(East China)Qingdao 266580China Department of Geosciences and Natural Resource Management University of CopenhagenCopenhagen-K 1350Denmark Shandong Provincial Key Laboratory of Deep Oil&Gas China University of Petroleum(East China)Qingdao 266580China Shaanxi Center of Mineral Geological Survey Shaanxi Institute of Geological SurveyXi'an 710068China School of Earth Sciences Yunnan UniversityKunming 650500China Department of Science and Technology Hebei GEO UniversityShijiazhuang 050031China College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China School of Architectural Engineering Binzhou UniversityBinzhou 256500China Research Institute of Petroleum Exploration and Development Shengli Oilfield CompanySINOPECDongying 257015China Key Laboratory of Geological Safety of Coastal Urban Underground Space Ministry of Natural ResourcesQingdao Geo-Engineering Surveying InstituteQingdao 266101China

The Lingshan Island scientific drill confirms that two episodes(Laiyang period and Qingshan period) of rifting developed in the central Sulu orogenic belt(SOB) in Late Mesozoic. With a set of methods including fieldwork, drilling, core logging, zircon U-Pb dating and whole rock geochemistry applied, the age, the depositional sequence and the deep dynamic mechanisms of rift evolution were unraveled. The stratigraphic sequence of the Laiyang-Qingshan Groups on Lingshan Island was composed of two different rifting sequences:(1) Laiyang Group(147–125 Ma), which consists of deep-water gravity flow deposits with interlayers of intermediate volcanic rocks;and(2) Lower Qingshan Group(125–119 Ma), which unconformably overlies the former sequence and contains subaerial volcanic deposits and terrestrial deposits. The tectonic environment changed during the evolution of these two episodes of rifting: the rift was in a NNW-SSE extensional environment in the Laiyang period and showed the typical passive rifting character that “lithospheric extension and rifting preceded volcanism”. The passive rifting period was ended by a short WNW-ESE compression at about 125 Ma. After that, the tectonic environment transferred to a strong NW-SE extensional environment and the rifting evolved into a volcanic arc basin in the Qingshan period. The igneous rocks are shoshonitic to high-K calc-alkaline trachyandesites to trachytes with a few intercalated lamprophyres and a rhyolite.The geochemical characteristics of the igneous rocks indicate that they are mantle-derived melts with a metasomatized mantle source and/or crustal contamination. In addition, an increased thinning of the lithosphere happened during the rifting episodes.The low-angle subduction of the Paleo-Pacific plate in the Jurassic weakened the thickened SOB lithospheric mantle. The rollback of the subducting plate started in late Jurassic to early Cretaceous, and the SOB lithospheric mantle was delaminated synchronously because of the gravity collapse. Thus, this caused passive r

关键词： Sulu orogenic belt Lingshan Island Late Mesozoic Rifting Slab subduction Basin dynamics

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病毒感染与睡眠障碍之间的关联性——基于NHANES数据库的横断面研究

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广西医学 2024年第1期46卷 122-128页

作者：莫初叶康旖雯袁宗祥张君涵王凤仪覃芳黄诗卉蒋俊俊梁浩叶力广西医科大学公共卫生学院广西艾滋病防治研究重点实验室广西南宁市530021 广西医科大学再生医学与医用生物资源开发应用协同创新中心广西南宁市530021

目的基于国家健康和营养检查调查(NHANES)数据库探讨多种病毒感染与睡眠障碍之间的关联性。方法选取NHANES数据库2009—2010年的横断面调查数据,根据睡眠障碍发生情况将研究对象分为睡眠障碍组与非睡眠障碍组。采用逆概率处理加权法(IP... 详细信息

目的基于国家健康和营养检查调查(NHANES)数据库探讨多种病毒感染与睡眠障碍之间的关联性。方法选取NHANES数据库2009—2010年的横断面调查数据,根据睡眠障碍发生情况将研究对象分为睡眠障碍组与非睡眠障碍组。采用逆概率处理加权法(IPTW)平衡两组研究对象的基线特征。采用χ^(2)检验及标准均数差(SMD)评估IPTW分析前后两组基线特征的均衡性;应用非条件Logistic回归(IPTW分析前)和加权Logistic回归(IPTW分析后)分析7种病毒感染与睡眠障碍之间的关联性。针对HAV感染与睡眠障碍之间的关联性进行亚组分析。结果共纳入2385名研究对象,其中146名纳入睡眠障碍组,2239名纳入非睡眠障碍组。IPTW分析前,两组的年龄、人群、家庭收入贫困比率(PIR)、吸烟的SMD>0.1,基本特征不均衡;IPTW分析后,两组的基线特征差异无统计学意义(SMD0.05),基本特征均衡。非条件Logistic回归结果显示,HAV感染、单纯疱疹病毒2型(HSV-2)感染与睡眠障碍存在相关性(P0.05)。亚组分析显示,HAV感染与睡眠障碍的关联性受年龄与教育水平等混杂因素显著影响(P交互作用<0.05)。结论经IPTW平衡基线特征后,HSV-2感染与睡眠障碍存在显著性关联。应对HSV-2感染者进行睡眠障碍情况筛查和干预,以提高该人群睡眠质量。

关键词：睡眠障碍病毒感染逆概率处理加权法国家健康和营养检查调查数据库

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Breeding High-Grain Quality and Blast Resistant Rice Variety Using Combination of Traditional Breeding and Marker-Assisted Selection

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Rice science 2021年第5期28卷 422-426,I0004-I0009页

作者： Zhou Zheng Sun liang Hu Wenbin Zhou Bin TAo Shuhua Zhang shihui LU Yanmei Zhao Zhenghong Chen Caiyan Key Laboratory of Agro-Ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Key Laboratory of indica Rice Genetics and Breeding in the Middle and Lower Reaches of Yangtze River Valley Ministry of Agriculture and Rural AffairsHunan Rice Research InstituteHunan Academy of Agricultural SciencesChangsha 410125China University of Chinese Academy of Science Beijing 100049China

We reported a novel rice variety developed by integrating the advantages of high eating quality from Xiangwanxiaa 17(XWX17)and rice blast resistance from Gumei 4(GM4)using a combination of traditional breeding and marker-assisted selection(MAS).Using molecular markers for QTLs/genes responsible for amylose content(AC),fragrance and blast resistance,three inbred lines were selected.

关键词： breeding Breeding integrating

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基于农艺性状鹰嘴豆抗旱核心种质库构建

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新疆农业科学 2022年第4期59卷 847-854页

作者：聂石辉王仙彭琳季良新疆农业科学院粮食作物研究所乌鲁木齐830091

【目的】运用多年田间试验及种质遗传多样性分析筛选出100份抗旱性表现优异种质为参试材料,结合田间抗旱鉴定构建鹰嘴豆抗旱核心资源库,为鹰嘴豆抗旱种质利用提供基础材料。【方法】比较随机取样、位点优先取样、偏离度取样策略及取样比... 详细信息

【目的】运用多年田间试验及种质遗传多样性分析筛选出100份抗旱性表现优异种质为参试材料,结合田间抗旱鉴定构建鹰嘴豆抗旱核心资源库,为鹰嘴豆抗旱种质利用提供基础材料。【方法】比较随机取样、位点优先取样、偏离度取样策略及取样比例,采用均值差异百分率、方差差异百分率、极差符合率以及变异系数变化率评价各核心子集农艺性状的变异保有量,筛选构建抗旱核心库。利用主成分分析确定鹰嘴豆抗旱种质核心库。【结果】采用的位点优先取样方法40%取样比例下构建的核心种质与原种质在多样性上无显著差异。并且检验种质各性状的均值与原种质符合率均大于96.33%,变异系数符合率大于97.25%,优于其它2种取样策略。主成分分析4个主成分包含各质量性状85%以上遗传多样性信息,确定构建的40份核心种质资源能够代表原种质资源遗传多样性。【结论】位点优先取样策略下,40%的取样比例所建立的鹰嘴豆抗旱核心种质资源库可以代表原种质资源的遗传多样性。

关键词：鹰嘴豆抗旱性农艺性状种质资源核心库

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The Partial Autocorrelation Function of an ARMA(1,1)Process

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东华理工大学学报(社会科学版) 1990年第2期 1-6页

作者： liang shihui Mao Huijuan(Guizhou University) ( Ningbo College)

In this paper,we obtain an explicit expression for the partialautoco-rrelation function of an ARMA(1,1)process and discuss its asymptoticbehaviour bricfly.

关键词： Autocorrelation Function Partial Autocorrelation Function Arma Process The Yule——Walker Equations.

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