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Integrated analysis of single-cell and bulk RNA sequencing data reveals immune-related lncRNA-mRNA prognostic signature in triple-negative breast cancer

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Genes & Diseases 2024年第2期11卷 571-574页

作者： Hongying zhao Lei Yu Lixia Wang Xiangzhe Yin Kailai Liu Wangyang Liu shihua Lin Li Wang College of Bioinformatics Science and Technology Harbin Medical UniversityHarbinHeilongjiang 150081China College of Biomedical Information and Engineering Hainan Medical UniversityHaikouHainan 571199China

Triple-negative breast cancer(TNBC)is an aggressive subtype characterized by extensive tumor heterogeneity,with limited treatment options and a poor prognosis.1 We used cell type annotation and trajectory analysis to identify two distinct differentiation states of epithelial cells,while tumor cells predominantly resided on one of these branches.Inferring the malignant state of epithelial cells based on copy number variation,280 tumor cells were eventually identified from epithelial cells.Differential genes between tumor cells and non-tumor cells were mainly enriched in immune-related functions and pathways.

关键词： breast cancer signature

Distribution and Formation Causes of PM_(2.5) and O_(3) Double High Pollution Events in China during 2013–20

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Advances in Atmospheric Sciences 2024年第6期41卷 1235-1250,I0004-I0021页

作者： Zhixuan TONG Yingying YAN Shaofei KONG Jintai LIN Nan CHEN Bo ZHU Jing MA Tianliang zhao shihua QI Department of Atmospheric Science School of Environmental SciencesChina University of GeosciencesWuhan 430074China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Research Centre for Complex Air Pollution of Hubei Province Wuhan 430074China Laboratory for Climate and Ocean–Atmosphere Studies Department of Atmospheric and Oceanic SciencesSchool of PhysicsPeking UniversityBeijing 100871China Eco-Environmental Monitoring Centre of Hubei Province Wuhan 430074China Key Laboratory of Atmospheric Chemistry China Meteorological AdministrationBeijing 100081China School of Atmospheric Physics Nanjing University of Information Science and TechnologyNanjing 210044China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China

Fine particulate matter(PM_(2.5))and ozone(O_(3))double high pollution(DHP)events have occurred frequently over China in recent years,but their causes are not completely clear.In this study,the spatiotemporal distribution of DHP events in China during 2013–20 is analyzed.The synoptic types affecting DHP events are identified with the Lamb–Jenkinson circulation classification method.The meteorological and chemical causes of DHP events controlled by the main synoptic types are further investigated.Results show that DHP events(1655 in total for China during 2013–20)mainly occur over the North China Plain,Yangtze River Delta,Pearl River Delta,Sichuan Basin,and Central China.The occurrence frequency increases by 5.1%during 2013–15,and then decreases by 56.1%during 2015–20.The main circulation types of DHP events are“cyclone”and“anticyclone”,accounting for over 40%of all DHP events over five main polluted regions in China,followed by southerly or easterly flat airflow types,like“southeast”,“southwest”,and“east”.Compared with non-DHP events,DHP events are characterized by static or weak wind,high temperature(20.9℃ versus 23.1℃)and low humidity(70.0%versus 64.9%).The diurnal cycles of meteorological conditions cause PM_(2.5)(0300–1200 LST,Local Standard Time=UTC+8 hours)and O_(3)(1500–2100 LST)to exceed the national standards at different periods of the DHP day.Three pollutant conversion indices further indicate the rapid secondary conversions during DHP events,and thus the concentrations of NO_(2),SO_(2) and volatile organic compounds decrease by 13.1%,4.7%and 4.4%,respectively.The results of this study can be informative for future decisions on the management of DHP events.

关键词： double high pollution events PM_(2.5) ozone spatiotemporal distribution meteorological causes chemical composition characteristics

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei Huang Jiayi Wen Xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian zhao shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal degeneration.However,it remains largely unclear how PINK1 and Parkin are expressed in mammalian brains.This has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small animals.Understanding this issue is critical for elucidating the in vivo roles of PINK1 and Parkin.Recently,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate brain.In the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate brain.We found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey brains.PINK1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable distribution.Immunofluorescent double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial stress.These findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

单纯心尖肥厚型心肌病进展为中部梗阻并室壁瘤形成1例

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中华心血管病杂志 2024年第1期52卷 79-81页

作者：喻诗琴杨凯赵世华中国医学科学院、北京协和医学院、国家心血管病中心、阜外医院磁共振科北京100037

该文报道1例青年男性患者因体检心电图异常就诊,进一步磁共振检查诊断为心尖肥厚型心肌病,在无心血管系统相关症状的情况下进展为中部梗阻并室壁瘤形成。本文通过心脏磁共振成像展示了心尖肥厚型心肌病进展形成室壁瘤的形态、功能及组... 详细信息

该文报道1例青年男性患者因体检心电图异常就诊,进一步磁共振检查诊断为心尖肥厚型心肌病,在无心血管系统相关症状的情况下进展为中部梗阻并室壁瘤形成。本文通过心脏磁共振成像展示了心尖肥厚型心肌病进展形成室壁瘤的形态、功能及组织学变化,其中腺苷负荷状态下心肌灌注缺损揭示了冠状动脉血流储备减低、劳力性心肌缺血可能是室壁瘤形成原因之一。心脏磁共振在心尖肥厚型心肌病的随访复查中具有重要价值。

关键词：心肌病,肥厚性心尖肥厚型心肌病室壁瘤

A CCD based machine vision system for real-time text detection

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Frontiers of Optoelectronics 2020年第4期13卷 418-424页

作者： shihua zhao Lipeng SUN Gang LI Yun LIU Binbing LIU State Grid Hunan Electric Power Corporation Limited Research Institute Changsha 410007China State Grid Hunan Electric Power Corporation Limited Changsha 410007China School of Optical and Electronics Information Huazhong University of Science and TechnologyWuhan 430074China

Text detection and recognition is a hot topic in computer vision,which is considered to be the further development of the traditional optical character recognition(OCR)technology.With the rapid development of machine vision system and the wide application of deep learning algorithms,text recognition has achieved excellent performance.In contrast,detecting text block from complex natural scenes is still a challenging task.At present,many advanced natural scene text detection algorithms have been proposed,but most of them run slow due to the complexity of the detection pipeline and can not be applied to industrial scenes.In this paper,we proposed a CCD based machine vision system for realtime text detection in invoice images.In this system,we applied optimizations from several aspects including the optical system,the hardware architecture,and the deep learning algorithm to improve the speed performance of the machine vision system.The experimental data confirms that the optimization methods can significantly improve the running speed of the machine vision system and make it meeting the real-time text detection requirements in industrial scenarios.

关键词： machine vision text detection optical character recognition(OCR) deep learning

High accuracy object detection via bounding box regression network

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Frontiers of Optoelectronics 2019年第3期12卷 324-331页

作者： Lipeng SUN shihua zhao Gang LI Binbing LIU State Grid Hunan Electric Power Corporation Limited Research Institute Changsha 410007China State Grid Hunan Electric Power Corporation Limited Changsha 410007China School of Optical and Electronics Information Huazhong University of Science and TechnologyWuhan 430074China

As one of the primary computer vision problems, object detection aims to find and locate semantic objects in digital images. Different with object classification, which only recognizes an object to a certain class, object detection also needs to extract accurate locations of objects. In the state-of-the-art object detection algorithms, bounding box regression plays a critical role in order to achieve high localization accuracy. Almost all the popular deep learning based object detection algorithms have utilized bounding box regression for fine tuning of object locations. However, while bounding box regression is widely used, there is few study focused on the underlying rationale, performance dependencies, and performance evaluation. In this paper, we proposed a dedicated deep neural network for bounding box regression, and presented several methods to improve its performance. Some ad hoc experiments are conducted to prove the effectiveness of the network. Also, we apply the network as an auxiliary module to the faster R-CNN algorithm and test them on some real-world images. Experiment results show certain performance improvements on detection accuracy in term of mean IOU.

关键词： deep learning object detection bounding box regression IOU distribution

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市政工程管线综合优化研究

科学技术创新 2024年第6期 196-199页

作者：赵世华超胜工程项目管理有限责任公司山东济南

本文针对当前市政工程管线综合规划存在管线路径较长、管线竖向空间布置剖面过大等问题,开展市政工程管线综合优化研究。以某产业区市政工程管线综合规划项目为例,对其进行管线综合优化目标函数的建立,根据优化目标,进行管线综合交叉口... 详细信息

本文针对当前市政工程管线综合规划存在管线路径较长、管线竖向空间布置剖面过大等问题,开展市政工程管线综合优化研究。以某产业区市政工程管线综合规划项目为例,对其进行管线综合优化目标函数的建立,根据优化目标,进行管线综合交叉口竖向优化。最后对优化效果分析得出,新的优化方法可以有效缩短管线路径和竖向空间布置剖面,同时在安全性、可靠性、经济性等方面也具备极高的优势。

关键词：市政工程管线综合优化

Diagnostic Accuracy of Three-Dimensional Whole-Heart Magnetic Resonance Angiography to Detect Coronary Artery Disease with Invasive Coronary Angiography as a Reference:A Meta-Analysis

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Cardiovascular Innovations and Applications 2020年第1期4卷 173-184页

作者： Shiqin Yu Chen Cui Minjie Lu shihua zhao Department of Cardiac MR Fuwai HospitalNational Center for Cardiovascular Diseases of ChinaChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.167 Beilishi Road100037 BeijingPeople’s Republic of China

Objective:We aimed to evaluate the diagnostic performance of three-dimensional whole-heart magnetic resonance coronary angiography(MRCA)in detecting coronary artery disease(CAD)with invasive coronary angiography as the reference standard.Methods:We searched PubMed and Embase for studies evaluating the diagnostic performance of three-dimensional whole-heart MRCA for the diagnosis of CAD with invasive coronary angiography as the reference standard.The bivariate mixed-effects regression model was applied to synthesize available data.The clinical utility of whole-heart MRCA was calculated by the posttest probability based on Bayes’s theorem.Results:Eighteen studies were included,of which 16 provided data at the artery level.Patient-based analysis revealed a pooled sensitivity of 0.90(95%confi dence interval[CI]0.87–0.93)and specifi city of 0.79(95%CI 0.73–0.84),while the pooled estimates were 0.86(95%CI 0.82–0.89)and 0.89(95%CI 0.84–0.92),respectively,at the artery level.The areas under the summary receiver operating characteristic curve were 0.93(95%CI 0.90–0.95)and 0.92(95%CI 0.90–0.94)at the patient and artery levels,respectively.With a pretest probability of 50%,the patients’posttest probabilities of CAD were 81%for positive results and 11%for negative results.Conclusions:Whole-heart MRCA can be an alternative noninvasive method for diagnosis and assessment of CAD.

关键词： magnetic resonance coronary angiography whole-heart coronary artery disease invasive coronary angiography

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心血管MRI用于二尖瓣病变进展

中国医学影像技术 2024年第2期40卷 290-293页

作者：宋燕燕陆敏杰赵世华国家心血管病中心北京协和医学院中国医学科学院阜外医院磁共振影像科北京100037

随着心血管MRI(CMRI)技术的进步,多模态CMRI已广泛用于评估二尖瓣病变,可显示瓣膜解剖学结构、评估瓣膜病变严重程度、量化心腔容积及心肌纤维化,在二尖瓣狭窄、二尖瓣关闭不全及其危险分层方面取得较多进展。本文围绕CMRI评估二尖瓣病... 详细信息

随着心血管MRI(CMRI)技术的进步,多模态CMRI已广泛用于评估二尖瓣病变,可显示瓣膜解剖学结构、评估瓣膜病变严重程度、量化心腔容积及心肌纤维化,在二尖瓣狭窄、二尖瓣关闭不全及其危险分层方面取得较多进展。本文围绕CMRI评估二尖瓣病变进展进行综述。

关键词：心脏瓣膜疾病二尖瓣磁共振成像