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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin shihua li Xiao-Jiang li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting liu Wei Huang Jiayi Wen Xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao shihua li Xiaojiang li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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Composite control method for stabilizing spacecraft attitude in terms of Rodrigues parameters

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Chinese Journal of Aeronautics 2013年第3期26卷 687-696页

作者： Sun Haibin li shihua School of Automation Southeast University Key Laboratory of Measurement and Control of CSE Ministry of Education

In this paper, the attitude stabilization problem of a rigid spacecraft described by Rodrigues parameters is investigated via a composite control strategy, which combines a feedback control law designed by a finite time control technique with a feedforward compensator based on a linear disturbance observer （DOB） method. By choosing a suitable coordinate transformation, the spacecraft dynamics can be divided into three second-order subsystems. Each subsystem includes a certain part and an uncertain part. By using the finite time control technique, a continuous finite time controller is designed for the certain part. The uncertain part is considered to be a lumped disturbance, which is estimated by a DOB, and a corresponding feedforward design is then implemented to compensate the disturbance. Simulation results are employed to confirm the effectiveness of the proposed approach.

关键词： Attitude control Composite control Disturbance observer Finite time control law Spacecraft

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ADAPTIVE SET STABIliZATION OF THE ATTITUDE OF A RIGID SPACECRAFT WITHOUT ANGULAR VELOCITY MEASUREMENTS

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Journal of Systems Science & Complexity 2011年第1期24卷 105-119页

作者： Shihong DING shihua li Qi li School of Automation Southeast University Nanjing 210096 China College of Electrical and Information Engineering Jiangsu University Zhenjiang 212013 China School of Automation Southeast University Nanjing 210096 China

The global adaptive set stabilization problem of the attitude of a rigid spacecraft is addressed in this paper. Two different cases are considered. First, by using adaptive backstepping method, the authors design a global adaptive control law for the attitude control system with unknown inertia matrix such that the attitude and the angular velocities can be globally asymptotically stabilized to a set consisting of two equilibria. And then, based on the obtained backstepping adaptive law, the authors consider the case that the angular velocities are not measurable. By introducing an auxiliary state, a semi-global adaptive set stabilization law without angular velocity measurements is also designed. It is rigorously proved that, for the two cases, both of the closed loop systems satisfy the set stability. The effectiveness of the proposed methods is verified by simulation results.

关键词： Adaptive control attitude stabilization backstepping quaternion spacecraft.

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A Model-Based Unmatched Disturbance Rejection Control Approach for Speed Regulation of a Converter-Driven DC Motor Using Output-Feedback

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IEEE/CAA Journal of Automatica Sinica 2022年第2期9卷 365-376页

作者： Lu Zhang Jun Yang shihua li School of Automation Southeast UniversityKey Laboratory of Measurement and Control of Complex Systems of EngineeringMinistry of Education IEEE Department of Aeronautical and Automotive Engineering Loughborough University

The speed regulation problem with only speed measurement is investigated in this paper for a permanent magnet direct current(DC)motor driven by a buck *** lumping all unknown matched/unmatched disturbances and uncertainties together,the traditional active disturbance rejection control(ADRC)approach provides an intuitive solution for the problem under ***,for such a higher-order disturbed system,the increase of poles for the extended state observer(ESO)therein will lead to drastically growth of observer gains,which causes severe noise *** paper aims to propose a new model-based disturbance rejection controller for the converter-driven DC motor system using *** of estimating lumped disturbances directly,a new observer is constructed to estimate the desired steady state of control signal as well as errors between the real states and their desired steady-state ***,a controller with only speed measurement is proposed by utilizing the *** performance of the proposed method is tested through experiments on *** is further shown via numerical calculations and experimental results that the poles of the observer within the proposed control approach can be largely increased without significantly increasing magnitude of the observer gains.

关键词： Bandwidth widening converter-driven direct current(DC)motor disturbance observer model-based disturbance rejection speed regulation

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Reduced-Order GPIO Based Dynamic Event-Triggered Tracking Control of a Networked One-DOF link Manipulator Without Velocity Measurement

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IEEE/CAA Journal of Automatica Sinica 2020年第3期7卷 725-734页

作者： Jiankun Sun Jun Yang shihua li School of Automation Southeast UniversityNanjing 210096China IEEE School of Automation Southeast UniversityKey Laboratory of Measurement and Control of CSEMinistry of EducationNanjing 210096China

In networked robot manipulators that deeply integrate control, communication and computation, the controller design needs to take into consideration the limited or costly system resources and the presence of disturbances/uncertainties. To cope with these requirements, this paper proposes a novel dynamic event-triggered robust tracking control method for a onedegree of freedom(DOF) link manipulator with external disturbance and system uncertainties via a reduced-order generalized proportional-integral observer(GPIO). By only using the sampled-data position signal, a new sampled-data robust output feedback tracking controller is proposed based on a reduced-order GPIO to attenuate the undesirable influence of the external disturbance and the system uncertainties. To save the communication resources, we propose a discrete-time dynamic event-triggering mechanism(DETM), where the estimates and the control signal are transmitted and computed only when the proposed discrete-time DETM is violated. It is shown that with the proposed control method, both tracking control properties and communication properties can be significantly improved. Finally, simulation results are shown to demonstrate the feasibility and efficacy of the proposed control approach.

关键词： Dynamic event-triggering mechanism(DETM) external disturbance and system uncertainties networked robot manipulator reduced-order generalized proportional-integral observer(GPIO) robust control

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INSTANTANEOUS KINEMATIC CHARACTERISTICS OF ASPECIAL 3-UPU PARALLEL MANIPULATOR

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Chinese Journal of Mechanical Engineering 2005年第3期18卷 376-381页

作者： li shihua Huang Zhen College of Mechanical Engineering Yanshan University Qinhuangdao 066004 China

The instantaneous kinematics of a special 3-UPU parallel platform manipulator is discussed. First, the instantaneous motions of the 3-UPU manipulator in four kinds of positions and a special manipulator are studied by reciprocal screw theory. Then, the principal screws in one of four positions are obtained. It is shown that the moving platform has five degrees of freedom （DOF） in the initial position or after a translation along the z-axis; In the generic position, the mechanism only has three DOF, moreover the three DOF characteristics are different in different position. The instantaneous kinematic characteristics of alike 3-UPU mechanisms are very different in different position and special structure. The results presented are important to the use of alike 3-UPU parallel manipulator and contribute to the mechanism theory .

关键词： Parallel manipulator Reciprocal screw Principal screws Instantaneous kinematic characteristics

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Recurrent Neural Network Inspired Finite-Time Control Design

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1527-1529页

作者： Jianan liu shihua li Rongjie liu School of Automation Southeast UniversityNanjing 210096China Department of Statistics Florida State UniversityFL 32304 USA IEEE

Dear Editor,This letter is concerned with the role of recurrent neural networks(RNNs)on the controller design for a class of nonlinear *** by the architectures of RNNs,the system states are stacked according to the dynamic along with time while the controller is represented as the neural network *** build the bridge between RNNs and finite-time controller,a novel activation function is imposed on RNNs to drive the convergence of states at finite-time and propel the overall control process *** stability proof is briefly provided for the convergence of the proposed finite-time *** last,a numerical simulation example is presented to illustrate the efficiency of the proposed *** networks can be classified as static(feedforward)and dynamic(recurrent)nets[1].The former nets do not perform well in dealing with training data and using any information of the local data structure[2].In contrast to the feedforward neural networks,RNNs are constituted by high dimensional hidden states with dynamics.

关键词： dynamics finite proof

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Therapeutic potential of berberine against neurodegenerative diseases

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Science China(life Sciences) 2015年第6期58卷 564-569页

作者： JIANG WenXiao li shihua li XiaoJiang Department of Microbiology and Molecular Genetics Emory University Department of Human Genetics Emory University

Berberine(BBR) is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine. Isolation of this compound was its induction into modern medicine, and its usefulness became quickly apparent as seen in its ability to combat bacterial diarrhea, type 2 diabetes, hypercholesterolemia, inflammation, heart diseases, and more. However, BBR's effects on neurodegenerative diseases remained relatively unexplored until its ability to stunt Alzheimer's disease(AD) progression was characterized. In this review, we will delve into the multi-faceted defensive capabilities and bio-molecular pathways of BBR against AD, Parkinson's disease(PD), and trauma-induced neurodegeneration. The multiple effects of BBR, some of which enhance neuro-protective factors/pathways and others counteract targets that induce neurodegeneration, suggest that there are many more branches to the diverse capabilities of BBR that have yet to be uncovered. The promising results seen provide a convincing and substantial basis to support further scientific exploration and development of the therapeutic potential of BBR against neurodegenerative diseases.

关键词： Huntington's disease berberine autophagy protein aggregation

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Adaptive fault-tolerant controller design for airbreathing hypersonic vehicle with input saturation

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Journal of Systems Engineering and Electronics 2013年第3期24卷 488-499页

作者： Haibin Sun shihua li Changyin Sun Key Laboratory of Measurement and Control of Complex Systems of Engineering(Ministry of Education) School of AutomationSoutheast University

The problem of fault-tolerant control is discussed for the longitudinal model of an airbreathing hypersonic vehicle （AHV） with actuator faults and external disturbances. Firstly, a fault-tolerant control strategy is presented for the longitudinal model of an AHV, which guarantees that velocity and altitude track their reference trajectories at an exponential convergence rate. However, this method needs to know the minimum value of the actuator efficiency factor and the upper bound of the external disturbances, which makes it not easy to implement. Then an improved adaptive fault-tolerant control scheme is proposed, where two adaptive laws are employed to estimate the upper bound of the external disturbances and the minimum value of the actuator efficiency factor, respectively. Secondly, the problem of designing a control scheme with control constraints is further considered, and a new adaptive fault-tolerant control strategy with input saturation is designed to guarantee that velocity and altitude track their reference trajectories. Finally, simulation results are given to show the effectiveness of the proposed methods.

关键词： airbreathing hypersonic vehicle (AHV) fault-tolerant control (FTC) adaptive control input saturation.

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