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赭曲霉毒素A的微生物脱毒研究进展

生物技术通报 2014年第12期30卷 18-23页

作者：贾欣徐诗涵梁志宏黄昆仑中国农业大学食品科学与营养工程学院北京100083

赭曲霉毒素A(Ochratoxin A,OTA)是一类聚酮化合物,是由曲霉属(Aspergillus spp.)和青霉属(Penicilliumspp.)等霉菌产生的次级代谢产物,具有强烈毒性。近年来,国内外已有大量关于OTA生物脱毒的研究,主要是OTA脱毒功能菌株的筛选,包括细... 详细信息

赭曲霉毒素A(Ochratoxin A,OTA)是一类聚酮化合物,是由曲霉属(Aspergillus spp.)和青霉属(Penicilliumspp.)等霉菌产生的次级代谢产物,具有强烈毒性。近年来,国内外已有大量关于OTA生物脱毒的研究,主要是OTA脱毒功能菌株的筛选,包括细菌、霉菌和酵母菌等。此外,对不同微生物脱毒机理的探索也是研究热点。对上述两方面的研究进展进行归纳和讨论。

关键词：生物脱毒赭曲霉毒素A 细菌真菌肠道微生物

颈前路可控前移融合术在颈椎前路翻修手术中的应用

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中国脊柱脊髓杂志 2022年第9期32卷 859-864页

作者：罗溪谢影琦许诗涵谢逸波孙璟川史建刚第二军医大学长征医院骨科上海市200003 中国人民解放军海军陆战队医院广东省潮州市521021 第二军医大学基础医学院学员一大队二队上海市200433

对于脊髓型颈椎病、颈椎后纵韧带骨化症(ossification of the posterior longitudinal ligament,OPLL)等神经压迫性疾病,大多数患者在手术减压后症状可得到长期缓解[1]。然而,少部分患者因术后神经压迫症状持续、反复或加重需要诉诸翻... 详细信息

对于脊髓型颈椎病、颈椎后纵韧带骨化症(ossification of the posterior longitudinal ligament,OPLL)等神经压迫性疾病,大多数患者在手术减压后症状可得到长期缓解[1]。然而,少部分患者因术后神经压迫症状持续、反复或加重需要诉诸翻修手术。压迫残留是颈椎翻修手术的重要原因[2.3],其相关的翻修率为6.6%~9.2%,为颈椎术后翻修原因第二位,仅次于远期的相邻节段病[3-7]。

关键词：颈椎后纵韧带骨化症脊髓型颈椎病神经压迫症状翻修手术手术减压颈椎前路融合术颈前路

价格机制对通勤者出发时间的影响:基于实验经济学的研究

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湖北成人教育学院学报 2023年第3期29卷 81-90页

作者：徐诗涵胡川张佳琦北京交通大学北京海淀100044

分析通勤者在复杂的交通系统中的出行时间行为选择是交通科学的核心问题之一,涉及到多个学科领域,研究具有较强的实践性。该研究基于实验经济学的研究方法,结合累积前景理论原理,通过实验室模拟实验,对价格机制的经典问题展开探究。并... 详细信息

分析通勤者在复杂的交通系统中的出行时间行为选择是交通科学的核心问题之一,涉及到多个学科领域,研究具有较强的实践性。该研究基于实验经济学的研究方法,结合累积前景理论原理,通过实验室模拟实验,对价格机制的经典问题展开探究。并通过对实验数据的分析,进行通勤者出发时间选择的相关研究,探寻价格机制对通勤者出发时间的影响,为政府公共服务提供研究理论支持,让市民拥有更加快捷高效的通勤体验。

关键词：通勤选择价格机制实验经济学累积前景理论

Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li xu Huiming xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

阻塞性睡眠呼吸暂停与心血管疾病的因果关系:一项两样本孟德尔随机化研究

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中国循证医学杂志 2023年第10期23卷 1137-1142页

作者：罗斌玉徐仕晗李逸雯王文婷刘艳飞黄璐琦刘玥中国中医科学院西苑医院国家中医心血管病临床医学研究中心北京100091 中国中医科学院西苑医院老年病二科北京100091 中国中医科学院北京100078

目的利用孟德尔随机化分析阻塞性睡眠呼吸暂停(OSA)及其典型症状(打鼾和白天嗜睡)与多种心血管疾病(高血压、冠心病、心肌梗死、心衰)的因果关系。方法利用芬兰数据库和英国生物样本库中的工具变量(IV)分别进行两样本孟德尔随机化(TS... 详细信息

目的利用孟德尔随机化分析阻塞性睡眠呼吸暂停(OSA)及其典型症状(打鼾和白天嗜睡)与多种心血管疾病(高血压、冠心病、心肌梗死、心衰)的因果关系。方法利用芬兰数据库和英国生物样本库中的工具变量(IV)分别进行两样本孟德尔随机化(TSMR)分析,以随机效应逆方差加权法(IVW)的结果为主。以MREgger法进行多效性分析、留一法进行敏感性分析来验证数据的可靠性。结果 OSA可以导致高血压[IVWβ=0.043,95%CI(0.012,0.074),P=0.006]和心衰[IVW β=0.234,95%CI(0.015,0.452),P=0.036]的发生。白天嗜睡对心衰[IVW β=1.139,95%CI(0.271,2.006),P=0.010]也有致病作用。OSA与冠心病和心梗,打鼾与4种心血管疾病以及白天嗜睡与高血压、冠心病、心梗之间无因果关联。结论 OSA和白天嗜睡对高血压和心衰存在致病效应,其中对心衰的影响最明显。

关键词：阻塞性睡眠呼吸暂停心血管疾病孟德尔随机化心力衰竭高血压

Rock fracture mechanism of buffer blasting with cushion layer at the borehole bottom

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 325-334页

作者： Xinguang Zhu Chenxi Ding Zhe Sui Hong Su xu Guo School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock *** involves analyses of the evolution patterns of blasting stress,characteristics of crack distribution,and rock fracture features in the ***,blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock *** experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock ***,the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum-discontinuum element method(CDEM)and the Landau explosion source model,with varying thicknesses of bottom cushion *** numerical simulation results indicate that with increasing cushion thickness,the absorption of energy generated by the explosion becomes more pronounced,resulting in fewer cracks in the bottom rock *** illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.

关键词： bottom cushion layer blasting crack propagation continuum-discontinuum element method dynamic stress intensity factor

Superhydrophobic and corrosion-resistant siloxane-modified MgAl-LDHs coatings on magnesium alloy prepared under mild conditions

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 450-463页

作者： Wenxi Zhang Zhangzelong Zhuo Dan xu Liang Wu Zhihui Xie Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province College of Chemistry and Chemical EngineeringChina West Normal UniversityNanchong 637002China College of Materials Science and Engineering/National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China

We have developed a superhydrophobic and corrosion-resistant LDH-W/PFDTMS composite coating on the surface of Mg *** composite comprised a tungstate-intercalated(LDH-W)underlayer that was grown at low temperature(relative to hydrothermal reaction conditions)under atmospheric pressure and an outer polysiloxane layer created from a solution containing perfluorodecyltrimethoxysilane(PFDTMS)using a simple immersion *** successful intercalation of tungstate into the LDH phase and the following formation of the polysiloxane layer were confirmed through X-ray diffraction(XRD),Fourier transform infrared(FTIR)spectroscopy,and X-ray photoelectron spectroscopy(XPS).The corrosion resistance of the LDH-W film,both before and after the PFDTMS modification,was evaluated using electrochemical impedance spectroscopy(EIS),Tafel curves,and immersion *** results showed that Mg coated with LDH-W/PFDTMS exhibited significantly enhanced corrosion protection compared to the unmodified LDHW film,with no apparent signs of corrosion after exposure to 3.5wt%NaCl solution for 15 ***,the LDH-W/PFDTMS coating demonstrated superior superhydrophobicity and self-cleaning properties against water and several common beverages,as confirmed by static contact angle and water-repellency *** results offer valuable insights into preparing superhydrophobic and corrosion-resistant LDH-based composite coatings on Mg alloy surfaces under relatively mild reaction conditions.

关键词： Mg alloy corrosion coating layered double hydroxide

Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： Guo-Fu xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

Blockchain for Network Slicing in 5G and Beyond:Survey and Challenges

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Journal of Communications and Information Networks 2022年第4期7卷 349-359页

作者： shihan Bao Yacong Liang Hui xu Department of CICT Mobile Communication Technology Co. Ltd.Beijing 100083China

Network slicing has gained popularity as a result of the advances in the fifth generation(5G)mobile *** slicing facilitates the support of different service types with varying requirements,which brings into light the slicing-aware next generation mobile network *** allowing resource sharing among multiple stakeholders,there is a long list of administrative negotiations among parties that have not established mutual *** ledger technology may be a solution to mitigate the above issues by taking its decentralized yet immutable and auditable ledger,which may help to ease administrative negotiations and build mutual trust among *** have been many research interests in this direction which focus on handling various problems in network *** paper aims at constructing this area of knowledge by introducing network slice from a standardization point of view to start with,and presenting security,privacy,and trust challenges of network slicing in 5G and beyond ***,this paper covers distributed ledger technologies basics and related approaches that tackle security,privacy,and trust threats in network slicing for 5G and beyond *** various proposals proposed in the literature are compared and ***,limitations of current work and open challenges are illustrated as well.

关键词： network slicing blockchain beyond 5G security privacy and trust