检索结果-南通市图书馆

Zinc(II)metal-organic framework eluting titanium implant as propulsive agent to boost the endothelium regeneration

在线全文

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2024年第6期18卷 123-131页

作者： Wen Liu Xiaoyu Wang Ying Li shihai Xia Wencheng Zhang Yakai Feng School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China College of Materials Science and Engineering Qingdao UniversityQingdao 266071China Department of Hepatopancreatobiliary and Splenic Medicine Affiliated HospitalLogistics University of People’s Armed Police ForceTianjin 300162China Department of Physiology and Pathophysiology Logistics University of Chinese People’s Armed Police ForceTianjin 300309China Frontiers Science Center for Synthetic Biology Tianjin UniversityTianjin 300072China Key Laboratory of Systems Bioengineering(Ministry of Education) Tianjin UniversityTianjin 300072China

The advent of antiproliferative drug-eluting vascular stents can dramatically reduce in-stent restenosis via inhibiting the hyperproliferation of vascular smooth muscle ***,the antiproliferative drugs also restrain the repair of the injured endothelial layer,which in turn leads to the very later in-stent *** points that competent endothelium plays a critical role in guaranteeing the long-term patency via maintaining vascular *** the regeneration of endothelium on the implanted vascular stents could be rendered as a promising strategy to reduce stent implantation *** this regard,bioactive zinc(II)metal-organic framework modified with endothelial cell-targeting Arg-Glu-Asp-Val peptide was embedded in poly(lactide-co-caprolactone)to serve as a functional coating on the surface of titanium substrate,which can promote the proliferation and migration of endothelial *** in vitro cell experiments revealed that the zinc(II)metal-organic framework embedded in the polymer coating was able to modulate the behaviors of endothelial cells owing to the bioactive effects of zinc ion and *** results confirmed that zinc(II)metal-organic framework eluting coating represented a new possibility for promoting the repair of the damaged endothelium with potential clinical implications in vascular-related biomaterials and tissue engineering applications.

关键词： Zinc(II)metal-organic framework vascular stent REDV peptide endothelium regeneration coating

Glucose metabolic reprogramming-related parameters for the prediction of 28-day neurological prognosis and all-cause mortality in patients after cardiac arrest:a prospective single-center observational study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2024年第3期15卷 197-205页

作者： Subi Abudurexiti shihai Xu Zhangping Sun Yi Jiang Ping Gong Department of Emergency Medicine Ruijin Hospital Affi liated to Shanghai Jiaotong University School of MedicineShanghai 200025China Department of Emergency Medicine Shenzhen People's Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affi liated HospitalSouthern University of Science and Technology)Shenzhen 518020China Department of Emergency Medicine the First Affi liated Hospital of Dalian Medical UniversityDalian 116011China Department of Emergency Medicine General Hospital of Tianjin Medical UniversityTianjin 300052China

BACKGROUND:We aimed to observe the dynamic changes in glucose metabolic reprogrammingrelated parameters and their ability to predict neurological prognosis and all-cause mortality in cardiac arrest patients after the restoration of spontaneous circulation(ROSC).METHODS:Adult cardiac arrest patients after ROSC who were admitted to the emergency or cardiac intensive care unit of the First Aflliated Hospital of Dalian Medical University from August 1,2017,to May 30,2021,were *** to 28-day survival,the patients were divided into a non-survival group(n=82) and a survival group(n=38).Healthy adult volunteers(n=40) of similar ages and sexes were selected as *** serum levels of glucose metabolic reprogrammingrelated parameters(lactate dehydrogenase [LDH],lactate and pyruvate),neuron-specific enolase(NSE) and interleukin 6(IL-6) were measured on days 1,3,and 7 after *** Acute Physiology and Chronic Health Evaluation II(APACHE II) score and Sequential Organ Failure Assessment(SOFA) score were *** Cerebral Performance Category(CPC) score was recorded on day 28 after ***:Following ROSC,the serum LDH(607.0 U/L vs.286.5 U/L),lactate(5.0 mmol/L vs.2.0 mmol/L),pyruvate(178.0 μmol/L vs.70.9 μmol/L),and lactate/pyruvate ratio(34.1 vs.22.1) significantly increased and were higher in the non-survivors than in the survivors on admission(all P<0.05).Moreover,the serum LDH,pyruvate,IL-6,APACHE II score,and SOFA score on days 1,3 and 7 after ROSC were significantly associated with 28-day poor neurological prognosis and 28-day all-cause mortality(all P<0.05).The serum LDH concentration on day 1 after ROSC had an area under the receiver operating characteristic curve(AUC) of 0.904 [95% confidence interval [95% CI]:0.851–0.957]) with 96.8% specificity for predicting 28-day neurological prognosis and an AUC of 0.950(95% CI:0.911–0.989) with 94.7% specificity for predicting 28-day all-cause mortality,which was the highest among the glucose metabo

关键词： Glucose metabolic reprogramming Lactate dehydrogenase Cardiac arrest Prognosis

Field-based evidence for the enrichment of intrinsic antibiotic resistome stimulated by plant-derived fertilizer in agricultural soil

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第1期135卷 728-740页

作者： shihai Liu Ziming Han Dong Zhu Xiao Luan Liujie Deng Liping Dong Min Yang Yu Zhang State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Environmental Protection Engineering Center for Harmless Treatment and Resource Utilization of Antibiotic Residues Khorgos 835007China University of Chinese Academy of Sciences Beijing 100049China

Animal manures have been demonstrated to enhance antibiotic resistance in agricultural ***,little is known about the effects of plant-derived fertilizer on soil antibiotic ***,metagenomic sequencing was used to investigate the effects of a plantderived fertilizer processed from sugarcane and beet on soil antibiotic resistance genes(ARGs)in a soybean field along crop growth *** profiles in the soils amended by plant-derived fertilizer were compared with those in the soils amended by chicken *** abundance and diversity of total ARGs in the soils amended by plant-derived fertilizer were significantly(P<0.05)elevated at the sprout stage,to a level comparable to that in the manured ***,unlike chicken manure mainly introducing manure-borne ARGs to soil,the plant-derived fertilizer was indicated to mainly enrich multidrug resistance genes in soil by nourishing indigenous *** with abundances in amended soils significantly(P<0.05)higher than in unamended soils at the sprout stage of soybean were considered as enriched *** in the abundance of the enriched ARGs was observed in both the amended soils from the sprout to the *** analysis further identified Proteobacteria and Bacteroidetes as the primary bacterial taxa involved in the temporal variation of the enriched ARGs in the soils amended by plant-derived fertilizer,while in manured soils were Firmicutes and *** revealed by multivariate statistical analyses,variation of the enriched ARGs in the soils amended by plant-derived fertilizer was majorly attributed to the response of co-occurred bacteria to depleting nutrients,which was different from the failed establishment of manure-borne bacteria in the manured *** study provided field-based evidence that plant-derived fertilizer stimulated the intrinsic antibiotic resistome,and proposed attention to the un-perceived risk since some clinically relevant ARGs originate and evolve fr

关键词： Organic fertilizer Intrinsic antibiotic resistance Indigenous bacteria Metagenomic sequencing

Sparse Reconstructive Evidential Clustering for Multi-View Data

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 459-473页

作者： Chaoyu Gong Yang you School of Computing National University of SingaporeSingapore

Although many multi-view clustering(MVC) algorithms with acceptable performances have been presented, to the best of our knowledge, nearly all of them need to be fed with the correct number of clusters. In addition, these existing algorithms create only the hard and fuzzy partitions for multi-view objects,which are often located in highly-overlapping areas of multi-view feature space. The adoption of hard and fuzzy partition ignores the ambiguity and uncertainty in the assignment of objects, likely leading to performance degradation. To address these issues, we propose a novel sparse reconstructive multi-view evidential clustering algorithm(SRMVEC). Based on a sparse reconstructive procedure, SRMVEC learns a shared affinity matrix across views, and maps multi-view objects to a 2-dimensional humanreadable chart by calculating 2 newly defined mathematical metrics for each object. From this chart, users can detect the number of clusters and select several objects existing in the dataset as cluster centers. Then, SRMVEC derives a credal partition under the framework of evidence theory, improving the fault tolerance of clustering. Ablation studies show the benefits of adopting the sparse reconstructive procedure and evidence theory. Besides,SRMVEC delivers effectiveness on benchmark datasets by outperforming some state-of-the-art methods.

关键词： Evidence theory multi-view clustering(MVC) optimization sparse reconstruction

Non-Deterministic Liveness-Enforcing Supervisor Tolerant to Sensor-Reading Modification Attacks

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 240-248页

作者： Dan you Shouguang Wang IEEE the School of Information and Electronic Engineering Sussex Artificial Intelligence InstituteZhejiang Gongshang UniversityHangzhou 310018China

In this paper, we study the supervisory control problem of discrete event systems assuming that cyber-attacks might occur. In particular, we focus on the problem of liveness enforcement and consider a sensor-reading modification attack(SM-attack) that may disguise the occurrence of an event as that of another event by intruding sensor communication channels. To solve the problem, we introduce non-deterministic supervisors in the paper, which associate to every observed sequence a set of possible control actions offline and choose a control action from the set randomly online to control the system. Specifically, given a bounded Petri net(PN) as the reference formalism and an SMattack, an algorithm that synthesizes a liveness-enforcing nondeterministic supervisor tolerant to the SM-attack is proposed for the first time.

关键词： Cyber-attacks cyber-physical system(CPS) liveness non-deterministic supervisors Petri net(PN)

Low crude protein formulation with supplemental amino acids for its impacts on intestinal health and growth performance of growing-finishing pigs

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2024年第4期15卷 1590-1606页

作者： Marcos Elias Duarte Wanpuech Parnsen shihai Zhang Marvio L.T.Abreu Sung Woo Kim Department of Animal Science North Carolina State UniversityRaleighNC 27695USA

Background Low crude protein(CP)formulations with supplemental amino acids(AA)are used to enhance intestinal health,reduce costs,minimize environmental impact,and maintain growth performance of ***,extensive reduction of dietary CP can compromise growth performance due to limited synthesis of non-essential AA and limited availability of bioactive compounds from protein supplements even when AA requirements are ***,implementing a low CP formulation can increase the net energy(NE)content in feeds causing excessive fat *** supplementation of functional AA,coupled with low CP formulation could further enhance intestinal health and glucose metabolism,improving nitrogen utilization,and growth *** experiments were conducted to evaluate the effects of low CP formulations with supplemental AA on the intestinal health and growth performance of growing-finishing *** In Exp.1,90 pigs(19.7±1.1 kg,45 barrows and 45 gilts)were assigned to 3 treatments:CON(18.0%CP,supplementing Lys,Met,and Thr),LCP(16.0%CP,supplementing Lys,Met,Thr,Trp,and Val),and LCPT(16.1%CP,LCP+0.05%SID Trp).In Exp.2,72 pigs(34.2±4.2 kg BW)were assigned to 3 treatments:CON(17.7%CP,meeting the requirements of Lys,Met,Thr,and Trp);LCP(15.0%CP,meeting Lys,Thr,Trp,Met,Val,Ile,and Phe);and VLCP(12.8%CP,meeting Lys,Thr,Trp,Met,Val,Ile,Phe,His,and Leu).In Exp.3,72 pigs(54.1±5.9 kg BW)were assigned to 3 treatments and fed experimental diets for 3 phases(grower 2,finishing 1,and finishing 2).Treatments were CON(18.0%,13.8%,12.7%CP for 3 phases;meeting Lys,Met,Thr,and Trp);LCP(13.5%,11.4%,10.4%CP for 3 phases;meeting Lys,Thr,Trp,Met,Val,Ile,and Phe);and LCPG(14.1%,12.8%,11.1%CP for 3 phases;LCP+Glu to match SID Glu with CON).All diets had 2.6 Mcal/kg *** In Exp.1,overall,the growth performance did not differ among *** LCPT increased(P<0.05)Claudin-1 expression in the duodenum and *** LCP and LCPT increased(P<0.05)CAT-1,4F2hc,and B0AT exp

关键词： Amino acids Growing-finishing pigs Growth performance Intestinal health Low crude protein formulation Net energy

A review of physicochemical properties of dissolved organic carbon and its impact over mountain glaciers

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2024年第1期21卷 1-19页

作者： NIU Hewen CHEN Mengxue KANG Shichang SHUKLA Tanuj QIN Huili GAO Wanni HUANG shihai ZHANG Fu State Key Laboratory of Cryospheric Sciences/National Field Science Observation and Research Station of Yulong Snow Mountain Cryosphere and Sustainable Development Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China School of Politics and International Relations Lanzhou UniversityLanzhou 730000China University of Chinese Academy of Sciences Beijing 10049China Dagu Glacier Scenic and Historic Interest Area Administration Luhua TownHeishui 615715China

Investigating the characteristics and transformation of water-soluble carbonaceous matter in the cryosphere regions is important for understanding biogeochemical process in the earth ***-soluble carbonaceous matter is a heterogeneous mixture of organic compounds that is soluble in aquatic *** its importance,we still lack systematic understanding for dissolved organic carbon(DOC)in several aspects including exact chemical composition and physical interactions with microorganisms,glacier *** review presents the chemical composition and physical properties of glacier DOC deposited through anthropogenic emission,terrestrial,and biogenic *** present the molecular composition of DOC and its effect over snow albedo and associated radiative *** indicate that DOC in snow/ice is made up of aromatic protein-like species,fulvic acid-like materials,and humic acid-like ***-absorbing impurities in surface snow and glacier ice cause considerable albedo reduction and the associated radiative forcing is definitely ***-soluble carbonaceous matter dominated the carbon transport in the high-altitude glacial *** to prevailing global warming and projected increase in carbon emission,the glacial DOC is expected to release,which will have strong underlying impacts on cryosphere *** results of this work have profound implications for better understanding the carbon cycle in high altitude cryosphere regions.A new compilation of globally distributed work is required,including large-scale measurements of glacial DOC over high-altitude cryosphere regions,to overcome and address the scientific challenges to constrain climate impacts of light-absorbing impurities related processes in Earth system and climate models.

关键词： Mountain glaciers Dissolved organic carbon Molecular composition Radiative forcing

A new 3D plastoelastohydrodynamic lubrication model for rough surfaces

在线全文

学校读者我要写书评

暂无评论

Friction 2024年第6期12卷 1176-1193页

作者： Shengyu you Jinyuan TANG Qiang WANG State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South UniversityChangsha 410083China

Plastoelastohydrodynamic lubrication of rough surfaces(R-PEHL)is a cutting-edge area of research in interface fluid-structure coupling *** existing R-PEHL model calculates the elastic-plastic deformation of rough surface by the Love equation in a semi-infinite space smooth surface,which deviates from the actual ***,it is an innovative work to study the exact solution of elastic-plastic deformation of rough surface and its influence on the solution results of R-PEHL *** this paper,a new contact calculation model of plastoelastohydrodynamic lubrication(PEHL)with three-dimensional(3D)rough surface is proposed by integrating numerical method of EHL and finite element *** new model eliminates an original error introduced by the assumption of semi-infinite space in contact calculation,providing wide applicability and high *** the given rough surfaces and working conditions,the study reveals that:(1)the oil film pressure calculated by the new model is lower than that of the smooth surface in semi-infinite space by 200–800 MPa;(2)the Mises stress of the new model is 2.5%–26.6%higher than that of the smooth surface in semi-infinite space;(3)compared with the semi-infinite space assumption,the rough surface plastic deformation of the new model is increased by 71%–173%,and the local plastic deformation singularity may appear under the semi-infinite space assumption;(4)the plastic deformation caused by the first contact cycle on the rough surface of the new model accounts for 66.7%–92.9%of the total plastic deformation,and the plastic deformation of the semi-infinite space accounts for 50%–83.3%.This study resolves the contradiction between the smooth surface assumption and the rough surface in the existing R-PEHL model,establishing a solid logic foundation for the accurate solution of R-PEHL model.

关键词： rough surface plastoelastohydrodynamic lubrication(PEHL) asperity plastic deformation semi-infinite space

Data-Driven Control of Linear Systems via Quantized Feedback

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2024年第1期37卷 152-168页

作者： LI Xingchen ZHAO Feiran you Keyou Department of Automation and BNRist Tsinghua UniversityBeijing 100084China

Quantized feedback control is fundamental to system synthesis with limited communication *** sharp contrast to the existing literature on quantized control which requires an explicit dynamical model,the authors study the quadratic stabilization and performance control problems with logarithmically quantized feedback in a direct data-driven framework,where the system state matrix is not exactly known and instead,belongs to an ambiguity set that is directly constructed from a finite number of noisy system *** this end,the authors firstly establish sufficient and necessary conditions via linear matrix inequalities for the existence of a common quantized controller that achieves our control objectives over the ambiguity ***,the authors provide necessary conditions on the data for the solvability of the LMIs,and determine the coarsest quantization density via semi-definite *** theoretical results are validated through numerical examples.

关键词： Data-driven control linear matrix inequalities linear systems quantized control.