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Glucose metabolic reprogramming-related parameters for the prediction of 28-day neurological prognosis and all-cause mortality in patients after cardiac arrest:a prospective single-center observational study

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World Journal of Emergency Medicine 2024年第3期15卷 197-205页

作者： Subi Abudurexiti shihai Xu Zhangping Sun Yi Jiang Ping Gong Department of Emergency Medicine Ruijin Hospital Affi liated to Shanghai Jiaotong University School of MedicineShanghai 200025China Department of Emergency Medicine Shenzhen People's Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affi liated HospitalSouthern University of Science and Technology)Shenzhen 518020China Department of Emergency Medicine the First Affi liated Hospital of Dalian Medical UniversityDalian 116011China Department of Emergency Medicine General Hospital of Tianjin Medical UniversityTianjin 300052China

BACKGROUND:We aimed to observe the dynamic changes in glucose metabolic reprogrammingrelated parameters and their ability to predict neurological prognosis and all-cause mortality in cardiac arrest patients after the restoration of spontaneous circulation(ROSC).METHODS:Adult cardiac arrest patients after ROSC who were admitted to the emergency or cardiac intensive care unit of the First Aflliated Hospital of Dalian Medical University from August 1,2017,to May 30,2021,were enrolled.According to 28-day survival,the patients were divided into a non-survival group(n=82) and a survival group(n=38).Healthy adult volunteers(n=40) of similar ages and sexes were selected as controls.The serum levels of glucose metabolic reprogrammingrelated parameters(lactate dehydrogenase [lDH],lactate and pyruvate),neuron-specific enolase(NSE) and interleukin 6(Il-6) were measured on days 1,3,and 7 after ROSC.The Acute Physiology and Chronic Health Evaluation II(APACHE II) score and Sequential Organ Failure Assessment(SOFA) score were calculated.The Cerebral Performance Category(CPC) score was recorded on day 28 after ROSC.RESUlTS:Following ROSC,the serum lDH(607.0 U/l vs.286.5 U/l),lactate(5.0 mmol/l vs.2.0 mmol/l),pyruvate(178.0 μmol/l vs.70.9 μmol/l),and lactate/pyruvate ratio(34.1 vs.22.1) significantly increased and were higher in the non-survivors than in the survivors on admission(all PlDH,pyruvate,Il-6,APACHE II score,and SOFA score on days 1,3 and 7 after ROSC were significantly associated with 28-day poor neurological prognosis and 28-day all-cause mortality(all PlDH concentration on day 1 after ROSC had an area under the receiver operating characteristic curve(AUC) of 0.904 [95% confidence interval [95% CI]:0.851–0.957]) with 96.8% specificity for predicting 28-day neurological prognosis and an AUC of 0.950(95% CI:0.911–0.989) with 94.7% specificity for predicting 28-day all-cause mortality,which was the highest among the glucose metabolic reprogramming-related parameters tested.CONC

关键词： Glucose metabolic reprogramming lactate dehydrogenase Cardiac arrest Prognosis

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Field-based evidence for the enrichment of intrinsic antibiotic resistome stimulated by plant-derived fertilizer in agricultural soil

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Journal of Environmental Sciences 2024年第1期135卷 728-740页

作者： shihai liu Ziming Han Dong Zhu Xiao luan liujie Deng liping Dong Min Yang Yu Zhang State Key laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Environmental Protection Engineering Center for Harmless Treatment and Resource Utilization of Antibiotic Residues Khorgos 835007China University of Chinese Academy of Sciences Beijing 100049China

Animal manures have been demonstrated to enhance antibiotic resistance in agricultural soils.However,little is known about the effects of plant-derived fertilizer on soil antibiotic resistome.Herein,metagenomic sequencing was used to investigate the effects of a plantderived fertilizer processed from sugarcane and beet on soil antibiotic resistance genes(ARGs)in a soybean field along crop growth stages.ARG profiles in the soils amended by plant-derived fertilizer were compared with those in the soils amended by chicken manure.The abundance and diversity of total ARGs in the soils amended by plant-derived fertilizer were significantly(Plevated at the sprout stage,to a level comparable to that in the manured soils.Whereas,unlike chicken manure mainly introducing manure-borne ARGs to soil,the plant-derived fertilizer was indicated to mainly enrich multidrug resistance genes in soil by nourishing indigenous bacteria.ARGs with abundances in amended soils significantly(Pls at the sprout stage of soybean were considered as enriched ARGs.Decrease in the abundance of the enriched ARGs was observed in both the amended soils from the sprout to the harvest.Network analysis further identified Proteobacteria and Bacteroidetes as the primary bacterial taxa involved in the temporal variation of the enriched ARGs in the soils amended by plant-derived fertilizer,while in manured soils were Firmicutes and Actinobacteria.As revealed by multivariate statistical analyses,variation of the enriched ARGs in the soils amended by plant-derived fertilizer was majorly attributed to the response of co-occurred bacteria to depleting nutrients,which was different from the failed establishment of manure-borne bacteria in the manured soils.Our study provided field-based evidence that plant-derived fertilizer stimulated the intrinsic antibiotic resistome,and proposed attention to the un-perceived risk since some clinically relevant ARGs originate and evolve from natural resistome.

关键词： Organic fertilizer Intrinsic antibiotic resistance Indigenous bacteria Metagenomic sequencing

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Exploring centimeter-sized crystals of bismuth-iodide perovskite toward highly sensitive X-ray detection

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Chinese Chemical letters 2024年第6期35卷 185-188页

作者： Xin Dong Jing liang Zhijin Xu Huajie Wu lei Wang shihai You Junhua luo lina li College of Chemistry Fuzhou UniversityFuzhou 350116China State Key laboratory of Structure Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China

lead-halide perovskites exhibit outstanding performance in X-ray detection due to their intrinsic features such as high charge carrier mobility,large atomic number,and long carrier lifetime,but the toxicity of lead is regarded as the major factor hindering their development.Here,we introduce organic molecule(R)-(-)-2-methylpiperazine(R-MPz)into the bismuth-based structure to synthesize lead-free(R)-(H_(2)MPz)BiI_(5)(R-MBI).The high-quality centimeter-sized single crystals have been obtained,which show a low dark current and superior environmental stability.Particularly,the single-crystal device of R-MBI exhibits a highμτproduct up to 1.88×10^(-4)cm^(2)/V and a low trap density of 1.21×10^(10)cm^(-3).Further,the detector displays excellent detection sensitivity of 263.58μC Gy_(air)^(-1)cm^(-2)and a favorable low detection limit of 4.35μGyair/s,both of which meet the requirement for medical diagnostics.These findings shed light on the exploration of innovative bismuth-based hybrid perovskites for high-performance X-ray detection.

关键词： Perovskite lead-free Bismuth-based X-ray detection Sensitivity

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A review of physicochemical properties of dissolved organic carbon and its impact over mountain glaciers

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Journal of Mountain Science 2024年第1期21卷 1-19页

作者： NIU Hewen CHEN Mengxue KANG Shichang SHUKlA Tanuj QIN Huili GAO Wanni HUANG shihai ZHANG Fu State Key laboratory of Cryospheric Sciences/National Field Science Observation and Research Station of Yulong Snow Mountain Cryosphere and Sustainable Development Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China School of Politics and International Relations Lanzhou UniversityLanzhou 730000China University of Chinese Academy of Sciences Beijing 10049China Dagu Glacier Scenic and Historic Interest Area Administration Luhua TownHeishui 615715China

Investigating the characteristics and transformation of water-soluble carbonaceous matter in the cryosphere regions is important for understanding biogeochemical process in the earth system.Water-soluble carbonaceous matter is a heterogeneous mixture of organic compounds that is soluble in aquatic environments.Despite its importance,we still lack systematic understanding for dissolved organic carbon(DOC)in several aspects including exact chemical composition and physical interactions with microorganisms,glacier meltwater.This review presents the chemical composition and physical properties of glacier DOC deposited through anthropogenic emission,terrestrial,and biogenic sources.We present the molecular composition of DOC and its effect over snow albedo and associated radiative forcings.Results indicate that DOC in snow/ice is made up of aromatic protein-like species,fulvic acid-like materials,and humic acid-like materials.light-absorbing impurities in surface snow and glacier ice cause considerable albedo reduction and the associated radiative forcing is definitely positive.Water-soluble carbonaceous matter dominated the carbon transport in the high-altitude glacial area.Owing to prevailing global warming and projected increase in carbon emission,the glacial DOC is expected to release,which will have strong underlying impacts on cryosphere ecosystem.The results of this work have profound implications for better understanding the carbon cycle in high altitude cryosphere regions.A new compilation of globally distributed work is required,including large-scale measurements of glacial DOC over high-altitude cryosphere regions,to overcome and address the scientific challenges to constrain climate impacts of light-absorbing impurities related processes in Earth system and climate models.

关键词： Mountain glaciers Dissolved organic carbon Molecular composition Radiative forcing

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Dietary supplementation of benzoic acid and essential oils combination enhances intestinal resilience against lPS stimulation in weaned piglets

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Journal of Animal Science and Biotechnology 2024年第2期15卷 878-897页

作者： Chang Cui Yulong Wei Yibo Wang Wen Ma Xiaoyu Zheng Jun Wang Ziwei Ma Caichi Wu licui Chu shihai Zhang Wutai Guan Fang Chen Guangdong Provincial Key laboratory of Animal Nutrition Control College of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China College of Animal Science and National Engineering Research Center for Breeding Swine Industry South China Agricultural UniversityGuangzhou 510642China Guangdong laboratory for lingnan Modern Agriculture South China Agricultural UniversityGuangzhou 510642China

Background The benefits of combining benzoic acid and essential oils(BAO)to mitigate intestinal impairment during the weaning process have been well established,while the detailed underlying mechanism has not been fully elucidated.Previous research has primarily focused on the reparative effects of BAO on intestinal injury,while neglecting its potential in enhancing intestinal stress resistance.Methods In this study,we investigated the pre-protective effect of BAO against lPS-induced stress using a modified experimental procedure.Piglets were pre-supplemented with BAO for 14 d,followed by a challenge with lPS or saline to collect blood and intestinal samples.Results Our findings demonstrated that BAO supplementation led to significant improvements in piglets’final weight,average daily gain,and feed intake/body gain ratio.Additionally,BAO supplementation positively influenced the composition of intestinal microbiota,increasing beneficial Actinobacteriota and Alloprevotella while reducing harmful Desulfobacterota,Prevotella and Oscillospira.Furthermore,BAO supplementation effectively mitigated oxidative disturbances and inflammatory responses induced by acute lPS challenge.This was evidenced by elevated levels of T-AOC,SOD,and GSH,as well as decreased levels of MDA,TNF-α,and Il-6 in the plasma.Moreover,piglets subjected to lPS challenge and pre-supplemented with BAO exhibited significant improvements in intestinal morphological structure and enhanced integrity,as indicated by restored expression levels of Occludin and Claudin-1 compared to the non-supplemented counterparts.Further analysis revealed that BAO supplementation enhanced the jejunal antioxidative capacity by increasing GSH-Px levels and decreasing MDA levels under the lPS challenge and stimulated the activation of the Nrf2 signaling pathway.Additionally,the reduction of TlR4/NF-κB/MAPK signaling pathways activation and proinflammatory factor were also observed in the jejunal of those piglets fed with BAO.Conclusions In summary,our study demonstrates that

关键词： Anti-stress Benzoic acid Essential oils Intestine lPS Weaned piglets

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中华优秀传统文化同科学社会主义价值观主张高度契合的道德观阐释

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当代世界社会主义问题 2024年第1期 19-25,164,165页

作者：张士海山东大学马克思主义学院济南250100

党的二十大报告关于中华优秀传统文化同科学社会主义价值观主张具有高度契合性的重要论断,不仅提取和凝练了中华优秀传统文化的特质禀赋和核心价值理念,还指明了马克思主义基本原理与中华优秀传统文化在中国语境中相契合的事实支点。其... 详细信息

党的二十大报告关于中华优秀传统文化同科学社会主义价值观主张具有高度契合性的重要论断,不仅提取和凝练了中华优秀传统文化的特质禀赋和核心价值理念,还指明了马克思主义基本原理与中华优秀传统文化在中国语境中相契合的事实支点。其中,道德作为衡量个体人格品质、调整社会生活方式、维系人与人之间社会关系的规范系统,是科学社会主义理论的一个重要范畴,而中华民族几千年的文明发展史建立了一套相对完整的伦理道德体系。

关键词：中华优秀传统文化社会主义价值观社会生活方式核心价值理念人格品质伦理道德体系中国语境道德观

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别集编纂与文学观念研究的四个维度

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湖南师范大学社会科学学报 2024年第3期53卷 1-12页

作者：何诗海浙江大学文学院浙江杭州310058

别集的主要功能是收录、保存作品,不像选本性总集那样,具有显著的文学批评功能。然而,别集内容、编次体例都比总集复杂,在文学思想和观念研究上自有其重要价值。探讨别集编纂与文学观念的关系,主要可从别集收录范围、编次体例、副文本... 详细信息

别集的主要功能是收录、保存作品,不像选本性总集那样,具有显著的文学批评功能。然而,别集内容、编次体例都比总集复杂,在文学思想和观念研究上自有其重要价值。探讨别集编纂与文学观念的关系,主要可从别集收录范围、编次体例、副文本以及别集编纂过程四个维度展开研究。

关键词：文学观念别集编纂体例副文本

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面向阵列级同时同频收发的宽带自干扰空域抑制

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电子与信息学报 2024年第5期46卷 1951-1957页

作者：林朗赵宏志邵士海唐友喜电子科技大学通信抗干扰全国重点实验室成都611731 电磁空间认知与智能控制技术实验室北京100089

具备阵列级同时同频收发能力的多功能一体化平台,面临发射阵列对接收阵列的强自干扰问题。针对这一问题,该文设计了一种宽带自干扰空域抑制方法,构造了限制主波束增益损失条件下,最小化残余自干扰和噪声功率的非凸优化问题,提出了交替... 详细信息

具备阵列级同时同频收发能力的多功能一体化平台,面临发射阵列对接收阵列的强自干扰问题。针对这一问题,该文设计了一种宽带自干扰空域抑制方法,构造了限制主波束增益损失条件下,最小化残余自干扰和噪声功率的非凸优化问题,提出了交替迭代的优化算法联合求解发射和接收数字波束成形系数,从理论上分析了所提算法的自干扰抑制极限性能,并给出了所提算法的计算复杂度。分析和仿真结果表明,给定2.4 GHz工作频率,100 MHz带宽,主波束增益损失限制在3 dB时,收发各30阵元的相控阵列宽带自干扰空域抑制能力,即有效各向同性隔离度达到168 dB,距离自干扰抑制性能极限差距7 dB。

关键词：同时同频收发数字波束成形空域自干扰抑制

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基于BP神经网络的儿童乘员头部损伤预测模型及评估参数研究

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汽车工程 2024年第2期46卷 329-336页

作者：王彦鑫李海岩崔世海贺丽娟吕文乐天津科技大学机械工程学院天津300222 现代汽车安全技术国际联合研究中心天津300222

智能座舱与虚拟测评规程的推广,给乘员损伤评价带来新挑战,损伤机理与损伤风险评估参数更加多样化。本文基于图斯特6岁儿童乘员损伤仿生模型与BP神经网络算法构建正面100%重叠刚性壁障工况中乘员坐姿角度与头部损伤指标相关性预测模型,... 详细信息

智能座舱与虚拟测评规程的推广,给乘员损伤评价带来新挑战,损伤机理与损伤风险评估参数更加多样化。本文基于图斯特6岁儿童乘员损伤仿生模型与BP神经网络算法构建正面100%重叠刚性壁障工况中乘员坐姿角度与头部损伤指标相关性预测模型,探究不同坐姿下头部损伤风险以及不同评价指标之间的相关性与差异性。结果表明,构建的相关性损伤预测模型具有良好的可信度(R2>0.90),可以用于损伤预测与分析。现有头部损伤评价指标在小角度坐姿范围内(95°~108°)对头损伤评估及预测具有良好的一致性,但是对于大角度坐姿乘员,不同损伤评价指标对头部损伤风险的评估存在显著差异。因此,目前实施的头部损伤评价参数具有局限性,未来虚拟测评中应综合运动学和生物力学参数对头部损伤风险进行更加全面的评估。该研究结果可以为儿童约束系统的改善、虚拟测评以及大角度坐姿乘员头部损伤评价参数的选取提供数据与理论支撑。

关键词：损伤仿生模型儿童乘员 BP神经网络虚拟测评坐姿角度

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高涡流比对低速双燃料船舶发动机天然气/空气混合及燃烧性能的影响

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内燃机工程 2024年第3期45卷 30-38,49页

作者：李大保刘世海刘龙中船动力(集团)有限公司上海201208 哈尔滨工程大学动力与能源工程学院哈尔滨150001

以X92DF超大缸径低速二冲程双燃料船用发动机为研究对象,基于三维数值计算分析了天然气和空气混合过程及燃烧特性,并研究了扫气和燃烧过程中缸内涡流强度对混合质量和火焰传播的影响。结果表明:由于上止点前缸内天然气和空气的混合气浓... 详细信息

以X92DF超大缸径低速二冲程双燃料船用发动机为研究对象,基于三维数值计算分析了天然气和空气混合过程及燃烧特性,并研究了扫气和燃烧过程中缸内涡流强度对混合质量和火焰传播的影响。结果表明:由于上止点前缸内天然气和空气的混合气浓度分布不均,造成局部高浓度区域出现燃烧异常现象,导致缸内压力振荡幅度增大。通过分析不同涡流强度对缸内天然气/空气的混合质量的影响可以得出,随着扫气过程中涡流强度的增大,上止点前缸内天然气高浓度区域面积明显减小,表明天然气和空气的混合质量得到明显提高。同时,随着缸内涡流比的增加,加快了预燃室射流火焰在主燃烧室内的传播速度和缸内天然气的燃烧速度。进一步研究得出缸内混合质量的提高可以有效地避免局部异常燃烧现象和降低压力振荡。最后,提出一种改善缸内混合质量和减小压力振荡的策略,为液态天然气在船机上的普及提供了一定了理论基础。

关键词：大缸径船舶发动机双燃料涡流比天然气/空气混合压力振荡

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