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BERI-BERI IN NANKING

中华医学杂志(英文版) 1934年第1期048卷 20-36页

作者： chi-shih yang K.K.HUANG Dept.ofMedicine Hsiang-YaMedicalCollege Changsha Dept.ofMedicine CentralHospital Nanking Dept.ofMedicine Hsiang-YaMedicalCollege Changsha Dept.ofMedicine CentralHospital Nanking

Beri-beri has long been known to be endemic in *** isparticularly common in the southern part of the country,where rice isthe main staple of *** is a disease not confined to the tropicalregions as once so considered,but rather related to the nature of thediet consumed by the *** our knowledge of the existence of this disease may betraced to the old chinese and Japanese records,a better understandingof its possible relationship with diet did not begin until the close of thelast century,when Eijkman in 1897(Ⅰ)demonstrated the experimentalproduction of polyneuritis in *** observed paralysis infowls fed on polished *** condition which he called polyneurifisgallinarum,has been frequently interpreted as analogous to beri-beri in

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Perovskite solar cell operational stability under vacuum for space application

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Perovskite solar cell operational stability under vacuum for...

Advancements in Liver Tumor Detection:A Comprehensive Review of Various Deep Learning Models

第七届新型太阳能电池材料科学与技术学术研讨会

作者： Yan Jiang shih-chi yang Stefano Pisoni Thierry Moser Fan Fu Ayodhya N.Tiwari Laboratory for Thin Films and Photovoltaics Empa–Swiss Federal Laboratories for Material Science and Technology

High power conversion efficiency,high specific power(W/g) and stowed packing efficiency(W/cm

关键词： perovskite solar cell stability vacuum degradation

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 91-122页

作者： Shanmugasundaram Hariharan D.Anandan Murugaperumal Krishnamoorthy Vinay Kukreja Nitin Goyal shih-Yu Chen Deptartment of Artificial Intelligence and Data Science Vardhaman College of EngineeringHyderabad501218India Deptartment of CSE V.S.B College of EngineeringKarur639111India Deptartment of Electrical and Electronics Engineering Vardhaman College of EngineeringHyderabad501218India Centre for Research Impact&Outcome Chitkara UniversityRajpura140401PunjabIndia Department of Computer Science and Engineering School of Engineering and TechnologyCentral University of HaryanaMahendergarh123031HaryanaIndia Department of Computer Science and Information Engineering National Yunlin University of Science and TechnologyYunlin64002Taiwan Intelligence Recognition Industry Service Research Center National Yunlin University of Science and TechnologyYunlin64002Taiwan

Liver cancer remains a leading cause of mortality worldwide,and precise diagnostic tools are essential for effective treatment *** Tumors(LTs)vary significantly in size,shape,and location,and can present with tissues of similar intensities,making automatically segmenting and classifying LTs from abdominal tomography images crucial and *** review examines recent advancements in Liver Segmentation(LS)and Tumor Segmentation(TS)algorithms,highlighting their strengths and limitations regarding precision,automation,and *** metrics are utilized to assess key detection algorithms and analytical methods,emphasizing their effectiveness and relevance in clinical *** review also addresses ongoing challenges in liver tumor segmentation and identification,such as managing high variability in patient data and ensuring robustness across different imaging *** suggests directions for future research,with insights into technological advancements that can enhance surgical planning and diagnostic accuracy by comparing popular *** paper contributes to a comprehensive understanding of current liver tumor detection techniques,provides a roadmap for future innovations,and improves diagnostic and therapeutic outcomes for liver cancer by integrating recent progress with remaining challenges.

关键词： Liver tumor detection liver tumor segmentation image processing liver tumor diagnosis feature extraction tumor classification deep learning machine learning

Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning Chang Liu Yu-chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

Herpes simplex virus 2-induced aseptic meningitis presenting with sudden deafness:A case report

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World Journal of Clinical Cases 2025年第8期13卷 22-25页

作者： Yuan-Cheng Liu shih-Hsuan Hsiao Peir-Rong Chen Department of Otolaryngology Hualien Tzu Chi HospitalHualien 970TaiwanChina Department of Otolaryngology Hualien Tzu Chi Hospitaland Department of OtolaryngologyHead and Neck SurgerySchool of MedicineTzu Chi UniversityHualien 970TaiwanChina

BACKGROUND Aseptic meningitis is defined as meningeal inflammation caused by various etio-logies with negative cerebrospinal fluid(CSF)bacterial *** most common etiologies are viruses[enteroviruses,arboviruses,and herpes simplex virus type 2(HSV-2)].Aseptic meningitis can have various presentations,including sensori-neural *** sensorineural deafness from mumps meningoencephalitis has been reported,cases of HSV-2-induced hearing loss are ***,we re-port a case of HSV-2-induced meningitis that presented with sudden *** SUMMARY A 68-year-old man experienced a profound sudden onset of left-sided hearing loss for one ***-tone audiograms demonstrated sudden left-sided sensorineural hearing loss(thresholds 80-90 dB).After treatment with high-dose steroids for 1 week,he experienced an acute consciousness change with left *** laboratory data showed no significant *** computed tomography without contrast and magnetic resonance imaging revealed no intracranial hemo-rrhage or obvious brain *** CSF analysis and the Multiplex PCR panels showed HSV-2 ***,under the diagnosis of herpes meningoenceph-alitis,acyclovir was prescribed and his symptoms gradually *** This case report further demonstrates that a viral infection could be a cause of sudden sensorineural hearing loss.

关键词： Aseptic meningitis Type 2 herpes simplex Sudden sensorineural hearing loss Immunocompromised Cerebrospinal fluid Case report

Prognostic factors for acute central retinal artery occlusion treated with hyperbaric oxygen:The Hong Kong study report number five

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World Journal of Methodology 2025年第2期15卷 117-124页

作者： Sunny chi Lik Au Steffi Shing Yee Chong Department of Ophthalmology Tung Wah Eastern HospitalHong Kong 999077China Department of Ophthalmology Pamela Youde Nethersole Eastern HospitalHong Kong 999077China

BACKGROUND Central retinal artery occlusion(CRAO)is a potentially blinding disease,and hyperbaric oxygen therapy(HBOT)is becoming increasingly popular with the support of scientific *** the presence of various acute management measures,there is no clear evidence on the gold standard treatment for *** To identify factors and imaging parameters associated with good visual outcome,which guide ophthalmologists in the triage of CRAO patients for *** Patients who suffered from CRAO and had a symptom onset≤6 h were recruited for a course of HBOT in a tertiary hospital after failing bedside *** demographics,onset time,CRAO eye parameters,and past medical history were prospectively *** outcomes after HBOT were also *** A total of 26 patients were included;the female-to-male ratio was 1:1.6,and the mean age was 67.5 years±13.3 years(range 44–89 years).The mean duration of follow-up and mean visual acuity(VA)improvement were 10.0 mo±5.3 mo and 0.48 logarithm of minimal angle of resolution(logMAR)±0.57 logMAR(approx-imately 9 letters in ETDRS)(P=0.0001,Z=-3.67),*** 1 mm zone of central macular thickness(CMT)on optical coherence tomography was not associated with VA changes(P=0.119);however,the 1-to-3 mm circular rim of CMT was fairly associated(P=0.02,Spearman's coefficient=0.45).Complete retinal perfusion time during fundus fluorescein angiography(FFA)was mode-rately associated(P=0.01,Spearman's coefficient=0.58)with visual outcome.

关键词： Central retinal artery occlusion Fundus fluorescein angiography Hyperbaric oxygen therapy Optical coherence tomography Stroke

Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei yang Di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie yang Ganggang Zhang Chen Wang Yanlian yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei Niu Yingkai Wang yang Liu Cheng yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

Retrospective analysis of pathological types and imaging features in pancreatic cancer: A comprehensive study

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 121-129页

作者： yang-Gang Luo Mei Wu Hong-Guang Chen Pathology Department Xuanhan County People’s HospitalDazhou 636150Sichuan ProvinceChina

BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late *** the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment *** To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging *** We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our *** types were determined by histopathological examination of the surgical spe-cimens or biopsy *** imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic *** analyses were performed to identify significant associations between pathological types and specific imaging *** There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare *** imaging features were identified in each pathological *** ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural *** tumors often appear as hypervascular lesions in contrast-enhanced *** analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging *** findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.

关键词： Pancreatic cancer Pathological types Imaging features Retrospective analysis Diagnostic accuracy