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Bioactivities,Mechanisms,Production,and Potential Application of Bile Acids in Preventing and Treating Infectious Diseases

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Engineering 2024年第7期38卷 13-26页

作者： Shuang Liu Shuo yang Biljan Blazekovic Lu Li Jidan Zhang yi Wang Experimental Research Center China Academy of Chinese Medical SciencesBeijing 100700China Faculty of Pharmacy and Biochemistry University of ZagrebZagreb 10000Croatia

Infectious diseases are a global public health problem,with emerging and re-emerging infectious diseases on the rise ***,their prevention and treatment are still major *** acids are common metabolites in both hosts and microorganisms that play a significant role in controlling the metabolism of lipids,glucose,and *** acids have historically been utilized as first-line,valuable therapeutic agents for related metabolic and hepatobiliary ***,bile acids are the major active ingredients of cow bezoar and bear bile,which are commonly used traditional Chinese medicines(TCMs)with the therapeutic effects of clearing heat,detoxification,and relieving wind and *** recent years,the promising performance of bile acids against infectious diseases has attracted attention from the scientific *** paper reviews for the first time the biological activities,possible mechanisms,production routes,and potential applications of bile acids in the treatment and prevention of infectious *** with previous reviews,we comprehensively summarize existing studies on the use of bile acids against infectious diseases caused by pathogenic microorganisms that are leading causes of global morbidity and *** addition,to ensure a stable supply of bile acids at affordable prices,it is necessary to clarify the biosynthesis of bile acids in vivo,which will assist scientists in elucidating the accumulation of bile acids and discovering how to engineer various bile acids by means of chemosynthesis,biosynthesis,and chemoenzymatic ***,we explore the current challenges in the field and recommend a development strategy for bile-acid-based drugs and the sustainable production of bile *** presented studies suggest that bile acids are potential novel therapeutic agents for managing infectious diseases and can be artificially synthesized in a sustainable way.

关键词： Bile acids Infectious diseases Bioactivities Mechanisms Anti-infective agents

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Lithography-free polarization-dependent absorber based on α-MoO_(3)

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Science China(Technological Sciences) 2024年第7期67卷 2147-2152页

作者： HU yang WU XiaoHu LI HongJu ZHAO yi LIU HaoTuo HUANG XiuQuan School of Power and Energy Northwestern Polytechnical UniversityXi’an 710072China Shandong Institute of Advanced Technology Jinan 250100China School of Physics Hefei University of TechnologyHefei 230009China Department of Academic Affairs Harbin Institute of Technology(Shenzhen)Shenzhen 518055China Key Laboratory of Advanced Manufacturing and Intelligent Technology Ministry of EducationHarbin University of Science and TechnologyHarbin 150080China

As a natural biaxial hyperbolic material, α-phase molybdenum trioxide(α-MoO_(3)) exhibits dielectric and metallic properties in the plane, rendering it an exceptional candidate for polarization-dependent devices. In this work, we design a lithography-free polarization-dependent absorber consisting of an α-MoO_(3)film, a germanium layer, and a silver substrate. The results show that a narrowband absorption of up to 0.99 is achieved at a wavelength of 12.2 μm for transverse magnetic polarization. In contrast, the absorption is only 0.06 at this wavelength for transverse electric polarization. This remarkable polarization-dependent absorption performance is attributed to the coupling of epsilon-near-zero modes and Fabry-Perot resonances, which is confirmed by the electric field and power dissipation density distributions. Furthermore, strong polarization-dependent performance could also be achieved when the crystal axis of α-MoO_(3)is rotated in the out-of-plane. This work demonstrates that in-plane anisotropic α-MoO_(3)has the potential for designing high polarization-dependent devices.

关键词： α-MoO_(3) polarization-dependent epsilon-near-zero modes Fabry-Perot resonances

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Ultrasonic manifestations and age distribution of internal abdominal hernia in children

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中国医学影像技术 2024年第8期40卷 1204-1207页

作者： KUANG Bin yang Chunjiang TANG yi Department of Ultrasound Children's Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of Pediatric Metabolism and Inflammatory DiseasesChongqing 400014China

Objective To observe the ultrasonic manifestations and age distribution of internal abdominal hernia in *** Data of 53 children with internal abdominal hernia confirmed by operation were retrospectively *** ultrasonic findings were observed,and the age distribution of children was *** Among 53 cases,"cross sign"was observed in 22 cases(22/53,41.51%),and"hernia ring beak sign"was detected in 26 cases(26/53,49.06%)by preoperative ultrasound,according to which 21 cases were diagnosed as internal abdominal hernia,with the accuracy of 39.62%(21/53).Meanwhile,manifestations of intestinal obstruction were noticed in 48 cases(48/53,90.57%),and intestinal necrosis was considered in 22 cases(22/53,41.51%).Four cases were misdiagnosed as intestinal perforation,appendicitis,intestinal atresia and volvulus,each in 1 *** onset age of postoperative adhesive band internal hernia was larger than that of mesenteric hiatal hernia(P0.05).Intestinal ischemic necrosis was found in 25 cases,while the incidence of intestinal necrosis in children aged≤1 year,>1 and≤3 years,>3 and≤7 years and those>7 years was 66.67%(12/18),33.33%(4/12),36.36%(4/11)and 41.67%(5/12),*** The characteristic ultrasonic findings of internal abdominal hernia in children included"cross sign"and"hernia ring beak sign".Internal abdominal hernia in children under 1 year had high risk of intestinal necrosis.

关键词： hernia,abdominal children ultrasonography

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Oral pyroptosis nanoinhibitor for the treatment of inflammatory bowel disease

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Nano Research 2024年第3期17卷 1748-1759页

作者： Zhenxing Zhu Dongtao Zhou yi yin Zhun Li Zhen Guo Yongchun Pan Yanfeng Gao Jingjing yang Weiming Zhu Yujun Song yi Li Department of General Surgery Affiliated Jinling HospitalMedical SchoolNanjing UniversityNanjing 210093China College of Engineering and Applied Sciences State Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China Department of General Surgery Affiliated Drum Tower HospitalMedical SchoolNanjing UniversityNanjing 210008China Department of Biochemistry and Molecular Biology School of Medicine&Holistic Integrative MedicineJiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Inflammatory bowel disease(IBD)is an autoimmune gastrointestinal disease characterized by chronic relapsing inflammation of the *** pyroptosis that exists in the inflamed intestine can activate damage signals and aggravate local inflammation in ***,we designed an oral pyroptosis nanoinhibitor,DXMS@CuM@PPADT@PSS(DCMP),which can target intestinal lesions,and respond to reactive oxygen species(ROS)to release active sites and drugs at the *** can inhibit the activation of the nucleotide-binding domain and leucine-rich repeat family pyrin domain containing 3(NLRP3)inflammasomes by scavenging ROS,resulting in the down-regulation of gasdermin D(GSDMD)cleavage thus inhibiting *** also improved intestinal barrier function,decreased inflammatory cytokine levels,and increased the diversity of gut microbiota in mice with *** work is believed to expand the biomedical application of nanomaterials for innate immunity modulation.

关键词： inflammatory bowel disease nanoinhibitors pyroptosis synergistic therapy antioxidant

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Preparation and properties of high-energy-density aluminum/boroncontaining gelled fuels

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Chinese Journal of Chemical Engineering 2024年第1期65卷 230-242页

作者： yi Chen Kang Xue yang Liu Lun Pan Xiangwen Zhang Ji-Jun Zou Key Laboratory for Green Chemical Technology of the Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Collaborative Innovative Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China Zhejiang Institute of Tianjin University Ningbo 315201China

Energetic nanofluid fuel has caught the attention of the field of aerospace liquid propellant for its high energy density(HED), but it suffers from the inevitable solid-liquid phase separation problem. To resolve this problem, herein we synthesized the high-Al-/B-containing(up to 30%(mass)) HED gelled fuels, with low-molecular-mass organic gellant Z, which show high net heat of combustion(NHOC), density, storage stability, and thixotropic properties. The characterizations indicate that the application of energetic particles to the gelled fuels obviously destroys their fibrous network structures but can provide the new particle-gellant gelation microstructures, resulting in the comparable stability between 1.0%(mass) Z/JP-10 + 30%(mass) Al or B and pure JP-10 gelled fuel. Moreover, the gelled fuels with high-content Al or B exhibit high shear-thinning property, recovery capability, and mechanical strength, which are favorable for their storage and utilization. Importantly, the prepared 1.0%(mass) Z/JP-10 + 30%(mass) B(or 1.0%(mass) Z/JP-10 + 30%(mass) Al) shows the density and NHOC 1.27 times(1.30) and 1.43 times(1.21)higher than pure JP-10, respectively. This work provides a facile and valid approach to the manufacturing of HED gelled fuels with high content of energetic particles for gel propellants.

关键词： Gelled fuels Energetic aluminum/boron Low-molecular-mass organic gellant Fuel property

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Inhibiting shuttle effect of lithium polysulfides by double metal selenides for high-performance lithium-sulfur batteries

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Rare Metals 2024年第6期43卷 2546-2559页

作者： Lei Li Xue-Jing yang yi-yang Li Bo Jin Hui Liu Meng-yang Cui Dong-Bo Guan Xing-You Lang Qing Jiang Key Laboratory of Automobile Materials Ministry of Educationand College of Materials Science and EngineeringJilin UniversityChangchun 130022China

Lithium-sulfur batteries(LSBs)have attracted the attention of more and more researchers due to the advantages of high energy density,environmental friendliness,and low production ***,the low electronic conductivity of active material and shuttling effect of lithium polysulfides(LiPSs)limit the commercial development of *** solve these problems,we design a core-shell composite with nitrogen-doped carbon(NC)and two types of selenides(FeSe_(2)-NC@ZnSe-NC).The FeSe_(2)-NC@ZnSe-NC has a strong adsorption capacity,and can effectively adsorb *** the same time,it also effectively alleviates the shuttling effect of LiPSs,and improves the utilization of the active substance during the charge/discharge reaction *** mechanism involved in FeSe_(2)-NC@ZnSe-NC is demonstrated by both experiments and density-functional theory(DFT)*** electrochemical test results indicate that LSB with S/FeSe_(2)-NC@ZnSe-NC delivers an initial discharge capacity of 1260 mAh·g^(-1)at *** after 500 cycles at 1C,the capacity decay rate per cycle is 0.031%,and the capacity retention rate is 85%.The FeSe_(2)-NC@ZnSe-NC core-shell structure verifies a rational strategy to construct an electrode material for high-performance LSBs.

关键词： Lithium-sulfur batteries Shuttling effect Metal selenide Nitrogen-doped carbon Lithium polysulfides

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Mice with type I interferon signaling deficiency are prone to epilepsy upon HSV-1 infection

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Virologica Sinica 2024年第2期39卷 251-263页

作者： Wei yang Chong-yang Tang Dong-ying Fan yi-Song Wang Pei-Gang Wang Jing An Guo-Ming Luan Beijing Key Laboratory of Epilepsy Sanbo Brain HospitalCapital Medical UniversityBeijing100093China Beijing Institute for Brain Disorders Capital Medical UniversityBeijing100093China Department of Neurosurgery Epilepsy CenterSanbo Brain HospitalCapital Medical UniversityBeijing100093China Department of Microbiology School of Basic Medical SciencesCapital Medical UniversityBeijing100069China Chinese Institute for Brain Research Beijing102206China

Viral encephalitis continues to be a significant public health *** our previous study,we discovered a lower expression of antiviral factors,such as IFN-β,STING and IFI16,in the brain tissues of patients with Rasmussen's encephalitis(RE),a rare chronic neurological disorder often occurred in children,characterized by unihemispheric brain ***,a higher cumulative viral score of human herpes viruses(HHVs)was also found to have a significant positive correlation with the unihemispheric atrophy in *** I IFNs(IFN-I)signaling is essential for innate anti-infection response by binding to IFN-α/βreceptor(IFNAR).In this study,we infected WT mice and IFNAR-deficient A6 mice with herpes simplex virus 1(HSV-1)via periocular injection to investigate the relationship between IFN-I signaling and HHVs-induced brain *** all mice exhibited typical viral encephalitis lesions in their brains,HSV-induced epilepsy was only observed in A6 *** gene expression matrix,functional enrichment analysis and protein-protein interaction network revealed four gene models that were positively related with HSV-induced ***,ten key genes with the highest scores were *** together,these findings indicate that intact IFN-I signaling can effectively limit HHVs induced neural symptoms and brain lesions,thereby confirming the positive correlation between IFN-I signaling repression and brain atrophy in RE and other HHVs encephalitis.

关键词： IFN-I signaling Human herpes viruses(HHVs) Rasmussen's encephalitis(RE)

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Resection of polyps involving the appendiceal orifice by combined endo-laparoscopic surgery: Two case reports

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1948-1952页

作者： Yue-yi Zhang Jun-yang Lu Qiang Wang Ai-Ming yang Department of Gastroenterology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of General Surgery State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

BACKGROUND The management of polyps involving the appendiceal orifice(AO)presents notable *** resection is frequently hindered by operational complexities,a heightened risk of incomplete removal,and an elevated risk of procedural complications,including ***,surgical resection may entail unnecessary excision of intestinal segments,leading to potential *** SUMMARY Here,we reported two patients who presented with polyps deeply situated within the AO,with indistinct boundaries making it challenging to ensure completeness using traditional endoscopic *** overcome these challenges,we em-ployed combined endo-laparoscopic surgery(CELS),achieving curative resection without postoperative *** The application of CELS in managing polyps involving the AO is emerging as a safe and effective treatment modality.

关键词： Polyps Laterally spreading tumor Appendiceal orifice Endoscopic resection Combined endo-laparoscopic surgery Case report

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General radical difluoromethylation using difluoroacetic anhydride via photoredox catalysis

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Science China Chemistry 2024年第8期67卷 2637-2646页

作者： Meng He Yankai yang Heng Zhang Zhipeng Guan Zhi-Bing Dong Hong yi Aiwen Lei School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan 430205China College of Chemistry and Molecular Sciences and Institute for Advanced Studies(IAS) Wuhan UniversityWuhan 430072China

CF_(2)H-containing molecules play pivotal roles in diverse fields from medicinal chemistry to materials science. However, the application of existing CF_(2)H reagents as a source of CF_(2)H radical is limited by their reactivity and preparation. Herein, we develop a simple and general visible-light-catalyzed radical difluoromethylation reaction of alkenes, dienes, and heteroaromatics using commercially available, easy-to-handle, and low-cost difluoroacetic anhydride as the CF_(2)H reagent. This scalable protocol enables the convenient synthesis of a range of CF_(2)H-containing compounds under mild conditions, exhibiting a broad substrate scope and functional group tolerance. Potential applications are further demonstrated by gram-scale synthesis, sunlight experiments, derivatization experiments as well as the synthesis of bioactive molecules.

关键词： radical difluoromethylation alkenes/dienes/heteroaromatics difluoroacetic anhydride photoredox

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Exploring hidden-charm and hidden-strange hexaquark states from lattice QCD

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 30-37页

作者： Hang Liu Jinchen He Liuming Liu Peng Sun Wei Wang yi-Bo yang Qi-An Zhang INPAC Key Laboratory for Particle Astrophysics and Cosmology(MOE)Shanghai Key Laboratory for Particle Physics and CosmologySchool of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Maryland Center for Fundamental Physics Department of PhysicsUniversity of MarylandCollege ParkMaryland 20742USA Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Department of Physics and Institute of Theoretical Physics Nanjing Normal UniversityNanjing 210023China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China International Centre for Theoretical Physics Asia-Pacific Beijing 100049/Hangzhou 310024China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Physics Beihang UniversityBeijing 102206China

Based on five different ensembles of newly generated(2+1)-flavor configurations with pion mass of approximately mπ■(140-310)MeV,we present a lattice analysis of hidden-charm and hidden-strange hexaquarks with the quark content■.The correlation matrices of two types of operators with JPC=0++,0-+,1++and 1--are simulated to extract the masses of the hexaquark candidates,which are subsequently extrapolated to the physical pion mass and continuum *** results indicate that ground state masses are below the■threshold and provide a characteristic signal for the experimental discovery of hexaquark candidates,which may enrich the versatile structure of multiquarks;moreover,it is an indispensable step to decipher the nonperturbative nature of the fundamental interactions of quarks and gluons.

关键词： quantum chromodynamics lattice QCD multiquark states

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