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Efficacy and safety of anti-vascular endothelial growth factor agents on corneal neovascularization: A meta-analysis

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World Journal of Clinical Cases 2023年第30期11卷 7337-7349页

作者： shih-Chung Lai El-Wui Loh Du-I Chiou chien-Tai Hong Department of Ophthalmology Shuang Ho HospitalNew Taipei City 23561TaiwanChina Center for Evidence-Based Health Care Department of Medical ResearchTaipei Medical University Shuang Ho HospitalNew Taipei City 23561TaiwanChina Cochrane Taiwan Taipei Medical UniversityTaipei 110TaiwanChina Graduate Institute of Clinical Medicine College of MedicineTaipei Medical UniversityTaipei 110TaiwanChina Department of Medical Imaging Taipei Medical University Shuang Ho HospitalNew Taipei City 23561TaiwanChina Department of Neurology Taipei Medical University-Shuang Ho HospitalNew Taipei 23561TaiwanChina

BACKGROUND Corneal neovascularization(CoNV)is the second major cause of *** endothelial growth factor(VEGF)inhibitors,e.g.,bevacizumab,have been used to prevent *** We conducted an updated systematic review and meta-analysis of clinical trials to examine the efficacy and safety of anti-VEGF in *** A literature search was conducted using three electronic *** difference(MD),standard mean difference(SMD),and relative risk(RR)are used to estimate the effect *** Nine randomized controlled and three non-randomized trials were *** pooled results demonstrated a significant reduction of CoNV area/Length(SMD=-1.17,95%CI:-1.58 to-0.75),best corrected visual acuity(MD=-0.54,95%CI:-0.91 to-0.17),and graft rejection(RR=0.44,95%CI:0.24 to 0.8)and failure(RR=0.39,95%CI:0.19 to 0.78)rates in the anti-VEGF group than the placebo group.A non-significant reduction of the epithelial defect was also observed in the bevacizumab group compared with the placebo(RR=0.56,95%CI:0.30 to 1.06).Compared with a placebo,the unsynthesizable trials also support that bevacizumab improves visual acuity,CoNV,graft rejection,and failure *** reporting other comparisons revealed the superiority of combined remedy with bevacizumab compared to other treatments in reducing *** Anti-VEGF agents,mainly bevacizumab,are an effective and safe treatment for CoNV of all causes and prevent corneal graft rejection and failure in corneal transplantation.

关键词： Efficacy Safety Anti-vascular endothelial growth factor agents Corneal neovascularization Bevacizumab

Clinical correlation of gallstone disease in a Chinese population in Taiwan:Experience at Cheng Hsin General Hospital

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World Journal of Gastroenterology 2006年第8期12卷 1281-1286页

作者： Chi-Ming Liu Tao-Hsin Tung Pesus Chou Victor Tze-Kai Chen Chung-Te Hsu Wu-Shyong chien Yeu-Tyng Lin Hsu-feng Lu Hui-Chuan shih Jorn-Hon Liu Community Medicine Research Center & Institute of Public Health National Yang-Ming University Cheng Hsin General Hospital Taipei Taiwan China Community Medicine Research Center & Institute of Public Health National Yang-Ming University Taipei TaiwanChina Cardinal Tien Hospital College of Medicine Fu-Jen Catholic University National Defence Medicine Center Taipei Taiwan China Department of Nursing Kaohsiung Military General Hospital Kaohsiung Taiwan China Faculty of Medicine School of Medicine National Yang-Ming University Cheng Hsin General Hospital TaipeiTaiwan China

AIM： TO explore the prevalence of gallstone disease （GSD） in Taiwan and condition-associated factors related to it. METHODS： We studied a total of 2386 healthy adults （1235 males and 1151 females） voluntarily admitted to Cheng Hsin General Hospital for a paid physical check-up between January 2002 and December 2002. Blood samples and ultrasound sonography results were collected. RESULTS： The overall prevalence of GSD among this study-population was 5.3%, including 1.7% （n=40） having a single stone, 2.3% （n = 55） having multiple stones, and 1.3% （n = 31） having cholecystectomy. The prevalence revealed a statistically significant increase with increasing age （P〈 0.0001）. Females exhibited a greater prevalence of multiple stones than did males （3.0% vs 1.7%, P= 0.04）. Using multiple logistic regression analysis, the following appeared to be significantly related to the prevalence of GSD： older age （40-49 years vs 〈40 years, OR= 1.63 [95% CI： 0.76-3.48], 50-59 years vs 〈40 years, OR=4.93 [95% CI： 2.43-9.99], 60-69 years vs 〈40 years, OR = 6.82 [95% CI： 3.19-14.60], ≥70 years vs 〈40 years, OR= 10.65 [95% CI： 4.78-23.73]）, higher BMI （≥27 kg/m^2 vs 〈24 kg/m^2, adjusted OR= 1.74 [95% CI： 1.04-2.88]）, and higher FPG （≥ 126 mg/dL vs 〈110 mg/dL, OR= 1.71, 95% CI： 1.01-2.96）. CONCLUSION： Older age （≥50 years）, obesity （BMI ≥ 27 kg/m^2）, and type 2 diabetes （FPG ≥126 mg/dL） are associated with the prevalence of GSD.

关键词： Cross-sectional study Gallstone disease Prevalence Risk factors

The study of using infrared thermal image to assist surgery of coronary artery bypass

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红外与毫米波学报 2018年第1期37卷 1-7页

作者： CHANG Chia-Jui TSAI chien-Sung TANG Shiang-feng YANG Chi-shih LIN Wen-Jen LIU Chiang-Lung CHEN Tzu-Chiang Defense Science Chung Cheng Institute of Technology National Defense University National Defense Medical Center Department of Surgery Materials & Electro-Optics Research Division National Chung Shun Institute of Technology Lee-Ming Institute of Technology Department of Mechanical Engineering

Digital infrared thermography is suitable for monitoring the planar two-dimensional temperature distribution of curved surfaces of objects by sensing their infrared radiation. Cardiac infrared thermography also has a thermal coronary angiography alias. This study proposes a digital image processing methodology for locating blood clot blockage. This methodology contains four consequent processes. The two-dimensional gray scale infrared thermograph pixels are first binarized and classified as background or coronary arteries using multi-thresh adaptive *** coronary artery contours are extracted from segmented raw pixels using continuous pepper-like pixel removal,erosion,subtraction,recursive neighborhood visiting,contour point-list construction and short edge *** the third process one coronary artery branch is selected by physicians for calculating the longest curved central axis using morphological thinning and neighborhood analysis. In the last process the nearest left and right distances from each pixel along the directional central axis to its corresponding boundary contour are added as the coronary artery variable diameter at the current pixel's position. A variable diameter versus straighten length diagram along this axial curved path is plotted to provide useful physiological information to the physician. An obstruction rate equation is then defined to calculate the possible vascular blockage positions with the local minimal rates. Finally,preoperative cases are tested to prove the predictive positions are correct in comparison to individual patient myocardial perfusion imaging.

关键词：红外技术毫米波光源仪器

Prevent bile duct injury by indocyanine green guide fluorescent imaging during laparoscopic cholecystectomy in liver transplantation recipient

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Hepatobiliary Surgery and Nutrition 2020年第6期9卷 817-819页

作者： Chee-chien Yong shih-Min Yin Yi-Ping Sng Chao-Long Chen Liver Transplantation Center and Department of Surgery Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung

Cholecystolithiasis with acute cholecystitis is a rare,late biliary complication occurring in liver transplantation(LT)recipients who received the liver graft with preserved donor’s *** laparoscopic cholecystectomy(LC)is not contraindicated after upper abdominal surgery,misunderstanding of the biliary anatomy due to inflammatory phenomena or severe adhesion might increase the risk of bile duct injury(BDI)(1).

关键词： injury anatomy bile

Evaluation of the Potential Inhibitory Activity of A Combination of ***,*** and *** on Helicobacter Pylori：A Randomized Double-Blind Placebo-Controlled Clinical Trial

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Chinese Journal of Integrative Medicine 2017年第3期23卷 176-182页

作者： chien-Ying Lee Hung-Che shih Min-chien Yu Ming-Yung Lee Ya-Lan Chang Ya-Yun Lai Yi-Ching Lee Yu-Hsiang Kuan Chun-Che Lin Institute of Medicine Chung Shan Medical UniversityTaichungTaiwan 40201China Department of Pharmacy Chung Shan Medical University HospitalTaichungTaiwan 40201China Department of Medicine Chung Shan Medical UniversityTaichungTaiwanChina Department of Integrated Chinese and Western Medicine Chung Shan Medical University HospitalTaichungTaiwan 40201China Department of Statistics and Informatics Science Providence UniversityChina 43301 Department of Applied Cosmetology National Tainan Junior College of NursingTaiwan 700 China Division of Hepatogastroent erology Department of Internal MedicineChung Shan Medical University HospitalTaichungTaiwan 40201China

Objective： To investigate whether three strains of probiotics, L. acidophilus, L. rhamnosus, and L. sporogenes, had significant inhibitive effects on Helicobacter pylori（H. pylori）. Methods： This is a 4-week, randomly assigned, parallel-group, doubled-blind, and placebo-controlled study. Fifty patients with a positive H. pylori infection urea breath test（△UBT） result 〉 10% and without ulcer symptoms were randomized into a treatment group and a placebo group by a computer generated allocation sheet with 1：1. These subjects took one capsule of probiotics or placebo twice daily. The primary measurement was the change in △UBT values. Results： The △UBT values during the 4-week treatment period and the 2-week follow-up period were not significantly different between the treatment group and the placebo group, indicating that the inhibitive effects on H. pylori were comparable between both groups. The monocyte count（%） was 5.77±1.11 in the treatment group versus 5.09±1.12 in the placebo group（P=0.044）, and the basophile count was 0.55±0.32 in the treatment group versus 0.36±0.23 in the placebo group（P=0.024） at week 2 of the treatment period, both of which reached statistical significance. The monocyte count was 5.75±1.26 in the treatment group and 4.72±0.99 in the placebo group at the end of the follow-up period（P=0.003）. Conclusions： There was no significant inhibitive effects of the three probiotic strains（L. acidophilus, L. rhamnosus, and L. sporogenes） on H. pylori. Probiotics can not play the same role as antibiotics in the eradication of H. pylori, the role of probiotics is likely to be important as adjuvant to the triple or quadruple therapy for H. pylori, especially in resistance cases.

关键词： probiotics Helicobacter pylori urea breath test randomized double-blind placebo-controlled trial

First report of furuncular myiasis caused by the larva of botfly,Dermatobia hominis,in a Taiwan Residents traveler

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Asian Pacific Journal of Tropical Biomedicine 2013年第3期3卷 229-231页

作者： Je-Ming Hu Chih-chien Wang Li-Lian Chao Chung-Shinn Lee chien-Ming shih Department of Surgery and Orthopaedics Tri-Service General Hospital Department of Parasitology and Tropical Medicine National Defense Medical Center Research Center for Biotechnology and Medicine Policy

A case of furuncular myiasis was reported for the first time in a 29-year-old young Taiwan Residents traveler returning from an ecotourism in ***-like lesions were observed on the top of his head and he complained of crawling sensations within his *** invasive larva of botfly,Dermatobia hominis,was extruded from the furuncular lesion of the *** of cutaneous myiasis for clinicians should be considered for a patient who has a furuncular lesion and has recently returned from a botfly-endemic area.

关键词： Furuncular myiasis Botfly Traveler Taiwan

Management of patients with stercoral perforation of the sigmoid colon:Report of five cases

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World Journal of Gastroenterology 2006年第3期12卷 500-503页

作者： Wen-shih Huang Chia-Siu Wang Ching-Chuan Hsieh Paul Y Lin Chih-chien Chin Jeng-Yi Wang Divisionof Colon and Rectal Surgery Chang Gung Memorial Hospital Putzu 613 Taiwan China Division of GeneralSurgery Chang Gung Memorial Hospital Pu-tzu 613 TaiwanChina Division of Anatomical Pathology Chang GungMemorial Hospital Pu-tzu 613 Taiwan China Graduate Institute of Clinical Medicine Chang Gung University Kwei-Shan Taiwan China

To our knowledge, stercoral perforation of the colon is rarely seen with fewer than 90 cases reported in the literature till date. We explored the principles of management to prevent impending mortality in five patients with this condition. Five patients, two males and three females, whose median age was 64 years, had sustained stercoral perforation of the sigmoid colon. Chronic constipation was the common symptom among these patients. Three patients underwent a Hartmann＇s procedure and another two were treated with segmental colectomy with anastomosis and diverting colostomy. There was one surgical mortality and the other patients had an uneventful hospital stay. Timely intervention to prevent and/or treat any associated sepsis along with extensive peritoneal lavage and surgical intervention to remove diseased colonic tissue at the primary stercoral ulceration site coupled with aggressive therapy for peritonitis are key treatment modalities in salvaging patients presenting with stercoral perforation of the colon.

关键词： Stercoral perforation Colon Management

The role of technological innovation,carbon finance,green energy,environmental awareness and urbanization towards carbon neutrality:Evidence from novel CUP-FM CUP-BC estimations

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Geoscience Frontiers 2024年第4期15卷 347-358页

作者： fengSheng chien School of Finance Fuzhou University of International Studies and TradeFuzhouChina Faculty of Business City University of MacaoMacaoChina Carbon Economy Research Center Fuzhou University of International Studies and TradeFuzhouChina

After COP21,various economies start putting efforts to fulfill the pledge and achieve carbon *** doing so,scholars highlight several essential factors that can curb carbon *** this lieu,the current study analyzes the role of technological innovation,carbon finance,environmental awareness,urbanization,and green energy like renewable energy consumption(REC)and renewable energy output(REO)on carbon neutrality in E7 countries covering the time span of *** employing CUP-FM and CUP-BC,it is revealed that technological innovation,carbon finance,environmental awareness,urbanization,REC,and REO have a positive connection with carbon neutrality in E7 *** study provides guidelines to the policymakers in developing policies regarding to obtain carbon neutrality using technological innovation,carbon finance,environmental awareness,and green energy.

关键词： Technological innovation Carbon finance Environmental awareness Urbanization Green energy Carbon neutrality

Machine learning-based comparison of factors influencing estimated glomerular filtration rate in Chinese women with or without nonalcoholic fatty liver

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World Journal of Clinical Cases 2024年第15期12卷 2506-2521页

作者： I-chien Chen Lin-Ju Chou shih-Chen Huang Ta-Wei Chu Shang-Sen Lee Department of Nursing Kaohsiung Armed Forces General HospitalKaohsiung 802Taiwan Department of Obstetrics and Gynecology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Chief Executive Officer's Office MJ Health Research FoundationTaipei 114Taiwan Department of Urology Taichung Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationTaichung 427Taiwan School of Medicine Tzu Chi UniversityHualian 970Taiwan Department of Urology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND The prevalence of non-alcoholic fatty liver(NAFLD)has increased *** with NAFLD are known to have higher chance for renal function *** past studies used traditional multiple linear regression(MLR)to identify risk factors for decreased estimated glomerular filtration rate(eGFR).However,medical research is increasingly relying on emerging machine learning(Mach-L)*** present study enrolled healthy women to identify factors affecting eGFR in subjects with and without NAFLD(NAFLD+,NAFLD-)and to rank their *** To uses three different Mach-L methods to identify key impact factors for eGFR in healthy women with and without *** A total of 65535 healthy female study participants were enrolled from the Taiwan MJ cohort,accounting for 32 independent variables including demographic,biochemistry and lifestyle parameters(independent variables),while eGFR was used as the dependent *** from MLR,three Mach-L methods were applied,including stochastic gradient boosting,eXtreme gradient boosting and elastic *** of estimation were used to define method accuracy,where smaller degree of error indicated better model *** Income,albumin,eGFR,High density lipoprotein-Cholesterol,phosphorus,forced expiratory volume in one second(FEV1),and sleep time were all lower in the NAFLD+group,while other factors were all significantly higher except for smoking ***-L had lower estimation errors,thus outperforming *** Model 1,age,uric acid(UA),FEV1,plasma calcium level(Ca),plasma albumin level(Alb)and T-bilirubin were the most important factors in the NAFLD+group,as opposed to age,UA,FEV1,Alb,lactic dehydrogenase(LDH)and Ca for the *** the importance percentage was much higher than the 2nd important factor,we built Model 2 by removing *** The eGFR were lower in the NAFLD+group compared to the NAFLD-group,with age being was the most important impact factor in both groups of he

关键词： Non-alcoholic fatty liver Estimated glomerular filtration rate Machine learning Chinese women