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Noninferiority clinical trial comparing the bowel cleansing efficacy of sodium phosphate tablets(Quiklean®)with a polyethylene glycol/bisacodyl kit

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World Journal of Gastroenterology 2021年第5期27卷 428-441页

作者： shih-Ya Hung Hung-chang Chen Tao-Wei Ke Jiann-Hwa Chen Koung-Hung Hsiao Hwei-Ming Wang Hua-Che Chiang Sheng-Chi chang Yi-chang Chen Ming-Hao Hsieh Yuan-Yao Tsai Yo-Wen Hsieh William Tzu-Liang Chen Graduate Institute of Acupuncture Science China Medical UniversityTaichung 40402Taiwan Department of Medical Research China Medical University HospitalTaichung 40447Taiwan Division of Colorectal Surgery Department of SurgeryChina Medical University HospitalTaichung 40447Taiwan Division of Gastroenterology Taipei Tzu Chi HospitalTaipei 23142Taiwan Division of Colorectal Surgery Taipei Tzu Chi HospitalTaipei 23142Taiwan Department of Pharmacy China Medical University HospitalTaichung 40447Taiwan Department of Colorectal Surgery China Medical University Hsinchu HospitalZhubei 30272Taiwan School of Medicine China Medical UniversityTaichung 40402Taiwan

BACKGROUND Efficient bowel cleansing is essential for a successful colonoscopy,but the ideal cleansing agent,volume,and pharmaceutical dosage form have yet to be ***-volume cleansers enhance patient *** To compare the bowel cleansing efficacy of 32-tablet sodium phosphate(Quiklean®)with 2-L polyethylene glycol(PEG)/bisacodyl(Klean-Prep/Dulcolax®)under identical dietary *** This multicenter,randomized,parallel-group,noninferiority clinical trial enrolled 472 outpatients,randomized 456 subjects,and scheduled 442 subjects to undergo colonoscopy(Quiklean®=222 and Klean-Prep/Dulcolax®=220).After bowel preparation,a colonoscopist performed the colonoscopy with video recorded for *** primary efficacy endpoint was the bowel cleansing quality using the Aronchick *** secondary endpoints were the bowel cleansing efficacy of three colon segments,tolerability and acceptability,safety using the Ottawa bowel preparation scale,questionnaires by subjects,and monitoring of adverse *** Success rates(Excellent+Good)of the bowel cleansing quality by Aronchick Scale were 98.6%(n=205)and 97.6%(n=204)in the Quiklean®and Klean-Prep/Dulcolax®groups,***®demonstrated noninferiority over Klean-Prep/Dulcolax®in colon cleansing *** showed better tolerability and acceptability in the overall experience(was rated as excellent;24.0%vs 17.2%;P=0.0016)and the taste of the study preparation(was rated as excellent,23.1%vs 13.4%;P<0.0001)than Klean-Prep/Dulcolax®.Safety profiles did not differ between the two *** data indicate that Quiklean®is an adequate,well-tolerated bowel cleansing preparation compared with the standard comparator Klean-Prep/Dulcolax®.CONCLUSION Quiklean®is sodium phosphate tablets available on Taiwan’s market for bowel preparation;it potentially offers patients an alternative to standard large-volume bowel preparation regimens and may,therefore,increase positive attitudes toward

关键词： Bowel preparation Clinical trial Colonoscopy Polyethylene glycol Sodium phosphate

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Stability of a Composite Wave of Two Separate Strong Viscous Shock Waves for 1-D Isentropic Navier-Stokes System

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Acta Mathematicae Applicatae Sinica 2023年第1期39卷 49-64页

作者： Lin chang School of Mathematics and Physics Handan UniversityHandan 056006China

In this paper, the large time behavior of solutions of 1-D isentropic Navier-Stokes system is investigated. It is shown that a composite wave consisting of two viscous shock waves is stable for the Cauchy problem provided that the two waves are initially far away from each other. Moreover the strengths of two waves could be arbitrarily large.

关键词： combination of two shock waves energy estimate asymptotic stability

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52 m/9 Gb/s PAM4 plastic optical fiber-underwater wireless laser transmission convergence with a laser beam reducer

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Chinese Optics Letters 2018年第5期16卷 42-46页

作者： Chung-Yi Li Hai-Han Lu Xu-Hong Huang Yun-chieh Wang Jen-chieh chang Pei-Hsien Chew Institute of Electro-Optical Engineering Taipei University of Technology Taipei 10608 China School of Information Science and Engineering Fujian University of Technology Fuzhou 350118 China

A 52 m/9 Gb/s four-level pulse amplitude modulation（PAM4） plastic optical fiber（POF）-underwater wireless laser transmission（UWLT） convergence with a laser beam reducer is proposed. A 52 m/9 Gb/s PAM4 POFUWLT convergence is practically demonstrated with the application of a laser beam reducer to reduce the collimated beam diameter. A 50 m graded-index（GI）-POF is employed as an underwater extender to efficiently enhance the coverage of UWLT. The performances of PAM4 POF-UWLT convergence in view of bit error rate（BER） and eye diagrams improve with the decrease of the collimated beam diameter because of the small amount of light absorbed by clear ocean water. Competent BER and eye diagrams（three independent eye diagrams） are achieved over a 50 m GI-POF transmission with a 2 m clear ocean water link.

关键词： POF GI PAM m/9 Gb/s PAM4 plastic optical fiber-underwater wireless laser transmission convergence with a laser beam reducer

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Effect of lactic acid bacteria isolated from fermented mustard on immunopotentiating activity

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Asian Pacific Journal of Tropical Biomedicine 2015年第4期5卷 281-286页

作者： Chen-Kai chang Shu-Chen Wang Chih-Kwang Chiu shih-Ying Chen Zong-Tsi Chen Pin-Der Duh Department of Food Science and Technology Chia Nan University of Pharmacy and Science Department of Health and Nutrition Chia Nan University of Pharmacy and Science Department of Medicinal Chemistry Chia Nan University of Pharmacy and Science

Objective: To investigate the effect of lactic acid bacteria isolated from fermented mustard on immunopotentiating activity Methods: One hundred and fifty nine strains of lactic acid bacteria isolated from traditional Taiwan fermented mustard were evaluated for their immunopotentiating activity on a murine macrophage cell line RAW ***: Of the strains, pronounced increases in the levels of nitric oxide(NO), tumor necrosis factor-α and interleukin-6 were observed in strains B0040, B0110 and B0145. Among them,strain B0145 had the highest NO and tumor necrosis factor-α generation in RAW 264.7 cells;strains B0040 and B0110 were also superior to that of Lactobacillus casei. These results demonstrated that NO and cytokines were effectively induced when the bacterial stimulants were treated with macrophages. In addition, strains B0040 and B0110 were identified as Lactobacillus plantarum, and B0145 as Weissella cibaria using 16 S rDNA ***: The results implicated selected strains may be regarded as a biological response modifier and had a broad application prospects in exploiting new functional food or as a feed additive.

关键词： Immunopotentiating activity Interleukin-6 Lactic acid bacteria Nitric oxide Tumor necrosis factor-α

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Explicit solution of the radial breathing mode frequency of single-wailed carbon nanotubes

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Acta Mechanica Sinica 2007年第2期23卷 159-162页

作者： Tienchong chang Shanghai Institute of Applied Mathematics anti Mecnamcs Shanghai University Shanghai 200072 China

On the basis of a molecular mechanics model, an analytical solution of the radial breathing mode （RBM） frequency of single-walled carbon nanotubes （SWCNTs） is obtained. The effects of tube chirality and tube diameter on the RBM frequency are investigated and good agreement between the present results and existing data is found. The present analytical formula indicates that the chirality and size dependent elastic properties are responsible for the effects of the chirality and small size on the RBM frequency of an SWCNT.

关键词： Carbon nanotubes.Radial breathing mode . Molecular mechanics

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机器学习在智能反射面辅助的通信系统中的应用综述

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北京工业大学学报 2025年第1期51卷 87-99页

作者：司鹏搏李双缘刘畅李萌北京工业大学信息学部北京100124 先进信息网络北京实验室北京100124

智能反射面(intelligent reflecting surfaces,IRS)可以通过大量低成本的无源反射元件巧妙地调整信号反射,从而动态改变无线信道,提高通信性能,目前已成为无线通信研究的焦点。然而,由于IRS的加入,整个通信系统变得更加复杂,系统的动态... 详细信息

智能反射面(intelligent reflecting surfaces,IRS)可以通过大量低成本的无源反射元件巧妙地调整信号反射,从而动态改变无线信道,提高通信性能,目前已成为无线通信研究的焦点。然而,由于IRS的加入,整个通信系统变得更加复杂,系统的动态性也更高,使通信系统面临着许多新的挑战。机器学习(machine learning,ML)具有很强的数据处理与自适应能力,能够不断适应变化的环境和需求,可以很好地应对通信系统中的许多挑战。因此,使用ML解决IRS辅助的通信系统中的问题,已经成为当前研究的重点。基于此,对ML在IRS系统中的应用进行了系统性的概述,从IRS辅助的通信系统中存在的问题入手,分别从反射因子的设计与优化、信道处理与建模、资源分配和管理、安全性增强4个方面对ML在IRS系统中的应用进行阐述和分析,并讨论了将ML应用在IRS系统中的优势及未来的发展趋势与挑战。

关键词：智能反射面(intelligent reflecting surfaces,IRS) 无线通信反射因子信道资源分配通信安全机器学习(machine learning,ML)

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The fabrication and application of Ni-DNA nanowire-based nanoelectronic devices

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Nano Research 2019年第6期12卷 1293-1300页

作者： Pang-Chia chang Chia-Yu chang Wen-Bin Jian Chiun-Jye Yuan Yu-chang Chen Chia-Ching chang Department of Electrophysics "National Chiao Tung University"Hsinchu 30010TaiwanChina Department of Biological Science and Technology "National Chiao Tung University"Hsinchu 30068TaiwanChina Center for Intelligent Drug Systems and Smart Bio-devices(IDS^2B) "National Chiao Tung University"Hsinchu 30068TaiwanChina Institute of Physics "Academia Sinica"Taipei 11529TaiwanChina

DNA is a self-assembled,double stranded natural molecule that can chelate and align nickel ions between its base *** fabrication of a DNA-guided nickel ion chain (Ni-DNA) device was successful,as indicated by the conducting currents exhibiting a Ni ion redox reaction-driven negative differential resistance effect,a property unique to mem-elements (1).The redox state of nickel ions in the Ni-DNA device is programmable by applying an external bias with different polarities and writing times (2).The multiple states of Ni-DNA-based memristive and memcapacitive systems were characterized (3).As such,the development of Ni-DNA nanowire device-based circuits in the near future is proposed.

关键词： DNA-guided nickel ion chain (Ni-DNA) negative differential resistance (NDR) memristive systemmem capacitive system nanowire

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Benign esophageal lesions: Endoscopic and pathologic features

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World Journal of Gastroenterology 2015年第4期21卷 1091-1098页

作者： Shu-Jung Tsai Ching-Chung Lin Chen-Wang chang Chien-Yuan Hung Tze-Yu Shieh Horng-Yuan Wang Shou-Chuan shih Ming-Jen Chen Division of Gastroenterology Department of Internal MedicineMackay Memorial Hospital Department of Nursing Nursing and Management Mackay Junior College of Medicine Mackay Medical College

Benign esophageal lesions have a wide spectrum of clinical and pathologic features. Understanding the endoscopic and pathologic features of esophageal lesions is essential for their detection, differential diagnosis, and management. The purpose of this review is to provide updated features that may help physicians to appropriately manage these esophageal lesions. The endoscopic features of 2997 patients are reviewed. In epithelial lesions, the frequency of occurrence was in the following order: glycogenic acanthosis, heterotopic gastric mucosa, squamous papilloma, hyperplastic polyp, ectopic sebaceous gland and xanthoma. In subepithelial lesions, the order was as follows: hemangioma, leiomyoma, dysphagia aortica and granular cell tumor. Most benign esophageal lesions can be diagnosed according to their endoscopic appearance and findings on routine biopsy, and submucosal lesions, by endoscopic resection. Management is generally based upon the confidence of diagnosis and whether the lesion causes symptoms. We suggest endoscopic resection of all granular cell tumors and squamous papillomas because, while rare, these lesions have malignant potential. Dysphagia aortica should be considered in the differential diagnosis of dysphagia in the elderly.

关键词： Benign tumor Esophagus Epithelial lesions Subepith

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Selection of time step for pseudodynamic testing

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Earthquake Engineering and Engineering Vibration 2011年第3期10卷 437-451页

作者： Shuenn-Yih chang Department of Civil Engineering Taipei University of Technology (NTUT)

Although the step degree of nonlinearity has been introduced to conduct basic analysis and error propagation analysis for the pseudodynamic testing of nonlinear systems, it cannot be reliably used to select an appropriate time step before performing a pseudodynamic test. Therefore, a novel parameter of instantaneous degree of nonlinearity is introduced to monitor the stiffness change at the end of a time step, and can thus be used to evaluate numerical and error propagation properties for nonlinear systems. Based on these properties, it is possible to select an appropriate time step to conduct a pseudodynamic test in advance. This possibility is very important in pseudodynamic testing, since the use of an arbitrary time step might lead to unreliable results or even destroy the test specimen. In this paper, guidelines are proposed for choosing an appropriate time step for accurate integration of nonlinear systems. These guidelines require estimation of the maximum instantaneous degree of nonlinearity and the solution of the initial natural frequency. The Newmark explicit method is chosen for this study. All the analytical results and the guidelines proposed are thoroughly confirmed with numerical examples.

关键词： pseudodynamic test nonlinear error propagation instantaneous degree of nonlinearity step degree of nonlinearity

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Nonlinear performance of classical damping

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Earthquake Engineering and Engineering Vibration 2013年第2期12卷 279-296页

作者： Shuenn-Yih chang Department of Civil Engineering Taipei University of Technology

The performance of a classical damping matrix, constructed either from the use of initial structural properties or current structural properties, in the step-by-step solution of a nonlinear multiple degree of freedom （MDOF） system is analytically evaluated. The analytical results are confirmed by numerical examples. Consequently, some conclusions are drawn from these analytical results that might be considered as rough guidelines for practical applications. It is found that a classical damping matrix constructed from initial structural properties is adequate for practical applications, since it has approximately the same damping effect as obtained by current structural properties and is more efficient in terms of computing.

关键词： classical damping nonlinear dynamic analysis integration method

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