检索结果-南通市图书馆

Journal of Integrative Plant Biology 2006年第4期48卷 390-399页

作者： Shi-Xin Zhu Hai-Ning Qin Chu shih Institute of Botany the Chinese Academy of Sciences Beijing 100093 China Bioengineering Department Zhengzhou University Zhengzhou 450001 China

The achene wail anatomy and surface sculpturing of 14 species representing Lactuca L. and related genera were Investigated to evaluate inter-and Intrageneric relationships. The achene wall anatomy of the studied species can be divided Into two types： winged and ribbed. The winged type is present in Lactuca L., Pterocypsela Shlh, Clcerblta Wallr., Chaetoserls Shlh and Stenoseris Shlh, and is characterized by protruding wings and costae in transverse section. Winged type achene mesocarps are composed of parenchymatous cells and fiber ceils, and the distinct fibrous strands are confined to the costae or wings of the achenes. The ribbed type is present in Notoseris shih and Paraprenanthes chang ex shih, and Is characterized by only having costae In transverse section. Fiber cells are continuous in the costae and intercostae, in surface sculpturing, the ornamentation and the shape of epidermal cells are different among these genera. The results Indicate that L. altalca and L. serrlola should be conspeclfic, and that L. dollchophylla is probably an Intermediate taxon between Lactuca and Chaetoserls. The results also support the separation of Pterocypseia, Paraprenanthes, Notoseris, Chaetoseris and Stenoserls from Lactuca and Clcerblta as independent entitles. Close affinities between Pterocypsela and Lactuca, Paraprenanthes and Notoserls, and Chaetoserls and Stenoserls are also proposed.

关键词： achene structure Compositae Lactuca Lactuceae surface sculpturing systematics.

Aryl hydrocarbon receptor signaling promotes ORMDL3- dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2019年第10期16卷 783-790页

作者： Hsueh-Chun Wang Tzu-Hsuan Wong Li-Ting Wang Hsiang-Han Su Hsiu-Yueh Yu Ai-Hsuan Wu Yu-Chun Lin Hua-Ling Chen Jau-Ling Suen shih-hsien Hsu Li-Chen Chen Yufeng Zhou Shau-Ku Huang Department of Medical Research China Medical University HospitalChina Medical University40402 TaichungTaiwanChina Graduate Institute of Medicine College of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Division of Allergy Asthma and RheumatologyDepartment of PediatricsChang Gung Memorial HospitalTaoyuanTaiwanChina National Institute of Environmental Health Sciences National Health Research InstitutesMiaoliTaiwanChina Research Center of Environmental Medicine Kaohsiung Medical UniversityKaohsiungTaiwanChina Center for Research Resources and Development Kaohsiung Medical UniversityKaohsiungTaiwanChina Community Medicine Research Center Chang Gung Memorial Hospital at KeelungKeelungTaiwanChina Department of Pediatrics Xiamen Chang Gung HospitalXiamenChina Johns Hopkins University School of Medicine BaltimoreMDUSA Key Laboratory of Neonatal Disease Children’s Hospital and Institute of Biomedical SciencesMinistry of HealthFudan University201102 ShanghaiChina Lou-Hu Hospital Shen-Zhen UniversityShen-ZhenChina

Aryl hydrocarbon receptor(AhR),a cellular chemical sensor,controls cellular homeostasis,and sphingosine-1-phosphate(S1P),a bioactive intermediate of sphingolipid metabolism,is believed to have a role in immunity and inflammation,but their potential crosstalk is currently *** aimed to determine whether there is a functional linkage between AhR signaling and sphingolipid *** showed that AhR ligands,including an environmental polycyclic aromatic hydrocarbon(PAH),induced S1P generation,and inhibited S1P lyase(S1PL)activity in resting cells,antigen/IgE-activated mast cells,and mouse lungs exposed to the AhR ligand alone or in combination with antigen *** reduction of S1PL activity was due to AhR-mediated oxidation of S1PL at residue 317,which was reversible by the addition of an antioxidant or in cells with knockdown of the ORMDL3 gene encoding an ER transmembrane protein,whereas C317A S1PL mutant-transfected cells were resistant to the AhR-mediated ***,analysis of AhR ligand-treated cells showed a time-dependent increase of the ORMDL3–S1PL complex,which was confirmed by FRET *** change increased the S1P levels,which in turn,induced mast cell degranulation via S1PR2 *** addition,elevated levels of plasma S1P were found in children with asthma compared to non-asthmatic *** results suggest a new regulatory pathway whereby the AhR–ligand axis induces ORMDL3-dependent S1P generation by inhibiting S1PL,which may contribute to the expression of allergic diseases.

关键词： Aryl hydrocarbon receptor ORMDL sphingolipid biosynthesis regulator 3 Sphingosine-1-phosphate Sphingosine-1-phosphate lyase

Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第8期6卷 2472-2483页

作者： Lin Gao Shanze Chen Malin Hong Wenbin Zhou Bilan Wang Junying Qiu Jinquan Xia Pan Zhao Li Fu Jigang Wang Yong Dai Ni Xie Qinhe Yang hsien-Da Huang Xiang Gao chang Zou Department of Clinical Medical Research Center The Second Clinical Medical CollegeJinan University(Shenzhen Peopled Hospital)The First Affiliated Hospital of Southern University of Science and TechnologyShenzhenGuangdongPR China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhouGuangdongPR China Department of Respiratory and Critical Care Medicine First Affiliated Hospital of Southern University of Science and TechnologyThe Second Clinical Medical CollegeJinan University(Shenzhen Peopled Hospital)Shenzhen Institute of Respiratory DiseasesShenzhenGuangdongPR China Shenzhen Public Service Platform on Tumor Precision Medicine and Molecular Diagnosis the Second Clinical Medical CollegeJinan University(Shenzhen People's Hospital)ShenzhenGuangdongPR China Department of Pharmacy West China Second University Hospital of Sichuan UniversityChengduPR China Guangdong Provincial Key Laboratory of Regional Immunity and Diseases Department of Pharmacology and International Cancer CenterShenzhen University Health Science CenterShenzhenGuangdongChina Department of Integrated Chinese and Western Medicine Jinan UniversityGuangzhouGuangdongPR China School of Life and Health Sciences The Chinese University of Kong HongShenzhenChina Warshel Institute for Computational Biology The Chinese University of HongKongShenzhenChina Department of Neurosurgery State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduPR China

Triple-negative breast cancer(TNBC)is the most challenging subtype of breast *** endeavor has been made to explore the molecular biology basis of ***,we reported a novel function of factor Kinectin 1(KTN1)as a carcinogenic promoter in ***1 expression in TNBC was increased compared with adjacent tissues or luminal or Her2 subtypes of breast cancer,and TNBC patients with high KTN1 expression have poor *** functional studies,knockdown of KTN1 inhibited the proliferation and invasiveness of TNBC both in vitro and in vivo,while overexpression of KTN1 promoted cancer cell proliferation and ***-seq analysis revealed that the interaction of cytokine-cytokine receptor,particularly CXCL8 gene,was upregulated by KTN1,which was supported by the further ***8 depletion inhibited the tumorigenesis and progression of ***,rescue experiments validated that KTN1-mediated cell growth acceleration in TNBC was dependent on CXCL8 both in vitro and in ***,it was found that KTN1 enhanced the phosphorylation of NF-κB/p65 protein at Ser536 site,and specifically bound to NF-κB/p65 protein in the nucleus and cytoplasm of ***,the transcription of CXCL8 gene was directly upregulated by the complex of KTN1 and NF-κB/p65 *** together,our results elucidated a novel mechanism of KTN1 gene in TNBC tumorigenesis and ***1 may be a potential molecular target for the development of TNBC treatment.

关键词： inhibited breast cancer

Carbon Dots as Artificial Peroxidases for Analytical Applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Analysis and Testing 2019年第3期3卷 191-205页

作者： shih-Chun Wei Yang-Wei Lin Huan-Tsung chang Department of Chemistry National Taiwan UniversityTaipei 10617Taiwan Department of Chemistry National Changhua University of EducationChanghua 50017Taiwan Department of Chemistry Chung Yuan Christian UniversityTaoyuan City 32023Taiwan

Nanozymes have become attractive in analytical and biomedical fields,mainly because of their low cost,long shelf life,and less environmental ***,nanozymes formed from nanomaterials having high surface area and rich active sites are interesting since their activities can be tuned through carefully controlling their size,morphology,and surface *** review article focuses on preparation of carbon dots(C dots)possessing peroxidase-like activity and their analytical *** highlight the important roles of the oxidation states and surface residues of C dots and their nanocomposites with metal,metal oxides,or metal sulfides playing on determining their specificity and sensitivity toward *** of C dot nanozymes(CDzymes)for developing sensitive and selective absorption,fluorescence,and elec-trochemical sensing systems in the presence of substrates are presented to show their potential in analytical *** example,CDzymes couple with glucose oxidase and cholesterol oxidase are specific and sensitive for quantitation of glucose and cholesterol,separately,when using 3,3′,5,5′-tetramethylbenzidine(TMB)as the signal *** review article concludes with possible strategies for enhancing and tuning the catalytic activity of CDzymes.

关键词： Nanozymes Peroxidase Carbon dots CDzymes Sensing

Increased extrinsic apoptotic pathway activity in patients with hepatocellular carcinoma following transarterial embolization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第42期17卷 4675-4681页

作者： shih-Ho Wang Li-Mien Chen Jane-Dar Lee Division of General Surgery Department of SurgeryKaohsiung Chang Gung Memorial Hospital and Chang Gung UniversityCollege of Medicine Division of Hematology/Oncology Department of MedicineTaichung Armed Forces General Hospital Central Taiwan University of Science and Technology Department of Surgery Taic-hung Armed Forces General Hospital

AIM:To determine the apoptosis pathway in residualviable hepatocellular carcinoma(HCC) tissues following transarterial embolization(TAE) .METHODS:Ten patients with HCC who received sur-gical resection after TAE were enrolled in the study group,and 24 patients with HCC who received surgical resection only served as the control group. In thestudy group,we measured the changes in tumor sizeand α fetoprotein(AFP) levels after TAE. All tissuesamples were taken from the residual tumors. The ex-pression of various apoptotic proteins was evaluatedvia immunoblotting procedures. The results were ana-lyzed using a Student's t ***:Tumor size and the AFP level decreased by46.2% and 55.3% after TAE,respectively. There wasno significant difference detected for the Bcl-2/Bax ratio or the cleaved caspase-9 expression levels in eithergroup. However,extrinsic apoptopic pathway-relate dexpression of Fas and cleaved caspase-8 expression were significantly higher in the study group than inthe control group(P < 0.05) . In addition,cleaved caspase-3 expression in the study group was higher(1.62-fold) than in control group(P < 0.05) .CONCLUSION:TAE is an effective palliative the rapy that decreases tumor size and AFP levels via an increase in extrinsic apoptosis path way in patients with unresectable HCC.

关键词：细胞凋亡栓塞通路动脉患者肝癌 Bcl-2/Bax 肿瘤组织

The Numerical Investigation of Blast Effect on the Wall with Porous Medium in Tunnel

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Numerical Investigation of Blast Effect on the Wall with...

Discrimination of Wild and Hatchery-Reared Black Porgy <i>Acanthopagrus schlegelii</i>Using Otolith Elements Analysis of Magnesium and Manganese

The 4th Across-strait Workshop on Shock Wave/Vortex Interaction

作者： Jik-chang Leong chang-hsien Tai Shi-wei Lo Department of Vehicle Engineering Pingtung University of Science and Technology

The physical phenomena associated with blast waves have been studied for more than a *** complex shock-shock and shock-vortex interaction phenomena which take place following the detonation of an explosive device include reflection,diffusion and consolidation *** prevent the bomb threat by terroristic organization,explosive accident in building or factory,many countries devote enormous expense and manpower to study method to prevent and decrease the destroy power during in an *** this study,the computational fluid dynamics (CFD) method is employed to simulate the interactions between shock waves and the wall with

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Open Journal of Marine Science 2019年第1期9卷 18-32页

作者： Weiche chang Chunhan shih Huangan Lin Chiahui Wang Pinghung chang Yingchou Lee Institute of Fisheries Science College of Life Science National Taiwan University Taiwan Institute of Oceanography Minjiang University Fuzhou China Department of Environmental Biology and Fisheries Science National Taiwan Ocean University Taiwan Hualien hsien Bureau of Agriculture Taiwan

Due to the decreasing resources of both inshore and offshore fisheries, many organizations have released fry to enhance their stock in recent years. The discrimination between wild and hatchery-reared individuals must be performed to assess the efficiency of the release. Fresh groundwater is generally used by hatchers in southwesternTaiwanto decrease salinity and to promote the growth of larvae prior to feeding;thus, the elemental composition of the otolith may be different in stocks, and this difference may be used for identification. This study used Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICPMS) to analyze the trace elements in the nuclei of otoliths from black porgy Acanthopagrus schlegelii, including six hatchery reared specimens from the Tainan County, three recaptured marked and ten captured unmarked specimens from the Miaoli County in Northwestern coast of Taiwan. Among the six hatchery and three recaptured marked specimens, which ranged from 4.9 to23.4 cmin body length, the nucleus zone (relative to within5 cmin size growth) of the otoliths showed higher magnesium concentrations than that observed on both edges. The distribution was similar to an inverse “V” shape. The otoliths also showed lower manganese concentrations near the nucleus and had higher values near the edges, resulting in a distribution similar to a “U” shape. According to the appeared shape of Mg2+/Ca2+ and Mn2+/Ca2+ ratio in the central area of the nucleus zone, this study determined six specimens which were from hatchery reared and three specimens were from wild among ten unmarked specimens captured from the Northwestern coast of Taiwan. Under the conditions used in this study, the absorption of calcium into the otolith was active and required energy in the seawater and freshwater, while the incorporation of magnesium and manganese was passive and was primarily affected by diffusion.

关键词： Black Porgy Hatchery-Reared Otolith Environmental Growth Marks Trace Element LA-ICPMS

Fast Forgery Detection with the Intrinsic Resampling Properties

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Information Security 2010年第1期1卷 11-22页

作者： Cheng-chang Lien Cheng-Lun shih Chih-Hsun Chou 不详

With the rapid progress of the image processing software, the image forgery can leave no visual clues on the tampered regions and make us unable to authenticate the image. In general, the image forgery technologies often utilizes the scaling, rotation or skewing operations to tamper some regions in the image, in which the resampling and interpolation processes are often demanded. By observing the detectable periodic distribution properties generated from the resampling and interpolation processes, we propose a novel method based on the intrinsic properties of resampling scheme to detect the tampered regions. The proposed method applies the pre-calculated resampling weighting table to detect the periodic properties of prediction error distribution. The experimental results show that the proposed method outperforms the conventional methods in terms of efficiency and accuracy.

关键词： Image Forgery Resampling Forgery Detection Intrinsic Properties of Resampling

Understanding the Lifestyle Correlates with Chronic Constipation and Self-Rated Health

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food and Nutrition Sciences 2015年第4期6卷 391-398页

作者： Li-Li chang Yu-Chen Lin Tsai chang Lo Ming-Chu Chen hsien-Wen Kuo Public Health Bureau of Miaoli County Government Miaoli Taiwan Institute of Environmental and Occupational Health Sciences National Yang-Ming University Taipei Taiwan School of Public Health National Defense Medical Center Taipei Taiwan

The objective of this study is to evaluate the healthy and unhealthy behaviors as risk factors for chronic constipation and self-rated health status. Eight hundred tenth students enrolled from a university in Miaoli city, Taiwan. Chronic constipation was assessed using Chinese questionnaire. Information of unhealthy and healthy lifestyles was interviewed by constructed questionnaire. Thirty-six percentage of university students were assessed as chronic constipation. Using multivariate logistic regression adjusted for age, sex, race and BMI, we found chronic constipation significantly correlated with frequency of consumption from snack, fast food, fried food, daily consumption of water, physical activity and junk food used as regular food. Moreover, these unhealthy behaviors significantly correlated with self-rated health status. Students with chronic constipation had poor self-rated health status. It is urgent to create healthy behaviors to reduce the risk for chronic constipation or upgrade self-rated health status in university students.

关键词： Unhealthy Lifestyles Chronic Constipation Self-Rated Health Status University Students

Artificial intelligence in gastrointestinal radiology: A review with special focus on recent development of magnetic resonance and computed tomography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Artificial Intelligence in Gastroenterology 2021年第2期2卷 27-41页

作者： Kai-Po chang shih-Huan Lin Yen-Wei Chu PhD Program in Medical Biotechnology National Chung Hsing UniversityTaichung 40227Taiwan Department of Pathology China Medical University HospitalTaichung 40447Taiwan Institute of Genomics and Bioinformatics National Chung Hsing UniversityTaichung 40227Taiwan Institute of Molecular Biology National Chung Hsing UniversityTaichung 40227Taiwan Agricultural Biotechnology Center National Chung Hsing UniversityTaichung 40227Taiwan Biotechnology Center National Chung Hsing UniversityTaichung 40227Taiwan PhD Program in Translational Medicine National Chung Hsing UniversityTaichung 40227Taiwan Rong Hsing Research Center for Translational Medicine Taichung 40227Taiwan

Artificial intelligence(AI),particularly the deep learning technology,have been proven influential to radiology in the recent *** ability in image classification,segmentation,detection and reconstruction tasks have substantially assisted diagnostic radiology,and has even been viewed as having the potential to perform better than radiologists in some *** radiology,an important subspecialty dealing with complex anatomy and various modalities including endoscopy,have especially attracted the attention of AI researchers and engineers ***,recently many tools have been developed for lesion detection and image construction in gastrointestinal radiology,particularly in the fields for which public databases are available,such as diagnostic abdominal magnetic resonance imaging(MRI)and computed tomography(CT).This review will provide a framework for understanding recent advancements of AI in gastrointestinal radiology,with a special focus on hepatic and pancreatobiliary diagnostic radiology with MRI and *** fields where AI is less developed,this review will also explain the difficulty in AI model training and possible strategies to overcome the technical *** authors’insights of possible future development will be addressed in the last section.

关键词： Artificial intelligence Deep learning Image diagnosis Radiology Magnetic resonance imaging Computed tomography