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<i>Wrinkled</i>1 (WRI1) Homologs, AP2-Type Transcription Factors Involving Master Regulation of Seed Storage Oil Synthesis in Castor Bean (<i>Ricinus communis</i>L.)

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American Journal of Plant Sciences 2013年第2期4卷 333-339页

作者： Daichi tajima Ayami Kaneko Masatsugu Sakamoto Yumena Ito Nong Thi Hue Masayuki Miyazaki Yushi Ishibashi Takashi Yuasa Mari Iwaya-Inoue Department of Bioresource Sciences Faculty of Agriculture Kyushu University Fu- kuoka Japan Department of Bioresource Sciences Faculty of Agriculture Kyushu University Fu- kuoka Ja-pan Fukuoka Agricultural Re- search Center Chikushino Japan Graduate School of Bioresource and Bioenvironmental Sciences Kyushu University Fukuoka Japan

Among APETALA2 (AP2)-type plant specific transcription factor family, WRINKLED1 (WRI1), has appeared to be a master gene transcriptionally regulating a set of carbon metabolism- and fatty acid synthesis (FAS)-related genes responsible for seed specific triacylglycerols (TAGs) storage in oil plants. B3 type transcription factors, such as ABI3 and FUS3, are known to be involved in seed development, such as seed storage protein synthesis and maturation. Based on the recent whole genome sequence data of castor bean (Ricinus communis L.), putative WRI1 homologs (RcWRI1, RcWRI2) specifically expressed in castor bean seed have been identified by comparing organ specific expression profiles among seed development-related transcription factors, seed storage specific genes (Ricin, RcOleosin) and a set of FAS genes including genes for sucrose synthase (RcSUS2), biotin carboxyl carrier protein (a subunit of acetyl-CoA carboxylase, RcBCCP2) and ketoacyl-acyl carrier protein synthase (RcKAS1). Immunoreactive signals with WRI1, FUS3 and ABI5-related polypeptides were also detected in seed specifically, consistent with the expression profiles of seed development-related genes. The WRI1 binding consensus sites, [CnTnG](n)(7)[CG], designated as the AW-box, were found at the promoter region of RcBCCP2 and RcKAS1. Thus, RcWRI1 possibly play a pivotal role in seed specific TAGs storage during seed development by directly activating FAS -related genes.

关键词： AP2 Castor Bean Fatty Acid Oil Seed Ricinus communis L. Transcription Factor WRI1

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肺癌危险因素──在日本大坂进行的追踪研究

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中华流行病学杂志 1997年第6期18卷 328-330页

作者：富永佑民 ToshiroTakezaki Kazuotajima 爱知县肿瘤研究所 DivisionofEpidemlology AichiCancerCenterResearchInstitute

在日本大坂进行了以人群为基础和环境因素与肺癌关系的追踪研究，研究对象为２４４８９名年龄在４０岁以上的居民。基本调查于１９８５年开始，以调查对象本人所填写的问卷为基础，在已进行的１０年追踪中，有１６１例为新发现的肺癌病... 详细信息

在日本大坂进行了以人群为基础和环境因素与肺癌关系的追踪研究，研究对象为２４４８９名年龄在４０岁以上的居民。基本调查于１９８５年开始，以调查对象本人所填写的问卷为基础，在已进行的１０年追踪中，有１６１例为新发现的肺癌病例。分析了各种环境因素与肺癌的关系，结果发现吸烟与肺癌有病因学联系。

关键词：吸烟危险因素肺肿瘤

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重庆地区人群半定量食物频数问卷的研制

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第三军医大学学报 2003年第19期25卷 1701-1705页

作者：周紫垣王文昌孙华明孙立平陈国华 Toshiro Takezaki Kazuo tajima 曹佳第三军医大学军事预防医学院卫生毒理学教研室重庆400038 第三军医大学军事预防医学院卫生统计学教研室重庆400038 Division of pidemiology and Prevention Aichi Cancer Center Research InstituteNagoyaJapan Division of Epidemiology and Prevention Aichi Cancer Center Research InstituteNagoyaJapan

目的　制订适用于对重庆城乡成年人群进行膳食营养概况分析的半定量食物频数问卷 (SQFFQ)。方法　采用 3日食物称量法对重庆城、乡成年人群进行膳食调查 ;采用累积百分贡献率 (CA)和多元回归 (MRA)两种方法分析 3 5种营养素与食物之间关... 详细信息

目的　制订适用于对重庆城乡成年人群进行膳食营养概况分析的半定量食物频数问卷 (SQFFQ)。方法　采用 3日食物称量法对重庆城、乡成年人群进行膳食调查 ;采用累积百分贡献率 (CA)和多元回归 (MRA)两种方法分析 3 5种营养素与食物之间关系 ,分别选出累积百分贡献率达 90 %以上或累积R2 达 0 .90以上的食物进入SQFFQ ;进一步合并城市和农村的SQFFQ ,制订最终能涵盖重庆城乡的SQFFQ。结果　重庆城市和农村地区人群能量、蛋白质、碳水化合物等主要营养素摄入的差异不显著 ,但农村人群脂肪摄入明显高于城市人群。在选入合并SQFFQ的 119种食物中 ,78种为城乡共有 ,2 2种为城市独有 ,6种为农村独有。最终制订的SQFFQ的营养素覆盖率有 3 3种在城、乡都达到了 90 %以上。结论　所制订的SQFFQ能较好地覆盖重庆地区人群的营养谱。

关键词：营养素摄入半定量食物频数问卷(SQFFQ)

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A case report of anaplastic carcinoma of the pancreas with remarkable intraductal tumor growth into the main pancreatic duct

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World Journal of Gastroenterology 2014年第3期20卷 852-856页

作者： Mitsuyoshi Okazaki Isamu Makino Hirohisa Kitagawa Shinichi Nakanuma Hironori Hayashi Hisatoshi Nakagawara Tomoharu Miyashita Hidehiro tajima Hiroyuki Takamura Tetsuo Ohta Department of Gastroenterologic Surgery Graduate School of Medical ScienceKanazawa University

We herein report a case of anaplastic carcinoma of the pancreas with remarkable intraductal tumor growth into the main pancreatic duct.A 76-year-old male was referred to our hospital for treatment of a pancreatic *** examinations revealed a poorly defined tumor in the main pancreatic duct in the body of the pancreas,accompanied with severe dilatation of the main pancreatic duct,which was diagnosed as an intraductal papillary-mucinous *** performed distal pancreatectomy and *** pathological examination revealed that the tumor consisted of a mixture of anaplastic carcinoma(giant cell type)and adenocarcinoma in the *** was a papillary projecting tumor composed of anaplastic carcinoma in the dilated main pancreatic *** patient is now receiving chemotherapy because liver metastasis was detected 12 mo after *** this case,we could observe a remarkable intraductal tumor growth into the main pancreatic *** also discuss the pathogenesis and characteristics of this rare tumor with specific tumor growth.

关键词： Anaplastic carcinoma Giant cell carcinoma Intraduc

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亚甲基四氢叶酸还原酶基因1298A→C多态与食管癌易感性关系的病例对照研究

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中华流行病学杂志 2004年第4期25卷 341-345页

作者：高长明 Takezaki Toshiro 吴建中曹海霞刘燕婷丁建华李苏平苏平胡旭开海涛 tajima Kazuo 江苏省肿瘤防治研究所流行病学研究室南京210009 日本爱知县がんセンター研究所疫学预防部淮安市楚州区卫生防疫站

目的研究亚甲基四氢叶酸还原酶(MTHFR)基因1298A→C多态及其和生活习惯相互作用与食管癌易感性的关系.方法在食管癌高发区的淮安市楚州区开展了一项病例对照研究(食管癌患者141例,人群对照228名), 调查研究对象的生活习惯,采用聚合酶链... 详细信息

目的研究亚甲基四氢叶酸还原酶(MTHFR)基因1298A→C多态及其和生活习惯相互作用与食管癌易感性的关系.方法在食管癌高发区的淮安市楚州区开展了一项病例对照研究(食管癌患者141例,人群对照228名), 调查研究对象的生活习惯,采用聚合酶链反应-限制性片段长度多态性技术检测研究对象的MTHFR 1298A→C基因型.结果①食管癌组中MTHFR 1298 AA、AC和CC基因型携带者的比例分别为 63.8%、 34.0%和 2.1%, 与对照组的 71.9%、 28.1%和 0.0%相比,差异有统计学意义( χ2MH= 6.69, P= 0.035).②在MTHFR 1298C等位基因携带者中,伴有吸烟习惯者发生食管癌的调整OR为 3.48(95%CI: 1.57～ 7.71),伴有经常饮酒的习惯者发生食管癌的调整OR为 2.91(95%CI: 1.20～ 7.08),无饮茶习惯者发生食管癌的调整OR为 3.52(95%CI: 1.64～ 7.54).MTHFR 1298AC和CC基因型与吸烟、饮酒和不饮茶在食管癌发生中的相互作用系数r分别为 3.05、 3.69和 6.30.结论 MTHFR 1298AC和CC基因型对吸烟、饮酒和不饮茶增加食管癌发生风险的作用有明显的放大效应.

关键词：亚甲基四氢叶酸还原酶基因 1298A→C多态食管癌易感性病例分析

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Metabolism for cyclosporin A during liver regeneration after partial hepatectomy in rats

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World Journal of Gastroenterology 2008年第41期14卷 6355-6359页

作者： Shigeki Nagayoshi Yujo Kawashita Susumu Eguchi Yukio Kamohara Mitsuhisa Takatsuki Shungo Miyamoto Satoshi Mochizuki Akihiko Soyama Hirotaka Tokai Masaaki Hidaka Yoshitsugu tajima Takashi Kanematsu Department of Transplantation and Digestive Surgery Graduate School of Biomedical Sciences Nagasaki University School of Medicine

AIM: To elucidate the metabolism and the effect of the cyclosporin A (CyA) as a representative immuno-suppressive drug used in transplantation in a partially hepatectomized rat model. METHODS: CyA was administered to rats that under- went a 70% hepatectomy. These rats were randomly assigned into three groups according to the dose of CyA administration as follows; (group 1) water, (group 2) 5 mg/kg CyA, (group 3) 10 mg/kg CyA. On post- operative days-1, 3, 7 and 14, the rats were killed to analyze the serum concentration of CyA, the liver re- generation ratio, biochemical or histological markers, and mRNA expression using reverse transcriptase-poly- merase chain reaction method to determine albumin and cytochrome p450 expression. RESULTS: The serum concentration of CyA in group 3 was significantly higher than group 2 during liver regeneration. CyA enhanced the liver regeneration in a dose dependent manner. The mRNA expression associ- ated with CyA metabolism was signifi cantly decreased on day 14, while preserving the albumin producing activity. CONCLUSION: These data indicate that the p-450 ac-tivity required to metabolize the CyA may be reduced during regeneration of the remnant liver after a hepa- tectomy, which may, therefore, be linked to diffi culty in controlling the optimal dose of CyA during early period of LDLT.

关键词：环孢菌素A 肝再生肝切除术疗效

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CYP2E1 RsaⅠpolymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking

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World Journal of Gastroenterology 2007年第43期13卷 5725-5730页

作者： Chang-Ming Gao Toshiro Takezaki Jian-Zhong Wu Min-Bin Chen Yan-Ting Liu Jian-Hua Ding Haruhiko Sugimura Jia Cao Nobuyuki Hamajima Kazuo tajima Division of Epidemiology Jiangsu ProvinceInstitute of Cancer Research Nanjing 210009 Jiangsu ProvinceChina Department of International Island andCommunity Medicine Kagoshima University Graduate Schoolof Medical and Dental Sciences 8-35-1 Sakuragaoka Kagoshima890-8544 Japan Molecular Toxicology Laboratory Third MilitaryMedical Universit School of Public Healthy Chongqing 400038China Department of Preventive MedicineBiostatistics and Medical Decision Making Nagoya UniversitySchool of Medicine Nagoya 466-8550 Japan Division of Epidemiology and Prevention AichiCancer Center Research Institute Nagoya 464-8681 Japan

AIM: To investigate associations between the RsaⅠ polymorphism of CYP2E1 and risk of colorectal cancer. METHODS: A case-control study was conducted with 315 colorectal cancer cases (105 colon, 210 rectal) and 439 population-based controls in Jiangsu Province of China. Genomic DNA samples were assayed for restriction fragment length polymorphisms in CYP2E1 by PCR amplification followed by digestion with Rsa Ⅰ. Information on smoking and alcohol drinking was collected using a questionnaire. Odds ratios (ORs) were estimated with an unconditional logistic model. RESULTS: The proportional distribution of the CYP2E1 RsaⅠc1/c1, c1/c2 and c2/c2 genotypes were 61.4%, 35.6% and 3.0% in controls, 60.6%, 33.7% and 5.8% in colon cancer cases, and 58.4%, 34.0% and 7.7% in rectal cancer cases, respectively. A significant difference was noted between controls and rectal cancer cases (P = 0.029), the c2/c2 genotype being associated with elevated OR (adjusted age, sex and status of the smoking and alcohol drinking) for rectal cancer (1.64, 95% CI, 1.12-2.41, vs c1 allele carriers), but not for colon cancer. In interaction analysis between the CYP2E1 RsaⅠgenotype and smoking and drinking habits, we found a significant cooperative action between the c2/c2 genotype and alcohol drinking in the sex-, age-adjusted ORs for both colon (4.74, 95% CI, 1.10-20.40) and rectal (5.75, 95% CI, 1.65-20.05) cancers. Among nonsmokers, the CYP2E1 RsaⅠc2/c2 genotype was also associated with elevated ORs in the two sites (1.95, 95% CI, 0.99-3.86 and 2.30, 95% CI, 1.32-3.99). CONCLUSION: The results of the present study suggest that the CYP2E1 c2/c2 genotype increases susceptibility to rectal cancer and the gene-environmental interactions between the CYP2E1 polymorphism and smoking or alcohol drinking exist for colorectal neoplasia in general.

关键词：结肠直肠癌基因多态性吸烟喝酒行为

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Clinical and radiological feature of lymphoepithelial cyst of the pancreas

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World Journal of Gastroenterology 2014年第45期20卷 17247-17253页

作者： Hirofumi Terakawa Isamu Makino Hisatoshi Nakagawara Tomoharu Miyashita Hidehiro tajima Hirohisa Kitagawa Takashi Fujimura Dai Inoue Kazuto Kozaka Toshifumi Gabata Tetsuo Ohta Department of Gastroenterologic surgery Graduate School of Medical Science Kanazawa University Department of Radiology Graduate School of Medical Science Kanazawa University

A lymphoepithelial cyst(LEC)of the pancreas is a rare benign *** patients with LEC of the pancreas have a good prognosis,it is important that these lesions are accurately differentiated from other more aggressive pancreatic neoplasms for an appropriate treatment *** studies have reported that a definitive diagnosis of LEC often cannot be obtained based solely on the findings of preoperative imaging(e.g.,Computed tomography or Magnetic resonance imaging).In this study,we reviewed four cases of pancreatic LECs to investigate the feature of *** reviewed these cases with regard to symptoms,imaging findings,surgical procedures,and other clinical *** found that LEC was associated with unique characteristics on imaging findings.A preoperative diagnosisof LEC may be possible by comprehensively evaluating its clinical and imaging findings.

关键词： Lymphoepithelial cyst Preoperative diagno-sis Magn

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Arterial steroid injection therapy can inhibit the progression of severe acute hepatic failure toward fulminant liver failure

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World Journal of Gastroenterology 2006年第41期12卷 6678-6682页

作者： Kazuhiro Kotoh Munechika Enjoji Makoto Nakamuta Tsuyoshi Yoshimoto Motoyuki Kohjima Shusuke Morizono Shinsaku Yamashita Yuki Horikawa Kengo Yoshimitsu Tsuyoshi tajima Yoshiki Asayama Kousei Ishigami Masakazu Hirakawa Department of Medicine and Bioregulatory Science Graduate School of Medical Science Kyushu University3-1-1 MaidashiHigashi-kuFukuoka 812-8582Japan Department of Clinical Radiology Graduate School of Medical ScienceKyushu University3-1-1 MaidashiHigashi-kuFukuoka 812-8582Japan

AIM: To utilize transcatheter arterial steroid injection therapy (TASIT) via the hepatic artery to reduce hepatic macrophage activity in patients with severe acute hepatic ***: Thirty-four patients with severe acute hepatic failure were admitted to our hospital between June 2002 to June 2006 providing for the possibility of liver transplantation (LT). Seventeen patients were treated using traditional liver supportive procedures, and the other 17 patients additionally underwent TASIT with 1000 mg methylprednisolone per day for 3 continuous days. RESULTS: Of the 17 patients who received TASIT, 13 were cured without any complications, 2 died, and 2 underwent LT. Of the 17 patients who did not receive TASIT, 4 were self-limiting, 7 died, and 6 underwent LT. Univariate logistic analysis revealed that ascites, serum albumin, prothrombin time, platelet count, and TASIT were significant variables for predicating the prognosis. Multivariate logistic regression analysis using stepwise variable selection showed that prothrombin time, platelet count, and TASIT were independent predictive factors. CONCLUSION: TASIT might effectively prevent the progression of severe acute hepatic failure to a fatal stage of fulminant liver failure.

关键词：动脉疾病病理治疗临床肝疾病

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Solitary recurrence of hilar cholangiocarcinoma in a mediastinai lymph node two years after curative resection

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World Journal of Gastroenterology 2007年第15期13卷 2243-2246页

作者： Yuichiro Ito Yoshitsugu tajima Fumihiko Fujita Ryuji Tsutsumi Tamotsu Kuroki Takashi Kanematsu Department of Transplantation and Digestive Surgery Nagasaki University Graduate School of Biomedical Sciences 1-7-1 SakamotoNagasaki 852-8501Japan

我们最近遇到了在一个纵隔淋巴节点的独居的复发在发生了的门 cholangiocarcinoma 的一个不平常的盒子在原发性瘤的药品切除术以后的二年。一个 64 年的老妇人与正确 hypochondrial 不快的抱怨进入我们的医院。在成像研究在左肝的管表... 详细信息

我们最近遇到了在一个纵隔淋巴节点的独居的复发在发生了的门 cholangiocarcinoma 的一个不平常的盒子在原发性瘤的药品切除术以后的二年。一个 64 年的老妇人与正确 hypochondrial 不快的抱怨进入我们的医院。在成像研究在左肝的管表明了门 cholangiocarcinoma 以后，肿瘤的药品切除术被执行，由与额外的肝的胆汁管的有尾的叶切除术，地区性的淋巴节点解剖，和切除术一起的左肝的叶切除术组成。没有节的转移组织学地被观察。在外科以后的二年，病人 thoracoscopically 被发现在以后的纵隔有一个小瘤，它是 resected。没有另外的肿的淋巴节点，本地复发，或远转移被注意。组织学地，小瘤证明了是一个变形淋巴节点，并且辅助 chemoradiation 治疗被开始。病人留下了很好跟随她的第一个手术的四年并且没在她的第二个手术以后有疾病复发 28 瞬间的证据。到我们的知识，这个案例是在在门 cholangiocarcinoma 的药品切除术以后的一个纵隔淋巴节点的独居的复发的第一份报告。

关键词：肝门胆管癌治疗性切除纵隔淋巴结复发

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