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Pre-sarcopenia and Mac-2 binding protein glycosylation isomer as predictors of recurrence and prognosis of early-stage hepatocellular carcinoma

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World Journal of Hepatology 2022年第7期14卷 1480-1494页

作者： Masato Nakai Kenichi Morikawa Shunichi Hosoda Sonoe Yoshida Akinori Kubo Yoshimasa Tokuchi Takashi Kitagataya Ren Yamada Masatsugu Ohara Takuya Sho Goki Suda Koji ogawa Naoya Sakamoto Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of MedicineSapporo 060-8638Japan

BACKGROUND The Mac-2 binding protein glycosylation isomer(M2BPGi),a fibrosis marker in various liver diseases,is reportedly a prognostic marker in patients with hepatocellular carcinoma(HCC)who underwent *** To evaluate whether the M2BPGi value,M2BP,and pre-sarcopenia before radiofrequency ablation(RFA)could be useful recurrence and prognostic markers in patients with early-stage *** In total,160 patients with early-stage primary HCC treated with RFA were separately analyzed as hepatitis C virus(HCV)-positive and *** contributing to recurrence and liver-related death,including M2BP,M2BPGi,and skeletal muscle mass index,were statistically ***-three patients were HCV-positive and 77 were *** In HCV-positive patients,only des-γ-carboxy-prothrombin≥23 mAU/mL was a significant poor prognostic factor affecting survival after *** HCV-negative patients,M2BPGi≥1.86 cutoff index was significantly associated with tumor recurrence,while M2BP was not.M2BPGi≥1.86 cutoff index(hazard ratio,4.89;95%confidence interval:1.97-12.18;P<0.001)and pre-sarcopenia(hazard ratio,3.34,95%confidence interval:1.19-9.37;P=0.022)were independent significant poor prognostic factors in HCV-negative *** In HCV-negative patients with primary HCC treated with RFA,lower M2BPGi contributed to a lower tumor recurrence rate and longer survival ***-sarcopenia contributed to the poor prognosis independently in HCV-negative *** factors might be useful recurrence and prognostic markers for early-stage primary HCC.

关键词： Mac-2 binding protein Mac-2 binding protein glycosylation isomer Pre-sarcopenia Primary hepatocellular carcinoma Radiofrequency ablation

Pion Effect of Nuclear Matter in a Chiral Sigma Model

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原子核物理评论 2009年第S1期26卷 75-78页

作者： Y.ogawa H.Toki A.Hosaka Research Center for Nuclear Physics (RCNP) Osaka University

We develop a new framework for the study of the nuclear matter based on the linear sigma model. We introduce a completely new viewpoint on the treatment of the nuclear matter with the inclusion of the pion. We extend the relativistic chiral mean field model by using the similar method in the tensor optimized shell model. We also regulate the pion-nucleon interaction by considering the form-factor and short range repulsion effects. We obtain the equation of state of nuclear matter and study the importance of the pion effect.

关键词： extended relativistic mean field model chiral symmetry pion exchange

二战期间,日本儿童对于犯罪-受害关系的复杂看法精神分析如何帮助协调中日关系?

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二战期间,日本儿童对于犯罪-受害关系的复杂看法精神分析如何帮助...

Efficacy of static magnetic field for pain of adjuvant arthritis rats

弗洛伊德与亚洲—发展与变革：亚洲背景下的精神分析——I...

作者： shigeyuki Mori Konan University

＜正＞由于在15年战争中（1931-1945）日本军队的侵略,使得中国和日本一直陷入一种复杂的犯罪-受害关系之中。不论是在外交问题上,还是双方的公民个体身上,其创伤性的后果至今都未能彻底修通,并且继续在两国之间留下阴影。或许日本会认...

＜正＞由于在15年战争中（1931-1945）日本军队的侵略,使得中国和日本一直陷入一种复杂的犯罪-受害关系之中。不论是在外交问题上,还是双方的公民个体身上,其创伤性的后果至今都未能彻底修通,并且继续在两国之间留下阴影。或许日本会认为,从现实的角度出发,

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Advances in Bioscience and Biotechnology 2012年第4期3卷 511-515页

作者： shigeyuki Kanai Norimasa Taniguchi Department of Physical Therapy Faculty of Health Science Kansai University of Health Science Osaka Japan Research Section for Magnetics Product Development Department Development Division PIP Co Ltd Osaka Japan

Rats suffering from adjuvant arthritis (AA) were used to examine the effect of a static magnetic field (SMF) upon pain relief. Rats were divided into SMF- treated AA rats, non-SMF treated AA rats and control rats. Following SMF stimulation, we measured blood flow volume in the paw and then reactive speed response to thermal stimulation. The AA groups exhibited significantly lower blood volume and reactivity to thermal stimulation compared to the control group. Compared to non-SMF, SMF exhibited increased blood flow volume in both the tail and paw, along with an increased reactive speed response to thermal stimulation. Our findings suggest that an improved of blood flow and reactive speed response, induced by SMF, appears to be effective for the relief of pain induced by chronic inflammation.

关键词： Static Magnetic Field (Smf) Adjuvant Arthritis (Aa) Blood Flow Reactive Speed Response

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精原干细胞：进展和前景

Asian Journal of Andrology 2015年第5期17卷 771-775,I0007-I0008页

作者： Mitsuru Komeya Takehiko ogawa Department of Urology Graduate School of Medicine Yokohama City University Yokohama 236-0004 Japan Laboratory of Proteomics Institute of Molecular Medicine and Life Science Yokohama City University Association of Medical Science Yokohama 236-0004 Japan

Twenty years ago, the transplantation of spermatogonial stem cells （SSCs） from a mouse to other recipient mice was shown to be feasible, which clearly demonstrated the functional identity of SSCs. Since then, several important new findings and other technical developments have followed, which included a new hypothesis on their cell kinetics and spermatogonial hierarchy in the testis, a culture method allowing their self-renewal and proliferation, a testis tissue organ culture method, which induced their complete differentiation up to sperm, and the in vitro induction of germ cells from embryonic stem cells and induced pluripotent stem cells. These advancements reinforced or advanced our understanding of this unique cell. Nonetheless, there are many unresolved questions in the study of spermatogonial stem cells and a long road remains until these cells can be used clinically in reproductive medicine.

关键词： in vitro spermatogenesis male infertility organ culture

Influence of morphology of hollow silica-alumina composite spheres on their activity for hydrolytic dehydrogenation of ammonia borane

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Journal of Advanced Ceramics 2017年第4期6卷 368-375页

作者： Naoki TOYAMA Ryota ogawa Haruki INOUE Shinobu OHKI Masataka TANSHO Tadashi SHIMIZU Tetsuo UMEGAKI Yoshiyuki KOJIMA Department of Materials&Applied Chemistry College of Science&EngineeringNihon University1-8-14Kanda-SurugadaiChiyoda-KuTokyo 101-8308Japan National Institute for Materials Science 3-13SakuraTsukubaIbaraki 305-0003Japan

Hollow silica-alumina composite spheres were prepared by a polystyrene(PS)template method using various amounts of PS *** hollow spheres prepared using 40 g were found to be with a diameter of about 300 nm in scanning electron microscopy,and transmission electron microscopy demonstrated their hollow sphere *** the nitrogen adsorption isotherm results,the homogeneous hollow spheres prepared using 40 g of the PS suspension were found to be an ordered pore *** activities of the hollow spheres prepared using various amounts of the PS suspension for hydrolytic dehydrogenation of ammonia borane were *** results showed that 10,7,and 6 mL of hydrogen were evolved from the aqueous ammonia borane solution in about 40 min in the presence of the hollow spheres prepared using 40,80,and 120 g of PS suspension,*** homogeneous hollow spheres with an ordered pore structure showed the highest activity among all the hollow *** amount of acid sites and the coordination number of aluminum active species were characterized using neutralization titration and solid-state ^(27)Al magic angle spinning nuclear magnetic resonance *** homogeneous hollow spheres with an ordered pore structure had high amount of acid sites and 4-coordinated aluminum *** relative proportion of 4-coordinated aluminum species was related to the dispersion of aluminum *** results indicate that the homogeneous hollow spheres with an ordered pore structure showed the high activity because of high amount of acid sites induced by the highly dispersed aluminum species.

关键词： ammonia borane morphology hollow silica-alumina composite spheres dispersion acid sites

Long-term effects of lamivudine treatment in Japanese chronic hepatitis B patients

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World Journal of Gastroenterology 2011年第24期17卷 2945-2952页

作者： Masayuki Murata Norihiro Furusyo Mami Unno Eiichi ogawa Kazuhiro Toyoda Hiroaki Taniai Hachiro Ohnishi Jun Hayashi Department of General Internal Medicine Kyushu University Hospital Department of Environmental Medicine and Infectious Disease Faculty of Medical SciencesKyushu University

AIM:To analyze the association between the emergence of tyrosine-methionine-asparatate-asparatate(YMDD) mutants(reverse transcription;rtM204I/V) and deterioration of liver function during long-term lamivudine treatment of Japanese patients with chronic hepatitis B virus(HBV) ***:The data of 61 consecutive Japanese patients with chronic hepatitis B who underwent continuous lamivudine treatment for more than 24 mo and had a virological response were *** of YMDD mutants was done by real-time polymerase chain reaction with LightCycler probe hybridization assay for up to 90 mo(mean,50.8 mo;range,24-90 mo).RESULTS:A mixed mutant-type(YMDD + tyrosine-isoleucine-asparatate-asparatate:YIDD or tyrosine-valineasparatate-asparatate:YVDD) or a mutant-type(YIDD or YVDD) were found in 57.4% of 61 patients at 1 year,78.7% of 61 patients at 2 years,79.6% of 49 patients at 3 years,70.5% of 34 patients at 4 years,68.4% of 19 patients at 5 years,57.1% of 14 patients at 6 years,and 33.3% of 6 patients at 7 *** the 61 patients,56(92%) had mixed mutant-or a *** 5(8%) had no mutants at each observation *** breakthrough was found in 26(46.4%) of 56 patients with YMDD mutants,20 of whom had a hepatitis flare-up:the remaining 30(53.6%) had neither a virological breakthrough nor a *** 20 patients who developed a hepatitis flare-up had a biochemical and virological response after adefovir was added to the lamivudine ***:Our results suggest that it is possible to continue lamivudine treatment,even after the emergence of YMDD mutants,up to the time that the patients develop a hepatitis flare-up.

关键词：慢性乙型肝炎拉米夫定患者治疗日本乙型肝炎病毒聚合酶链反应突变体

Single-cell analysis for identification of T-cell clonotypes associated with IgG4 production of autoimmune pancreatitis

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Gastroenterology Report 2023年第1期11卷 590-592页

作者： Kensuke Shibata Nao Fujimori Takamasa Oono Daisuke Motooka Daisuke Okuzaki Koh-Hei Sonoda Yoshihiro ogawa Sho Yamasaki Department of Microbiology and Immunology Graduate School of MedicineYamaguchi UniversityUbeJapan Department of Ophthalmology Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Department of Molecular Immunology Research Institute for Microbial DiseasesOsaka UniversitySuitaJapan Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Single Cell Genomics Human ImmunologyWorld Premier International Research Center Initiative Immunology Frontier Research CenterOsaka UniversitySuitaJapan Genome Information Research Center Research Institute for Microbial DiseasesOsaka UniversitySuitaJapan Laboratory of Molecular Immunology Immunology Frontier Research CenterOsaka UniversitySuitaJapan Division of Molecular Immunology Medical Mycology Research CenterChiba UniversityChibaJapan

Introduction Autoimmune pancreatitis(AIP)is one of the recently established immunoglobulin G4-related diseases(IgG4-RD)[1].The detailed pathogenic mechanisms have been an intensive research area for prophylactic and therapeutic purposes because aberrant immune activation and tissue fibrosis in AIP are the major factors that worsen the disease outcomes in these patients.

关键词： IgG4 pancreatitis diseases

A Virtual Router Cluster System Based on the Separation of the Control Plane and the Data Plane

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信息通信技术 2012年第2期6卷 48-53页

作者： Kentaro ogawa NTT NETWORK SERVICE SYSTEM LABORATORIES NTT CORPORATION Tokyo 100-0004

This paper proposes a virtual router cluster system based on the separation of the control plane and the data plane from multiple perspectives,such as architecture,key technologies,scenarios and *** some extent,the virtual cluster simplifies network topology and management,achieves automatic *** and saves the IP *** is a kind of low-cost expansion method of aggregation equipment port density.

关键词：摘要编辑部编辑工作读者