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Gastrointestinal polyposis with esophageal polyposis is useful for early diagnosis of Cowden's disease

World Journal of Gastroenterology 2008年第37期14卷 5755-5759页

作者： Ken Umemura Sho Takagi Yasushi Ishigaki Masahiro Iwabuchi shigeru kuroki Yoshitaka Kinouchi Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of MedicineSendai 980-8574 Japan Division of Molecular Metabolism and Diabetes Tohoku University Graduate School of MedicineSendai 980-8574 Japan Department of Gastroenterology Sendai Medical CenterSendai 980-8574 Japan Department of Dermatology Kurihara Central HospitalKurihara 228-0014 Japan

Cowden's disease, one of the several hamartoma syndromes, is characterized by hyperplastic lesions and hamartomas distributed in the whole body. About thirty percent of patients with Cowden's disease have been reported to be complicated by malignant tumors. Based on the criteria of the International Cowden Consortium, this disease is mainly diagnosed as trichilemmoma of the face and oral mucosal papillomatosis. However, Cowden's disease patients themselves often do not recognize trichilemmoma of the face and oral mucosal papillomatosis. We report a case of Cowden's disease in a 33-year-old female patient who was diagnosed based on the characteristic findings at gastrointestinal endoscopy. Clinically, the patient was aware of having bloody stools. Multiple polyps found endoscopically in the esophagus, stomach, ileum, colon and rectum showed histopathologically hamartomatous changes and epithelial hyperplasia. Physical examination revealed oral papillomatosis and facial trichilemmomas. A germline mutation in exon 8 of the phosphatase and tensin homolog deleted on chromosome ten (PTEN) gene was found in this case. It was a point mutation of C to T at codon 1003 (CGA→TGA, arginine→stop codon). The characteristic findings on gastrointestinal endoscopy led us to a diagnosis of Cowden's disease. It has been reported that gastrointestinal polyposis with esophageal polyposis is found in about 85.7% of Japanese patients with Cowden's disease. The characteristic findings on gastrointestinal endoscopy can be a useful diagnostic clue to Cowden's disease.

关键词：胃肠息肉食管息肉早期诊断错构瘤

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The Effect of Umami Stimulation on Salivary Secretion Rate and Duration

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Health 2024年第1期16卷 52-59页

作者： Eri Sambuichi Rumi Nishimura Shiho Morishita shigeru Watanabe Department of Oral Health Sciences School of Health Sciences Meikai University Urayasu Japan Department of Oral Epidemiology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan

Purpose: Umami reportedly promotes salivation. We aimed to investigate the effects of taste stimuli on slow and fast salivary secretion in humans using umami, sweet, and sour stimuli. Methods: Eight healthy women participated between 14:00 and 15:00, taking the circadian rhythm of salivary secretion into account. The types and concentrations of the taste solutions were glutamic acid (1.7 × 10−3 M), inosinic acid (9.8 × 10−3 M), and guanylic acid (9.8 × 10−3 M) for umami stimulation, citric acid (6.5 × 10−3 M) for acidity stimulation, and sucrose (1.6 × 10−2 M) for sweetness stimulation. First, the unstimulated salivary flow rate was measured. Then, 3 ml of a flavor solution was dropped under the tongue using a syringe. The saliva was expelled into an aluminum cup every minute and weighed. The first minute’s value minus 3 ml flavor solution was the stimulated salivary secretion rate produced by each flavor. The time-to-return to the initial unstimulated salivary flow rate was the duration of the stimulated saliva secretion rate. Results: The mean unstimulated salivary flow rate across participants was 0.64 ± 0.25 ml/min (range: 0.23 - 1.03 ml/min). The highest amount of saliva was induced by citric acid. There were significant differences between citric acid and the other flavor solutions (p < 0.05 for glutamic acid, inosinic acid, and sucrose;p < 0.01 for guanylic acid). There were no significant differences in duration of salivation between the flavor solutions. When the participants were divided into slow (0.45 ± 0.16 ml/min) and fast groups (0.83 ± 0.15 ml/min) based on their median resting salivary secretion rate, there were no significant differences between the two groups in the amount of saliva secreted at 1 minute after stimulation and the duration of the salivary secretion rate. Conclusion: Umami stimulation was effective in slowing salivary secretion and sustaining salivary secretion after stimulation.

关键词： Salivary Secretion Umami Flavor Oral Health Stimulated Salivary Secretion

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An Experimental Study of Carbon Dioxide Condensation in Mini Channels

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Journal of Thermal Science 2004年第4期13卷 358-365页

作者： shigeru KOYAMA Institute of Advanced Material Study Kyushu University Kasuga-koen 6-1 Kasuga-shi Fukuoka 816-8580Japan

In this study, the local characteristics of pressure drop and heat transfer were investigated experimentally for carbon dioxide condensation in a multi-port extruded aluminum test section, which had 10 circular channels each with 1.31 mm inner diameter. The CO2 was cooled with cooling water flow inside the copper blocks that were attached at both sides of the test section. The temperatures at the outer surface of the test section were measured with 24 K-type thermocouples embedded in the upper and lower surfaces along the length. Local heat fluxes were measured with 12 heat flux sensors to estimate the local enthalpies, temperatures and heat transfer coefficients. Bulk mean temperatures of CO2 at the inlet and outlet of the test section were measured with 2 K-type thermocouples. The measurements were performed for the pressure ranged from 6.48 to 7.3 MPa, inlet temperature of CO2 from 21.63 to 31.33℃, heat flux from 1.10 to 8.12 kW/m2, mass velocity from 123.2 to 315.2 kg/m2s, and vapor quality from 0 to 1. The results indicate that pressure drop is very small along the test section, heat transfer coefficient in the two-phase region is higher than that in the single-phase, and mass velocity has important effect on condensation heat transfer characteristics. In addition, experimental data were compared with previous correlations and large discrepancies were observed.

关键词： carbon dioxide condensation heat transfer pressure drop mini channels.

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Research on Lightning Protection of Overhead Power Distribution Lines

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高电压技术 2013年第10期39卷 2317-2328页

作者： shigeru Yokoyama Tomoyuki Sato Graduate School of Engineering Shizuoka University Shizuoka 4228526 Japan Tohoku Electric Power Company Sendai 9808550 Japan

There are two major protective methods against lightning outages on overhead distribution *** is a surge arrester,and the other is an overhead ground *** surge arresters have rather constant effect regardless of the cause of the lightning *** the other hand,the effect of an overhead ground wire is quite different in two major causes,the direct lightning hit and the induced *** is sufficient to provide surge arresters with an interval of 300 m for protection against the induced overvoltage caused by the nearby lightning *** of an overhead ground wire together with surge arresters is effective for lightning protection against the direct lightning hit to a distribution *** of surge arresters is the popular outage when the outage caused by the insulation break decreases ***,the existence of nearby trees leads to the line break due to the side flash from a *** lightning protection equipment with ZnO arrester components is popular in *** of a pole transformer and application of an electromagnetic analysis method,such as FDTD method,to surge phenomena is considerably advanced.

关键词：架空配电线路防雷保护雷击感应过电压时域有限差分方法架空地线避雷器防护方法直接雷击

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Mitochondrial haplogroups associated with Japanese centenarians, Alzheimer's patients, Parkinson's patients, type 2 diabetic patients and healthy non-obese young males

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Journal of Genetics and Genomics 2009年第7期36卷 425-434页

作者： shigeru Takasaki Toyo University Izumino 1-1-1 Ouragun Itakuracho Gunma 374-0193 Japan

The relationships between five classes of Japanese people （i.e., 96 centenarians, 96 Alzheimer＇s disease （AD） patients, 96 Parkinson＇s disease （PD） patients, 96 type 2 diabetic （T2D） patients, and 96 healthy non-obese young males） and their mitochondrial single nucleotide polymorphism （mtSNP） frequencies at individual mtDNA positions of the entire mitochondrial genome were examined using the radial basis function （RBF） network and the modified method. New findings of mitochondrial haplogroups were obtained for individual classes. The five classes of people were associated with the following haplogroups： Japanese centenarians-M7b2, D4b2a, and B5b; Japanese AD patients-G2a, B4cl, and N9b1; Japanese PD patients-M7b2, B4e, and B5b; Japanese T2D patients-B5b, M8al, G, D4, and F1; and Japanese healthy non-obese young males-D4g and D4b1b. From the points of common haplogroups among the five classes, the cente- narians have the common haplogroups M7b2 and B5b with the PD patients and common haplogroup B5b with the T2D patients. In addition, the 112 Japanese semi-supercentenarians （over 105 years old） recently reported were also examined by the method proposed. The results obtained were the haplogroups D4a, B4c1a, M7b2, F1, M1, and B5b. These results are different from the previously reported haplogroup classifications. As the proposed analysis method can predict a person＇s mtSNP constitution and the probabilities of becoming a centenarian, AD patient, PD patient, or T2D patient, it may be useful in initial diagnosis of various diseases.

关键词： mtSNPs haplogroup semi-supercentenarians centenarians Alzheimer's disease Parkinson's disease type 2 diabetic patients healthy non-obese young males radial basis function (RBF)

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Photocatalytic single electron transfer reactions on TiO2 semiconductor

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Science China Chemistry 2019年第11期62卷 1439-1449页

作者： Hideto Miyabe shigeru Kohtani School of Pharmacy Hyogo University of Health Sciences

The use of inorganic semiconductor particles such as titanium dioxide(TiO2)has received relatively less attention in organic chemistry,although semiconductor particles have been widely used as a single electron transfer photocatalyst in waterpurification,air-cleaning,and *** recent years,the photocatalysis on semiconductor particles has become an active area of research even in organic chemistry,since the heterogeneous semiconductor photocatalysis leads to the unique redox organic *** an early stage,the semiconductor photocatalysis was applied to the oxidation of organic *** particles have also the potential to induce the reductive chemical transformations in the absence of oxygen(O2),by using the suitable sacrificial hole *** this review,we summarize the representative examples of the reductive and oxidative organic reactions using semiconductor particles and the recent applications to the stereoselective reactions.

关键词： photocatalyst semiconductor titanium dioxide oxidation reduction radical

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Ageing Society and Assistive Products

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稀有金属材料与工程 2006年第A3期35卷 67-70页

作者： shigeru Yamauchi Department of Health Science and Social Welfare Faculty of Human Sciences Waseda UniversityMikajima 2-579-15TokorozawaSaitama 359-1192Japan

North East Asian countries are facing to rapid increase in aged population *** most recent values of aged population ratios are 19.5%,8.7%,and 6.9%,for Japan,Korea and China,*** of the welfare services in the aged society is provision of assistive *** control systems are commonly adopted in modern assistive products and sensors are indispensable for control *** systems,such as fire alarm,smoke detectors,and gas leak detectors,have been regarded as indispensable to safety of elderly persons and persons with *** application of chemical sensors in home care of elderly persons is in the field of personal care and personal medical *** for personal medical treatment include that for medical treatment in home care and that to keep elderly persons *** market is expected in the latter one.

关键词： population ageing assistive products long term care personal mental treatment

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Silicon photonics for telecom and data‐com applications

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Opto-Electronic Advances 2020年第10期3卷 31-56页

作者： Kiyoshi Asakawa Yoshimasa Sugimoto shigeru Nakamura Associate Program University of TsukubaTsukubaIbaraki 305-8571Japan. Nanotechnology Innovation Station National Institute for Materials Science(NIMS)1-2-1 SengenTsukubaIbaraki 305-0047Japan. Biometrics Research Laboratories NEC Corporation1131HinodeAbikoChiba 270-1198Japan.

In recent decades,silicon photonics has attracted much attention in telecom and data-com *** of high refractive-index contrast waveguides on silicon-on-insulator(SOI),a variety of integrated photonic passive and active devices have been implemented supported by excellent optical properties of silicon in the mid-infrared *** main advantage of the silicon photonics is the ability to use complementary metal oxide semiconductor(CMOS)process-compatible fabrication technologies,resulting in high-volume production at low *** the other hand,explosively growing traffic in the telecom,data center and high-performance computer demands the data flow to have high speed,wide bandwidth,low cost,and high energy-efficiency,as well as the photonics and electronics to be integrated for ultra-fast data transfer in *** practical applications,silicon photonics started with optical interconnect transceivers in the data-com first,and has been now extended to innovative applications such as multi-port optical switches in the telecom network node and integrated optical phased arrays(OPAs)in light detection and ranging(LiDAR).This paper overviews the progresses of silicon photonics from four points reflecting the recent advances mentioned ***-based silicon photonic platform technologies,applications to optical transceiver in the data-com network,applications to multi-port optical switches in the telecom network and applications to OPA in LiDAR system.

关键词： silicon photonics integration of photonics and electronics CMOS process-compatible fabrication optical interconnect transceiver optical multi-port switch optical phased array

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The structural elucidation of Eisenstein's formula

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Science China Mathematics 2010年第9期53卷 2341-2350页

作者： HASHIMOTO Masahiro KANEMITSU shigeru Department of Mathematics Wakayama College of TechnologyNoda-machi Gobo-shi 649-15Japan Graduate School of Advanced Technology Kinki University IizukaFukuoka 820-8555Japan

In this paper,we shall give a complete structural description of generalizations of the classical Eisenstein formula that expresses the first periodic Bernoulli polynomial as a finite combination of cotangent values,as a relation between two bases of the vector space of periodic Dirichlet *** shall also determine the limiting behavior of them,giving rise to Gauss' famous closed formula for the values of the digamma function at rational points on the one hand and elucidation of Eisenstein-Wang's formulas in the context of Kubert functions on the other.W shall reveal that most of the relevant previous results are the combinations of the generalized Eisenstein formula and the functional equation.

关键词： Eisenstein formula Hurwitz zeta-function polylogarithm function Gauss formula

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A Study of Quantitative Progress Evaluation Models for Open Source Projects

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Journal of Software Engineering and Applications 2022年第5期15卷 183-196页

作者： Hironobu Sone Yoshinobu Tamura shigeru Yamada Graduate School of Sciences and Technology for Innovation Yamaguchi University Yamaguchi Japan Graduate School of Engineering Tottori University Tottori Japan

Open source software (OSS) has become an indispensable part of society, not only for personal use but also for corporate use. Projects developed and operated by OSS are called open source projects, and the number of such projects is increasing. On the other hand, because anyone can participate in an open source project, the progress of the project is uncertain due to differences in project members’ skills, development environments, and time zones of activity. Therefore, many users and companies need to understand the development and operation status of open source project. Then, the developers carefully make decisions on upgrading or installing new OSS. In this paper, we focus on the maintenance effort estimation for open source projects considering uncertainty. Also, we evaluate the project quantitatively using Earned Value Management (EVM). Moreover, we examine the appropriateness of the model for predicting the maintenance effort expeditures. Furthermore, we discuss the appropriateness of this EVM method.

关键词： Open Source Software Stochastic Differential Equation Earned Value Management Software Reliability Growth Model

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