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Journal of Water Resource and Protection 2013年第3期5卷 283-293页

作者： Toshisuke Maruyama Masashi yoshida Keiji Takase Hiroshi Takimoto shigeo Ishikawa College of Bioresource Science Nihon University Tokyo Japan Faculty of Environmental Science Ishikawa Prefectural University Nonoichi Japan

The hypothesis that the product of discharge and concentration of nitrogen (N) in river water is equal to the atmospheric deposition was verified in the mountainous basin of the Tedori River in Japan. To verify this relationship, long-term data?are required to eliminate the effect of short-term variation of the N components. The basin has very high mountains, including Mount Hakusan (2702 maltitude), which is covered with deep snow in winter. Therefore, limited data were used for the estimation of the deposition of the entire basin by assuming a linear relationship of altitude. As a result, it was found that the estimated N concentration coincided well with observed concentrations at six sites—the Shiramine and Kuwajima (upper stream), Nakajima (lower stream) and Dainichi dam, Tedori dam and Senami sites (middle stream). The seasonal variation of N concentrations was low in the snowmelt period and high in autumn through to winter. This was not due to the larger discharge in snowmelt season as it was also found that N deposition was high in winter and low in spring, which indicated a clear relationship between N concentration and monthly atmospheric deposition including N storage in snow pack.

关键词： Nitrogen Balance Wet and Dry Deposition Altitude Dependence of Atmospheric Deposition and Precipitation Nitrogen in Snowpack

Quantitative Analysis of the Rate of Geochemical Weathering of Sulfur from Sedimentary Rocks Using Atmospheric Deposition, Concentration and River Discharge Data

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Journal of Water Resource and Protection 2013年第5期5卷 511-519页

作者： Toshisuke Maruyama Masashi yoshida Keiji Takase Hiroshi Takimoto shigeo Ishikawa Sadao Nagasaka College of Bioresource Science Nihon University Kanagawa Japan Faculty of Environmental Science Ishikawa Prefectural University Ishikawa Japan

Quantitative analysis of the rate of geochemical weathering of sulfur (S) from sedimentary rocks (GeoS) was conducted using concentration (Cs) and discharge (Qs) data from the Tedori River and atmospheric deposition (AtdepS) in the basin. First, S fluxes were calculated using 16 years of Cs and Qs data. The annual average discharge of S (TotalS) was estimated at 8597 ton·year-1 (117.3 kg·ha-1·year-1). Of this, 1331 ton·year-1 was AtdepS (18.2 kg·ha-1·year-1) and another 7266 ton·year-1 was GeoS (99.1 kg·ha-1·year-1). Monthly changes in TotalS were investigated, which showed that GeoS was highest in summer, because of the air temperature, while AtdepS peaked in winter because of seasonal wind. Using Qs and AtdepS corrected for altitude, TotalS, AtdepS and GeoS were estimated at six sites, and among these sites we found that the TotalS per unit area values were random, depending on the site characteristics. In particular, the discharge from the Kuwajima site was remarkably high suggesting that the sedimentary rocks at this site had higher pyrite content than at the other sites. Finally, we also assessed the relationship between the characteristics of sedimentary rocks and GeoS in a range of rivers in the Hokuriku Region, and found that there was a close relationship between concentrations of SO42- greater than 10 mg·l-1 and sedimentary rocks containing the pyrite group. In addition, we estimated that the influence of GeoS was present when the concentration of SO42- in river water was greater than 2 - 3 mg·l-1 in the Hokuriku region.

关键词： Sulfur Balance Wet and Dry Deposition Sulfur Concentration Altitude Dependence Sulfur Discharge from Pyrite

Long-Term Assessment of Nitrogen Pollution Load Potential for Groundwater by Mass Balance Analysis in the Tedori River Alluvial Fan Area, Japan

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Journal of Water Resource and Protection 2013年第2期5卷 171-182页

作者： Toshisuke Maruyama Masashi yoshida Keiji Takase Hiroshi Takimoto shigeo Ishikawa Sadao Nagasaka College of Bioresource Sciences Nihon University Nonoichi Japan Faculty of Bioresources and Environmental Science Ishikawa Prefectural University Nonoichi Japan

To evaluate the nitrogen pollution load in an aquifer, a water and nitrogen balance analysis was conducted over a thirty-five year period at five yearly intervals. First, we established a two-horizon model comprising a channel/soil horizon, and an aquifer horizon, with exchange of water between the aquifer and river. The nitrogen balance was estimated from the product of nitrogen concentration and water flow obtained from the water balance analysis. The aquifer nitrogen balance results were as follows: 1) In the aquifer horizon, the total nitrogen pollution load potential (NPLP) peaked in the period 1981-1990 at 1800 t·yr-1;following this the NPLP rapidly decreased to about 600 t·yr-1 in the period 2006-2010. The largest NPLP input component of 1000 t·yr-1 in the period 1976-1990 was from farmland. Subsequently, farmland NPLP decreased to only 400 t·yr-1 between 2006 and 2010. The second largest input component, 600 t·yr-1, was effluent from wastewater treatment works (WWTWs) in the period 1986-1990;this also decreased markedly to about 100 t·yr-1 between 2006 and 2010;2) The difference between input and output in the aquifer horizon, used as an index of groundwater pollution, peaked in the period 1986-1990 at about 1200 t·yr-1. This gradually decreased to about 200 t·yr-1 by 2006-2010. 3) The temporal change in NPLP coincided with the nitrogen concentration of the rivers in the study area. In addition, nitrogen concentrations in two test wells were 1.0 mg·l-1 at a depth of 150 m and only 0.25 mg·l-1 at 50 m, suggesting gradual percolation of the nitrogen polluted water deeper in the aquifer.

关键词： Water Balance Nitrogen Balance Groundwater Pollution Sewage Treatment Water Pollution from Farmland Nitrogen Pollution Load Potential

Successful treatment with rifampin for fulminant antibiotics-associated colitis in a patient with non-Hodgkin's lymphoma

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World Journal of Gastroenterology 2004年第5期10卷 765-766页

作者： Kenichi Nomura Yosuke Matsumoto Naohisa yoshida Sawako Taji Naoki Wakabayashi Shoji Mitsufuji shigeo Horiike Masuji Morita Takeshi Okanoue Masafumi Taniwaki Molecular Hematology and Oncology Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan School of Nursing Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan Clinical Molecular Genetics and Laboratory Medicine Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan

A 74-year-old man was admitted to the hospital because of chemotherapy for relapsed non-Hodgkin's lymphoma (NHL).The patient became febrile and experienced diarrhea after chemotherapy. Although ceftazidime and amikacin sulfate were administered as empiric therapy, diarrhea was *** several days, stool cytotoxin assay for clostridium difficile (C. difficile) was positive and he was diagnosed as having antibiotics-associated colitis (AAC). Although antibiotics were discontinued and both oral vancomycin and metronidazole were administrated, disease was not improved. To rule out the presence of an additional cause of diarrhea, colon fiberoscopic examination was performed. It revealed multiple deep ulcerative lesions at right side colon, surface erosive and minute erosive lesions in all continuous *** were not seen. These findings are compatible with AAC without pseudomembranes. There are no reports that the rifampin is effective on refractory ***, we administered oral rifampin for the current *** reasons are 1) conventional antibiotics were not effective,2) rifampin has excellent in vitro activity against C. difficile,and 3) the efficacy of rifampin on relapsing colitis due to *** is established. After administration of rifampin, fever alleviated and diarrhea was improved. Because AAC may result in significant mortality, patients with refractory or fulminant AAC should be treated with oral rifampin from outset.

关键词：暴发性抗生素相关性大肠炎利福平非何杰金氏淋巴瘤抗药性羧形菌病例报告

The Efficacy of the Consumption of n-3 Polyunsaturated Fatty Acids for the Maintenance of Remission in Patients with Inflammatory Bowel Disease

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Food and Nutrition Sciences 2018年第2期9卷 105-118页

作者： Kan Uchiyama Hiroko Aiki Aki Matsumura Kanako Saruta Ai Yuasa Zensho Ito Shinichiro Takami Keisuke Saito Yuichiro Ohtaki Shizuka Suzuki Susumu Hayashi shigeo Koido Hiroshi yoshida Toshifumi Ohkusa Masayuki Saruta Department of Internal Medicine Division of Gastroenterology and Hepatology The Jikei University Kashiwa Hospital Kashiwa Japan Department of Nutrition The Jikei University Kashiwa Hospital Kashiwa Japan Department of Laboratory Medicine The Jikei University Kashiwa Hospital Kashiwa Japan Department of Internal Medicine Division of Gastroenterology and Hepatology The Jikei University Hospital Tokyo Japan

The aim of the present study was to investigate the efficacy of the actual consuming n-3 PUFA for remission-maintenance in IBD patients. A questionnaire on the dietary habits of patients one month before hospitalization (Q1) was completed by 24 patients with IBD (10 ulcerative colitis (UC) subjects and 14 Crohn’s disease (CD) subjects) treated at our hospital. We educated the study subjects about an n-3 PUFA diet, and a follow-up survey (Q2) was conducted 6 to 12 months after discharge. Disease activity was evaluated using the International Organization for the Study of Inflammatory Bowel Disease (IOIBD) score and/or the Crohn’s Disease Activity Index (CDAI) score for CD and the partial UCDAI score without endoscopic evaluation for UC. Q1 showed that the average n-3 and n-6 PUFA intakes were 1673 ± 1651 mg and 9146 ± 5217 mg, respectively, and the average n-3/n-6 ratio was 0.27 ± 0.31. In Q2, the intake of n-3 PUFA was significantly higher (3671 ± 1684 mg, p < 0.001), whereas the n-6 PUFA intake decreased significantly (5217 ± 1973 mg, p < 0.001) compared to those in Q1. As a consequence, the dietary n-3/ n-6 ratio was significantly increased (0.87 ± 0.60, p < 0.001). Maintenance of the remission rate was significantly higher in IBD patients who complied with the n-3 diet, and these patients maintained a dietary n-3/n-6 ratio of 0.432 or higher (17 of 23 cases;70.8%, p < 0.03) compared to that observed for IBD patients who did not comply with the diet. These results emphasize the importance of adjusting dietary PUFA and suggest that the n-3 diet may be effective in maintaining the remission of IBD.

关键词： Crohn’s Disease Inflammatory Bowel Disease N-3 Diet Polyunsaturated Fatty Acid Ulcerative Colitis

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四氢生物蝶呤反应性苯丙氨酸羟化酶缺乏症

中国当代儿科杂志 2005年第4期7卷 301-304页

作者： Haruo SHINTAKU shigeo KURE Toshihiro OHURA Yoshiyuki OKANO Misao OHWADA Naruji SUGIYAMA Nobuo SAKURA Ichiro yoshida Makoto YOSHINO Yohichi MATSUBARA Ken SUZUKI Kikumaro AOKI Teruo KITAGAWA 大阪市立大学医学院儿科大阪日本545-8585

目的四氢生物蝶呤(BH4)可以使BH4缺乏症病人的血液苯丙氨酸水平正常化,但是对苯丙酮酸尿症(PKU)病人无效。最近在新生儿PKU筛查中发现了对BH4有反应的轻度PKU患者。本研究将探讨BH4和苯丙氨酸羟化酶(PAH)基因突变在对BH4有反应的轻度PK... 详细信息

目的四氢生物蝶呤(BH4)可以使BH4缺乏症病人的血液苯丙氨酸水平正常化,但是对苯丙酮酸尿症(PKU)病人无效。最近在新生儿PKU筛查中发现了对BH4有反应的轻度PKU患者。本研究将探讨BH4和苯丙氨酸羟化酶(PAH)基因突变在对BH4有反应的轻度PKU和轻度高苯丙酸血症(HPA)患者中的作用。方法对经新生儿PKU筛查中发现的生物蝶呤代谢正常的轻度HPA患者,进行单次(10mg/kg)、4次、1周[20 mg/(kg·d)]的BH4口服负荷试验及长期BH4治疗,评估其对BH4口服负荷试验的反应性。结果在单剂量BH4口服负荷试验中,典型PKU患者的血苯丙氨酸水平没有降低。在单剂量BH4口服负荷试验中血苯丙氨酸水平下降超过20%的患者,在4次BH4口服负荷试验中下降亦超过20%。1周BH4负荷试验确认在单剂量和4次BH4负荷试验中表现出弱反应性的病人对BH4有反应。许多患轻度PKU和轻度HPA且有R241C基因位点的病人,都对BH4治疗有反应。在无BH4反应性的典型PKU病人中未发现R241C、P407S和A373T基因突变。结论1周BH4负荷试验用于诊断BH4反应性PAH缺乏症最为有效。等位基因R241C、P407S和A373T与轻度HPA和轻度PKU病人具有H4反应性有关。BH4治疗是针对轻度HPA和轻度PKU的一种新颖、有效的药物治疗,有望代替限制苯丙氨酸饮食的方法。

关键词：苯丙氨酸尿症四氢生物蝶呤突变基因儿童

Use of cone-shaped polypropylene mesh for perineal herniorrhaphy in dogs

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畜牧与兽医 2012年第S2期44卷 43-43页

作者： Kenji Teshima Kazushi Asano Kumiko Ishigaki Mamiko Seki Takahiro Suzuki Seri Komazaki Gentoku Iida Orie yoshida Kazuya Edamura shigeo Tanaka Animal Medical Center Nihon University Laboratory of Veterinary Surgery Department of Veterinary MedicineCollege of Bioresource SciencesNihon University Laboratory of Comprehensive Veterinary Clinical Studies Department of Veterinary MedicineCollege of Bioresource SciencesNihon University

Unilateral or bilateral perineal hernia results from the failure of the muscular pelvic diaphragm,and is commonly observed in male *** study aimed to investigate the outcome of herniorrhaphy technique with the cone-shaped polypropylene mesh in dogs with perineal hernia.1 Materials and Methods Between October 2008 and July 2012,39 dogs(71 perineal hernias)underwent herniorrhaphy with polypropylene mesh(PROLENE MeshJohnson&Johnson)formed in the shape of a *** apex of corn-shaped mesh was inserted into the hernia region,and the bottom was sutured to sacrotuberous ligament,internal obturator muscle,external anal sphincter and residual coccygeal muscle.

关键词： polypropylene shaped hernia muscular bilateral obturator sphincter inserted ligament diaphragm