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Characterization of Three Homoeologous cDNAs Encoding Chloroplast-targeted Aminolevulinic Acid Dehydratase in Common Wheat

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Journal of Integrative Plant Biology 2011年第12期53卷 942-950页

作者： Yu Takenouchi Haruka Nakajima Kengo Kanamaru shigeo takumi Laboratory of Plant Genetics Graduate School of Agricultural Science Kobe University Kobe 657-8501 Japan Laboratory of Biological Chemistry Graduate School of Agricultural Science Kobe University Kobe 657-8501 Japan

In the tetrapyrrole biosynthetic pathway of higher plants, 5-aminolevulinic acid （ALA） is metabolized by ALA dehydratase （ALAD）. Here, we isolated ALAD1 cDNA from common wheat （Triticum aestivum L.） and its diploid progenitors, and produced transgenic tobacco plants expressing the wheat ALAD1 gene. The ALAD1 genes were highly conserved among wheat relatives, and three homoeologous loci of wheat ALAD1 （TaALAD1） were equally transcribed in common wheat. A transient expression assay of a TaALAD1-GFP （green fluorescent protein） fusion protein suggested that TaALAD1 is localized in chloroplasts. Overexpression of TaALAD1 in transgenic tobacco resulted in a significant increase in ALAD activity in leaves. Moreover, the transgenic tobacco showed vigorous growth and increased survival rate on medium containing ALA at herbicidal concentrations. These results indicate that wheat ALAD1 has catalytic activity in metabolizing ALA in plastids, and that ectopic expression of TaALAD1 in transgenic plants increases their tolerance to ALA application at high concentrations.

关键词： 5-aminolevulinic acid chloroplast targeting herbicide resistance transgenic tobacco Triticum aestivum 5-aminolevulinic acid dehydratase transcriptional control

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An ever-increasing metabolic dysfunction-associated fatty liver disease-related hepatocellular carcinoma:what are problems and countermeasures?

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 941-944页

作者： shigeo Shimose Tsubasa Tsutsumi Dan Nakano Tomoya Sano Keisuke Amano takumi Kawaguchi Division of Gastroenterology Department of MedicineKurume University School of MedicineKurumeJapan

Hepatocellular carcinoma(HCC)is the third leading cause of cancer deaths worldwide(1).HCC has been classified into viral or non-viral HCC according to the etiology and the incidence of viral HCC is *** contrast,the incidence of non-viral HCC is increasing and fatty liver is becoming a major etiology for the *** 2020,a new concept of fatty liver disease,metabolic dysfunction-associated fatty liver disease(MAFLD).

关键词： Hepatoma hepatic steatosis metabolic syndrome viral hepatitis lenvatinib(LEN)

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Challenges and prospects in prediction and treatment for hepatocellular carcinoma with microvascular invasion

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Hepatobiliary Surgery and Nutrition 2019年第6期8卷 651-654页

作者： takumi Kawaguchi shigeo Shimose Takuji Torimura Division of Gastroenterology Department of MedicineKurume University School of MedicineKurumeJapan

Microvascular invasion(MVI)is an independent risk factor for early recurrence of hepatocellular carcinoma(HCC)after local treatment as well as poor prognosis in patients with HCC(1-3).MVI is an important factor for management of patients with HCC;however,MVI is based on a histopathological diagnosis using resected surgical specimens and is thus difficult to determine ***,Lee et *** a new MVI risk score using the following 4 non-histological parameters:(I)alpha-fetoprotein(AFP);(II)protein induced by vitamin K absence-II(PIVKA-II);(III)arterial peritumoral enhancement on hepatobiliary phase of magnetic resonance imaging(MRI);(IV)peritumoral hypointensity on hepatobiliary phase of MRI(4).They also reported that,in HCC patients with MVI,the HCC recurrence rate was lower in patients treated with hepatic resection than with radiofrequency ablation(RFA)and proposed that patients with HCC who were at high risk of MVI should be treated with hepatic resection rather than RFA(4).This editorial summarizes the recent progress of the prediction method for MVI and discusses the therapeutic strategy for small HCC with MVI.

关键词： vitamin diagnosis treatment

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