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World Journal of Gastroenterology 2014年第12期20卷 3335-3342页

作者： Masayuki Ishii Toru Mizuguchi Masaki Kawamoto Makoto Meguro shigenori ota Toshihiko Nishidate Kenji Okita Yasutohsi Kimura Thomas T Hui Koichi Hirata Department of Surgery Surgical Oncology and ScienceSapporo Medical University Hospital Sapporo Medical University Department of Surgery Children’s Hospital and Research Center Oakland

AIM: To compare the prognoses of hepatocellular carcinoma (HCC) patients that underwent anatomic liver resection (AR) or non-anatomic liver resection (NAR) using propensity score-matched populations.

关键词： Anatomical liver resection Propensity score analysis Hepatocellular carcinoma

Current standard values of health utility scores for evaluating costeffectiveness in liver disease:A meta-analysis

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World Journal of Gastroenterology 2022年第31期28卷 4442-4455页

作者： Tomohiro Ishinuki shigenori ota Kohei Harada Masaki Kawamoto Makoto Meguro Goro Kutomi Hiroomi Tatsumi Keisuke Harada Koji Miyanishi Toru Kato Toshio Ohyanagi Thomas T Hui Toru Mizuguchi Department of Nursing Surgical SciencesSapporo Medical UniversitySapporo 0608556Japan Departments of Surgery Surgical Science and OncologySapporo Medical UniversitySapporo 0608543Japan Department of Radiology Sapporo Medical UniversitySapporo 0608543Japan Departments of Surgery Nemuro City HospitalNemuro 0870008Japan Departments of Surgery Sapporo Satozuka HospitalSapporo 0040811Japan Department of Intensive Care Medicine Sapporo Medical UniversitySapporo 0608543Japan Department of Emergency Medicine Sapporo Medical UniversitySapporo 0608543Japan Department of Medical Oncology Sapporo Medical UniversitySapporo 0608543Japan Department of Liberal Arts and Sciences Center for Medical EducationSapporo Medical UniversitySapporo 0608556Japan Departments of Surgery Stanford University School of MedicineStanford94598United States

BACKGROUND Health utility assessments have been developed for various conditions,including chronic liver *** utility scores are required for socio-economic evaluations,which can aid the distribution of national ***,the standard health utility assessment scores for specific health conditions are largely *** To summarize the health utility scores,including the EuroQOL 5-dimensions 5-levels(EQ-5D-5L),EuroQol-visual analogue scale,short from-36(SF-36),RAND-36,and Health Utilities Index(HUI)-Mark2/Mark3 scores,for the normal population and chronic liver disease *** A systematic literature search of PubMed and MEDLINE,including the Cochrane Library,was ***-analysis was performed using the RevMan *** means and standard deviations were combined using the StatsToDo online web *** The EQ-5D-5L and SF-36 can be used for health utility evaluations during antiviral therapy for hepatitis ***-Mark2/Mark3 indicated that the health utility scores of hepatitis B patients are roughly 30% better than those of hepatitis C *** The EQ-5D-5L is the most popular questionnaire for health utility *** assessments that allow free registration would be useful for evaluating health utility in patients with liver disease.

关键词： Quality of life EuroQOL 5-dimensions 5-levels Short from-36 RAND-36 Health Utilities Index-Mark

Low-dose steroid pretreatment ameliorates the transient impairment of liver regeneration

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World Journal of Gastroenterology 2012年第9期18卷 905-914页

作者： Toshihito Shibata Toru Mizuguchi Yukio Nakamura Masaki Kawamoto Makoto Meguro shigenori ota Koichi Hirata Hidekazu Ooe Toshihiro Mitaka Department of Surgery Ⅰ Sapporo Medical University Hospital Department of Tissue Development and Regeneration Molecular PathophysiologyFrontier Medical Research InstituteSapporo Medical University School of Medicine

AIM： To determine if liver regeneration （LR） could be dis- turbed following radiofrequency （RF） ablation and whe- ther modification of LR by steroid administration occurs.

关键词： Liver regeneration Radiofrequency ablation Steroid Tumor necrosis factor Hepatectomy

Energy-efficient buffer and service rate allocation in manufacturing systems using hybrid machine learning and evolutionary algorithms

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Advances in Manufacturing 2024年第2期12卷 227-251页

作者： Si-Xiao Gao Hui Liu Jun ota Key Laboratory of Traffic Safety on Track of Ministry of Education Institute of Artificial Intelligence and Robotics(IAIR)School of Traffic and Transportation EngineeringCentral South UniversityChangsha410075People’s Republic of China Research into Artifacts Center for Engineering School of EngineeringThe University of TokyoTokyoJapan

Currently,simultaneous buffer and service rate allocation is a topic of interest in the optimization of manufacturing *** allocation problems have been solved previously to satisfy economic requirements;however,owing to the progress of green manufacturing,energy conservation and environmental protection have become increasingly ***,an energy-efficient approach is developed to maximize the throughput and minimize the energy consumption of manufacturing systems,subject to the total buffer capacity,total service rate,and predefined energy *** energy-efficient approach integrates the simulated annealing-non-dominated sorting genetic algorithm-II with the honey badger algorithm-histogram-based gradient boosting regression *** former algorithm searches for Pareto-optimal solutions of sufficient *** latter algorithm builds prediction models to rapidly calculate the throughput,energy consumption,and energy *** examples show that the proposed hybrid approach can achieve a better solution quality compared with previously reported ***,the prediction models can rapidly evaluate manufacturing systems with sufficient *** study benefits the multi-objective optimization of green manufacturing systems.

关键词： Energy-efficient allocation Multi-objective optimization Energy efficiency Energy consumption Machine learning

Prognostic roles of preoperative α-fetoprotein and des-γ-carboxy prothrombin in hepatocellular carcinoma patients

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World Journal of Gastroenterology 2015年第16期21卷 4933-4945页

作者： Makoto Meguro Toru Mizuguchi Toshihiko Nishidate Kenji Okita Masayuki Ishii shigenori ota Tomomi Ueki Emi Akizuki Koichi Hirata Department of Surgery Surgical Oncology and ScienceSapporo Medical University School of Medicine

AIM:To clarify the utility of using des-γ-carboxy prothrombin(DCP)andα-fetoprotein(AFP)levels to predict the prognosis of hepatocellular carcinoma(HCC)in patients with hepatitis B virus(HBV)and the hepatitis C virus(HCV)***:A total of 205 patients with HCC(105patients with HBV infection 100 patients with HCV infection)who underwent primary hepatectomy between January 2004 and May 2012 were enrolled *** AFP and DCP levels were used to create interactive dot diagrams to predict recurrence within 2 years after hepatectomy,and cutoff levels were *** in the HBV and HCV groups were classified into three groups:a group with low AFP and DCP levels(LL group),a group in which one of the two parameters was high and the other was low(HL group),and a group with high AFP and DCP levels(HH group).Liver function parameters,the postoperative recurrence-free survival rate,and postoperative overall survival were compared between *** survival curves were compared by logrank test using the Kaplan-Meier *** analysis using a Cox forward stepwise logistic regression model was conducted for a ***:The preoperative AFP cutoff levels for recurrence within 2 years after hepatectomy in the HBV and HCV groups were 529.8 ng/m L and 60 m AU/m L,respectively;for preoperative DCP levels,the cutoff levels were 21.0 ng/m L in the HBV group and 67 m AU/m L in the HCV *** HBV group was significantly different from the other groups in terms of vascular invasion,major hepatectomy,volume of intraoperative blood loss,and surgical *** differences were found between the LL group,the HL group,and the HH group in terms of both mean disease-free survival time(MDFST)and mean overall survival time(MOST):64.81±7.47 vs 36.63±7.62 vs 18.98±6.17mo(P=0.001)and 85.30±6.55 vs 59.44±7.87 vs46.57±11.20 mo(P=0.018).In contrast,the HCV group exhibited a significant difference in tumor size,vascular invasion,volu

关键词： Hepatocellular carcinoma Hepatitis B Hepatitis C Des-γ-carboxy prothrombin α-fetoprotein

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World Journal of Meta-Analysis 2021年第1期9卷 88-100页

作者： Tomohiro Ishinuki shigenori ota Kohei Harada Hiroomi Tatsumi Keisuke Harada Koji Miyanishi MinoruNagayama Ichiro Takemasa Toshio Ohyanagi Thomas T Hui Toru Mizuguchi Department of Nursing Surgical SciencesSapporo Medical UniversitySapporo 060-8556Japan Departments of Surgery Surgical Science and OncologySapporo Medical UniversitySapporo 060-8543Japan Division of Radiology Sapporo Medical UniversitySapporo 060-8543Japan Department of Intensive Care Medicine Sapporo Medical University HospitalSapporo 060-8543Japan Department of Emergency Medicine Sapporo Medical University HospitalSapporo 060-8543Japan Department of Medical Oncology Sapporo Medical University HospitalSapporo 060-8543Japan Department of Liberal Arts and Sciences Center for Medical EducationSapporo Medical UniversitySapporo 060-8556Japan Department of Surgery Division of Pediatric SurgeryStanford University School of MedicineStanfordCA 94598United States

BACKGROUND Mortality after hepatectomy has decreased,and the quality of various surgical approaches to hepatectomy have been *** assessments of quality of life(QOL)after hepatectomy have been developed and investigated in different clinical *** To conduct a systematic review and meta-analysis to examine two clinical topics:Laparoscopic hepatectomy vs open hepatectomy,and preoperative QOL status vs postoperative QOL *** A systematic literature search was performed using PubMed and MEDLINE,including the Cochrane Library *** following inclusion criteria were set for inclusion in this meta-analysis:(1)Studies comparing preoperative QOL and postoperative QOL;and(2)Studies comparing QOL between laparoscopic hepatectomy and open *** A total of 8 articles were included in this *** was better after laparoscopic hepatectomy than after open *** The outcomes of evaluations of QOL after hepatectomy can depend on the type of questionnaire used,the timing of the assessment,and the etiology of the hepatic disease.

关键词： Quality of life Hepatectomy Laparoscopy Transarterial chemoembolization Functional Assessment of Cancer Therapy–Hepatobiliary 36-Item Short-Form Health Survey European Organisation for Research and Treatment of Cancer Quality of Life Core Questionnaire

Maturation of robotic liver resection during the last decade:A systematic review and meta-analysis

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World Journal of Meta-Analysis 2021年第5期9卷 462-473页

作者： Tomohiro Ishinuki shigenori ota Kohei Harada Makoto Meguro Masaki Kawamoto Goro Kutomi Hiroomi Tatsumi Keisuke Harada Koji Miyanishi Ichiro Takemasa Toshio Ohyanagi Thomas T Hui Toru Mizuguchi Department of Nursing Surgical SciencesSapporo Medical UniversitySapporo 0608556HokkaidoJapan Departments of Surgery Surgical Science and OncologySapporo Medical UniversitySapporo 0608543HokkaidoJapan Division of Radiology Sapporo Medical UniversitySapporo 060-8543HokkaidoJapan Departments of Surgery Sapporo Satozuka HospitalSapporo 0048686Japan Departments of Surgery Nemuro City HospitalNemuro 0878686HokkaidoJapan Department of Surgery School of MedicineSapporo Medical UniversitySapporo 0608543HokkaidoJapan Department of Intensive Care Medicine Sapporo Medical University HospitalSapporo 0608543HokkaidoJapan Department of Emergency Medicine Sapporo Medical UniversitySapporo 0606543HokkaidoJapan Department of Medical Oncology Sapporo Medical UniversitySapporo 0608543HokkaidoJapan Department of Liberal Arts and Sciences Center for Medical EducationSapporo Medical UniversitySapporo 0608556HokkaidoJapan Department of Surgery Division of Pediatric SurgeryStanford University School of MedicineStanfordCA 94598United States

BACKGROUND Minimally invasive hepatectomy techniques have developed rapidly since *** laparoscopic liver resection(LLR)has become the primary approach for managing liver tumors and procuring donor organs for liver *** liver resection(RLR)has emerged during the last *** technical status of RLR seems to be *** To conduct a systematic review and meta-analysis comparing the short-term clinical outcomes of LLR and RLR over two 5-year *** A systematic literature search was performed using PubMed and Medline,including the Cochrane *** following inclusion criteria were set for the meta-analysis:(1)Studies comparing LLR vs RLR;and(2)Studies that described clinical outcomes,such as the operative time,intraoperative bleeding,intraoperative conversion rate,and postoperative *** A total of 25 articles were included in this meta-analysis after 40 articles had been subjected to full-text *** studies were divided into early(n=14)and recent(n=11)*** the recent group,the operative time did not differ significantly between LLR and RLR(P=0.70),whereas in the early group the operative time of LLR was significantly shorter than that of RLR(P<0.001).CONCLUSION The initial disadvantages of RLR,such as its long operation time,have been overcome during the last 5 *** other clinical outcomes of RLR are comparable to those of *** cost and quality-of-life outcomes of RLR should be evaluated in future studies to promote its routine clinical use.

关键词： Hepatectomy Laparoscopy Robot Operation time

No-touch isolation technique in emergency pancreaticoduodenectomy for neoplastic hemorrhage: Two case reports and review of literature

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1910-1917页

作者： Akihiro Cho Satoshi Katagiri Masao ota Shunsuke Onizawa Ryota Higuchi Toshiya Sugishita Yukiko Niwa Takeshi Ishita Toshihiko Mouri Akita Kato Moe Iwata Division of Gastroenterological Surgery Tokyo Women’s Medical UniversityYachiyo Medical CenterChiba 276-8524Japan

BACKGROUND Emergency pancreaticoduodenectomy(EPD)is a rare event for complex periam-pullary *** intraoperative blood loss is correlated with poor post-operative *** SUMMARY Two patients underwent EPD using a no-touch isolation technique,in which all arteries supplying the pancreatic head region were ligated and divided before manipulation of the pancreatic head and *** operative times were 220 and 239 min,and the blood loss was 70 and 270 g,*** patients were discharged on the 14^(th) and 10^(th) postoperative day,***-two patients underwent EPD for the treatment of neoplastic *** mean operative time was 361.6 min,and the mean blood loss was 747.3 *** comp-lication rate was 37.5%.The in-hospital mortality rate was 9.38%.CONCLUSION The no-touch isolation technique is feasible,safe,and effective for reducing intraoperative blood loss in EPD.

关键词： No-touch isolation technique Pancreaticoduodenectomy Emergency pancre-aticoduodenectomy Neoplastic bleeding Superior mesenteric artery first approach Case report

Comprehensive review of post-liver resection surgical complications and a new universal classification and grading system

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World Journal of Hepatology 2014年第10期6卷 745-751页

作者： Masayuki Ishii Toru Mizuguchi Kohei Harada shigenori ota Makoto Meguro Tomomi Ueki Toshihiko Nishidate Kenji Okita Koichi Hirata Department of Surgery Surgical Oncology and ScienceSapporo Medical University Postgraduate School of Medicine

Liver resection is the gold standard treatment for certain liver tumors such as hepatocellular carcinoma and metastatic liver tumors. Some patients with such tumors already have reduced liver function due to chronic hepatitis, liver cirrhosis, or chemotherapy-associated steatohepatitis before surgery. Therefore, complications due to poor liver function are inevitable after liver resection. Although the mortality rate of liver resection has been reduced to a few percent in recent case series, its overall morbidity rate is reported to range from 4.1% to 47.7%. The large degree of variation in the post-liver resection morbidity rates reported in previous studies might be due to the lack of consen-sus regarding the definitions and classification of postliver resection complications. The Clavien-Dindo(CD) classification of post-operative complications is widely accepted internationally. However, it is hard to apply to some major post-liver resection complications because the consensus definitions and grading systems for posthepatectomy liver failure and bile leakage established by the International Study Group of Liver Surgery are incompatible with the CD classification. Therefore, a unified classification of post-liver resection complications has to be established to allow comparisons between academic reports.

关键词： Complication Liver failure Bile leakage Renal failure Ascites Coagulation disorder Surgical site infection

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日本站前广场的建设特征及对我国的启示

都市快轨交通 2024年第3期37卷 170-177页

作者：马飞太田充徐畅日本筑波大学系统情报工学院日本筑波北京大学城市规划与设计学院广东深圳518055

随着中国轨道交通和城市化进程的不断发展,单一功能的站前广场规划已无法满足当下多样化的城市建设需求。本研究通过对日本站前广场的建设历史和相关规划标准的梳理,针对日本多个不同级别城市的站前广场进行实地调研,并且分析代表性案... 详细信息

随着中国轨道交通和城市化进程的不断发展,单一功能的站前广场规划已无法满足当下多样化的城市建设需求。本研究通过对日本站前广场的建设历史和相关规划标准的梳理,针对日本多个不同级别城市的站前广场进行实地调研,并且分析代表性案例的空间规划和开发方式,总结出日本站前广场的规划经验:重视站前广场在站城一体化开发中的空间调节作用,根据规划需求调整广场的城市功能;广场建设要结合站点周边地区发展特点,注重广场的灵活布局和多样化利用;广场规划各阶段设立合作组织,注重广场各建设部门的相互沟通和责任划分以及制定持续的利用者参与机制和完善的广场运营制度等,以期为中国轨道交通可持续发展和合理的城市空间规划提供参考和借鉴。

关键词：日本铁路公共交通城市空间站点开发站前广场