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Early effects of oral administration of omeprazole and roxatidine on intragastric pH

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第1期13卷 29-34页

作者： Hiroshi iida Shingo KATO Yusuke SEKINO Eiji SAKAI Takashi UCHIYAMA Hiroki ENDO Kunihiro HOSONO Yasunari SAKAMOTO Koji FUJITA Masato YONEDA Tomoko KOIDE Hirokazu TAKAHASHI Chikako TOKORO Ayumu GOTO Yasunobu ABE Noritoshi KOBAYASHI Kensuke KUBOTA Eiji GOTOH Shin MAEDA Atsushi NAKAJIMA Masahiko INAMORI Gastroenterology Division Yokohama City University School of Medicine Department of Medical Education Yokohama City University School of Medicine Office of Postgraduate Medical Education Yokohama City University Hospital

Objective:The ideal medication for the treatment of acid-related diseases,e.g.,peptic ulcers,stress-related gastric bleeding,functional dyspepsia,and gastroesophageal reflux disease,should have a rapid onset of action to promote hemostasis and relieve the *** aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor,omeprazole 20 mg,and an H2-receptor antagonist,roxatidine 75 ***:Ten Helicobacter pylori-negative male subjects participated in this randomized,two-way crossover *** pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 *** administration was separated by a 7-d washout ***:During the 6-h study period,the average pH after administration of roxatidine was higher than that after administration of omeprazole(median:4.45 vs.2.65;P=0.0367).Also during the 6-h study period,a longer duration of maintenance at pH above 2,5,and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg(median:90.6% vs.55.2%,P=0.0284;43.7% vs.10.6%,P=0.0125;40.3% vs.3.3%,P=0.0125;respectively).Conclusions:In Helicobacter pylori-negative healthy male subjects,oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg.

关键词：奥美拉唑胃溃疡 pH值口服早期质子泵抑制剂相关性疾病受体拮抗剂

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Influence of a Program Combining Amusement and Exercise on Subjective Well-Being: Six-Month Intervention Study with a Complex-Type Program for Community-Dwelling Elderly Subjects

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Open Journal of Preventive Medicine 2018年第8期8卷 266-281页

作者： Nami Kawabata Tadayuki iida Hideki Miyaguchi Masafumi Kunishige Chinami Ishizuki Hiroko Hashimoto Yasuhiro Ito Toshihide Harada Program in Biological System Sciences Graduate School of Comprehensive Scientific Research Prefectural University of Hiroshima Shobara Japan Department of Rehabilitation/Occupational Therapist Faculty of Health Sciences Hiroshima Cosmopolitan University Hiroshima Japan Department of Physical Therapy Faculty of Health and Welfare Prefectural University of Hiroshima Mihara Japan Department of Human Behavior Science of Occupational Therapy Health Sciences Major Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Division of Occupational Therapy Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Department of Occupational Therapy Faculty of Health Sciences Morinomiya University of Medical Sciences Osaka Japan School of Health Sciences Fujita Health University Toyoake Japan

Background: Health promotion for the elderly mainly targets improvements in physical function, and a lack of strengthening of subjective well-being as well as the creation of interaction-providing opportunities for activity and participation has been reported. Evaluations of positive and negative aspects for subjective well-being are needed. Elderly subjects were intervened through a 6-month complex-type program combining amusement and exercise and its influences on subjective well-being and physical and physiological functions were investigated. Methods: Subjects in this survey were 37 healthy elderly females living in M city, Hiroshima Prefecture (age: 69.7 ± 5.9 years old), and the survey was performed between September 2016 and March 2017. The complex-type program comprised amusement and exercise programs. The survey was performed at 4 time points during the intervention period: before the intervention and 1, 3, and 6 months during the intervention. Subjective well-being (Japanese version of the Subjective Well-being Inventory (SUBI): Mental health scores, Mental fatigue scores), salivary amylase levels, and the locomotive syndrome risk test (two-step test, stand-up test, and 25-question risk assessment) were surveyed at each time point. Regarding the duration of the intervention as a factor, changes in salivary amylase levels were analyzed using repeated measures one-way ANOVA and SUBI was tested using the Friedman test (EZR Ver 1.32). In addition, the relationship between the locomotive syndrome risk level and duration of the intervention was examined using Fisher’s test. Results: SUBI and the locomotive syndrome risk level significantly differed with time during the intervention. Slight changes were observed in salivary amylase levels during the intervention. Conclusion: The present results suggest that the complex-type program promoted interactions among community-dwelling elderly subjects and positively influenced the maintenance of and improvements in phys

关键词： Subjective Well-Being SUBI The Elderly Amusement Exercise

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STE—2反场箍缩极向偏滤器实验的首批结果

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国外核聚变与等离子体应用 1995年第1期 23-27页

作者： iida.,M 胡明

已在有一个外偏滤器室的放电容器中产生了有单极向零的反场箍缩。在目前的实验中没有装上导电壳。极向偏滤器位形维持的时间为壁的时间常数，在磁起伏中ｍ＝１撕裂模的优势不受偏滤器位形的影响。采用偏滤器位形和在偏滤器电流达到主等... 详细信息

已在有一个外偏滤器室的放电容器中产生了有单极向零的反场箍缩。在目前的实验中没有装上导电壳。极向偏滤器位形维持的时间为壁的时间常数，在磁起伏中ｍ＝１撕裂模的优势不受偏滤器位形的影响。采用偏滤器位形和在偏滤器电流达到主等离子体电流的３０％的情况下，极向偏滤器都没有引起对等离子体性能的有害效应。

关键词：反场箍缩极向偏滤器偏滤器位形电流

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空气弹簧在无气状态下铁道车辆仿真模型的建立

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国外铁道车辆 2020年第5期57卷 29-34页

作者： [日]Tadanobu iida 周冬妍(译) 赵云生(校) 不详

介绍了铁道车辆用空气弹簧在无气状态下的运行试验结果并建立了无气空气弹簧仿真模型。通过对比仿真结果与试验结果,验证了仿真模型的有效性。

关键词：铁道车辆空气弹簧仿真日本

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论出口主导型经济的脆弱性

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日本研究 2009年第3期 37-39页

作者：饭田和人崔岩日本明治大学政治经济学部

在本次国际金融危机的影响下,日本实体经济在出口大幅度下降的影响下出现了急速的下滑。其原因需要深入到日本经济的内在结构中加以分析。在2002年以来的本次经济周期复苏阶段,表现为外需主导型,但是究其内容看却与以往的外需主导有着... 详细信息

在本次国际金融危机的影响下,日本实体经济在出口大幅度下降的影响下出现了急速的下滑。其原因需要深入到日本经济的内在结构中加以分析。在2002年以来的本次经济周期复苏阶段,表现为外需主导型,但是究其内容看却与以往的外需主导有着很大的不同,即外需扩大并没有能够拉动内需,因而经济复苏的力度是微弱的。其背后的原因在于全球资本的全方位配置弱化了出口拉动内需的力量,以及美国国内的过剩消费。此外,其他的原因还表现为雇用质量的下降等。

关键词：全球资本出口主导型经济东亚生产网络

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Tetraquark and Pentaquark Systems in Lattice QCD

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Journal of Modern Physics 2016年第8期7卷 774-789页

作者： Fumiko Okiharu Takumi Doi Hiroko Ichie Hideaki iida Noriyoshi Ishii Makoto Oka Hideo Suganuma Toru T. Takahashi Faculty of Education Niigata University Niigata Japan Theoretical Research Division Nishina Center RIKEN Wako Japan Department of Physics Tokyo Institute of Technology Tokyo Japan Research and Education Center for Natural Sciences Keio University Kanagawa Japan Research Center for Nuclear Physics (RCNP) Osaka University Ibaraki Japan Department of Physics Graduate School of Science Kyoto University Kyoto Japan Gunma National College of Technology Maebashi Japan

We study multi-quark systems in lattice QCD. First, we revisit and summarize our accurate mass measurements of low-lying 5Q states with J = 1/2 and I = 0 in both positive- and negative-parity channels in anisotropic lattice QCD. The lowest positive-parity 5Q state is found to have a large mass of about 2.24 GeV after the chiral extrapolation. To single out the compact 5Q state from NK scattering states, we use the hybrid boundary condition (HBC), and find no evidence of the compact 5Q state below 1.75 GeV in the negative-parity channel. Second, we study the multi-quark potential in lattice QCD to clarify the inter-quark interaction in multi-quark systems. The 5Q potential V5Q for the QQ--QQ system is found to be well described by the “OGE Coulomb plus multi-Y Ansatz”: The sum of the one-gluon-exchange (OGE) Coulomb term and the multi-Y-type linear term based on the flux-tube picture. The 4Q potential V4Q for the QQ- system is also described by the OGE Coulomb plus multi-Y Ansatz, when QQ and are well separated. The 4Q system is described as a “two-meson” state with disconnected flux tubes, when the nearest quark and antiquark pair are spatially close. We observe a lattice-QCD evidence for the “flip-flop”, i.e., the fluxtube recombination between the connected 4Q state and the “two-meson” state. On the confinement mechanism, the lattice QCD results indicate the flux-tube-type linear confinement in multi-quark hadrons. Finally, we propose a proper quark-model Hamiltonian based on the lattice QCD results.

关键词： Lattice QCD Multi-Quarks Quark Confinement Exotic Hadrons

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Expression of 5-Lipoxygenase in human colorectal cancer

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World Journal of Gastroenterology 2006年第39期12卷 6355-6360页

作者： Labile Togba Soumaoro Satoru iida Hiroyuki Uetake Megumi Ishiguro Yoko Takagi Tetsuro Higuchi Masamichi Yasuno Masayuki Enomoto Kenichi Sugihara Department of Surgical Oncology Graduate School Tokyo Medical and Dental University Tokyo 113-8519 Japan Department of Translational Oncology Graduate School Tokyo Medical and Dental University Tokyo 113-8519 Japan

AIM: To evaluate the 5-lipoxygenases (Loxs) expression level in human colorectal cancer specimens in order to determine its clinicopathologic significance in human tumorigenesis. METHODS: The relative quantity of 5-Lox mRNA in paired 91 colorectal tumor and adjacent normal mucosa samples was determined by real time quantitative PCR. Additionally, the expression of 5-Lox and cyclooxygenase (Cox)-2 proteins was also examined using immunohistochemical staining methods. RESULTS: There was a marked increase in 5-Lox mRNA levels in the tumor compared with paired normal mucosa samples (P < 0.0001). Sixty six (72.5%) tumors showed high 5-Lox mRNA levels. The positivity rate of 5-Lox and Cox-2 protein expression was 68.7% and 79.1% respectively. There was a significant association between tumoral 5-Lox mRNA level and tumor size (Rho = 0.392, P = 0.0002), depth or vessel invasion. CONCLUSION: These results suggest that 5-Lox is up-regulated in colorectal cancer and that inhibition of its expression might be valuable in the prevention and treatment of colorectal cancer.

关键词： 5-脂肪氧合酶结肠癌直肠癌环氧合酶-2

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rare type of pancreatitis as the first presentation ofanti-neutrophil cytoplasmic antibody-related vasculitis

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World Journal of Gastroenterology 2016年第7期22卷 2383-2390页

作者： Tomoya iida Takeya Adachi Tetsuya Tabeya Suguru Nakagaki Takashi Yabana Akira Goto Yoshihiro Kondo Kiyoshi Kasai Department of Gastroenterology Otaru City General HospitalOtaruHokkaido 047-8550Japan Department of Internal Medicine of Connective Tissue Disease Otaru City General HospitalOtaruHokkaido 047-8550Japan Department of Diagnostic Pathology Otaru City General HospitalOtaruHokkaido 047-8550Japan

A pancreatic tumor was suspected on the abdominal ultrasound of a 72-year-old man. Abdominal computed tomography showed pancreatic enlargement as well as a diffuse, poorly enhanced area in the pancreas; endoscopic ultrasound-guided fine needle aspiration biopsy and endoscopic retrograde cholangiopancreatography failed to provide a definitive diagnosis. Based on the trend of improvement of the pancreatic enlargement, the treatment plan involved follow-up examinations. Later, he was hospitalized with an alveolar hemorrhage and rapidly progressive glomerulonephritis; he tested positive for myeloperoxidase-anti-neutrophil cytoplasmic antibody(ANCA) and was diagnosed with ANCArelated vasculitis, specifically microscopic polyangiitis. It appears that factors such as thrombus formation caused by the vasculitis in the early stages of ANCArelated vasculitis cause abnormal distribution of the pancreatic blood flow, resulting in non-uniform pancreatitis. Pancreatic lesions in ANCA-related vasculitis are very rare. Only a few cases have been reported previously. Therefore, we report our case and a review of the literature.

关键词： pancreas Pancreatitis Antibodies Antineutrophilcytoplasmic Vasculitis Microscopic polyCASE angiitis

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A Case of Acute Cauda Equina Syndrome for Combined Lumbar Ossification of the Posterior Longitudinal and Yellow Ligament

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Open Journal of Orthopedics 2014年第6期4卷 145-149页

作者： Kazumasa Nakamura Yuichirou Yokoyama Akihito Wada Yasuhiro Inoue Keiji Hasegawa Shintaro Tsuge Hiroshi Takahashi Yasuaki iida Department of Orthopaedic Surgery School of Medicine Toho University Tokyo Japan

Acute cauda equina syndrome is known as a symptom of lumbar disc herniation, but to date, there have been no reports of cases caused by lumbar vertebral ligament ossification. We encountered a 61-year-old female patient with acute cauda equina syndrome associated with lumbar vertebral OPLL and OLF. The symptoms were improved by emergency laminectomy. One year after the surgery, the disturbances of gait and urination have been resolved.

关键词： Lumbar Spine Ossification of the Yellow Ligament Ossification of the Posterior Longitudinal Ligament Cauda Equina Syndrome

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Over-the-scope-clipping system for anastomotic leak after colorectal surgery:Report of two cases

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World Journal of Gastroenterology 2014年第24期20卷 7984-7987页

作者： Hirotoshi Kobayashi Akifumi Kikuchi Satoshi Okazaki Megumi Ishiguro Toshiaki Ishikawa Satoru iida Hiroyuki Uetake Kenichi Sugihara Center for Minimally Invasive Surgery Tokyo Medical and Dental UniversityTokyo 113-8519Japan Department of Surgical Oncology Graduate SchoolTokyo Medical and Dental UniversityTokyo 113-8519Japan Department of Translational Oncology Graduate SchoolTokyo Medical and Dental UniversityTokyo 113-8519Japan

An anastomotic leak is one of the major complications following colorectal *** treatments for anastomotic leak are total parenteral nutrition or temporary *** over-the-scope-clipping(OTSC)system was originally developed to treat intestinal perforation or to close the tissue after natural orifice transluminal endoscopic *** cases of successful management of an anastomotic leak after colorectal surgery using the OTSC system are *** patient avoided a temporary *** the other,hospitalization was shortened by the use of the OTSC *** OTSC system can be a potential option in the management of anastomotic leaks after colorectal surgery.

关键词： Over-the-scope-clipping Colorectal cancerAnastomot

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