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Subjective symptoms related to depression and suicidal risk in a Japanese community: a cross-sectional study

Open Journal of Psychiatry 2011年第2期1卷 40-48页

作者： shigeki takemura Kouichi Yoshimasu Jin Fukumoto Hiroichi Yamamoto Kazuhisa Miyashita 不详

BACKGROUND: This cross-sectional study aimed to assess the association between self-reported somatic and mental symptoms and the presence of major depressive disorder (MDD) and suicidal risk among community dwellers in Japan. METHODS: From two locations in Japan, we recruited 734 community dwellers who underwent an annual health screening. Basic symptoms of MDD, dysthymia, and the presence of associated suicidal risk were determined using a brief structured diagnostic psychiatric interview, Mini International Neuropsychiatric Interview (MINI). Information regarding self-reported somatic and mental symptoms was obtained from a self-administered questionnaire used in the annual health check-up. Suicidal risk was evaluated on the basis of six relevant questions asked in MINI. Logistic regression model was used to calculate age- and gender-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for MDD. Further adjustment for basic symptoms of MDD was performed to calculate ORs and CIs for suicidal risk. RESULTS: A myriad of somatic symptoms, including headache, heavy headedness, eye strain, and shoulder stiffness [adjusted OR (95% CI), 11.4 (1.22 - 107) at location 1;5.17 (1.23 - 21.7) at location 2], were associated with the presence of MDD. Dysmenorrhea [6.07 (1.14 - 32.3) at location 1] and dysesthesia, arthralgia, and swelling in the extremities [2.72 (1.14 - 6.47) at location 2] were significantly associated with an increase in suicidal risk, independent of the presence of basic symptoms of MDD. CONCLUSION: Several somatic symptoms, especially pain-related ones, may serve as possible signs of depression and suicidal risk among community dwellers.

关键词： Epidemiology Somatic Symptoms Depression Suicide Community Dwellers

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Are <i>Umezu</i>polyphenols in the Japanese plum (<i>Prunus mume</i>) protective against mild hypertension and oxidation? Evidence from a double-blind randomized placebo-controlled trial

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Open Journal of Preventive Medicine 2013年第9期3卷 561-569页

作者： shigeki takemura Kouichi Yoshimasu Kanae Mure Jin Fukumoto Nobuhiro Nishio Naomi Kitano Kunihiro Kishida Fumiko Yano Takahiko Mitani Tatsuya Takeshita Kazuhisa Miyashita Department of Hygiene School of Medicine Wakayama Medical University Wakayama Japan Department of Public Health School of Medicine Wakayama Medical University Wakayama Japan Faculty of Biology-Oriented Science and Technology Kinki University Wakayama Japan Faculty of Biology-Oriented Science and Technology Kinki University Wakayama Japan Wakayama Industry Promotion Foundation Wakayama Japan

Medications or lifestyle changes to prevent or improve hypertension often press considerable efforts on patients suffering from mild hypertension. Beverages including Umezu polyphenols (UP), polyphenols in Japanese plums, may help them to control their blood pressure. Healthy medical students, workers, and community dwellers who had some concerns about their blood pressure were randomized in a doubleblind manner into UP ingesting and placebo groups. The first two samples (medical students and workers) were placed in a preliminary study, and based on the results from that study, and the dose of UP for the community dwellers was determined. All three groups were followed for 5 weeks, and blood pressure, as well as biochemical markers related to hypertension and atherosclerosis and self-perceived quality-of-life outcomes, was monitored during that period. Group × time interactions on blood pressure changes were examined. For the community dwellers, blood pressure changes did not significantly differ between the UP ingesting and placebo groups. And although studies of students and workers showed subtle differences in blood pressure among the UP and placebo groups, a dose-dependent effect of UP on decreasing blood pressure could not be confirmed. On the other hand, anti-oxidative effects of UP were confirmed especially among male drinkers who were community dwellers. For the community dwellers, self-perceived physical health significantly improved in those who ingested UP. In conclusion, UP might prevent oxidation. A longer monitoring period as well as a higher dose of UP might enable us to confirm effects of UP against hypertension.

关键词： Hypertension Prevention Antioxidants Japanese Plum Polyphenol

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Mathematical Modeling of Possibility Markov Chains by Possibility Theory

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Applied Mathematics 2024年第8期15卷 499-507页

作者： Yoshiki Uemura takemura Kazuhisa Kenji Kita Analog Image Technology Development Laboratory Nara Japan Department of Psychology Waseda University Tokyo Japan MILAI Technologies Inc. Tokushima Japan

Statistical regression models are input-oriented estimation models that account for observation errors. On the other hand, an output-oriented possibility regression model that accounts for system fluctuations is proposed. Furthermore, the possibility Markov chain is proposed, which has a disidentifiable state (posterior) and a nondiscriminable state (prior). In this paper, we first take up the entity efficiency evaluation problem as a case study of the posterior non-discriminable production possibility region and mention Fuzzy DEA with fuzzy constraints. Next, the case study of the ex-ante non-discriminable event setting is discussed. Finally, we introduce the measure of the fuzzy number and the equality relation and attempt to model the possibility Markov chain mathematically. Furthermore, we show that under ergodic conditions, the direct sum state can be decomposed and reintegrated using fuzzy OR logic. We had already constructed the Possibility Markov process based on the indifferent state of this world. In this paper, we try to extend it to the indifferent event in another world. It should be noted that we can obtain the possibility transfer matrix by full use of possibility theory.

关键词： Possibility Markov Chain Ergodic Condition Direct Sum State Prior Indiscriminate State Posterior Discriminatory State

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Report for Type 2 Bayes-Fuzzy Estimation in No-Data Problem

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Applied Mathematics 2024年第1期15卷 46-50页

作者： Houju Hori Jr. Kazuhisa takemura Yukio Matsumoto Nara Cmmunity Tsubakikishi Shrine Nara Japan Department of Psychology Waseda University Tokyo Japan The Institute of Mathematical Statistics Tachikawa Japan

It is well known that the system (1 + 1) can be unequal to 2, because this system has both observation error and system error. Furthermore, we must provide our mustered service within our cool head and warm heart, where two states of nature are existing upon us. Any system is regarded as the two-dimensional variable error model. On the other hand, we consider that the fuzziness is existing in this system. Though we can usually obtain the fuzzy number from the possibility theory, it is not fuzzy but possibility, because the possibility function is as same as the likelihood function, and we can obtain the possibility measure by the maximal likelihood method (i.e. max product method proposed by Dr. Hideo Tanaka). Therefore, Fuzzy is regarded as the only one case according to Vague, which has both some state of nature in this world and another state of nature in the other world. Here, we can consider that Type 1 Vague Event in other world can be obtained by mapping and translating from Type 1 fuzzy Event in this world. We named this estimation as Type 1 Bayes-Fuzzy Estimation. When the Vague Events were abnormal (ex. under War), we need to consider that another world could exist around other world. In this case, we call it Type 2 Bayes-Fuzzy Estimation. Where Hori et al. constructed the stochastic different equation upon Type 1 Vague Events, along with the general following probabilistic introduction method from the single regression model, multi-regression model, AR model, Markov (decision) process, to the stochastic different equation. Furthermore, we showed that the system theory approach is Possibility Markov Process, and that the making decision approach is Sequential Bayes Estimation, too. After all, Type 1 Bays-Fuzzy estimation is the special case in Bayes estimation, because the pareto solutions can exist in two stochastic different equations upon Type 2 Vague Events, after we ignore one equation each other (note that this is Type 1 case), we can obtain both its

关键词： Bayes-Fuzzy Estimation Possibility Markov Process Possibility Reserved Judgement

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Fundamental Study on Alkali-Activated Slag System with Sodium Carbonate or Calcium Hydroxide

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Journal of Materials Science and Chemical Engineering 2024年第6期12卷 55-70页

作者： Seunghyun Na Wenyan Zhang Yuichi Ichikawa Masaya Komatsu Aoi takemura Department of Architecture Nishinippon Institute of Technology Fukuoka Japan School of Materials Science and Engineering Henan Polytechnic University Jiaozuo China Fukuya Corporation Fukuoka Japan

Cement as a building material, has high fluidity, compressive strength, and durability, but carbon dioxide emissions during cement production are a major problem. As one of the countermeasures, alkali-activated cement using blast furnace slag powder with alkaline stimulants is considered to be a very promising solution for reducing carbon dioxide emissions, but there is a lack of information about the fundamental properties of alkali-activated materials. This study presents an experimental investigation of the fundamental properties of an alkali-activated slag system with sodium carbonate (NC) and calcium hydroxide (CH). The effects of calcium sulfo-aluminate (CSA) and shrinkage reducing agent (SRA) on the properties of blast furnace slag (BFS) based alkali-activated mixture were also investigated. In the experiments, fundamental characteristics including compressive strength, drying shrinkage, and water penetration tests of mortar were evaluated. Porosity, pH, and ignition loss were measured to verify the effectiveness of the materials. The experimental investigation revealed that the compressive strength was increased with the increasing replacement rates of NC in the BFS mortar, and in the case of water to BFS ratio of 0.45 with sodium carbonation addition contents 10 wt.%, the compressive strength for 28 days of curing reaches more than 50 MPa. Low water to BFS ratio and higher addition ratio of NC had a positive effect on the compressive strength development of mortar. Incorporating NC into BFS would affect the decrease in porosity and increase in ignition loss, leading to higher compressive strength. There was a negligible change to the compressive strength, porosity, pH, and ignition loss of BFS samples made with CH, thus, the addition rates of CH to BFS have no or little significant effect on the fundamental properties of alkali-activated cement. From the results of drying shrinkage and water penetration tests, the addition of NC and CH only to BFS exhibited

关键词： Alkali-Activated Cement Compressive Strength Drying Shrinkage Water Penetration Characteristic

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Calcium signaling: the role of inositol phosphates and the mechanisms of Ca~(2+) entry

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中国药理学与毒理学杂志 1991年第4期5卷 246-254页

作者： Haruo takemura Chiu-Yin KWAN Oepartment of Pharmacology Sapporo Medical College S. 1 W. 17 Sapporo 060 Japan Smooth Muscle Research Program Department of Biomedical Sciences McMaster University Hamilton Ontario. Canada L8N 3Z5

Activation of surface membrane receptors provokes a variety of cellular responses by initiating a series of specific biochemical reactions which are responsible for the membrane transducing mechanisms and the subsequent Ca2+signaling process. Ca2+ is well known as a second messenger that an early consequence of receptor activation is usually the synthesis

关键词：药理学毒理学杂志

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IN SEARCH OF A WORKABLE DIVISION OF LABOR BETWEEN NATIONAL AND INTERNATIONAL CRIMINAL JURISDICTIONS

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Frontiers of Law in China-Selected Publications from Chinese Universities 2012年第2期7卷 225-243页

作者： Hitomi takemura Faculty of Law Kyushu International University Fukuoka Japan

This article deals with the question of the universal application of law from the perspective of necessary division of labor between national and international criminal jurisdictions. Applying international criminal justice fairly enhances its legitimacy, and international criminal law＇s procedural aspects also must be fair. The universal application of international criminal law in multiple forums seems to be ensured by means of the proper division of labor between national and international criminal jurisdictions.

关键词： criminal law ad hoc

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Added value of indocyanine green fluorescence imaging in liver surgery

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 310-317页

作者： Nobuyuki takemura Kyoji Ito Fuyuki Inagaki Fuminori Mihara Norihiro Kokudo Department of Surgery Hepato-Biliary Pancreatic Surgery DivisionNational Center for Global Health and Medicine1-21-1 ToyamaShinjyuku-kuTokyo162-8655Japan

Recently,indocyanine green(ICG)fluorescence imaging has been widely used as a substitute for cholangiography in hepatobiliary surgery,to detect hepatic tumors,for accurate anatomical hepatectomy,and to increase the safety and accuracy of minimally invasive(laparoscopic and robotic)*** clinical relevance of this method has been increasing gradually,as new procedures develop in this *** important roles and the latest added value of ICG fluorescence imaging in liver surgery are discussed in this report.

关键词： Florescence imaging Indocyanine green Hepatocellular carcinoma Colorectal metastasis Hepatectomy Minimally invasive surgery

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Role of surgical resection for non-colorectal non-neuroendocrine liver metastases

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World Journal of Hepatology 2017年第5期9卷 242-251页

作者： Nobuyuki takemura Akio Saiura Department of Gastroenterological Surgery JR Tokyo General Hospital Department of Gastroenterological Surgery Cancer Institute Ariake Hospital Japanese Foundation for Cancer Research

It is widely accepted that the indications for hepatectomy in colorectal cancer liver metastases and liver metastases of neuro-endocrine tumors result in relatively better prognoses, whereas, the indications and prognoses of hepatectomy for non-colorectal non-neuroendocrine liver metastases(NCNNLM) remain controversial owing to the limited number of cases and the heterogeneity of the primary diseases. There have been many publications on NCNNLM; however, its background heterogeneity makes it difficult to reach a specific conclusion. This heterogeneous disease group should be discussed in the order from its general to specific aspect. The present review paper describes the general prognosis and risk factors associated with NCNNLM while specifically focusing on the liver metastases of each primary disease. A multidisciplinary approach that takes into consideration appropriate timing for hepatectomy combined with chemotherapy may prolong survival and/or contribute to the improvement of the quality of life while giving respite from systemic chemotherapy.

关键词： Non-colorectal non-neuroendocrine liver metastasis Metastatic liver tumor Hepatectomy Gastric cancer liver metastasis Gastrointestinal stromal tumor liver metastasis Breast cancer liver metastasis Melanoma liver metastasis Sarcoma liver metastasis Renal cell carcinoma liver metastasis Ovarian cancer liver metastasis

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Niche Differentiation of Phenol-Degrading Microorganisms in UASB Granular Sludge as Revealed by Fluorescence in situ Hybridization

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Engineering 2022年第2期8卷 61-66页

作者： Kengo Kubota Kei Igarashi Masayoshi Yamada Yasuyuki takemura Yu-You Li Hideki Harada Department of Civil and Environmental Engineering Tohoku UniversitySendai 980-8579Japan Department of Urban Environmental Design and Engineering National Institute of TechnologyKagoshima CollegeKirishima 899-5193Japan New Industry Creation Hatchery Center Tohoku UniversitySendai 980-8579Japan

A microbial community structure of granules harvested from an anaerobic sludge blanket reactor treating phenolic wastewater was investigated using fluorescence in situ hybridization(FISH)and clone library *** of Syntrophorhabdaceae and Cryptanaerobacter were observed to be responsible for phenol *** accurate taxonomic assignment of Cryptanaerobacter clones,phylogenetic analysis using nearly full-length 16S ribosomal RNA(rRNA)gene sequences was *** oligonucleotide probes were designed to detect the following three taxonomic groups:Syntrophorhabdaceae,Cryptanaerobacter,and *** analysis of thin sections of anaerobic granules showed a random distribution of bacteria and ***,a well-defined distribution of Syntrophorhabdaceae,Cryptanaerobacter,and Syntrophus was *** and Syntrophus were found on the outer layer of the granules and were closely associated with each other,while Syntrophorhabdaceae was located in the deeper part of the *** specific distribution of the bacteria is most likely due to their metabolic association and affinity for the *** degradation in the granular sludge was observed to be carried out in the following ***,Cryptanaerobacter converts phenol to benzoate,which is then degraded by Syntrophus into *** syntrophic degradation of phenol occurs near the surface of the granule,where the phenol concen-tration is *** the deeper part of the granule,where the phenol concentration is lower,Syntrophorhabdaceae degrades phenol into *** observed that Syntrophorhabdaceae is less likely to produce benzoate as an intermediate to feed the neighboring organisms,which contradicts the theo-ries presented by previous studies.

关键词： Cryptanaerobacter Fluorescence in situ hybridization Anaerobic phenol degradation Syntrophorhabdaceae Syntrophus UASB granular sludge

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