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Optimal Link Tolls for Multi-node and Multi-link Transportation Networks Taking into Account the Welfare Cost of Fund Procurement

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Journal of Traffic and Transportation Engineering 2018年第3期6卷 121-133页

作者： Hidenori Ikeshita Atsushi fukuda Road Policy Group Japan Institute of Country-ology and EngineeringTokyo 1050001Japan Department of Transportation Systems Engineering College of Science and TechnologyNihon UniversityChiba 2748501Japan

This study discusses the optimal link toll,which maximizes social surplus under a user equilibrium condition,with imperfect substitution assumption for route choice in a transportation network with many nodes and links,as well as taking into account the welfare cost of funds *** contrast to previous studies,this study formulates optimal link tolls,taking into account the marginal cost of public funds(MCF),which is the marginal welfare loss of taxpayers due to a marginal tax *** formula for optimal tolls on links is derived from the following *** is MCF classified into two,not taking into account funding(MCF equal to-1)and pricing for funding(MCF does not equal-1).Another is tolls classified into two,pricing on all links(full link pricing),and pricing on a specific link(partial link pricing).Following the above conditions,this study succeeds in deriving the formula for optimal tolls on a full network with many links and ***,this study indicates two calculation methods:one is to solve analytically or numerically for when the functional form of link flow demand is *** the functional form is unknown,such as a perfect substitution case,it is necessary to carry out iteration until convergence:with the traffic assignment given the price level and with a change in price level based on the traffic assignment.

关键词： Optimal tolls congestion MCF procurement of funds

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人类胚胎植入过程中的细胞黏附分子(英文)

生理学报 2012年第3期64卷 247-258页

作者： Michiko N.fukuda Kazuhiro Sugihara 桑福德/伯纳姆医学研究所癌症中心拉霍亚加利福尼亚州美国滨松医科大学妇产科学系滨松静冈县日本

人类胚胎植入过程不仅受到在进化上保守的机制调节,而且也受到人类一种独有的机制调节。有证据显示,细胞黏附分子L-选择蛋白和trophinin在人类胚胎植入过程扮演独特的角色。在本文中,我们描述了L-选择素和trophinin的黏蛋白糖配体的双... 详细信息

人类胚胎植入过程不仅受到在进化上保守的机制调节,而且也受到人类一种独有的机制调节。有证据显示,细胞黏附分子L-选择蛋白和trophinin在人类胚胎植入过程扮演独特的角色。在本文中,我们描述了L-选择素和trophinin的黏蛋白糖配体的双重作用,也描述了trophinin相关蛋白bystin和tastin的双重作用。我们随后描述了滋养外胚层细胞和子宫内膜上皮细胞中由trophinin调节的信号转导。本综述也涵盖了钙依粘连蛋白和整合素在人类胚胎植入过程中的作用。

关键词：胚胎植入促性腺激素凋亡

Role of targeted therapy in metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2016年第9期8卷 642-655页

作者： Yoshihito Ohhara Naoki fukuda Satoshi Takeuchi Rio Honma Yasushi Shimizu Ichiro Kinoshita Hirotoshi Dosaka-Akita Department of Medical Oncology Hokkaido University Graduate School of MedicineSapporoHokkaido 060-8638Japan

Colorectal cancer(CRC) is a significant cause of cancer-related morbidity and mortality all over the *** of cytotoxic and biologic agents have prolonged the survival in metastatic CRC(mC RC),with a median overall survival of approximately 2 years and more in the past two *** biologic agents that have proven clinical benefits in m CRC mainly target vascular endothelial growth factor(VEGF) and epidermal growth factor receptor(EGFR).In particular,bevacizumab targeting VEGF and cetuximab and panitumumab targeting EGFR have demonstrated sig-nificant survival benefits in combination with cytotoxic chemotherapy in the first-line,second-line,or salvage ***,ramucirumab,and regorafenib are also used in second-line or salvage *** retrospective analyses have shown that KRAS or NRAS mutations were negative predictive markers for anti-EGFR *** on the evidence from large rand-omized clinical trials,personalized therapy is necessary for patients with m CRC according to their tumor biology and *** aim of this paper was to summarize the results of the major randomized clinical trials and highlight the benefits of the molecular targeted agents in patients with mC RC.

关键词： Metastatic colorectal cancer Aflibercept Ramucirumab Regorafenib Cetuximab Panitumumab Targeted therapy Bevacizumab

Continued Diagnostic Difficulties in Preoperatively Differentiating Lipiodized Oil and Residual Metallic Material: A Case Report

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Case Reports in Clinical Medicine 2016年第4期5卷 125-129页

作者： Masashi Haraguchi Shinichiro Ito Kohei Kotera Aya Fukushima Toshio fukuda Hirotaka Tokai Kazumasa Noda Masataka Hirabaru Toshiyuki Adachi Nobuhiro Tada Keiji Inoue Shinya Onizuka shigeki Minami Department of Surgery Nagasaki Harbor Medical Center City Hospital Nagasaki Japan Department of Obstetrics and Gynecology Nagasaki Harbor Medical Center City Hospital Nagasaki Japan Department of Radiology Nagasaki Harbor Medical Center City Hospital Nagasaki Japan

Retained foreign objects in the abdomen and pelvis are serious clinical problems yet the imaging required can present difficulties. Prolonged retention of lipiodized oil used for hysterosalpingography over years is very rare. However, lipiodized oil had previously been misdiagnosed as residual metallic material. We are reporting a case in which the latest computed tomography (CT) equipment seemed inadequate for obtaining a clear pre-operative diagnosis. Here, we describe the case of a 33-year-old Japanese female whose pelvis had contained retained lipiodized oil that had been suspected as residual metallic material. The preoperative diagnosis was very difficult and included three-dimensional computed tomography (3D-CT) of unclear results despite expectations of resolution. By laparoscopic surgery, we removed a cyst of approximately 2 cm containing a yellowish oily fluid. Postoperatively, we demonstrated that the fluid was lipiodized oil. A postoperative experiment to attempt distinguishing lipiodized oil from metal through gemstone spectral CT imaging did not offer clarity either. Distinguishing between retained lipiodized oil and metallic material in the abdominal cavity may still present unexpected difficulties even with the latest medical equipments.

关键词： Lipiodized Oil Hysterosalpingography Residual Metallic Material

Integration of body-mounted ultrasoft organic solar cell on cyborg insects with intact mobility

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npj Flexible Electronics 2022年第1期6卷 726-734页

作者： Yujiro Kakei Shumpei Katayama Shinyoung Lee Masahito Takakuwa Kazuya Furusawa Shinjiro Umezu Hirotaka Sato Kenjiro fukuda Takao Someya Center for Emergent Matter Science RIKEN2-1 HirosawaWakoSaitama 351-0198Japan Department of Integrative Bioscience and Biomedical Engineering Center for Advanced Biomedical SciencesTWIns Waseda Univerisity2-2 Wakamatsu-choShinjuku-kuTokyo 162-8480Japan Department of Modern Mechanical Engineering Waseda University3-4-1 OkuboShinjuku-kuTokyo 169-8555Japan Department of Applied Chemistry and Food Science Faculty of Environmental and Information SciencesFukui University of Technology3-6-1 GakuenFukui 910-8505Japan School of Mechanical and Aerospace Engineering Nanyang Technological UniversityN3.2-01-2065 Nanyang DriveSingapore 637460Singapore Thin-Film Device Laboratory RIKEN2-1 HirosawaWakoSaitama 351-0198Japan Electrical and Electronic Engineering and Information Systems The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan

Cyborg insects have been proposed for applications such as urban search and ***-mounted energy-harvesting devices are critical for expanding the range of activity and functionality of cyborg ***,their power outputs are limited to less than 1 mW,which is considerably lower than those required for wireless locomotion *** area and load of the energy harvesting device considerably impair the mobility of tiny ***,we describe the integration of an ultrasoft organic solar cell module on cyborg insects that preserves their motion *** quantified system design strategy,developed using a combination of ultrathin film electronics and an adhesive-nonadhesive interleaving structure to perform basic insect motion,successfully achieved the fundamental locomotion of traversing and *** body-mounted ultrathin organic solar cell module achieves a power output of 17.2 *** demonstrate its feasibility by displaying the recharging wireless locomotion control of cyborg insects.

关键词： mounted harvesting considerably

Preventing pancreatic fistula after distal pancreatectomy: An invagination method

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World Journal of Gastroenterology 2017年第8期23卷 1507-1512页

作者： Nagato Katsura Yasuhiro Kawai Takashi Gomi Kenji Okumura Takahiko Hoashi Seijun fukuda Katsushi Takebayashi Kenji Shimizu Masugi Satoh Department of Surgery Misugikai Otokoyama Hospital Department of Surgery Misugikai Satoh HospitalYobuhigashimachi Hirakata

Following an increase in the use of the GIA stapler for treating a pancreatic stump, more techniques to prevent postoperative pancreatic juice leakage have been required. We describe one successful case using our new technique of invaginating the cut end of the pancreas into the stomach to prevent a pancrea-tic fistula(PF) from occurring. A 50-year-old woman with pancreatic cancer in the tail of the pancreas underwent distal pancreatectomy, causing a grade A PF. We resected the distal pancreas without additional reinforcement to invaginate the stump into the gastric posterior wall with single layer anastomosis using a 3-0 absorbable suture. The drain tubes were removed on the third postoperative day. Although a grade A PF was noted, the patient was discharged on foot on the eleventh postoperative day. Our technique may be a suitable method for patients with a pancreatic body and tail tumor.

关键词： Amylases Pancreatectomy Pancreatic fistula Pancreatic juice Neoplasms

Localized type 1 autoimmune pancreatitis superimposed upon preexisting intraductal papillary mucinous neoplasms

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World Journal of Gastroenterology 2013年第47期19卷 9127-9132页

作者： Takahiro Urata Yoshiki Naito Yoshihiro Izumi Yoshi Takekuma Hiroshi Yokomizo Michiko Nagamine Seiji fukuda Kenji Notohara Michio Hifumi Department of Gastroenterology Japanese Red Cross Kumamoto HospitalKumamoto 861-8520Japan Department of Pathology Kurume University School of MedicineKurume CityFukuoka 830-0011Japan Department of Surgery Japanese Red Cross Kumamoto HospitalKumamoto 861-8520Japan Department of Pathology Japanese Red Cross Kumamoto HospitalKumamoto 861-8520Japan Department of Anatomic Pathology Kurashiki Central HospitalKurashiki CityOkayama 701-01Japan

A 70-year-old woman was found to have 2 cystic lesions in the head of the pancreas on abdominal ultrasonography during a routine medical *** ultrasonography(EUS)and magnetic resonance cholangiopancreatography showed multilocular cysts in the head of the pancreas without dilation of the main pancreatic *** patient was followed-up semiannually with imaging studies for suspected branch duct-type intraductal papillary mucinous neoplasm(IPMN).At 3 years after initial presentation,hypoechoic lesions were observed around each pancreatic cyst by ***-weighted imaging showed high-intensity regions corresponding to these ***,a diagnosis of invasive carcinoma derived from IPMN could not be excluded,and subtotal stomach-preserving pancreaticoduodenectomy was *** macroscopic examination of the surgical specimen showed whitish solid masses in the head of the pancreas,with multilocular cysts within each ***,each solid mass consisted of inflammatory cells such as lymphocytes and plasma ***,immunochemical staining revealed immunoglobulin G4-positive cells,and many obliterating phlebitides were *** cysts consisted of mucus-producing epithelial cells and showed a papillary growth *** on these findings,we diagnosed multiple localized type 1 autoimmune pancreatitis occurring only in the vicinity of the branch ducttype IPMN.

关键词： Autoimmune pancreatitis Intraductal papillary mucinous neoplasm Immunoglobulin G4 Endoscopic ultrasonography Diffusion-weighted imaging

A New Species of the Genus Rhabdophis Fitzinger,1843(Squamata:Colubridae)in Southwestern Sichuan,China

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Asian Herpetological Research 2020年第2期11卷 95-107页

作者： Yige PIAO Zening CHEN Yanqing WU Shengchao SHI Hirohiko TAKEUCHI Teppei JONO Masaya fukuda Akira MORI Yezhong TANG Qin CHEN Li DING Chengdu Institute of Biology Chinese Academy of SciencesChengdu 610041SichuanChina University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education College of Life SciencesSichuan UniversityChengdu 610065SichuanChina Nanjing Institute of Environmental Sciences Ministry of Ecology and Environment of ChinaNanjing 210042JiangsuChina College of Bioresource Sciences Nihon UniversityFujisawaKanagawa 2520880Japan Tropical Biosphere Research Center University of the RyukyusNishiharaOkinawa 9030213Japan Department of Zoology Graduate School of ScienceKyoto UniversitySakyoKyoto 6068502Japan

The genus Rhabdophis is a group of widely distributed snakes with more than 20 *** field surveys uncovered a species in southwestern China,which has long been considered as *** molecular and morphological analyses revealed it as a new species Rhabdophis chiwen *** on 12 specimens,this new species is distinguished by the following characters:1)dorsal body saddlebrown,dorsal scales typically with black margins forming spots and stripes,the margin of the outer row forming two faint dorsolateral black cross-bars alongside body;2)ventral scales 151–159,the outer margin of ventral scales and several lateral rows of dorsal scales forming ventrolateral longitudinal brownish-red coloration,with faint black spots in the middle of ventral scales;3)a black oblique stripe present below eyes,often with a black spot between the 2 nd and 3 rd supralabial and a black stripe on the 5 th supralabial;4)eyes dark khaki,pupils black;5)infralabials usually 7,the first four in contact with anterior chin-shields;6)temporal scales 1+1;7)dorsal scales in 15 rows,feebly keeled except the outer 1–2 rows;8)anal scale divided;subcaudals 45–59;9)preocular 1 and postoculars 3(occasionally 2);10)body medium-sized(snout-vent length:adult males 404–431 mm,adult females 409–476 mm);11)tail moderate(tail length/total length in adult males 0.205–0.238,in adult females0.172–0.193).With the discovery of this new species,the total number of species in genus Rhabdophis is 28 with 12 th species known to occur in China.

关键词： Rhabdophis chiwen sp.nov. morphology Natricinae phylogenetics taxonomy

Diagnostic sensitivity of imaging modalities for hepatocellular carcinoma smaller than 2 cm

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World Journal of Gastroenterology 2010年第33期16卷 4187-4192页

作者： Keiji Mita Soo Ryang Kim Masatoshi Kudo Susumu Imoto Taisuke Nakajima Kenji Ando Katsumi fukuda Toshiyuki Matsuoka Yoko Maekawa Yoshitake Hayashi Department of Gastroenterology Kobe Asahi Hospital Department of Gastroenterology and Hepatology Kinki University School of Medicine Department of Radiology Osaka City University Medical School Department of Surgery Hyogo Cancer Center Center for Infectious Diseases Kobe University Graduate School of Medicine

AIM:To compare the imaging results with histology and to evaluate the diagnostic sensitivity of imaging modalities for hepatocellular carcinoma(HCC)smaller than 2 ***:Nodules smaller than 2 cm(n=34)revealed by ultrasonography(US)in 29 patients with liver cirrhosis were *** diagnosis of HCC was performed by ultrasonographic guidance:moderately-differentiated HCC(n=24);well-differentiated HCC(n=10).The patterns disclosed by the four imaging modalities defined the conclusive diagnosis of HCC:(1)contrast-enhanced computed tomography(CECT),hypervascularity in the arterial phase and washout in the equilibrium phase;(2)Sonazoid contrast-enhanced US(CEUS),hypervascularity in the early vascular phase and defect in the Kupffer phase;(3)gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid(Gd-EOBDTPA)-enhanced magnetic resonance imaging(MRI),hypervascularity in the arterial phase and/or defect in the hepatobiliary phase;and(4)CT arterioportal angiography:hypervascularity by CT during arteriography and/ or perfusion defect by CT during arterial ***:Overall,the sensitivity of diagnosing HCC smaller than 2 cm was 52.9%(18/34)(95%CI:35.170.2)by CECT;67.6%(23/34)(95%CI:49.5-82.6)by Sonazoid CEUS;76.5%(26/34)(95%CI:58.8-89.3) by Gd-EOB-DTPA MRI;and 88.2%(30/34)(95%CI: 72.5-96.7)by CT arterioportal *** diagnostic sensitivity of detecting moderately-differentiated HCC by CECT,Sonazoid CEUS,Gd-EOB-DTPA MRI and CT arterioportal angiography was 62.5%(15/24)(95%CI: 40.6-81.2),79.2%(19/24)(95%CI:57.8-92.9),75.0% (18/24)(95%CI:53.3-90.2)and 95.8%(23/24)(95% CI:78.9-99.9),respectively.A significant difference(P< 0.05)was observed between CECT and CT arterioportal angiography in all *** was no difference between Sonazoid CEUS,Gd-EOB-DTPA MRI,and CT arterioportal *** combined sensitivity of Sonazoid CEUS and Gd-EOB-DTPA MRI was 94.1%(32/34).CONCLUSION:Changing the main diagnostic modality for HCC smaller than 2 cm

关键词： Computed tomography arterioportal angi- ography Contrast-enhanced computed tomography Diagnostic sensitivity Gd-EOB-DTPA-enhanced magnetic resonance imaging Hepatocellular carcinoma smaller than 2 cm:Sonazoid contrast-enhanced ultrasonography