检索结果-南通市图书馆

Hypoxia-inducible factor 1 alpha and vascular endothelial growth factor overexpression in ischemic colitis

World Journal of Gastroenterology 2005年第10期11卷 1535-1539页

作者： Tomoyuki Okuda Takeshi Azuma Masahiro Ohtani Ryuho Masaki Yoshiyuki ito Yukinao Yamazaki shigeji ito Masaru Kuriyama Second Department of Internal Medicine Department of Endoscopic Medicine Department of Internal Medicine

AIM: To examine the etiology and pathophysiology in human ischemic colitis from the viewpoint of ischemic factors such as hypoxia-inducible factor 1 alpha (HIF-1 alpha and vascular endothelial growth factor (VEGF). METHODS: Thirteen patients with ischemic colitis and 21 normal controls underwent colonoscopy. The follow-up colonoscopy was performed in 8 patients at 7 to 10 d after the occurrence of ischemic colitis. Biopsy samples were subjected to real-time RT-PCR and immunohistochemistry to detect the expression of HIF-1 alpha and VEGF. RESULTS: HIF-1 alpha and VEGF expression were found in the normal colon tissues by RT-PCR and immunohistochemistry. HIF-1 alpha and VEGF were overexpressed in the lesions of ischemic colitis. Overexpressed HIF-1 alpha and VEGF RNA quickly decreased to the normal level in the scar regions at 7 to 10 d after the occurrence of ischemic colitis. CONCLUSION: Constant expression of HIF-1 alpha and VEGF in normal human colon tissue suggested that HIF-1 alpha and VEGF play an important role in maintaining tissue integrity. We confirmed the ischemic crisis in ischemic colitis at the molecular level, demonstrating overexpression of HIF-1 alpha and VEGF in ischemic lesions. These ischemic factors may play an important role in the pathophysiology of ischemic colitis.

关键词： Ischemic colitis HIF-1 alpha VEGF

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Theory of Zero-Resistance States Generated by Radiation in GaAs/AlGaAs

引用

Journal of Modern Physics 2012年第7期3卷 546-552页

作者： shigeji Fujita Kei ito Akira Suzuki Department of Physics Faculty of Science Tokyo University of Science Shinjuku-ku Tokyo Japan Department of Physics University at Bu_alo SUNY Bu_alo NY USA Research Division National Center for University Entrance Examinations Meguro-ku Tokyo Japan

Mani observed zero-registance states similar to those quantum-Hall-effect states in GaAs/AlGaAs but without the Hall resistance plateaus upon the application of radiations [R. G. Mani, Physica E 22, 1 (2004)]. An interpretation is presented. The applied radiation excites “holes”. The condensed composite (c)-bosons formed in the excited channel create a superconducting state with an energy gap. The supercondensate suppresses the non-condensed c-bosons at the higher energy, but it cannot suppress the c-fermions in the base channel, and the small normal current accompanied by the Hall field yeilds a B-linear Hall resistivity.

关键词： Superconducting (Zero-Resistance) States Composite-Boson (Fermion) B-Linear Hall Resistivity Phonon (Fluxon) Exchange

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：