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An autopsy case of granulocyte-colony-stimulating-factor- producing extrahepatic bile duct carcinoma

World Journal of Gastroenterology 2008年第18期14卷 2924-2927页

作者： Satoru Matsuyama Tomonori Shimonishi Hirofumi Yoshimura Kensaku Higaki Kenji Nasu Mariko Toyooka shigehisa aoki Keiko Watanabe Hajime Sugihara Department of Surgery Takagi Hospital141-11Sakemi Ohkawa-CityFukuoka 831-0016Japan Department of Pathology Takagi Hospital141-11SakemiOhkawa-City Fukuoka 831-0016 Japan Department of Pathology and Biodefence Faculty of Medicine Saga University 5-1-1 Nabeshima Saga-City Saga 849-8501 Japan

A 79-year-old man was referred to this department due to the presence of extrahepatic bile duct carcinoma with a tumor at the left chest wall. The lesion was suspected to be a metastasis of bile duct carcinoma to the left wall, however, computed tomography (CT) revealed no regional lymph node or liver metastases. In addition, cytological and pathological examinations did not show malignancy. At the time of admission, the white blood cell count was 21 460 cells/μL (neutrophils, 18 240 cells/μL) and this elevated to 106 040 before death. In addition, serum granulocyte colony-stimulating factor (G-CSF) was elevated. At 28 d after admission, the patient died. An autopsy showed a poorly differentiated adenocarcinoma with sarcomatous change, which had slightly invaded into the pancreas around the bile duct, and was found in the distal bile duct with multiple metastases to the chest wall, lung, kidney, adrenal body, liver, mesentery, vertebra and mediastinal and para-aortic lymph nodes, without locoregional lymph node and liver metastasis. The cancer cells showed positive immunohistochemical staining for anti-G-CSF antibody. This is believed to be the first report of an extrahepatic bile duct carcinoma that produces G-CSF. Since G-CSF-producing carcinoma and sarcomatous change of the biliary tract leads to poor prognosis, early diagnosis and treatment are needed. When infection is ruled out, the G-CSF in serum should be examined. In addition, examinations such as bonescintigraphy and chest CT should also be considered for distant metastasis.

关键词： Bile duct carcinoma Granulocyte colony-stimulating factor Multiple metastases Autopsy

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Acute renal failure associated with acute non-fulminant hepatitis B

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World Journal of Hepatology 2013年第2期5卷 82-85页

作者： Tomoya Kishi Yuji Ikeda Tsuyoshi Takashima Shuichi Rikitake Motoaki Miyazono shigehisa aoki Takanobu Sakemi Toshihiko Mizuta Kazuma Fujimoto Department of Internal Medicine Saga University Faculty of MedicineSaga 849-8501Japan Department of Pathology and Biodefense Center for ResearchSaga University Faculty of MedicineSaga 849-8501Japan Development in Higher Education Saga University Faculty of MedicineSaga 849-8501Japan

A 38-year-old female presenting with a high fever of 39 ℃ developed severe liver dysfunction and acute renal failure(ARF).In tests for a hepatitis associated virus,an Immunoglobulin M-anti-hepatitis B virus core antibody was the only positive ***,the progression of ARF coincided with the pole period of liver damage and all the other assumed causes for the ARF were ***,this case was diagnosed as ARF caused by acute hepatitis *** associated with non-fulminant hepatitis has been infrequently reported,usually in association with acute hepatitis *** case is considered to be an extremely rare and interesting case.

关键词： Acute hepatitis B Acute renal failure Nonfulminant hepatitis Acute tubular necrosis Hyperimmune response

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The History of Habits:A Critical Unknown in the History of Chinese Medicine

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Chinese Medicine and Culture 2023年第3期6卷 297-300页

作者： shigehisa Kuriyama Edwin O.Reischauer Institute of Japanese Studies Center for Government and International Studies(CGIS)Harvard UniversityCambridge 02138USA

This essay articulates a new conceptual distinction-that between repertories and habits-and urges that the history of habits is the most critical unknown in the study of Chinese medical history.

关键词： Habits Repertories Traditional Chinese medicine Unsolved problems

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Principle for obtaining high joint quality in dissimilar friction welding of Ti-6Al-4V alloy and SUS316L stainless steel

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Journal of Materials Science & Technology 2020年第11期42卷 211-224页

作者： Huihong Liu Yo aoki Yasuhiro aoki Kohsaku Ushioda Hidetoshi Fujii Joining and Welding Research Institute Osaka UniversityIbarakiOsaka 567-0047Japan

Ti-6Al-4V alloy(Ti64)and SUS316 L stainless steel rods were dissimilarly friction *** focusing on the detailed observation of interface microstructural evolution during the friction welding(FW),the relationship between the processing conditions,weld interface microstructure,and mechanical properties of the obtained joints were systematically investigated to elucidate the principle for obtaining a high joint quality in the FW of Ti64 and SUS316L.A higher friction pressure produced a lower welding temperature in the FW,hence suppressing the thick intermetallic compound layer ***,hard and brittle Ti64/SUS316L mechanically mixed layers generally formed especially at the weld interface periphery due to the high temperature increasing rate,high rotation linear velocity and high outward flow velocity of the *** harmful layers tended to induce the cracks/voids formation at the weld interfaces hence deteriorating the joints’mechanical *** rotation speed reduction and liquid CO2 cooling during the entire processing decreased the temperature increasing rate,rotation linear velocity and outward flow velocity of the Ti64 at the weld interface ***,they suppressed the formation of the harmful mechanically mixed layers,facilitated the homogeneous and sound interface microstructure generation,and finally produced a high-quality dissimilar joint in the FW of Ti64 and SUS316L.

关键词： Friction welding Titanium alloy Stainless steel Microstructure formation mechanism Mechanically mixed layers

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Low Threshold GaInAsP/InP Membrane BH-DFB Lasers

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光学学报 2003年第S1期23卷 315-316页

作者： shigehisa Arai TakeshiOkamoto YuichiOnodera TatsuyaYamazaki ShigeoTamura Research Center for Quantum Effect Electronics Tokyo Institute of Technology 2-12-1 O-okayama Meguro-ku Tokyo 152-8552 Japan Japan Science and Technology Corporation - CREST

A single mode operation of 1.55μm-wavelength GaInAsP/InP membrane BH-DFB laser was demonstrated under RT-CW optical pumping with a threshold power of 1.5 mW and a sub-mode suppression-ratio (SMSR) of 42 dB. We also demonstrated a membrane-based laser array which covers a wavelength span of 72 nm with a fluctuation of less than±1.2nm.

关键词： optical pumping single mode

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Baryon-Baryon interactions from lattice QCD

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Chinese Physics C 2010年第9期34卷 1236-1240页

作者： S.aoki Graduate School of Pure and Applied Sciences University of Tsukuba

We report on new attempt to investigate baryon-baryon interactions in lattice *** the Bethe-Salpeter （BS） wave function,we have successfully extracted the nucleon-nucleon （NN） potentials in quenched QCD simulations,which reproduce qualitative features of modern NN *** method has been extended to obtain the tensor potential as well as the central potential and also applied to the hyperonnucleon （YN） interactions,in both quenched and full QCD.

关键词： nucelon-nucelon potential Bethe-Salpeter wave function lattice QCD hyperon-nucleon interactions tensor potential

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s cascade reinforcement likely when sympatric tnd allopatric populations exchange migrants？

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Current Zoology 2016年第2期62卷 155-167页

作者： Roman YUKILEVICH Fumio aoki Department of Biology Union College Schenectady NY 12308 Department of Ecology and Evolution Stony Brook University Stony Brook NY 11794

When partially reproductively isolated species come back into secondary contact, these taxa may diverge in mating preferences and sexual cues to avoid maladaptive hybridization, a process known as reinforcement. This phenomenon often leads to reproductive character displacement （RCD） between sympatric and allopatric populations of reinforcing species that differ in their exposure to hybridization. Recent discussions have reinvigorated the idea that RCD may give rise to additional speciation between conspecific sympatric and allopatric populations, dubbing the concept ＂cascade reinforcement.＂ Despite some empirical studies supporting cascade reinforcement, we still know very little about the conditions for its evolution. In the present article, we address this question by developing an individual-based population genetic model that explicitly simulates cascade reinforcement when one of the hybridizing species is split into sympatric and allopatric populations. Our results show that when sympatric and allopatric populations reside in the same environment and only differ in their exposure to maladaptive hybridization, migration between them generally inhibits the evolution of cascade by spreading the reinforcement alleles from sympatry into allopatry and erasing RCD. Under these conditions, cascade reinforcement only evolved when migration rate between sympatric and allopatric populations was very low. This indicates that stabilizing sexual selection in allopatry is generally ineffective in preventing the spread of reinforcement alleles. Only when sympatric and allopatric populations experienced divergent ecological selection did cascade reinforcement evolve in the presence of substantial migration. These predictions clarify the conditions for cascade reinforcement and facilitate our understanding of existing cases in nature.

关键词： Dobzhansky-Muller incompatibilities hybrid zones reproductive character displacement reproductive isolation secondary contact sexual isolation speciation

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Attenuation and Distortion of Compression Waves Propagating in Very Long Tube

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Journal of Thermal Science 2011年第1期20卷 53-57页

作者： Shinya NAKAMURA Daisuke SASA Toshiyuki aoki Graduate School of Engineering Sciences Kyushu UniversityKasugaFukuoka816-8580Japan

A lot of phenomena related to propagating various waves are seen when the high-speed train goes through the tunnel,the gas pipeline is broken due to an accident or the air brake of the wagon *** instance,a compression wave generated ahead of a high-speed train entering a tunnel propagates to the tunnel exit and spouts as a micro pressure wave,which causes an exploding *** order to estimate the magnitude correctly,the mechanism of the attenuation and distortion of a compression wave propagating along a very long tunnel must be understood and the experimental information on these phenomena is *** experimental investigation is carried out to clarify the attenuation and distortion of the propagating compression wave in a very long *** results show that the strength of a compression wave decreases with *** attenuation and distortion of compression waves are affected by the initial waveform of the compression wave and by the unsteady boundary layer induced by the propagating *** shape of a compression wave becomes different with the propagating distance;that is,a shock wave appears just head of a wavefront and an overshoot on pressure distribution is observed behind a shock wave due to the transition of the unsteady boundary layer.

关键词： Propagating Compression Wave Very Long Tube Micro-pressure Wave High-Speed Train

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Changes over time in treatment for obstructive jaundice

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3074-3077页

作者： Hideki aoki Department of Surgery National Hospital Organization Iwakuni Clinical CenterIwakuni 740-8510YamaguchiJapan

This editorial discusses an article by Peng et *** study reviewed the efficacy and safety of a new approach for treating obstructive *** the pathophysiology of obstructive jaundice has not yet been fully elucidated,pro-gress has been made in its *** are two aspects of obstructive jaundice:Cholestatic status and absence of bile in the intestinal *** biliary drainage resolved both the ***,endoscopic retrograde biliary drainage(ERBD)has replaced percutaneous transhepatic biliary drainage,and ERBD is transitioning to endoscopic ultrasound guided biliary *** editorial briefly explains the mechanism and treatment of obstructive jaundice and the prospects of this new internal biliary drainage technique.

关键词： Obstructive jaundice Intestinal permeability Biliary drainage Endoscopic retrograde biliary drainage Endoscopic ultrasound guided biliary drainage

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Identification of CO_2 disposal locations in an ocean general circulation model of the North Pacific

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Acta Oceanologica Sinica 2009年第1期28卷 15-24页

作者： XU Yongfu aoki Shigeaki HARADA Koh State Key Laboratory of Atmospheric Boundal7 Layer Physics and Atmospheric Chemistl＇y Institute of Atmos- pheric Physics Chinese Academy of Sciences Beijing 100029 China Institute for Environmental Management Technology National Institute for kdvanced Industrial Science and Technology Tsukuha lbaraki 305-8569 Japan

A basin-wide ocean general circulation model of the North Pacific is used to identify which location is more efficient for ocean CO2 sequestration in the North *** injection depths at each one of fifteen locations are *** terms of effectiveness index（EI） and escape factor（EF）,it is clear that the effectiveness increases with increasing latitude at the end of the 50 a injection ***-by-site differences in the EI can be over 9% for the 1 000 m injection depth in the western North Pacific at the end of 50 a of continuous *** difference is much larger for the 500 m *** difference decreases with increasing injection ***,the site-by-site difference is small for the injection in the eastern North *** sequestration is more efficient for the injection in the east than in the *** the 500 m injection depth,the difference in effectiveness between the west and the east is over 10% at the end of 50 a injection *** largest concentration of sequestered CO2 increases with increasing injection *** the injection in both the western and central North Pacific,the largest exchange flux always appears to be at about 42°N,150°E,whereas for the injection in the eastern area the large flux appears to be in the equatorial region（120°W）.

关键词： ocean carbon disposal north Pacific Ocean numerical modelling sequestration

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