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Incidence and localization of lymphoid follicles in early colorectal neoplasms

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World Journal of Gastroenterology 2005年第43期11卷 6863-6866页

作者： Kuang-I Fu Yasushi Sano shigeharu kato Takahiro Fujii Ikura Koba Takayuki Yoshino Atsushi Ochiai Shigeaki Yoshida Takahiro Fujimori Division of Gastrointestinal Oncology and Digestive Endoscopy Division of Pathology Department of Surgical and Molecular Pathology

AIM: To investigate the incidence and localizations of lymphoid follicles (LFs) in early colorectal neoplasms in human beings.METHODS: From July 1992 to September 1999, a total of 1 324 early colorectal neoplasms were removed endoscopically or surgically at our hospital; 1 031 (77.9%)were available for analysis in this study. Localization of LFs was defined histologically: as submucosal LFs, if located under the muscularis mucosa; and as intramucosal LFs, if located across or oyer the muscularis mucosa.RESULTS: Histologically, the materials included 903intramucosal neoplasms and 128 submucosal cancers.Overall incidence of LFs was 27.2% (280/1 031). The incidence of LFs was significantly higher in females (33.6% vs 24.9%,P=0.0064), the right-sided colon (32.2% vs 25.6%, P=0.0403) and in flat or depressed type lesions (34.6% vs 25.2%, P＜0.0001)as compared to males, left-sided colon and protruding type lesions, respectively. The incidences of intramucosal neoplasms and submucosal cancers were 24.3% and 43.8%, respectively (P＜0.0001). Localizations of LFs (intramucosal LF/submucosal LF) in depressed, flat,and protruding types were 1/24, 14/36, and 131/74,respectively.CONCLUSION: The incidence of LFs in early human colorectal neoplasms significantly differs by gender,location, macroscopic type, and histology. Moreover,localization significantly differs by macroscopic type.

关键词：淋巴卵泡结肠息肉直肠息肉病理机制

Magnifying colonoscopy as a non-biopsy technique for differential diagnosis of non-neoplastic and neoplastic lesions

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World Journal of Gastroenterology 2006年第9期12卷 1416-1420页

作者： shigeharu kato Kuang I Fu Yasushi Sano Takahiro Fujii Yutaka Saito Takahisa Matsuda Ikuro Koba Shigeaki Yoshida Takahiro Fujimori Division of Gastrointestinal Oncology and Digestive Endoscopy National Cancer Center Hospital East KashiwaChiba 277-8577Japan Division of Gastrointestinal Oncology and Digestive Endoscopy National Cancer Center Hospital East KashiwaChiba 277-8577Japan Department of Surgical and Molecular PathologyDokkyo University School of Medicine880 KitakobaysashiMibuShimotugaTochigi 321-0293Japan Division of Endoscopy National Cancer Center Hospital TsukijiTokyo 104-0045Japan Department of Surgical and Molecular Pathology Dokkyo University School of Medicine 880 KitakobaysashiMibuShimotugaTochigi 321-0293Japan

瞄准：为了澄清与放大结肠镜检查观察的粘膜地窟模式是否对可行，把非肿瘤的息肉与肿瘤的息肉区分开来。方法：从通过 2000 年 3 月的 1999 年 6 月，有 210 损害的 180 个连续病人与放大结肠镜诊断了(CF-200Z，天堂光有限公司，东京，... 详细信息

瞄准：为了澄清与放大结肠镜检查观察的粘膜地窟模式是否对可行，把非肿瘤的息肉与肿瘤的息肉区分开来。方法：从通过 2000 年 3 月的 1999 年 6 月，有 210 损害的 180 个连续病人与放大结肠镜诊断了(CF-200Z，天堂光有限公司，东京，日本) 被注册。有 0.2% 靛青洋红染料的放大和多彩石印版内视镜检查法为粘膜地窟观察被用于每损害。损害出现打字我和 II 地窟模式被活体检视组织学地认为非肿瘤、检验，而损害证明到 V 地窟模式的类型 III 被移开内视镜的联盟者或通过手术。内视镜的诊断和 histologic 诊断的关联然后被调查。结果：在内视镜检查法， 24 损害证明我或 II 坑模式，和 186 损害显示出的一种类型打 III 到 V 坑模式。与 histologic 检查， 26 损害作为非肿瘤的息肉被诊断，并且 184 损害作为肿瘤的息肉被诊断。全面诊断精确性是 99.1%(208/210 ) 。敏感和特性是 92.3%(24/26 ) 并且 99.8%(184/186 ) 分别地。结论：放大结肠镜检查能作为一种非活体检视技术被使用区分肿瘤、非肿瘤的息肉。

关键词：结肠镜检查活组织检查肿瘤检查方法

Pneumoscrotum: A rare manifestation of perforation associated with therapeutic colonoscopy

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World Journal of Gastroenterology 2005年第32期11卷 5061-5063页

作者： Kuang-I Fu Yasushi Sano shigeharu kato Takahiro Fujii Masanori Sugito Masato Ono Norio Saito Kiyotaka Kawashima Shigeaki Yoshida Takahiro Fujimori Division of Gastrointestinal Oncology and Digestive EndoscopyNational Cancer Center Hospital East KashiwaChiba 277-8577Japan Division of SurgeryNational Cancer Center Hospital East KashiwaChiba 277-8577Japan Department of Surgical and Molecular PathologyDokkyo University School of Medicine 880 KitakobaysashiMibuShimotugaTochigi 321-0293Japan

Pneumoscrotum is uncommon and also rarely reported as a complication associated with colonic perforation. A case of colonic perforation in delayed fashion associated with EMR, revealed by pneumoscrotum, is reported and the associated literatures are reviewed. A 52-year-old male received piecemeal EMR for a laterally spreading tumor 35 mm in size in our hospital. He complained of enlargement of the scrotum and revisited our hospital the day after the procedure. A diagnosis of pneumoscrotum was made, and as most such cases have been reported to be associated with pneumoperitoneum, colonic perforation was suspected. Free air but no fluid collection was found by abdominal computed tomography, and delayed colonic perforation was diagnosed. However, as there were no clinical signs of peritoneal irritation,conservative treatment was administered and the patient recovered uneventfully. Pneumoscrotum could be a sign of colonic perforation after EMR, and treatment should be carefully chosen.

关键词：结肠镜治疗方法并发症肠穿孔

Primary signet-ring cell carcinoma of the colon at early stage: A case report and a review of the literature

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World Journal of Gastroenterology 2006年第21期12卷 3446-3449页

作者： Kuang-I Fu Yasushi Sano shigeharu kato Hiroki Saito Atsushi Ochiai Takahiro Fujimori Yutaka Saito Takahisa Matsuda Takahiro Fujii Shigeaki Yoshida Division of Gastrointestinal Oncology and Digestive Endoscopy National Cancer Center Hospital East KashiwaChiba 277-8577Japan Department of Surgical and Molecular PathologyDokkyo University School of Medicine880 KitakobaysashiMibuShimotugaTochigi 321-0293Japan Division of Gastrointestinal Oncology and Digestive Endoscopy National Cancer Center Hospital East KashiwaChiba 277-8577Japan Division of Pathology National Cancer Center East Research Institute Chiba 277-8577Japan Department of Surgical and Molecular Pathology Dokkyo University School of Medicine 880 KitakobaysashiMibuShimotugaTochigi 321-0293Japan Division of Endoscopy National Cancer Center Hospital TsukijiTokyo 104-0045Japan

经历了外科到将切除的一个 67 岁的人多重胃的癌症 4 年以前，为监视结肠镜检查访问了我们的医院。揭示的结肠镜检查一变色，在直径的 7 公里，有在结肠左曲附近的横向的冒号的中央消沉的提高公寓的损害。尽管内视镜检查法和钡灌肠的调... 详细信息

经历了外科到将切除的一个 67 岁的人多重胃的癌症 4 年以前，为监视结肠镜检查访问了我们的医院。揭示的结肠镜检查一变色，在直径的 7 公里，有在结肠左曲附近的横向的冒号的中央消沉的提高公寓的损害。尽管内视镜检查法和钡灌肠的调查结果粘膜下层侵略是暗示的，病人选择了经历内视镜的粘膜切除术。resected 标本的病理学的检查揭示了图章戒指房间癌和积极外科的边缘。第二个手术被动，并且到淋巴结的剩余肿瘤或转移都没在 resected 标本被发现。由在一个早阶段检测并且对待的图章戒指房间癌组成的三原色表面的癌症是极其稀罕的。我们在场一个盒子和评论文学。

关键词：结肠癌内窥镜检查病理机制临床

Depressed-type (0-IIc) colorectal neoplasm in patients with family history of first-degree relatives with colorectal cancer:A cross-sectional study

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World Journal of Gastroenterology 2006年第19期12卷 3082-3087页

作者： Junko Iwasaki Yasushi Sano Kuang-I Fu Ai Machida Tatsuya Okuno Hikaru Kuwamura Takayuki Yoshino Kiyomi Mera shigeharu kato Atsushi Ohtsu Shigeaki Yoshida Takahiro Fujii Division of Digestive Endoscopy and Gastrointestinal Oncology National Cancer Center Hospital East ChibaJapan TF Clinic Tokyo Japan

瞄准：调查关联沮丧类型(0-IIc ) 与颜色渲染一度的亲戚(FDR ) 的表面的瘤和家庭历史表面的癌症(CRC ) 。方法：这代表性的研究在国家癌症中心医院东方从 2000 年 6 月被进行到 2002 年 10 月。经历起始的全部的结肠镜检查的合格病人被... 详细信息

瞄准：调查关联沮丧类型(0-IIc ) 与颜色渲染一度的亲戚(FDR ) 的表面的瘤和家庭历史表面的癌症(CRC ) 。方法：这代表性的研究在国家癌症中心医院东方从 2000 年 6 月被进行到 2002 年 10 月。经历起始的全部的结肠镜检查的合格病人被一张问询表在 colonoscopic 考试以前在 FDR 之中关于 CRC 的家庭历史调查。所有内视镜的调查结果在结肠镜检查期间被记录，早阶段瘤 / 癌症的宏观的分类被分类进二种类型(0-IIc 对非 0-IIc ) 。机会比率(或) 并且 95% 信心间隔(CI ) 被 univariate 并且多计算变量与 CRC 估计在 FDR 的宏观的特征和 clinicopathological 数据包括性，年龄，和家庭历史之间的协会的逻辑回归。结果：在有 CRC 和性和年龄调整的全面早阶段瘤的 FDR 的家庭历史之间的一个协会的 OR 是 1.85 (95% CI：1.31-2.61， P = 0.0004 ) ，那为非 0-IIc 瘤是 1.71 (95% CI：1.22-2.41， P = 0.0017 ) 并且为 0-IIc 颜色，表面的瘤是 2.78 (95% CI：1.49-5.16， P = 0.0031 ) 。结论：我们的学习证明在有 CRC 和 0-IIc 的 FDR 的家庭历史之间的一个重要协会渲染表面的瘤。当有有 CRC 的 FDR 的家庭历史的病人经历结肠镜检查时， colonoscopists 应该小心地检查不仅水虫息似，而且沮丧类型(0-IIc ) 损害。

关键词：结肠直肠癌结肠镜检查遗传疾病水螅

Vitamin D and calcium are required at the time of denosumab administration during osteoporosis treatment

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Bone Research 2017年第4期5卷 384-390页

作者： Yukio Nakamura Takako Suzuki Mikio Kamimura Kohei Murakami Shota Ikegami shigeharu Uchiyama Hiroyuki kato Department of Orthopedic Surgery Shinshu University School of MedicineMatsumotoJapan Department of Orthopedic Surgery Showa-lnan General HospitalKornaganeJapan Center of Osteoporosis and Spinal Disorders Kamimura Orthopaedic ClinicMatsumotoJapan

To evaluate the differences in outcomes of treatment with denosumab alone or denosumab combined with vitamin D and calcium supplementation in patients with primary osteoporosis. Patients were split into a denosumab monotherapy group （18 cases） or a denosumab plus vitamin D supplementation group （combination group; 23 cases）. We measured serum bone alkaline phosphatase （BAP）, tartrate-resistant acid phosphatase （TRACP）-5b and urinary N-terminal telopeptide of type-I collagen （NTX） at baseline, 1 week, as well as at I month and 2, 4, 8 and 12 months. We also measured bone mineral density （BMD） of L1-4 lumbar vertebrae （L）-BMD and bilateral hips （H）-BMD at baseline and at 4, 8 and 12 months. There was no significant difference in patient background. TRACP-5b and urinary NTX were significantly suppressed in both groups from I week to 12 months （except at 12 months for NTX）. In the combination group, TRACP-5b was significantly decreased compared with the denosumab monotherapy group at 2 and 4 months （P 〈 0.05）. BAP was significantly suppressed in both groups at 2-12 months. L-BMD significantly increased at 8 and 12 months （8.9%） in the combination group and at 4, 8 and 12 months （6.0%） in the denosumab monotherapy group, compared with those before treatment. H-BMD was significantly increased in the combination group （3.6%） compared with the denosumab group （1.2%） at 12 months （P 〈 0.05）. Compared with denosumab monotherapy, combination therapy of denosumab with vitamin D and calcium stopped the decrease in calcium caused by denosumab, inhibited bone metabolism to a greater extent, and increased BMD （especially at the hips）.

关键词： BMD TRACP Vitamin D and calcium are required at the time of denosumab administration during osteoporosis treatment NTX

Two-year clinical outcome of denosumab treatment alone and in combination with teriparatide in Japanese treatment-naive postmenopausal osteoporotic women

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Bone Research 2017年第2期5卷 152-158页

作者： Yukio Nakamura Takako Suzuki Mikio Kamimura Shota Ikegami Kohei Murakami shigeharu Uchiyama Akira Taguchi Hiroyuki kato Department of Orthopedic Surgery Shinshu University School of Medicine Matsumoto Japan Department of Orthopedic Surgery Showa-Inan General Hospital Komagane Japan Center of Osteoporosis and Spinal Disorders Kamimura Orthopaedic Clinic Matsumoto Japan and Department of Oral and Maxillofacial Radiology Matsumoto Dental University Shiojiri Japan

This randomized prospective study aimed to evaluate the clinical outcome of denosumab treatment alone and in combination with teriparatide in treatment-naive postmenopausal Japanese female patients with osteoporosis. Thirty patients were randomly assigned to two groups:(1) denosumab group(denosumab alone, n=13); and(2) combination group(denosumab+teriparatide, n=17). Serum bone-specific alkaline phosphatase(BAP), serum tartrate-resistant acid phosphatase(TRACP)-5b, urinary cross-linked N-terminal telopeptides of type I collagen(NTX), and bone mineral density(BMD) of L1–4 lumbar vertebrae(L-BMD)and bilateral total hips(H-BMD) were determined at the first visit and at various time points up to 24 months post-treatment to determine percentage changes. Serum TRACP-5b and urinary NTX were equally suppressed in both groups and maintained at low levels, with slight increases at 12, 18 and 24 months. BAP was significantly decreased in both groups from 4 to 24 months, with significant differences between the groups at 4, 8 and 15 months(P<0.05). L-BMD was significantly increased at most time points in both groups, with a significant difference between the combination group and denosumab group at 24 months(17.2% increase versus 9.6% increase; P<0.05). There was no significant difference in H-BMD between the two groups, although the levels tended to be higher in the combination group than in the denosumab group(9.5% increase versus 5.6% increase). These findings suggest that denosumab+teriparatide combination therapy may represent an important treatment for primary osteoporotic patients at high risk of vertebral fracture.

关键词： teriparatide denosumab treatment