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C1orf106, an innate immunity activator, is amplified in breast cancer and is required for basal-like/luminal progenitor fate decision

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Science China(Life Sciences) 2019年第9期62卷 1229-1242页

作者： Ji Ma Cheng liu Decao Yang Jiagui Song Jing Zhang Tianzhuo Wang Mengyuan Wang Weizhi Xu Xueying Li shigang Ding Jun Zhan Hongquan Zhang Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of AnatomyHistology and Embryologyand State Key Laboratory of Natural and Biomimetic DrugsPeking University Health Science CenterBeijing 100191China Department of Gastroenterology Peking University Third HospitalBeijing 100191China

Basal-like breast cancer with a luminal progenitor gene expression profile is an aggressive subtype of breast cancer with a poorer prognosis compared with other subtypes.However,genes that specifically promote basal-like breast cancer development remain largely unknown.Here,we report that a novel gene C1orf106 plays an important role in maintaining the feature of basal-like/luminal progenitors.C1orf106 is frequently amplified and overexpressed in basal-like breast cancer and is associated with a poor outcome in patients.In human TCGA database,C1orf106 expression was correlated with upregulation of ELF5 and downregulation of GATA3,two transcription factors that regulate mammary gland stem cell fate.Enhanced expression of C1orf106 promotes tumor progression and expression of basal-like/luminal progenitor marker ELF5;depletion of C1orf106 suppresses tumorigenesis and expression of basal-like/luminal progenitor marker GATA3.These findings suggest that C1orf106 maintains the basal-like/luminal progenitor character through balancing the expression of ELF5 and GATA3.Taken together,we demonstrated that C1orf106 is an important regulator for basal-like/luminal progenitors and targeting C1orf106 is of therapeutic value for breast cancer.

关键词： C1orf106 basal-like luminal progenitor breast cancer ELF5 GATA3

基于优化有限差分和混合吸收边界条件的三维VTI介质声波和弹性波数值模拟

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地球物理学报 2018年第7期61卷 2950-2968页

作者：徐世刚刘洋中国石油大学(北京)油气资源与探测国家重点实验室北京102249 中国石油大学(北京)CNPC物探重点实验室北京102249

传统有限差分系数是通过泰勒级数展开求取的,这样导致所计算的频散曲线在大波数区域会产生较强的数值误差.针对二阶空间偏导数的显式有限差分离散,本文发展了一种新的优化差分系数方法:首先将泰勒级数展开与多点采样方法结合应用于空间... 详细信息

传统有限差分系数是通过泰勒级数展开求取的,这样导致所计算的频散曲线在大波数区域会产生较强的数值误差.针对二阶空间偏导数的显式有限差分离散,本文发展了一种新的优化差分系数方法:首先将泰勒级数展开与多点采样方法结合应用于空间频散关系,基于最大范数建立直观有效的优化目标函数,采用Remez算法求解该目标函数,从而获得最优化差分系数.利用优化有限差分方法求解三维垂直对称轴横向各向同性(VTI)介质中的声波和弹性波方程.另外,本文将二维混合吸收边界条件推广到三维VTI介质中,用于吸收人工截断边界反射;基于各向异性特征,合理调整了边界区域的速度值来提高吸收效果.考虑到三维情况下计算效率的问题,本文波场外推过程中采用图形处理器(GPU)取代传统的中央处理器(CPU).数值精度分析表明,相比较于传统的泰勒级数展开方法,优化有限差分方法在大波数区域对频散误差的压制效果更明显.在三维均匀和修改的Hess VTI模型中的数值模拟实验证明了本文方法具有更高的精度与效率,混合吸收边界条件在三维VTI介质中具有良好的边界吸收效果.

关键词：数值模拟有限差分优化方法各向异性波动方程混合吸收边界条件图形处理器

指压合谷穴治疗全口义齿初戴者恶心的效果观察

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中国基层医药 2022年第7期29卷 985-988页

作者：鹿时刚刘国存济宁医学院附属湖西医院单县中心医院神经内科菏泽274300 济宁医学院附属湖西医院单县中心医院口腔科菏泽274300

目的观察指压合谷穴治疗全口义齿初戴者恶心的效果,寻找更好地减轻全口义齿初戴者恶心的方法。方法选取济宁医学院附属湖西医院2016年6月至2019年12月全口义齿初戴者41例,采用随机数字表法分为两组,观察组21例,采用指压合谷治疗,分别于... 详细信息

目的观察指压合谷穴治疗全口义齿初戴者恶心的效果,寻找更好地减轻全口义齿初戴者恶心的方法。方法选取济宁医学院附属湖西医院2016年6月至2019年12月全口义齿初戴者41例,采用随机数字表法分为两组,观察组21例,采用指压合谷治疗,分别于戴义齿前和三餐饭前按压合谷穴3 min;对照组20例,采用自己适应法治疗。两组于戴义齿后3 d、7 d、14 d复诊,记录无恶心例数、吞咽功能正常例数、咀嚼效率,比较两组效果。结果观察组戴义齿3 d、7 d无恶心分别为85.71%(18/21)、95.24%(20/21),均高于对照组的45.00%(9/20)、65.00%(13/20)(χ^(2)=5.58、4.19,均P0.05)。观察组戴义齿3 d吞咽功能正常率为57.14%(12/21),高于对照组的15.00%(3/20)(χ^(2)=8.16,P0.05)。观察组戴义齿3 d、7 d咀嚼效率分别为(42.03±5.02)%、(50.34±5.05)%,均高于对照组的(37.00±4.00)%、(47.13±4.03)%,均差异有统计学意义(t=3.51,1.65,均P0.05)。结论指压合谷穴用于减轻全口义齿初戴者恶心的临床疗效好,可缩短全口义齿初戴者的适应时间。

关键词：义齿全口恶心呕吐合谷穴位按压咀嚼吞咽

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基于门控卷积神经网络的图像超分辨重建算法

光电子．激光 2022年第6期33卷 637-642页

作者：王文安梁新刚刘侍刚陕西师范大学现代教学技术教育部重点实验室陕西西安710062 陕西师范大学计算机科学学院陕西西安710119

近年来,卷积神经网络被广泛应用于图像超分辨率领域。针对基于卷积神经网络的超分辨率算法存在图像特征提取不充分,参数量大和训练难度大等问题,本文提出了一种基于门控卷积神经网络(gated convolutional neural network, GCNN)的轻量... 详细信息

近年来,卷积神经网络被广泛应用于图像超分辨率领域。针对基于卷积神经网络的超分辨率算法存在图像特征提取不充分,参数量大和训练难度大等问题,本文提出了一种基于门控卷积神经网络(gated convolutional neural network, GCNN)的轻量级图像超分辨率重建算法。首先,通过卷积操作对原始低分辨率图像进行浅层特征提取。之后,通过门控残差块(gated residual block, GRB)和长短残差连接充分提取图像特征,其高效的结构也能加速网络训练过程。GRB中的门控单元(gated unit, GU)使用区域自注意力机制提取输入特征图中的每个特征点权值,紧接着将门控权值与输入特征逐元素相乘作为GU输出。最后,使用亚像素卷积和卷积模块重建出高分辨率图像。在Set14、BSD100、Urban100和Manga109数据集上进行实验,并和经典方法进行对比,本文算法有更高的峰值信噪比(peak signal-to-noise ratio,PSNR)和结构相似性(structural similarity,SSIM),重建出的图像有更清晰的轮廓边缘和细节信息。

关键词：超分辨率门控单元门控残差块轻量级卷积神经网络

某院2021—2022年门诊和急诊处方点评情况分析

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中国实用乡村医生杂志 2024年第1期31卷 36-38页

作者：刘永霞南通市通州区石港中心卫生院药剂科江苏南通226351

目的对南通市通州区石港中心卫生院近2年来的门诊和急诊处方进行点评,分析处方不合理发生情况,并提出对策。方法采用分层随机抽样方法抽取2021年1月—2022年12月南通市通州区石港中心卫生院门诊和急诊处方158 577张为点评对象,分析处... 详细信息

目的对南通市通州区石港中心卫生院近2年来的门诊和急诊处方进行点评,分析处方不合理发生情况,并提出对策。方法采用分层随机抽样方法抽取2021年1月—2022年12月南通市通州区石港中心卫生院门诊和急诊处方158 577张为点评对象,分析处方不合理发生情况。结果 158 577张处方中不合理处方3 954张,不合理率为2.49%;其中急诊处方不合理率为2.50%,门诊处方不合理率为2.49%。2021年处方不合理率为2.50%,急诊和门诊处方不合理率均为2.50%。2022年处方不合理率为2.49%,门诊和急诊处方不合理率均为2.49%。3 954张不合理处方中以用药不适宜处方为主,占62.77%,不规范处方占37.23%。结论该卫生院存在较高的处方不合理率,其中处方不合理又以用药不适宜为主,应加强处方相关的监管力度,以及临床医师合理书写处方等相关的培训,以提高处方合理率和用药合理性。

关键词：卫生院门诊急诊处方不合理点评

Tracing of dye molecules in living plants through NaGdF_4:Yb^(3+),Er^(3+)fluorescent nanoprobes

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Journal of Rare Earths 2019年第3期37卷 237-241页

作者： Xiaofeng Wu Ya'nan Zhang Shiping Zhan Jin Li Guozheng Nie shigang Hu Cong Yan Shaobing Wu Shengbin Cheng Junshan Hu Lichun Shi Yunxin liu School of Information and Electrical Engineering Hunan University of Science and Technology College of Physics and Electronics Science Hunan University of Science and Technology Key Laboratory of Organic Polymer Photoelectric Materials School of Science Xijing University

In this paper, we demonstrated trace of dye molecules in living plants. The NaGdF4:Yb^(3+),Er^(3+) nanoparticles probe was used to detect the rhodamine B(RhB) in bean sprout. It is found that the fluorescencedye can be efficiently imbibed during the growing process and the absorbance presented a position dependence effect, which was supported by the upconversion spectra and the fluorescent image characterization. In addition, the concentration of the residual RhB in bean sprout can be efficiently traced by the synthesized probe based on the fluorescent resonant energy transfer. Finally, the relation between the excitation power, concentration and the ratio of yellow to green emission are discussed in detail. These results can be helpful in understanding the RhB dye molecules absorbance process in vegetable growth and provide an efficient way to trace the residual dyes in vivo plant.

关键词： Rare-earth-doped materials Biological sensing and sensors Fluorescence Luminescence Upconversion nanoprobes

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日本最新安全与防卫战略调整分析

国家安全论坛 2023年第1期 26-36,90页

作者：刘世刚军事科学院战争研究院

日本近期正式通过《国家安全保障战略》《国家防卫战略》和《防卫力量发展计划》三份重要战略文件,展开新一轮安全战略与军事战略调整。日本此次战略调整主要变化有:日本对华威胁判断升级,中国成其头号“战略挑战者”;日本防卫战略由守... 详细信息

日本近期正式通过《国家安全保障战略》《国家防卫战略》和《防卫力量发展计划》三份重要战略文件,展开新一轮安全战略与军事战略调整。日本此次战略调整主要变化有:日本对华威胁判断升级,中国成其头号“战略挑战者”;日本防卫战略由守转攻,强调要发展和使用“反击能力”;日本防卫力量建设全面提速,重点扩充远程打击手段。日本最新战略调整的意图主要有:进一步突破和平宪法体制束缚;进一步提升战略威慑力;放手发展海外军事干预能力,试图获取先发制人打击资格。日本此轮战略调整对外指向性明显,对亚太地区安全影响不容小觑。

关键词：日本国家安全战略防卫战略反击能力

The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation

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Genomics, Proteomics & Bioinformatics 2023年第1期21卷 203-215页

作者： Xiumei Xing Cheng Ai Tianjiao Wang Yang Li Huitao liu Pengfei Hu Guiwu Wang Huamiao liu Hongliang Wang Ranran Zhang Junjun Zheng Xiaobo Wang Lei Wang Yuxiao Chang Qian Qian Jinghua Yu Lixin Tang shigang Wu Xiujuan Shao Alun Li Peng Cui Wei Zhan Sheng Zhao Zhichao Wu Xiqun Shao Yimeng Dong Min Rong Yihong Tan Xuezhe Cui Shuzhuo Chang Xingchao Song Tongao Yang Limin Sun Yan Ju Pei Zhao Huanhuan Fan Ying liu Xinhui Wang Wanyun Yang Min Yang Tao Wei Shanshan Song Jiaping Xu Zhigang Yue Qiqi Liang Chunyi Li Jue Ruan Fuhe Yang Key Laboratory of Genetics Breeding and Reproduction of Special Economic AnimalsMinistry of Agriculture and Rural AffairsInstitute of Special Animal and Plant SciencesChinese Academy of Agricultural SciencesChangchun 130112China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China CAS Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China Annoroad Gene Technology(Beijing)Co. LtdBeijing 100176China Novogene Bioinformatics Institute Beijing 100083China

Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika deer.We generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments.Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT genes.The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation.Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals.

关键词： Sika deer Whole-genome sequencing Chromosome-scale assembly Oak leaf Tannin tolerance

Survey on key security technologies for space information networks

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Journal of Communications and Information Networks 2016年第1期1卷 72-85页

作者： liu Jianwei liu Weiran WU Qianhong LI Dawei CHEN shigang School of Electronic and Information Engineering Beihang UniversityBeijing 100191China Department of Computer and Information of Science and Engineering University of FloridaGainesville FL 32611USA

SIN(Space Information Network)is expected to play an increasing role in providing real-time,flexible,and integrated communication and data transmission services in an efficient manner.Nowadays,SIN has been widely developed for position navigation,environment monitor,traffic management,counter-terrorism,etc.However,security is a major concern in SIN,since the satellites,spacecrafts,and aircrafts are susceptible to a variety of traditional/specific network-based attacks,including eavesdropping,session hijacking,and illegal accessing.The network architecture and security issues of SIN were reviewed.Various security requirements were discussed that should be considered when designing SIN.And existing solutions proposed to meet these requirements were surveyed.The key challenges and key technologies that still require extensive research and development for securing SIN were indentifed.

关键词： space information network network architecture data encryption key management access authentication