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抑郁焦虑共病及抑郁症病人抉择加工策略研究

青岛大学医学院学报 2014年第6期50卷 481-483,486页

作者：徐圣芬郭宗君李玉焕赤海娇陈娟刘世恩青岛大学医学院附属医院特需保健科山东青岛266003 青岛市精神卫生中心陕西省西安兵器工业五二一医院青岛大学医学院附属医院医学影像科

目的探讨抑郁焦虑共病病人及抑郁症病人抉择加工策略的异同。方法依据中国精神疾病诊断与分类标准第3版（CCMD-3）选取抑郁焦虑共病病人、抑郁症病人和正常对照者各30例。应用E-prime程序编制3种类型（风险、含糊和确定）的抉择任务，... 详细信息

目的探讨抑郁焦虑共病病人及抑郁症病人抉择加工策略的异同。方法依据中国精神疾病诊断与分类标准第3版（CCMD-3）选取抑郁焦虑共病病人、抑郁症病人和正常对照者各30例。应用E-prime程序编制3种类型（风险、含糊和确定）的抉择任务，所有被试均完成上述抉择任务，记录反应时、正确率和风险偏好。结果在3种类型抉择条件下，3组间反应时比较，差异均有统计学意义（F=27．968～43．557，P〈0．01）；任一抉择类型下，共病组和抑郁组与对照组比较，反应时均显著延长（t=6．758～8．918，P〈0．01）；而各组内3种不同抉择类型之间反应时比较，仅对照组风险抉择反应时显著长于含糊抉择反应时（F=3．671，t=2．693，P〈0．01）。在同一类型抉择条件下，3组间正确率比较，差异均无统计学意义（P〉0．05）；而各组内3种不同抉择类型之间正确率比较，差异均有统计学意义（F=14．237～28．039，P〈0．01），3组在风险和含糊抉择类型下的正确率均低于确定抉择类型下的正确率（t=4．269～6．269，P〈0．01）。在风险、含糊抉择类型下，3组间风险偏好比较，差异均无统计学意义（P〉0．05）；而各组内风险偏好比较，仅共病组在风险抉择时的风险偏好显著低于含糊抉择时的风险偏好（t=1．916，P〈0．05）。结论抑郁焦虑共病和抑郁症病人抉择反应时较正常人延长；共病病人在含糊抉择类型下更倾向于冒险。

关键词：抑郁症焦虑抉择风险

N-doped carbon supported Pd catalysts for N-formylation of amines with CO2/H2

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Science China Chemistry 2018年第6期61卷 725-731页

作者： Xiaoying Luo Hongye Zhang Zhengang Ke Cailing Wu shien Guo Yunyan Wu Bo Yu Zhimin liu Beijing National Laboratory for Molecular Sciences Key Laboratory of Colloid Interface and Thermodynamics CAS Research/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

Using mesoporous N-doped carbons(NCs)derived from glucose and melamine as the supports,a series of Pd/NC catalysts were prepared,in which Pd nanoparticles with average size<2.0 nm were uniformly distributed on the *** was indicated that the resultant Pd/NC catalysts were effective for N-formylation of amines with CO_2and H_2in ethanol without any ***,the catalyst Pd/NC-800-6.9%containing quaternary N showed the best performance,affording a series of formylamides in good or even excellent *** investigation reveals that the interaction between the Pd nanoparticles and quaternary nitrogen in the NC support was responsible for the good performance of the catalyst.

关键词： Pd/NC C–N formation N-formylation CO2 H2

A Novel Route to Synthesize N,N-Dimethyl Arylmethylamines from Aryl Aldehydes, Hexamethylenetetramine and Hydrogen

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Chinese Journal of Chemistry 2020年第8期38卷 842-846页

作者： Zhengang Ke Bo Yu Yunyan Wu Yanfei Zhao Peng Yang shien Guo Zhimin liu Beijing National Laboratory for Molecular Sciences Key Laboratory of ColloidInterface and ThermodynamicsCAS Research/Education Centre for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Physical Science Laboratory Huairou National Comprehensive Science CenterBeijing 101407China

Developing simple and green routes to access valuable chemicals is of ***,we present a green and novel route to synthesize N,N-dimethyl arylmethylamines(DAMAs)from hexamethylenetetramine(HMTA)and aryl aldehydes in the presence of hydrogen,and a series of DAMAs can be obtained in good *** approach opens the precedent for HMTA as N,N-dimethylamine source to synthesize chemicals with N,N-dimethylamine group,which has promising applications for N-containing chemicals synthesis.

关键词： synthesis. amines synthesize

ARPC1B通过Wnt/β-catenin信号通路调节卵巢癌对顺铂的耐药性

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广西医科大学学报 2024年第5期41卷 653-659页

作者：周海琴莫世恩黄俊宁刘婷基况燕广西医科大学第一附属医院妇产科南宁530021 区域性高发肿瘤早期防治研究教育部重点实验室〔广西医科大学〕南宁530021 广西区域性高发肿瘤早期防治研究重点实验室南宁530021

目的:探讨ARPC1B通过Wnt/β-catenin信号通路对卵巢癌(OC)顺铂耐药的影响及其作用机制。方法:比较OC细胞(SKOV3)与卵巢癌耐药细胞(SKOV3/DDP细胞)对顺铂的半抑制浓度(IC50)值以及ARPC1B的表达;构建稳定沉默ARPC1B的卵巢癌耐药细胞系,细... 详细信息

目的:探讨ARPC1B通过Wnt/β-catenin信号通路对卵巢癌(OC)顺铂耐药的影响及其作用机制。方法:比较OC细胞(SKOV3)与卵巢癌耐药细胞(SKOV3/DDP细胞)对顺铂的半抑制浓度(IC50)值以及ARPC1B的表达;构建稳定沉默ARPC1B的卵巢癌耐药细胞系,细胞计数试剂盒(CCK-8)检测敲低ARPC1B后SKOV3/DDP细胞对顺铂IC50值,克隆形成实验、Transwell和划痕实验分别检测SKOV3/DDP细胞增殖和迁移能力,流式细胞术检测细胞凋亡,蛋白质免疫印迹法(western blotting)检测凋亡相关蛋白及Wnt/β-catenin信号通路关键分子蛋白表达水平的变化。结果:SKOV3/DDP细胞的耐药指数>2,且AR-PC1B在SKOV3/DDP细胞中高表达(P<0.05)。沉默ARPC1B后SKOV3/DDP细胞对顺铂的IC50值下降,增殖和迁移能力减弱(P<0.05);ARPC1B敲低组细胞中BAX和Cleaved-Caspase 3蛋白以及凋亡率显著升高,而Bcl-2、β-catenin、c-myc和cyclin D1蛋白表达水平降低(P<0.05)。结论:ARPC1B可能通过Wnt/β-catenin信号通路抑制SKOV3/DDP细胞凋亡,进而增强SKOV3/DDP细胞对顺铂的耐药性。

关键词：卵巢癌 ARPC1B 顺铂耐药 Wnt/β-catenin 凋亡

Ultrafine VN nanodots induced generation of abundant cobalt single-atom active sites on nitrogen-doped carbon nanotube for efficient hydrogen evolution

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Journal of Energy Chemistry 2022年第5期31卷 646-657页

作者： Yan Cheng Juhui Gong Bo Cao Xuan Xu Peng Jing shien-Ping Feng Rui Cheng Baocang liu Rui Gao Jun Zhang School of Chemistry and Chemical Engineering Inner Mongolia Engineering and Technology Research Center for Catalytic Conversion and Utilization of Carbon Resource Molecules&Inner Mongolia Key Lab of Nanoscience and NanotechnologyInner Mongolia UniversityHohhot 010020Inner MongoliaChina Department of Mechanical Engineering The University of Hong KongHong Kong 999077China

Development of highly active and stable non-noble electrocatalysts with well-defined nanostructures is crucial for efficient hydrogen evolution reaction(HER). Herein, a novel three-dimensional(3D) selfsupported electrode consists of vanadium nitride(VN) nanodots and Co nanoparticles co-embedded and highly active single Co atoms anchored in N-doped carbon nanotubes supported on carbon cloth(VN-Co@CoSAs-NCNTs/CC) is fabricated via a one-step in situ nanoconfined pyrolysis strategy, which shows remarkable enhanced HER electrocatalytic activity in acidic medium. During pyrolysis, the formed VN nanodots induce the generation of atomic Co Nxsites in NCNTs, contributing to superior electrocatalytic activity. Experimental and density functional theory(DFT) calculation results reveal that the electrode has multiple accessible active sites, fast reaction kinetics, low charge/mass transfer resistances,high conductivity, as well as downshifted d-band center with a thermodynamically favorable hydrogen adsorption free energy(△G_(H·)), all of which greatly boost the HER performance. As a result, the VNCo@CoSAs-NCNTs/CC electrode displays superb catalytic performance toward HER with a low overpotential of 29 mV at 10 mA cm^(-2) in acidic medium, which could maintain for at least 60 h of stable performance. This work opens a facile avenue to explore low-cost, high performance, but inexpensive metals/nitrogen-doped carbon composite electrocatalysts for HER.

关键词： Single cobalt atoms Nitrogen-doped carbon nanotubes Vanadium nitride nanodots Cobalt nanoparticles Hydrogen evolution reaction

Engineering of SnO_(2)/TiO_(2) heterojunction compact interface with efficient charge transfer pathway for photocatalytic hydrogen evolution

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Chinese Chemical Letters 2023年第1期34卷 483-486页

作者： Hongli Wang Jianan liu Xudong Xiao Huiyuan Meng Jie Wu Chuanyu Guo Mang Zheng Xiaolei Wang shien Guo Baojiang Jiang Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150000China School of Safety Engineering Heilongjiang University of Science and TechnologyHarbin 150022China Institute of Advanced Materials(IAM) College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang 330022China

Fabricating an efficient charge transfer pathway at the compact interface between two kinds of semiconductors is an important strategy for designing hydrogen production heterojunction *** this work,we prepared a compact,stable and oxygen vacancy-rich photocatalyst(SnO_(2)/TiO_(2) heterostructure)via a simple and reasonable in-situ synthesis ***,SnCl_(2)–2H_(2)O is hydrolyzed on the TiO_(2) *** the pyrolysis process,SnO_(2) nanoparticles(5 nm)were dispersed on the surface of ultrathin TiO_(2) nanosheets ***,the heterojunction system can offer abundant oxygen vacancies,which can act as active sites for catalytic ***,the interfacial contact of SnO_(2)/TiO_(2) grading semiconductor oxide is uniform and tight,which can promote the separation and migration of photogenerated *** shown in the experimental results,the hydrogen production rate of SnO_(2)/TiO_(2) is 16.7 mmol h^(-1)g^(-1)(4.4 times higher than that of TiO_(2)),which is owing to its good dynamical *** work demonstrates an efficient strategy of tight combining SnO_(2)/TiO_(2) with abundant oxygen vacancies to improve catalytic efficiency.

关键词： Photocatalysis SnO_(2)-TiO_(2)heterojunction Solvent thermal Charge transfer Hydrogen evolution

Prediction of early-stage hepatocellular carcinoma using Onco Scan chromosomal copy number aberration data

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World Journal of Gastroenterology 2017年第44期23卷 7818-7829页

作者： Ming-Chin Yu Chao-Wei Lee Yun-shien Lee Jang-Hau Lian Chia-Lung Tsai Yi-Ping liu Chun-Hsing Wu Chi-Neu Tsai Department of Surgery Chang Gung Memorial Hospital Department of Surgery Xiamen Chang Gung Hospital Graduate Institute of Clinical Medical Sciences Chang Gung University Genomic Medicine Core Laboratory Chang Gung Memorial Hospital Department of Biotechnology Ming-Chuan University Department of Pediatrics Chang Gung Memorial Hospital

AIM To identify chromosomal copy number aberrations(CNAs) in early-stage hepatocellular carcinoma(HCC) and analyze whether they are correlated with patient *** One hundred and twenty patients with early-stage HCC were enrolled in our study, with the collection of formalin fixed, paraffin-embedded(FFPE) specimens and clinicopathological data. Tumor areas were marked by certified pathologists on a hematoxylin and eosinstained slide, and cancer and adjacent non-cancerous tissues underwent extraction of DNA, which was analyzed with the Affymetrix Onco Scan platform to assess CNAs and loss of heterozygosity(LOH). Ten individuals with nonmalignant disease were used as the control group. Another cohort consisting of 40 patients with stage Ⅰ/Ⅱ HCC were enrolled to analyze gene expression and to correlate findings with the Onco Scan *** Copy number amplifications occurred at chromosomes 1 q21.1-q44 and 8 q12.3-24.3 and deletions were found at 4 q13.1-q35.2, 8 p 23.2-21.1, 16 q23.3-24.3, and 17 p13.3-12, while LOH commonly occurred at 1 p32.3, 3 p21.31, 8 p23.2-21.1, 16 q22.1-24.3, and 17 p 13.3-11 in early-stage HCC. Using Cox regression analysis, we also found that a higher percentage of genome change(≥ 60%) was an independent factor for worse prognosis in early-stage HCC(P = 0.031). Among the 875 genes in the Onco Scan Gene Chip, six were independent predictors of worse disease-free survival, of which three were amplified(MYC, ELAC2, and SYK) and three were deleted(GAK, MECOM, and WRN). Further, patients with HCC who exhibited ≥ 3 CNAs involving these six genes have worse outcomes compared to those who had < 3 CNAs(P < 0.001). Similarly, Asian patients with stage I HCC from The Cancer Genome Atlas harboring CNAs with these genes were also predicted to have poorer *** Patients with early-stage HCC and increased genome change or CNAs involving MYC, ELAC2, SYK, GAK, MECOM, or WRN are at risk for poorer outcome after resection.

关键词： Early-stage hepatocellular carcinoma Copy number aberration Prognosis Onco Scan Molecular inversion probe

“问题导向”下促进深度学习的教学实践研究——以小学数学为例

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课程．教材．教法 2023年第1期43卷 131-137页

作者：赵世恩刘子钰首都师范大学初等教育学院北京100048

在教育领域,深度学习一直是研究的热点。尽管人们对深度学习的概念有着不同的理解,但有一点达成了共识,即深度学习发生的前提是学生要面对具有挑战性的问题,在解决问题的过程中理解所学的知识,提升数学素养。问题解决与深度学习有着天... 详细信息

在教育领域,深度学习一直是研究的热点。尽管人们对深度学习的概念有着不同的理解,但有一点达成了共识,即深度学习发生的前提是学生要面对具有挑战性的问题,在解决问题的过程中理解所学的知识,提升数学素养。问题解决与深度学习有着天然的联系。教师应充分利用数学的本质特征,积极地挖掘教材,有意识地设计具有挑战性的问题,激活学生原有的认知,提升学生分析问题和解决问题的能力,从而达到深度学习的要求。

关键词：问题导向问题解决深度学习小学数学教学实践

庆阳驴mtDNA D-loop区遗传多样性及起源分析

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中国畜牧兽医 2024年第2期51卷 601-613页

作者：施海娜王永杰梁万鹏耿智广李世恩徐振飞刘刚刘哲庆阳市农业科学研究院庆阳745000 宁夏回族自治区水产研究所银川750001 全国畜牧总站北京100193 甘肃农业大学动物科学技术学院兰州730070

[目的]研究庆阳驴养殖群体的遗传多样性与母系起源,了解其遗传信息,为保护庆阳驴种质资源、选育和遗传改良工作提供理论依据。[方法]随机选取133头庆阳驴,对其线粒体DNA(mitochondrial DNA,mtDNA)D-loop区序列进行PCR扩增、测序及比对,... 详细信息

[目的]研究庆阳驴养殖群体的遗传多样性与母系起源,了解其遗传信息,为保护庆阳驴种质资源、选育和遗传改良工作提供理论依据。[方法]随机选取133头庆阳驴,对其线粒体DNA(mitochondrial DNA,mtDNA)D-loop区序列进行PCR扩增、测序及比对,并探讨庆阳驴的遗传多样性与母系起源。[结果]在获得的520 bp D-loop碱基序列中,AT含量(57.3%)高于GC含量(42.8%),表现出碱基的偏倚性;检测到38个变异位点,包含8个碱基对的转换;其核苷酸多样性(Pi)、单倍型多样性(Hd)、平均核苷酸差异(K)分别为0.01591、0.895和8.274,与欧洲家驴和中国家驴研究的平均值相比较低,说明该驴品种核苷酸变异较为贫乏。庆阳驴mtDNA D-loop区存在35个单倍型,单倍型之间的遗传距离为0.002~0.042。系统进化结果显示,庆阳驴存在2个线粒体支系,表明其具有2个母系起源,且遗传距离表明,庆阳驴与克罗地亚家驴之间的遗传距离较近。[结论]本研究从分子水平初步揭示庆阳驴核苷酸变异比较贫乏,杂交程度高,mtDNA遗传多态性正逐步丧失,应加强庆阳驴品种的遗传资源保护工作。

关键词：庆阳驴 mtDNA D-loop区遗传多样性起源

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