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A new prognostic histopathologic classification of nasopharyngeal carcinoma

Chinese Journal of Cancer 2016年第6期35卷 30-45页

作者： Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam shie-lee cheah Ming lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Department of Molecular Diagnostics Sun Yat-sen University Cancer Center Department of Pathology National Taiwan University HospitalNational Taiwan University College of Medicine Department of Anatomical and Cellular Pathology Hong Kong Cancer Institute and Sir YK Pao Centre for CancerFaculty of MedicineThe Chinese University of Hong Kong Department of Pathology Singapore General Hospital Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center Department of Pathology Sun Yat-sen University Cancer Center Division of Epidemiology Department of Health Research and PolicyStanford University School of Medicine Health Sciences Practice ExponentInc. Department of Otolaryngology National Taiwan University HospitalNational Taiwan University College of Medicine Department of Clinical Oncology Hong Kong Cancer Institute and Sir YK Pao Centre for CancerFaculty of MedicineThe Chinese University of Hong Kong Division of Radiation Oncology National Cancer CenterSingapore Department of Radiation Oncology Cancer Institute and HospitalChinese Academy of Medical Sciences Department of Radiation Oncology The Affiliated Hospital of Bengbu Medical College Department of Pathology Cancer Institute and HospitalChinese Academy of Medical Sciences Department of Radiation Oncology Guangxi Medical University Department of Pathology Hunan Provincial Cancer Hospital Department of Radiation Oncology Sun Yat-sen University Cancer Center Department of Pathology Fujian Provincial Cancer Hospital Department of Pathology The First Affiliated HospitalSun Yat-sen University Department of Pathology Sun Yat-sen Memorial HospitalSun Yat-sen University Department of Pathology The Third Affiliated HospitalSun Yat-sen University Department of Experiment Research Sun Yat-sen University Cancer Center Department of Medical Epidemiology and Biostatistics Karolinska Institutet Departments of Mi

Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic *** study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment ***:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from *** efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed *** used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis.

关键词： Nasopharyngeal carcinoma Pathologic classification Prognosis

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Targeting cell surface receptors for axon regeneration in the central nervous system

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Neural Regeneration Research 2016年第12期11卷 1884-1887页

作者： Menghon cheah Melissa R.Andrews John van Geest Centre for Brain Repair University of Cambridge School of Medicine University of St.Andrews

Axon regeneration in the CNS is largely unsuccessful due to excess inhibitory extrinsic factors within lesion sites together with an intrinsic inability of neurons to regrow following injury. Recent work demonstrates that forced expression of certain neuronal transmembrane receptors can recapitulate neuronal growth resulting in successful growth within and through inhibitory lesion environments. More specifically, neuronal expression of integrin receptors such as alpha9beta1 integrin which binds the extracellular matrix glycoprotein tenascin-C, trk receptors such as trk B which binds the neurotrophic factor BDNF, and receptor PTPσ which binds chondroitin sulphate proteoglycans, have all been show to significantly enhance regeneration of injured axons. We discuss how reintroduction of these receptors in damaged neurons facilitates signalling from the internal environment of the cell with the external environment of the lesion milieu, effectively resulting in growth and repair following injury. In summary, we suggest an appropriate balance of intrinsic and extrinsic factors are required to obtain substantial axon regeneration.

关键词： axon regeneration dorsal root ganglion extracellular matrix integrin tenascin-c trk receptors

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Precision medicine in inflammatory bowel disease:Individualizing the use of biologics and small molecule therapies

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World Journal of Gastroenterology 2023年第10期29卷 1539-1550页

作者： Eric cheah James Guoxian Huang Department of Gastroenterology and Clinical Nutrition The Royal Children's Hospital MelbourneParkvilleVIC 3052Australia Department of Paediatrics Khoo Teck Puat-National University Children's Medical InstituteNational University Health SystemSingapore 119228Singapore Department of Paediatrics Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore

The advent of biologics and small molecules in inflammatory bowel disease(IBD)has marked a significant turning point in the prognosis of IBD,decreasing the rates of corticosteroid dependence,hospitalizations and improving overall quality of *** introduction of biosimilars has also increased affordability and enhanced access to these otherwise costly targeted *** do not yet represent a complete panacea:A subset of patients do not respond to first-line anti-tumor necrosis factor(TNF)-alpha agents or may subsequently demonstrate a secondary loss of *** who fail to respond to anti-TNF agents typically have a poorer response rate to second-line *** is uncertain which patient would benefit from a different sequencing of biologics or even a combination of biologic *** introduction of newer classes of biologics and small molecules may provide alternative therapeutic targets for patients with refractory *** review examines the therapeutic ceiling in current treatment strategies of IBD and the potential paradigm shifts in the future.

关键词： Precision medicine Therapeutic ceiling Inflammatory bowel disease Biologics Small molecules

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Gigantic electric-field-induced second harmonic generation from an organic conjugated polymer enhanced by a band-edge effect

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Light(Science & Applications) 2019年第1期8卷 1006-1011页

作者： Shumei Chen King Fai Li Guixin Li Kok Wai cheah Shuang Zhang School of Physics and Astronomy University of BirminghamBirmingham B152TTUK Department of Materials Science and Engineering Shenzhen Institute for Quantum Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China Department of Physics Hong Kong Baptist UniversityKowloon TongHong KongChina

Electric-field-induced second harmonic generation(EFISH),a third-order nonlinear process,arises from the interaction between the electric field of an external bias and that of two incident *** can be used to dynamically control the nonlinear optical response of materials and is therefore promising for active nonlinear ***,it has been challenging to achieve a strong modulation with EFISH in conventional nonlinear ***,we report a large tunability of an EFISH signal from a subwavelength-thick polymer film sandwiched between a transparent electrode and a metallic *** exploiting the band-edge-enhanced third-order nonlinear susceptibility of the organic conjugated polymer,we successfully demonstrate a gigantic EFISH effect with a modulation ratio up to 422%V^(−1) at a pumping wavelength of 840 *** band-edge-enhanced EFISH opens new avenues for modulating the intensity of SHG signals and for controlling nonlinear electro-optic interactions in nanophotonic devices.

关键词： nonlinear harmonic conjugated

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Determination of Water Quality of Rivers under Various Land Use Activities Using Physico-chemical Parameters and Bacterial Populations in Northern Peninsular Malaysia

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湿地科学 2016年第6期14卷 788-798页

作者： Ezatul Huda Muhd Redzuan cheah Suhaila Abdul Hamid School of Biological Sciences Universiti Sains Malaysia

A study on water quality of rivers with different land use activities by using physico-chemical parameters and bacterial population was conducted around Kedah, Penang and Perak, Malaysia. The water quality parameters such as dissolved oxygen(DO), five-day biochemical oxygen demand(BOD5), chemical oxygen demand(COD), total dissolved solids(TDS), total suspended solids(TSS), nitrate, p H, ammonia-nitrogen, water temperature, water depth and velocity were measured and the densities of bacteria which were total coliform(TC) and fecal coliform(FC) were monitored simultaneously using IDEXX-Colilert?technique from selected rivers. The greatest population of TC and FC(>2 419.6 n MPN/100ml) were recorded from industrial rivers while the lowest reading recorded in less disturbed rivers with less than 1 MPN/100 ml. Total coliform count categorized all rivers into Class I and FC count showed five rivers fell into Class I(Sungai Sedim, Bukit Hijau, Teluk Bahang, Kurau and Tukun), two rivers fell into Class IIA(Sungai Batu Hampar and Salleh) and eight rivers fell into IIB categories(Sungai Jerejak,Pinang, Air Hitam, Kluang, Chelong, Titi Hayun and Cherok Tokun). There was a significant difference between the TC population with TSS content(r=0.43), TDS content(r=0.813), river depth(r=0.513) and DO level(r=-0.401) from all selected *** coliform population was greatly influenced by contents of BOD5(r=0.456), COD(r=0.531), TSS(r=0.813), TDS(r=0.724), and water temperature(r=0.711). The rivers with industrial land-use setting recorded the highest range of water quality index scores and fell into Class III(Sungai Jerejak, Air Hitam and Kluang) and Class V(Sungai Pinang). Both plantation rivers(Sungai Chelong and Sungai Salleh) fell into Class II and all recreational and less disturbed rivers fell into Class I.

关键词：湿地生态系统服务价值评价生态保护

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