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Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2791-2803页

作者： Gang Yang Jinpeng Cao Jian Qin Xinyue Mei shidong deng Yingjiao Xia Jun Zhao Junxiang Wang Tao Luan Daxiang Chen Peiyu Huang Cheng Chen Xi Sun Qi Luo Jie Su Yunhui Zhang Nanshan Zhong Zhongfang Wang The Affiliated Hospital of Kunming University of Science and Technology.Department of Respiratory and Critical Care Medicine The First People’s Hospital of Yunnan provinceKunmingYunnanChina Guangzhou National Laboratory BiolandGuangzhouGuangdongChina State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouChina

The immunoprotective components control COVID-19 disease severity,as well as long-term adaptive immunity maintenance and subsequent reinfection risk discrepancies across initial COVID-19 severity,remain ***,we longitudinally analyzed SARS-CoV-2-specific immune effectors during the acute infection and convalescent phases of 165 patients with COVID-19 categorized by *** found that early and robust SARS-CoV-2-specific CD4^(+)and CD8^(+)T cell responses ameliorate disease progression and shortened hospital stay,while delayed and attenuated virus-specific CD8^(+)T cell responses are prominent severe COVID-19 *** antiviral antibody generation rather than titer level associates with severe ***,initial COVID-19 severity imprints the long-term maintenance of SARS-CoV-2-specific adaptive immunity,demonstrating that severe convalescents exhibited more sustained virus-specific antibodies and memory T cell responses compared to mild/moderate ***,initial COVID-19 severity inversely correlates with SARS-CoV-2 reinfection ***,our study unravels the complicated interaction between temporal characteristics of virus-specific T cell responses and COVID-19 severity to guide future SARS-CoV-2 wave management.

关键词： severity immunity infection

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电动机低电压保护误动作分析及处理

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大氮肥 2013年第3期36卷 187-189页

作者：胡进邓世东中国石化湖北化肥分公司湖北枝江443200

介绍电动机低电压保护的原理,针对DMP371微机电动机保护测控装置低电压保护误动作原因进行分析,采取改写DMP371微机电动机保护测控装置程序,解决低电压误动作的问题。

关键词：电动机低电压保护 PT断线逻辑模块电流闭锁

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沉默SNHG1基因对膀胱癌细胞增殖、凋亡、迁移和铁死亡的影响

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中华临床医师杂志（电子版） 2023年第7期17卷 804-811页

作者：邓世栋刘凌志郭大勇王超黄忠欣张晖辉南华大学附属第一医院泌尿外科湖南衡阳421000 南华大学医院管理研究所湖南衡阳421000

目的观察沉默SNHG1基因对膀胱癌细胞增殖、凋亡、迁移和铁死亡的影响。方法通过qPCR检测SNHG1在人膀胱癌T24和5637细胞株的表达。构建SNHG1 shRNA并建立对照组(shCtrl)、敲低组(shSNHG1)。通过CCK8法、流式细胞术、Transwell实验和ELIS... 详细信息

目的观察沉默SNHG1基因对膀胱癌细胞增殖、凋亡、迁移和铁死亡的影响。方法通过qPCR检测SNHG1在人膀胱癌T24和5637细胞株的表达。构建SNHG1 shRNA并建立对照组(shCtrl)、敲低组(shSNHG1)。通过CCK8法、流式细胞术、Transwell实验和ELISA分别检测细胞增殖、凋亡、迁移和铁死亡水平的变化。qPCR检测PTEN、AKT、GPX4、ACSL4、Caspase3、CyclinD1相关基因的表达水平。结果与人膀胱上皮永生化细胞SV-HUC-1相比,SNHG1在T24和5637细胞中的表达明显上调(P<0.001)。与对照组相比,shSNHG1组细胞的增殖和迁移能力被显著抑制(P<0.001),凋亡和铁死亡水平显著增加(P<0.001和P<0.05)。shSNHG1组细胞PTEN、ACSL4和Caspase3的基因表达水平显著上升(P<0.001),GPX4、AKT和CyclinD1的基因表达水平显著下降(P<0.01和P<0.001)。结论沉默SNHG1的表达能够抑制人膀胱癌细胞的增殖和迁移,促进其细胞凋亡和铁死亡,其机制可能与诱导PTEN、ACSL4和Caspase3的表达,抑制GPX4、AKT和CyclinD1的表达有关。

关键词：膀胱癌 SNHG1 增殖凋亡迁移铁死亡

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基于故障树的发射机故障诊断

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舰船电子工程 2013年第1期33卷 111-112,133页

作者：钟飞刘传伟邓世东何爱林中国人民解放军91604部队

故障树分析方法是一种实用的故障分析方法。根据输入的故障征兆自动寻找匹配的底事件,然后生成顶事件故障树并求出最小割集,按照最小割集重要度大的部件优先检测的顺序生成测试流程,提示操作人员按照测试流程进行测试并找出故障源。通... 详细信息

故障树分析方法是一种实用的故障分析方法。根据输入的故障征兆自动寻找匹配的底事件,然后生成顶事件故障树并求出最小割集,按照最小割集重要度大的部件优先检测的顺序生成测试流程,提示操作人员按照测试流程进行测试并找出故障源。通过对某发射机分系统建立故障树模型,进行定性、定量分析计算。利用构建故障树来进行电子设备故障诊断分析,不仅可以方便推理机构寻找潜在故障或进行故障诊断,而且可以进一步预测未来系统故障发生的概率,便于电子装备故障的检测与定位。

关键词：故障树分析故障诊断最小割集重要度

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Mechanical properties and influence mechanism of confined concrete arches in high-stress tunnels

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International Journal of Mining Science and Technology 2023年第7期33卷 829-841页

作者： Bei Jiang Zhongxin Xin Xiufeng Zhang Yusong deng Mingzi Wang shidong Li Wentao Ren State Key Laboratory for Geo-mechanics and Deep Underground Engineering China University of Mining and Technology-BeijingBeijing 100083China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China Research Center of Geotechnical and Structural Engineering Shandong UniversityJinan 250061China Shandong Energy Group Co. Ltd.Jinan 250014China

Deep underground projects(e.g., coal mines), are often faced with complex conditions such as high stress and extremely soft rock. The strength and rigidity of the traditional support system are often insufficient,which makes it difficult to meet the requirements of ground control under complex conditions. As a new support form with high strength and rigidity, the confined concrete arch plays an important role in controlling the rock deformation under complex conditions. The section shape of the tunnel has an important impact on the mechanical properties and design of the support system. However, studies on the mechanical properties and influence mechanism of the new confined concrete arch are rarely reported. To this end, the mechanical properties of traditional U-shaped steel and new confined concrete arches are compared and comparative tests on arches of circular and straight-leg semicircular shapes in deep tunnels are conducted. A large mechanical testing system for underground engineering support structure is developed. The mechanical properties and influence mechanism of confined concrete arches with different section shapes under different loading modes and cross-section parameters are systematically studied. Test results show that the bearing capacity of the confined concrete arch is 2.10 times that of the U-shaped steel arch, and the bearing capacity of the circular confined concrete arch is 2.27 times that of the straight-leg semicircular arch. Among the various influencing factors and their engineering parameters,the lateral stress coefficient has the greatest impact on the bearing capacity of the confined concrete arch,followed by the steel pipe wall thickness, steel strength, and core concrete strength. Subsequently, the economic index of bearing capacity and cost is established, and the optimization design method for the confined concrete arch is proposed. Finally, this design method is applied to a high-stress tunnel under complex conditions, and the d

关键词： High-stress tunnel Confined concrete arch Section shape Mechanical properties Design method

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SNHG1在泌尿男生殖系统肿瘤中的研究进展

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中南医学科学杂志 2022年第4期50卷 610-613页

作者：邓世栋刘凌志郭大勇王超张晖辉南华大学衡阳医学院附属第一医院泌尿外科湖南省衡阳市421001

长链非编码RNAs(lncRNAs)是含有超过200个核苷酸的非编码RNA。lncRNAs不参与蛋白质编码,但在染色质修饰、转录和转录后处理的水平上调节基因的表达。长链非编码核仁小RNA宿主基因1(SNHG1)在肾癌、前列腺癌、膀胱癌等泌尿男生殖系统肿瘤... 详细信息

长链非编码RNAs(lncRNAs)是含有超过200个核苷酸的非编码RNA。lncRNAs不参与蛋白质编码,但在染色质修饰、转录和转录后处理的水平上调节基因的表达。长链非编码核仁小RNA宿主基因1(SNHG1)在肾癌、前列腺癌、膀胱癌等泌尿男生殖系统肿瘤中表达异常,并在一系列细胞生物学功能中发挥重要的调控作用,参与肿瘤细胞的侵袭、增殖、转移和自噬等生物学行为。本文对SNHG1在泌尿男生殖系统肿瘤中的最新研究进展做一综述。

关键词： SNHG1 泌尿男生殖系统肿瘤生物学功能

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Activity Detection for Enhanced Configured-Grant:A Practical Perspective

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China Communications 2022年第3期19卷 181-191页

作者： Chenmin Sha shidong Zhou Department of Electronic Engineering Tsinghua UniversityBeijing 100084China

We try to extend the current configuredgrant(CG)uplink scheme in 5G New Radio(NR)to support massive potential users and study activity detection under this *** of the continuously varying channel and the multiple repetition scheme are utilized to improve the detection accuracy,which can be an enhancement to existing activity detection *** results under 3 GPP TDL(Tapped Delay Line)fading channel show the superiority of our *** system-level simulation reveals that enhancements on activity detection can improve reliability and reduce latency.

关键词： configured-grant massive access activity detection

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Achievable Secrecy Rate Region of Two-Way Communication with Secret Key Feedback

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Tsinghua Science and Technology 2018年第2期23卷 126-134页

作者： Tao Li shidong Zhou Department of Electronic Engineering State Key Laboratory on Microwave and Digital Communications and National Laboratory for Information Science and Technology Tsinghua University Beijing100084 China. Department of Electronic Engineering and State Key Laboratory oil Microwave and Digital Communications Tsinghua University Beijing 100084 China.

This paper investigates the achievable secrecy rate region of the Gaussian two-way wiretap channel,which describes the simultaneous secure two-way transmission of a confidential message. Through adjusting the time-sharing factor and the rate at which the random secret key is fed back, the allocation and optimization for the secrecy rates of two-way communication are achieved. Under peak and average power constraints, the achievable secrecy rate regions of the two-way communication are derived respectively.

关键词： physical layer security two-way communication feed back one-time-pad random secret key secrecy rate region

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Evolution of Ultrastrong Langmuir Turbulence

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Chinese Physics Letters 1991年第1期8卷 13-16页

作者： MU Jianlin CAI shidong CCAST-World Laboratory and Institute of Physics Academia SinicaBeijing 100080

We report here our recent studies of ultrastrong Langmuir iubulence by numerical simulation in two-fluid *** nonlinear phenomena,such as the formation and collapse of solitons,the onset of wavebreaking,the burnout and reborn of cavitons and so on,are observed in the *** intense cavitons(|E|^(2)/2coTa≈3 and δn/n0≈0.3) caused by relative weak pump0(|E|^(2)/2coTa≈0.05) and fluctuations (δnc/n0≈0.003) can exist in the system which are beyond the approximation of the Zakhorov model.

关键词： breaking intense approximation

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Approximating the Gaussian as a Sum of Exponentials and its Applications to the Fast Gauss Transform

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Communications in Computational Physics 2022年第1期31卷 1-26页

作者： shidong Jiang Leslie Greengard Department of Mathematical Sciences New Jersey Institute of TechnologyNewarkNJ 07102USA Courant Institute of Mathematical Sciences New York UniversityNew YorkNY 10012USA Center for Computational Mathematics Flatiron InstituteSimons FoundationNew YorkNY 10010USA

We develop efficient and accurate sum-of-exponential(SOE)approximations for the Gaussian using rational approximation of the exponential function on the negative real *** digit accuracy can be obtained with eight terms and ten digit accuracy can be obtained with twelve *** representation is of potential interest in approximation theory but we focus here on its use in accelerating the fast Gauss transform(FGT)in one and two *** one-dimensional scheme is particularly straightforward and easy to implement,requiring only twenty-four lines of MATLAB *** two-dimensional version requires some care with data structures,but is significantly more efficient than existing *** a detailed presentation of the theoretical foundations,we demonstrate the performance of the fast transforms with several numerical experiments.

关键词： Fast Gauss transform sum-of-exponential approximation best rational approximation model reduction

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