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Thioperamide treats neonatal hypoxic-ischemic encephalopathy by postsynaptic H1 receptors

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Neural Regeneration Research 2013年第19期8卷 1814-1822页

作者： Feiyong Jia Lin Du Yunpeng Hao shicheng liu Ning Li Huiyi Jiang Division of Pediatric Neurorehabilitation Department of Pediatrics Second Part of First Hospital of Jilin University

Thioperamide, a selective histamine H3 receptor antagonist, can increase histamine content in the brain, improve brain edema, and exert a neuroprotective effect. This study aimed to examine the mechanism of action of thioperamide during brain edema in a rat model of neonatal hypoxic ischemic encephalopathy. Our results showed that thioperamide significantly decreased brain water content and malondialdehyde levels, while significantly increased histamine levels and superoxide dismutase activity in the hippocampus. This evidence demonstrates that thioperamide could pre vent oxidative damage and attenuate brain edema following neonatal hypoxicischemic encepha Iopathy. We further observed that changes in the above indexes occurred after combined treatment of thioperamide with the H1 receptor antagonist, pyrilamine, and the H2 receptor antagonist, ci metidine. Experimental findings indicated that pyrilamine reversed the effects of thioperamide; however, cimetidine had no significant influence on the effects of thioperamide. Our present findings suggest that thioperamide can increase brain histamine content and attenuate brain edema and oxidative damage by acting in combination with postsynaptic H1 receptors in a rat model of neo natal hypoxicischemic encephalopathy.

关键词： neural regeneration thioperamide histamine histamine receptor antagonist cimetidine pyrilamineneonatal hypoxic-ischemic encephalopathy brain edema hippocampus malondialdehyde super-oxide dismutase grants-supported paper neuroregeneration

Smith-Kingsmore syndrome with nystagmus as the initial symptom

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Acta Epileptologica 2023年第4期6卷 256-263页

作者： Meiling Cai Yanfei Zhao He Wang shicheng liu Huiyi Jiang Department of Pediatric The First Hospital of Jilin UniversityChangchun130021China

Background Smith-Kingsmore syndrome(SKS)is a rare autosomal dominant disorder caused by de novo mutations of gene MTOR in most cases and germline mosaicism in a few *** first case of SKS was reported in *** incidence of SKS remains *** clinical manifestations of SKS are diverse,and common features are macrocephaly,intellectual disability,and *** patients with SKS have special facial *** presentation The case was a 5-month-old baby girl,who was admitted to the hospital for nystagmus,delayed development for 2 months,and intermittent convulsions for 2 *** patient had a head circumference of 42 cm(+2SD),and showed facial deformity,low limb muscle tension,large areas of pigmentation,as well as mosaic patchy and strip-like pigment loss in her trunk and ***,her development was lagging behind *** examination did not reveal other *** was diagnosed with SKS based on whole-exome sequencing combined with clinical symptoms and *** successively received treatment with adrenocorticotropic hormone,methylprednisolone sodium succinate,topiramate,levetiracetam,and zonisamide to reduce the number of convulsions in a short time,but drug resistance appeared *** combined treatment with multiple antiseizure medications,the patient still had seizures,but the amplitude of limb movement during the seizures was reduced compared to that before *** This case expanded the phenotypic spectrum of SKS for *** also review the related literature to promote the awareness,diagnosis,clinical management,and follow-up of SKS patients with MTOR mutations.

关键词： MTOR gene Smith-Kingsmore syndrome Nystagmus EEG

Ultrastructure　study　of　the　diatom──Ⅱ．Synedra，Cyclophora，Plagiogramma，Opephora，Fragilaria　and　Pseudostaurosira

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Acta Oceanologica Sinica 1994年第4期13卷 579-588页

作者： liu shicheng (Department of Biology, Xiamen University, Xiamen 361005, China)

Six genera and thirteen species of diatoms are collected from the intertidal zone of Xisha Islands,Hainan Province, and observated under the transmitted light microscopy (LM), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). of them, four new species, and one genus are newly recorded (marked).They are: Synedra cyclophoroides sp. nov., Cycolophora tenuis, Plagiogramma parva sp. nov., Plagiogramme pandurata sp. nov., P. atomus, P. reimeri, Opephora elliptica sp. nov. O. martyi, O. olsenii,O. sp. Fragilaria brevistriata v. elliptica; F. construens and Pseudostaurosira brevistriata.

关键词： Diatom Ultrastructure Synedra Cyclophora Plagiogramma Opephora Fragilaria Pseudostaurosira.

Marine　diatoms　of　the　Xisha　Islands，　South　China　Sea　Mastogloia　Thw，　Ex，　Wm，　Smith：　species　of　Group　Ellipticae

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Acta Oceanologica Sinica 1995年第1期14卷 59-71页

作者： liu shicheng(Department of Biology, Xiamen University, Xiamen 361005, China)

Seventeen species of diatoms of the genus Mastogloia are recorded. For selected species, the external andinternal valve structures are investigated under LM, TEM and SEM microscopes. M. sp. (M. af. cocconeiformis)is d... 详细信息

关键词： Mastogloia Ellipticae diatom fine structure

Numerical Investigation into the Air Flow Distributions of the Air Conditioning System in the Modular Data Center

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Advances in Applied Mathematics and Mechanics 2019年第1期11卷 91-107页

作者： Hao Dong Ziqiang Qin shicheng liu Yao Li Yingying Shen Haibo Wang Yitong Zong XiaojunWu Haiqing Si College of Aerospace Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Civil Aviation and Flight Nanjing University of Aeronautics and AstronauticsNanjing 210016China China Aerodynamics Research and Development Center Mianyang 621000China

Data center plays an increasingly important role in everyday *** data center is becoming more and more powerful,energy consumption is also increasing *** air conditioning system occupies at least 50 percent of the total energy ***,delicate analysis on the air conditioning system could help to reduce energy consumption in data *** advanced Finite Volume Method with RNG k-ε model and convective heat exchange model is used in this paper to study the airflow and the temperature distribution of modular data center under different ***,the calculation formula of convective heat transfer coefficient for plate flow is adopted to simplify analysis;and fans on the back of racks are simplified to be walls with a certain pressure *** reveal that,in the case where air conditioners are arranged face-to-face,the temperature distribution on the back of racks is not uniform,and local high temperature points emerge near the side wall of air *** analyzing the distribution of air flow and temperature,geometric model is optimized by using a diagonal rack arrangement and drilling holes on the side *** the same energy consumption situation,the overall maximum temperature of the optimized model is reduced by 2.3℃ compared with that of the original one,and the maximum temperature on the server surface is reduced by 1℃.Based on the optimized model,the effect of the hot aisle distance on the temperature distribution is *** simulating four different cases with various distances of hot aisle of 100cm,120cm,130cm and 150cm,it is found that the temperature is generally lower and distributed more evenly in the case with 120cm hot aisle *** demonstrates that the distance of hot aisle has an effect on temperature.

关键词： Modular data center air conditioning temperature distribution hot/cold aisle CFD

Studies on marine nanodiatoms in Fujian coastal waters of China in winter

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Acta Oceanologica Sinica 1995年第2期14卷 261-268页

作者： liu shicheng Gao Yahui and Cheng Zhaodi(Department of Biology, Xiamen University, Xiamen 361005, China)

For the first time, nanodiatoms (20μm) in the coastal waters of Xiamen, Shandu, Fuqing, Haitan, Putian and Meizhou of Fujian Province along the western coast of the Taiwan Strait are quantitatively counted by TEM in the paper. The results show that the number of nanodiatoms from all the station is more than that of microdiatoms, accounting for 92% of the species collected. This indicates that nanodiatoms constitute a large microcosm of the whole diatom group. Unfortunately, the lower resolution of light microscopes which have been used in the study of diatoms in the past makes this unneglectable microcosm unnoticed. Thanks to TEM, 47 species of nanodiatoms are identified and four of them are for the first time recorded in China. The new records are Hantzschia spectabilis, Navicula crucigera, Nav. spicula andNitzs. rosenstockii. The positive correlation between the contents of chlorophyll a and diatom cell number in the waters of Xiamen Harbour, which were determined simultaneously, shows that the variation of chlorophyll a content in the waters reflects, on the whole, the change of diatom number. In addition, the successful culture of nanodiatoms in the studies provides alternatives for the screening of high quality aquaculture feed.

关键词： Fujian coast nanodiatoms microdiatoms

B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1251-1268页

作者： Cefan Zhou Xiaoting Zhu Nanxi liu Xueying Dong Xuewen Zhang Huili Huang Yu Tang shicheng liu Mengyu Hu Ming Wang Xiaoling Deng Shi Li Rui Zhang Yuan Huang Hao Lyu Shuai Xiao Sang Luo Declan William Ali Marek Michalak Xing-Zhen Chen Zhentian Wang Jingfeng Tang National“111”Center for Cellular Regulation and Molecular Pharmaceutics Key Laboratory of Fermentation Engineering(Ministry of Education)Hubei University of TechnologyWuhan 430068China Membrane Protein Disease Research Group Department of PhysiologyFaculty of Medicine and DentistryUniversity of AlbertaEdmontonAB T6G2R3Canada Cooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province) Hubei Key Laboratory of Industrial MicrobiologyHubei University of TechnologyWuhanChina Department of Systems Biology for Medicine School of Basic Medical SciencesFudan Universityand Shanghai Fifth People’s HospitalFudan UniversityShanghai 200433China Department of Clinical Laboratory Renmin Hospital of Wuhan UniversityWuhan 430060China Ningxia Key Laboratory of Stem Cell and Regenerative Medicine General Hospital of Ningxia Medical UniversityNingxia 750001China Department of Biological Sciences University of AlbertaEdmontonAB T6G2R3Canada Department of Biochemistry University of AlbertaEdmontonAB T6G2R3Canada

Abnormal activation of Wnt/β-catenin-mediated transcription is closely associated with the malignancy of pancreatic *** with sequence similarity 83 member A(FAM83A)was shown recently to have oncogenic effects in a variety of cancer types,but the biological roles and molecular mechanisms of FAM83A in pancreatic cancer need further ***,we newly discovered that FAM83A binds directly toβ-catenin and inhibits the assembly of the cytoplasmic destruction complex thus inhibiting the subsequent phosphorylation and ***83A is mainly phosphorylated by the SRC non-receptor kinase family member BLK(B-lymphoid tyrosine kinase)at tyrosine 138 residue within the DUF1669 domain that mediates the FAM83A-β-catenin ***,FAM83A tyrosine 138 phosphorylation enhances oncogenic Wnt/β-catenin-mediated transcription through promotingβ-catenin-TCF4 interaction and showed an elevated nucleus translocation,which inhibits the recruitment of histone deacetylases by *** also showed that FAM83A is a direct downstream target of Wnt/β-catenin signaling and correlates with the levels of Wnt target genes in human clinical pancreatic cancer ***,the inhibitory peptides that target the FAM83A-β-catenin interaction significantly suppressed pancreatic cancer growth and metastasis in vitro and in *** results revealed that blocking the FAM83A cascade signaling defines a therapeutic target in human pancreatic cancer.

关键词： FAM83A elevated phosphorylation

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高氮奥氏体钢低温断面的晶体学分析

金属学报 2007年第12期43卷 1233-1238页

作者：陈汝淑刘德义刘世程刘世永大连交通大学材料科学与工程学院大连116028 大连海事大学机电与材料工程学院大连116026

用扫描电镜对18Cr-18Mn-0.7N高氮奥氏体钢的组织及低温脆断断面的晶体学特征进行了分析.结果表明:低温脆断断口上有退火孪晶界断面、沿晶断面及穿晶断面3种断裂刻面.退火孪晶界断面为一光滑、平坦的{111}面,上有折线状台阶,其它3组{111... 详细信息

用扫描电镜对18Cr-18Mn-0.7N高氮奥氏体钢的组织及低温脆断断面的晶体学特征进行了分析.结果表明:低温脆断断口上有退火孪晶界断面、沿晶断面及穿晶断面3种断裂刻面.退火孪晶界断面为一光滑、平坦的{111}面,上有折线状台阶,其它3组{111)面上的形变组织在退火孪晶界断面上形成3组交角为60°的直线状平行迹线;沿晶断面为一光滑曲面,{111}面的形变组织在其上形成几组不同交角的曲线状平行迹线;穿晶断面粗糙不平,显示平行于{111}面的台阶、河流花样或棱状花样,它们是不同{111}面上的裂纹在扩展中合并形成的.

关键词：高氮奥氏体钢低温脆断断裂刻面晶体学特征形变组织迹线

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网格法在储量计算中的应用

油气地质与采收率 2006年第4期13卷 28-30页

作者：柳世成中国石化股份胜利油田分公司地质科学研究院山东东营257015

随着油田开发的不断深入,合理、准确地计算石油地质储量是搞清油层剩余油分布的关键因素之一。通过对传统储量计算方法利弊的分析,引入网格法计算储量。通过对每个井层储量参数的网格化,可得到每个网格的储量。探讨了网格法计算储量的... 详细信息

随着油田开发的不断深入,合理、准确地计算石油地质储量是搞清油层剩余油分布的关键因素之一。通过对传统储量计算方法利弊的分析,引入网格法计算储量。通过对每个井层储量参数的网格化,可得到每个网格的储量。探讨了网格法计算储量的原理、适用条件、优势以及计算结果的关键影响因素。分析表明,利用网格法计算储量更为合理、准确,便于进行各种分析评价。该方法已应用于孤东油田七区西,并取得了较好的效果。

关键词：网格法储量计算储层参数孤东油田