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Enhanced mechanical property by introducing bimodal grains structures in Cu-Ta alloys fabricated by mechanical alloying

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Journal of Materials Science & Technology 2024年第5期172卷 104-112页

作者： Ningyu Li Yongqin Chang Mingyang Li Yuxiang Chen Xinrui Luo shichao pei Fan Yang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Xi’an Rare Metal Materials Institute Co.Ltd Xi’an 710016China

Dispersion-strengthened copper alloys can achieve ultra-high strength,but usually at the expense of duc-tility.In this study,a strategy for overcoming strength-ductility tradeoffof Cu alloys is realized through the introduction of bimodal grains structures.Cu-Ta alloys with only 0.5 at.%Ta content were successfully prepared by mechanical alloying combined with spark plasm sintering.The samples prepared by one-step and two-step ball milling methods are named as Cu-Ta(Ⅰ)and Cu-Ta(Ⅱ),respectively.The microstructural characterizations revealed that ultra-fine equiaxed grains with uniformly dispersed Ta precipitates were obtained in the Cu-Ta alloys.High strength of 377 MPa for yield strength together with elongation of∼8%was obtained in Cu-Ta(Ⅰ).Bimodal grains structures composed of fine-grain zones and coarse-grain zones were successfully introduced into Cu-Ta(Ⅱ)by a two-step ball milling approach,and both yield strength(463 MPa)and elongation(∼15%)were significantly synergistic enhanced.The hardness values of both Cu-Ta(Ⅰ)and Cu-Ta(Ⅱ)were almost kept nearly constant with the increase of annealing time,and the softening temperatures of Cu-Ta(Ⅰ)and Cu-Ta(Ⅱ)are 1018 and 1013℃,reaching 93.9%and 93.5%T m of pure Cu(1083℃),respectively.It reveals that the Cu-0.5 at.%Ta alloys exhibit excellent thermal stability and exceptional softening resistance.Ta nanoclusters with semi-coherent structures play an essential role in enhancing the strength and microstructural stability of alloys.Bimodal structures are beneficial to the activation of back stress strengthening and the initiation and propagation of microcracks,thus obtaining the extraordinary combination of strength and elongation.This study provides a new way to fabricate dispersion-strengthened Cu alloys with high strength,high elongation,excellent thermal stability and softening resistance,which have potential application value in the field of the future fusion reactor.

关键词： Cu-Ta alloy Mechanical alloying Ta precipitates Bimodal structures Mechanical property

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低活化Fe_(36.41)Cr_(28.06)V_(35.53)单相中熵合金的成分设计、组织演化及性能研究

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稀有金属材料与工程 2022年第12期51卷 4542-4550页

作者：罗新蕊王辉裴世超杨帆郑丹丹陈宇翔李宁宇常永勤北京科技大学北京100083 成都大学高等研究院四川成都610106

根据核聚变堆领域的要求使用低活化材料以及考虑到未来工程应用需要降低成本,选用低活化、低成本的Fe、Cr、V元素,依据最小吉布斯自由能准则设计出非等原子比Fe_(36.41)Cr_(28.06)V_(35.53)单相中熵合金。采用真空熔炼的方法制备出该合... 详细信息

根据核聚变堆领域的要求使用低活化材料以及考虑到未来工程应用需要降低成本,选用低活化、低成本的Fe、Cr、V元素,依据最小吉布斯自由能准则设计出非等原子比Fe_(36.41)Cr_(28.06)V_(35.53)单相中熵合金。采用真空熔炼的方法制备出该合金,并对其进行适当的热机处理。发现非等比Fe_(36.41)Cr_(28.06)V_(35.53)合金在不同热机处理过程中没有发生相变,均为单相bcc固溶体,说明该合金相结构非常稳定。同时也与依据最小吉布斯自由能准则设计的结果吻合得非常好。Fe_(36.41)Cr_(28.06)V_(35.53)合金的硬度高于传统耐热合金,在不同热机加工状态下合金的压缩塑性均大于50%,实现了强度和塑性的良好配合。在压缩变形过程中,由于偏析元素与位错的相互作用,合金的压缩应力-应变曲线出现锯齿流变行为。对Fe_(36.41)Cr_(28.06)V_(35.53)合金进行了详细的微观组织表征,解释了该合金性能优异的微观机制。

关键词： Fe_(36.41)Cr_(28.06)V_(35.53)合金吉布斯自由能低活化微观组织

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Chimeric cerebral organoids reveal the essentials of neuronal and astrocytic APOE4 for Alzheimer's tau pathology

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2545-2554页

作者： shichao Huang Zhen Zhang Junwei Cao Yongchun Yu Gang pei State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of Sciences200031 ShanghaiChina Institutes of Brain Science State Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain ScienceFudan University200032 ShanghaiChina Shanghai Key Laboratory of Signaling and Disease Research Laboratory of Receptor-based BiomedicineThe Collaborative Innovation Center for Brain ScienceSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina

The apolipoprotein E4(APOE4)genotype is one of the strongest genetic risk factors for Alzheimer’s disease(AD),and is generally believed to cause widespread pathological alterations in various types of brain cells.Here,we developed a novel engineering method of creating the chimeric human cerebral organoids(chCOs)to assess the differential roles of APOE4 in neurons and astrocytes.First,the astrogenic factors NFIB and SOX9 were introduced into induced pluripotent stem cells(iPSCs)to accelerate the induction of astrocytes.Then the above induced iPSCs were mixed and cocultured with noninfected iPSCs under the standard culturing condition of cerebral organoids.As anticipated,the functional astrocytes were detected as early as 45 days,and it helped more neurons matured in chCOs in comparation of the control human cerebral organoids(hCOs).More interestingly,this method enabled us to generate chCOs containing neurons and astrocytes with different genotypes,namely APOE3 or APOE4.Then,it was found in chCOs that astrocytic APOE4 already significantly promoted lipid droplet formation and cholesterol accumulation in neurons while both astrocytic and neuronal APOE4 contributed to the maximum effect.Most notably,we observed that the cooccurrence of astrocytic and neuronal APOE4 were required to elevate neuronal phosphorylated tau levels in chCOs while Aβlevels were increased in chCOs with neuronal APOE4.Altogether,our results not only revealed the essence of both neuronal and astrocytic APOE4 for tau pathology,but also suggested chCOs as a valuable pathological model for AD research and drug discovery.

关键词： cerebral alterations neuronal

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A low-profile dual-polarization programmable dual-beam scanning antenna array

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Frontiers of Information Technology & Electronic Engineering 2023年第10期24卷 1504-1512页

作者： shichao ZHU Yuanfan NING Hongbo CHU pei XIAO Gaosheng LI College of Electrical and Information Engineering Hunan UniversityChangsha 410082China

low-profile dual-polarization dual-beam scanning antenna array based on holographic control theory is presented in this paper.The radiating elements are ingeniously designed to achieve reconfigurable polarization and modulation of the radiation phase by controlling the state of the PIN diodes integrated on each element.A 72-channel series-parallel equal-amplitude and in-phase feeding network is integrated with the radiating array to achieve low-profile characteristics.The two-dimensional(2D)dynamic and accurate deflection of the beam is achieved by a designed direct current(DC)bias circuit that digitally encodes the antenna array using the single-chip microcontroller.A 2-element subarray and a 6x12 array have been fabricated and the digitally controllable radiation pattern of this antenna system has been experimentally verified.The antenna system can achieve the beam scanning of-30°to 30°with a step-scan of 5°at 11 GHz.

关键词： antenna polarization beam

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应力分析在锅炉设计中的作用

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锅炉制造 2011年第4期 14-16页

作者：裴世超侯勇庆哈尔滨锅炉厂有限责任公司黑龙江哈尔滨150046

本文从技术的角度,举例详细说明了应力分析工作在锅炉设计制造过程中的作用———通过优化设计,节约时间、控制成本,从而提高企业生产效率及经济效益。

关键词：应力分析锅炉设计经济

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Claw-shaped flexible and low-impedance conductive polymer electrodes for EEG recordings: Anemone dry electrode

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Science China(Technological Sciences) 2023年第1期66卷 255-266页

作者： SHI ZhongYan JIANG Bo LIANG shichao ZHANG JiangTao SUO DingJie WU JingLong CHEN DuanDuan pei GuangYing YAN TianYi School of Life Science Bejing Institute of TechnologyBejing 100081China School of Medical Technology Beijing Institute of Technology Bejing 100081China

Electroencephalogram(EEG) signals provide important brain information in healthcare settings. Wet electrodes have several limitations, including their time-consuming preparation and no long-term acquisition, and dry electrodes have become a promising candidate. However, dry electrodes face several challenges related to signal quality, comfort, conductivity and cost.This study aims to develop and evaluate a novel dry electrode for EEG recordings. The electrode material properties are characterized by electrochemical, mechanical force, and skin measurements. The electrode performance is evaluated by comparing the impedance, signal-to-noise ratio(SNR), and EEG signal features of the proposed electrode with those of a wet electrode and two commercial dry electrodes. The dry electrode design is based on the biological structure of the sea anemone and demonstrates an improved scalp fit and reduced signal noise and motion artifacts. The electrode materials include advanced conducting polymers combined with thermoplastic elastomers(TPEs) and carbon nanotubes(CNTs), which exhibit good electrical conductivity, mechanical properties, and safety. A low-cost injection molding fabrication method is proposed. The dry electrodes show a scalp contact impedance of 7 kΩ at 20 Hz, which is lower than that of wet and commercial dry electrodes.Resting-state EEG and event-related potential signals collected by the anemone dry electrode achieved more than 90% similarity with signals acquired by wet electrodes. Thus, a low-cost, comfortable anemone dry electrode that exhibits excellent EEG recording performance is presented. The anemone dry electrode represents an important technological advance in material and structural design for EEG recording sensors.

关键词： dry electrodes electroencephalogram(EEG) ultra-conductive polymer scalp simulation flexible and low-impedance

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Baicalein inhibits SARS-CoV-2/VSV replication with interfering mitochondrial oxidative phosphorylation in a mPTP dependent manner

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Signal Transduction and Targeted Therapy 2020年第1期5卷 259-261页

作者： shichao Huang Yu’e Liu Yanan Zhang Ru Zhang ChengJie Zhu Lihong Fan Gang pei Bo Zhang Yufeng Shi Tongji University Cancer Center Shanghai Tenth People’s Hospital of Tongji UniversitySchool of MedicineSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceInstitute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghaiChina Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety MegaScienceChinese Academy of Sciences430071 WuhanChina Shanghai Key Laboratory of Signaling and Disease Research Collaborative Innovation Center for Brain ScienceSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Center for Brain and Spinal Cord Research School of MedicineTongji University200092 ShanghaiChina

Dear Editor,The ongoing outbreak of pneumonia(coronavirus disease 2019,COVID-19)caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has become a global health emergency.Scutellaria Baicalensis Georgi extract,a Traditional Chinese Medicine(TCM)widely used for treating infection of multiple different viruses,1 also shows beneficial effects when treating COVID-19.However,underline mechanism for broad antiviral activity of Scutellaria B.extract remains elusive,which limits its further application.

关键词： Scutellaria acute respiratory

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气藏型地下储气库天然气损耗量研究进展与建议

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天然气工业 2023年第10期43卷 149-155页

作者：胥洪成刘君兰丁国生李晓松范家屹宋丽娜郭世超赵凯裴根中国石油勘探开发研究院中国石油天然气集团有限公司油气地下储库工程重点实验室中国石油吉林油田公司勘探开发研究院

天然气损耗量是直接影响地下储气库(以下简称储气库)安全生产和效益运营的关键参数,随着储气库的注采运行,天然气损耗准确评价显得越来越重要。国内对天然气损耗量的评价技术目前仍处于初级阶段,现有评价体系适用性较为受限。为此,在调... 详细信息

天然气损耗量是直接影响地下储气库(以下简称储气库)安全生产和效益运营的关键参数,随着储气库的注采运行,天然气损耗准确评价显得越来越重要。国内对天然气损耗量的评价技术目前仍处于初级阶段,现有评价体系适用性较为受限。为此,在调研国内外关于地下储气库天然气损耗产生原因、天然气损耗量评价方法、天然气损耗监控措施等方面研究的基础上,梳理了储气库天然气损耗量评价和控制方法,并对预防我国储气库天然气损耗方面提出了管理建议。研究结果表明:①天然气损耗产生的原因主要包括储气地质体因素、井筒因素和地面设施因素,其中井筒因素和地面设施因素造成的损耗量低、易监控和计量,储气地质体因素造成的损耗隐蔽、难以直接计量。②定容气藏型储气库损耗计算方法主要有库存核实法和状态方程法,强水驱气藏型储气库主要采用产能变化分析法来估算损耗量。③成熟天然气市场国家的储气库建有完备的监检测系统,在运行过程中会持续跟踪与优化生产情况,定期开展天然气损耗量评价,并利用四维地质力学方法进行仿真模拟与在线预警。结论认为,我国储气库应完善储气地质体-井筒-地面“三位一体”的监检测系统,重视全生命周期动态监测与损耗评价,保障储气库安全高效运行。

关键词：地下储气库枯竭气藏天然气损耗损耗构成损耗机理损耗评价方法监控措施

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Rhamnosyl Phenylpropanoids Ameliorate Alzheimer’s Disease-like Pathology via Mitochondrial Function Regulations

Rhamnosyl Phenylpropanoids Ameliorate Alzheimer’s Disease-l...

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2020年糖科学青年科技论坛

作者： Xin Cao shichao Huang Biao Yu Gang pei Zhongshan Hospital Institute of Clinical Science Fudan University State Key Laboratory of Bioorganic and Natural Products Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryChinese Academy of Sciences State Key Laboratory of Cell Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of Sciences Shanghai Key Laboratory of Signaling and Disease Research Collaborative Innovation Center for Brain ScienceSchool of Life Sciences and TechnologyTongji University

Abnormal neural progenitor cell（NPC） proliferation and neurogenesis are associated with pathophysiology of Alzheimer’s disease（AD）.Mitochondrial dysfunction is one of the most prominent features of AD and is considered to be involved in impairment of neural progenitor cell proliferation and neurogenesis.In the present study,it was found that oral administration of PL201 A and analogues,the designed phenylpropanoid rhamnosides,promoted NPC proliferation and neurogenesis and ameliorated cognitive impairment in transgenic AD mice.Furthermore,PL201 A attenuated amyloid-β induced mitochondrial dysfunction and promote NPC proliferation in vitro.The mechanistic study showed that PL201 A restored activation of AMP-regulated protein kinase–retinoblastoma signaling,which was suppressed by amyloid-β.The findings suggest that PL201 A and analogues may represent a promising regenerative therapeutic agent for cognition decline in neurodegenerative diseases.

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Vehicle State Estimation of Skid-Steered Wheeled Vehicle Based on Extended Kalman Filter

Vehicle State Estimation of Skid-Steered Wheeled Vehicle Bas...

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2018中国汽车工程学会年会

作者： pei Weiya LI Xueyuan WANG Lei LI shichao Beijing Institute of Technology

In this paper,an extent Kalman filter based on a dynamic model of skid-steered wheeled vehicle is proposed to estimate and update state parameters of vehicle in real-time.The state of the vehicle will be more accurate analysed,and this method of observing and estimating the state parameters of skid-steered wheeled vehicle can be applied in various fields.First,a 3-degree-of-freedom vehicle dynamics model and a tire model of 6×6-wheel skid-steered vehicle are established.Then,an extended Kalman filter-based estimator is presented.It was used to estimate the vehicle’s yaw rate,the sideslip angle,and the longitudinal speed as well as the velocity difference between the left-side wheels and the right-side wheels,longitudinal acceleration and the lateral acceleration are proposed.Finally,the simulation experiments of TruckSim and Matlab/Simulink are used to verify the proposed algorithm.The simulation and experimental results show that the developed observer canreliably estimate vehicle states.

关键词： skid-steered vehicle extended kalman filter vehicle state estimation

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