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一种基于凸轮机构的线性负刚度装置及其隔振特性分析

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内蒙古工业大学学报（自然科学版） 2022年第2期41卷 115-119页

作者：邢士博吕书锋宋晓娟内蒙古工业大学理学院呼和浩特010051 内蒙古工业大学机械工程学院呼和浩特010051

提出了一种基于直动滚子推杆移动凸轮机构的线性负刚度装置,通过对该装置的静力学分析,根据要实现的线性负刚度条件,设计了凸轮的理论廓线及实际廓线,然后将该装置与正刚度弹簧并联形成主动隔振系统,建立了隔振系统的动力学方程,分析了... 详细信息

提出了一种基于直动滚子推杆移动凸轮机构的线性负刚度装置,通过对该装置的静力学分析,根据要实现的线性负刚度条件,设计了凸轮的理论廓线及实际廓线,然后将该装置与正刚度弹簧并联形成主动隔振系统,建立了隔振系统的动力学方程,分析了隔振系统的隔振特性。结果表明:引入线性负刚度装置后,系统的固有频率降低,隔振频带变宽,高频激励下的隔振效果改善。

关键词：线性负刚度移动凸轮机构主动隔振力传递率

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自密实混凝土在预制综合管廊生产中的实践

新型建筑材料 2018年第5期45卷 5-9页

作者：吴成浩解建光李进周利睿邢士波李可可耿飞南京航空航天大学土木工程系江苏南京210016 江苏方洋科技投资发展有限公司江苏连云港222066 山东龙泉管道股份有限公司山东淄博255000

以水胶比、砂率和掺合料为主要因素,进行预制管廊用自密实混凝土的配制试验,测试分析了拌合物的坍落扩展度、扩展时间T500以及混凝土的抗压强度等性能,并应用于管廊构件的实际生产。结果表明,一定范围内,随着水胶比、砂率以及掺合料掺... 详细信息

以水胶比、砂率和掺合料为主要因素,进行预制管廊用自密实混凝土的配制试验,测试分析了拌合物的坍落扩展度、扩展时间T500以及混凝土的抗压强度等性能,并应用于管廊构件的实际生产。结果表明,一定范围内,随着水胶比、砂率以及掺合料掺量的增加,混凝土的流动性及工作性能也会有所改善,增量过大则会降低自密实混凝土的性能。研究成果为自密实混凝土运用于预制综合管廊提供实践经验。

关键词：自密实混凝土综合管廊工作性能浇筑工艺表观质量

Particle motion behavior during gasiication of foam carrier in lost foam-squeeze casting of 20%TiC/ZG270-500 composites

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China Foundry 2013年第6期10卷 367-373页

作者： Bin shibo xing Shuming Guo Lijun Bao Peiwei School of Mechanical ElectronicControl Engineering Beijing Jiaotong University

The particle motion behavior affects the distribution of particles in the metal matrix and finally determines the mechanical properties of the particle reinforced metal-matrix composites. To obtain a uniform distribution of TiC particles and excellent strengthening effect in 20%TiC/ZG270-500 composites fabricated by lost foam-squeeze casting （LFSC）, the particle motion behavior in the gas gap and the conditions of the particles getting into the molten steel were investigated. The results show that the airflow velocity （vl） and TiC particle motion velocity （up） change little with the pouring temperature （Tp）, increase with an increase in metal filling velocity （Vp）, ratios of cross sections of in-gate/orifice （AAAo） and orifice/mould cavity （AolAI）, but the increase trend of up is more intense. The airflow pressure （P1） changes little with Tp and Ao/A1, but increases with the increasing of vp and AJAo. Besides, there is a critical velocity （v ＋｜3YLG cosθ/ppdp｜1/2）for the particles getting into the molten steel. The higher the particle motion velocity, the easier the particles get into the molten steel and the more uniform the distribution of the particles in the steel matrix. When Tp = 1,873 K, vp = 30 mm.s-1, AJAo =10 and Ao/AI = 0.02 in this study, the biggest TiC particle motion velocity （20.59 m.s-~） can be gained, and the steel matrix with the most uniformly distributed TiC particles and fine grains are obtained.

关键词： lost foam-squeeze casting (LFSC) particle motion velocity critical velocity particle distribution

基于SPOC的“三环五育一融合”教学模式的构建和应用——以母婴护理X证书培训课程为例

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卫生职业教育 2024年第3期42卷 74-78页

作者：李启立石少婷邢世波王莉莉李倩倩山东省莱阳卫生学校山东烟台265200

“互联网+”教育背景下,“线上+线下”混合教学模式被广泛应用,以母婴护理X证书培训课程为例,构建基于小规模限制性在线课程(SPOC)的“三环五育一融合”教学模式,以提升学生综合能力、信息化水平和核心素养。

关键词：小规模限制性在线课程母婴护理 X证书

Cross-neutralization of SARS coronavirus-specific antibodies against bat SARS-like coronaviruses

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Science China(Life Sciences) 2017年第12期60卷 1399-1402页

作者： Lei-Ping Zeng xing-Yi Ge Cheng Peng Wanbo Tai shibo Jiang Lanying Du Zheng-Li Shi CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of Virology Chinese Academy of Sciences Lindsley F.Kimball Research Institute New York Blood Center Key Laboratory of Medical Molecular Virology of MOE/MOH School of Basic Medical Sciences Fudan University

Dear Editor,The 2002–2003 global pandemic caused by severe acute respiratory syndrome coronavirus（SARS-CoV）infected around 8,000 people with 10%mortality（http：//***/csr/sars/en/）.

关键词： Cross-neutralization of SARS coronavirus-specific antibodies bat SARS-like coronaviruses

A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1652-1661页

作者： Jie Zhou Wei Xu Zezhong Liu Chao Wang Shuai Xia Qiaoshuai Lan Yanxing Cai Shan Su Jing Pu Lixiao xing Youhua Xie Lu Lu shibo Jiang Qian Wang Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical Sciences and BSL-3 FacilityShanghai Institute of Infectious Diseases and BiosecurityFudan UniversityShanghai 200032China State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijing 100850China

The development of broad-spectrum antivirals against human coronaviruses(HCoVs)is critical to combat the current coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants,as well as future outbreaks of emerging *** have previously identified a polyethylene glycol-conjugated(PEGylated)lipopeptide,EK1C4,with potent pan-CoV fusion inhibitory ***,PEG linkers in peptide or protein drugs may reduce stability or induce anti-PEG antibodies in ***,we herein report the design and synthesis of a series of dePEGylated lipopeptide-based pan-CoV fusion inhibitors featuring the replacement of the PEG linker with amino acids in the heptad repeat 2 C-terminal fragment(HR2-CF)of *** these lipopeptides,EKL1C showed the most potent inhibitory activity against infection by SARS-CoV-2 and its spike(S)mutants,as well as other HCoVs and some bat SARS-related coronaviruses(SARSr-CoVs)*** dePEGylated lipopeptide EKL1C exhibited significantly stronger resistance to proteolytic enzymes,better metabolic stability in mouse serum,higher thermostability than the PEGylated lipopeptide EK1C4,suggesting that EKL1C could be further developed as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases.

关键词： Coronavirus Lipopeptide SARS-CoV-2 Polyethylene glycol Fusion inhibitor

Variability and correlation analysis of physical and mechanical indexes of loess in western Liaoning

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Global Geology 2012年第4期15卷 286-290页

作者： YAO Kang WANG Changming xing Yudong LI shibo YANG Lina College of Construction Engineering Jilin University Communication Planning & Design Institute of Liaoning Province

Based on the method of probability and statistics, the authors analyzed the physical and mechanical properties of loess in specified area, and discussed its main indexes, the coefficient of variation, and the corre- lation among the physical and mechanical indexes. Regression equations are built among those indexes, the re- suits show that the variability of mechanical indexes is higher than that of the physical indexes, and the physical indexes have better correlation than the relation between physical and mechanical indexes. The conclusions of this study would contribute to further research about loess in western Liaoning.

关键词： loess variability correlation western Liaoning

HMGB1 involved in Asbestos-induced Malignant Mesothelioma

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HMGB1 involved in Asbestos-induced Malignant Mesothelioma

2017环境与公共健康学术会议暨中国环境科学学会环境医学与健康分会、中国毒理学会生化与分子毒理专业委员会2017年年会

作者： shibo Ying Zhaoqiang Jiang xing Zhang Jianlin Lou Institute of Occupational Diseases Zhejiang Academy of Medical Sciences

Malignant mesothelioma(MM)is considered as an aggressive tumor usually caused by exposure to environmental or occupational asbestos,which develops in the parietal pleura or *** mobility group box 1(HMGB1) functions as a pro-inflammatory cytokine,which is one of alarm molecules in inflammatory disorders and ***,the underlying mechanism is unclear yet.

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中国循证医学杂志 2024年第8期24卷 887-892页

作者：仲文庆周世博俞兴北京中医药大学东直门医院骨三科北京100010

目的采用双向两样本孟德尔随机化研究方法评估颈椎相关疾病与原发性高血压之间的因果关系。方法研究数据来自全基因组关联研究汇总数据集,选取颈椎痛、颈椎间盘病变、颈椎根部病变、颈部神经及脊髓损伤4类颈椎相关疾病以及原发性高血压... 详细信息

目的采用双向两样本孟德尔随机化研究方法评估颈椎相关疾病与原发性高血压之间的因果关系。方法研究数据来自全基因组关联研究汇总数据集,选取颈椎痛、颈椎间盘病变、颈椎根部病变、颈部神经及脊髓损伤4类颈椎相关疾病以及原发性高血压数据为研究对象。选取相关单核苷酸多态性作为工具变量,主要以逆方差加权模型比值比评估颈椎相关疾病与原发性高血压之间的因果关系。采用Cochran’s Q检验检测异质性,MR-Egger截距项及MR-PRESSO检测多效性,采用留一法进行敏感性分析。结果颈椎痛与原发性高血压存在正向因果关系[OR=1.01,95%CI(1.00,1.02),P=0.019];原发性高血压与颈椎间盘病变存在正向因果关系[OR=4.08,95%CI(1.57,10.61),P=0.004];颈椎根部病变、颈部神经及脊髓损伤与原发性高血压无明显因果关系。可靠性评价表明,研究结果可靠。结论颈椎痛是原发性高血压的危险因素,原发性高血压是颈椎间盘病变的危险因素;颈椎根部病变、颈部神经及脊髓损伤可能与原发性高血压之间不存在相关性。

关键词：孟德尔随机化颈椎相关疾病原发性高血压因果关系