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Global trends in diabetic eye disease research from 2012 to 2021

Neural Regeneration Research 2024年第10期19卷 2310-2320页

作者： Yuan Yuan Shangli Ji Yali Song Zhaodi Che Lu Xiao shibo tang Jia Xiao Aier School of Ophthalmology Central South UniversityChangshaHunan ProvinceChina Changsha Aier Eye Hospital ChangshaHunan ProvinceChina Aier Eye Institute ChangshaHunan ProvinceChina Department of Metabolic and Bariatric Surgery The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina

Diabetic eye disease refers to a group of eye complications that occur in diabetic patients and include diabetic retinopathy, diabetic macular edema, diabetic cataracts, and diabetic glaucoma. However, the global epidemiology of these conditions has not been well characterized. In this study, we collected information on diabetic eye disease-related research grants from seven representative countries––the United States, China, Japan, the United Kingdom, Spain, Germany, and France––by searching for all global diabetic eye disease journal articles in the Web of Science and Pub Med databases, all global registered clinical trials in the Clinical Trials database, and new drugs approved by the United States, China, Japan, and EU agencies from 2012 to 2021. During this time period, diabetic retinopathy accounted for the vast majority(89.53%) of the 2288 government research grants that were funded to investigate diabetic eye disease, followed by diabetic macular edema(9.27%). The United States granted the most research funding for diabetic eye disease out of the seven countries assessed. The research objectives of grants focusing on diabetic retinopathy and diabetic macular edema differed by country. Additionally, the United States was dominant in terms of research output, publishing 17.53% of global papers about diabetic eye disease and receiving 22.58% of total citations. The United States and the United Kingdom led international collaborations in research into diabetic eye disease. Of the 415 clinical trials that we identified, diabetic macular edema was the major disease that was targeted for drug development(58.19%). Approximately half of the trials(49.13%) pertained to angiogenesis. However, few drugs were approved for ophthalmic(40 out of 1830;2.19%) and diabetic eye disease(3 out of 1830;0.02%) applications. Our findings show that basic and translational research related to diabetic eye disease in the past decade has not been highly active, and has yielded few new treatment methods and newly approved drugs.

关键词： clinical trials diabetic cataracts diabetic eye disease diabetic glaucoma diabetic macular edema diabetic retinopathy drug development global research publication research grant

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Lycium barbarum glycopeptide(wolfberry extract)slows N-methyl-N-nitrosourea-induced degradation of photoreceptors

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Neural Regeneration Research 2024年第10期19卷 2290-2298页

作者： Qihang Kong Xiu Han Haiyang Cheng Jiayu Liu Huijun Zhang tangrong Dong Jiansu Chen Kwok-Fai So Xuesong Mi Ying Xu shibo tang Department of Ophthalmology Aier Eye HospitalJinan UniversityGuangzhouGuangdong ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Guangdong-Hong Kong-Macao Institute of CNS Regeneration Key Laboratory of CNS Regeneration(Ministry of Education)Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Ophthalmology Guangzhou Panyu Central HospitalGuangzhouGuangdong ProvinceChina School of Stomatology Jinan UniversityGuangzhouGuangdong ProvinceChina Aier Academician Station ChangshaHunan ProvinceChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina State Key Laboratory of Brain and Cognitive Sciences Hong Kong Special Administrative RegionChina

Photoreceptor cell degeneration leads to blindness, for which there is currently no effective treatment. Our previous studies have shown that Lycium barbarum(L. barbarum) polysaccharide(LBP) protects degenerated photoreceptors in rd1, a transgenic mouse model of retinitis pigmentosa. L. barbarum glycopeptide(Lb GP) is an immunoreactive glycoprotein extracted from LBP. In this study, we investigated the potential protective effect of Lb GP on a chemically induced photoreceptor-degenerative mouse model. Wild-type mice received the following: oral administration of Lb GP as a protective pre-treatment on days 1–7;intraperitoneal administration of 40 mg/kg N-methylN-nitrosourea to induce photoreceptor injury on day 7;and continuation of orally administered Lb GP on days 8–14. Treatment with Lb GP increased photoreceptor survival and improved the structure of photoreceptors, retinal photoresponse, and visual behaviors of mice with photoreceptor degeneration. Lb GP was also found to partially inhibit the activation of microglia in N-methyl-N-nitrosourea-injured retinas and significantly decreased the expression of two pro-inflammatory cytokines. In conclusion, Lb GP effectively slowed the rate of photoreceptor degeneration in N-methyl-N-nitrosourea-injured mice, possibly through an anti-inflammatory mechanism, and has potential as a candidate drug for the clinical treatment of photoreceptor degeneration.

关键词： anti-inflammation inherited retinal diseases Lycium barbarum glycopeptide N-methyl-N-nitrosourea opsin photoreceptor reactive gliosis retinal degeneration retinitis pigmentosa rhodopsin

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Identifying spatiotemporal information of the point pollutant source indoors based on the adjoint-regularization method

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Building Simulation 2023年第4期16卷 589-602页

作者： Yuanqi Jing Fei Li Zhonglin Gu shibo tang College of Urban Construction Nanjing Tech UniversityNanjing 210009China

Fast and accurate identification of the pollutant source location and release rate is important for improving indoor air quality.From the perspective of public health,identification of the airborne pathogen source in public buildings is particularly important for ensuring people’s safety and health.The existing adjoint probability method has difficulty in distinguishing the temporal source,and the optimization algorithm can only analyze a few potential sources in space.This study proposed an algorithm combining the adjoint-pulse and regularization methods to identify the spatiotemporal information of the point pollutant source in an entire room space.We first obtained a series of source-receptor response matrices using the adjoint-pulse method in the room based on the validated CFD model,and then used the regularization method and composite Bayesian inference to identify the release rate and location of the dynamic pollutant source.The results showed that the MAPEs(mean absolute percentage errors)of estimated source intensities were almost less than 15%,and the source localization success rates were above 25/30 in this study.This method has the potential to be used to identify the airborne pathogen source in public buildings combined with sensors for disease-specific biomarkers.

关键词： regularization algorithm adjoint method CFD model inverse problem source retrieval

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Increased Expression of Intercellular Adhesion Molecule-1,Vascular Cellular Adhesion Molecule-1 and Leukocyte Common Antigen in Diabetic Rat Retina

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Eye Science 2003年第3期19卷 176-183页

作者： Ningyan Bai shibo tang Jing Ma Yan Luo Shaofeng Lin Zhongshan Ophthalmic Center Sun Yat-sen UniversityGuangzhou 510060China

Purpose: To understand the expression and distribution of intercellular adhesion molecule- 1(ICAM- 1),vascular cellular adhesion molecule- 1 (VCAM- 1)and CD45 (Leukocyte Common Antigen) in the control nondiabetic and various courses of diabetic rats retina. To explore the role of adhesion molecules (Ams) and the adhesion of leukocytes to vascular endothelial cells via Ams in diabetic retinopathy(DR).Methods: Sixty healthy adult male Wistar rats were randomly divided into diabetic groups(induced by Streptozotocin, STZ) and normal control groups. Rats in these two groups were further randomly divided into 3, 7, 14, 30, 90 and 180 days-group,including 5 rats respectively. The immunohistochemical studies of ICAM-1, VCAM-1 and CD45 were carried out in the retinal digest preparations or retinal paraffin sections, and the results were analyzed qualitatively, semi-quantitatively.Results: No positive reaction of VCAM-1 was found, and weak reactions of ICAM-1,CD45 were found in nondiabetic rats retina. The difference of 6 control groups had no statistical significance(P > 0.05). The increased ICAM-1 and CD45 staining pattern were detectable 3 days after diabetes induction, and a few VCAM-1 positive cells were observed in the retinal blood capillaries. The difference of diabetes and control is significant( P < 0.05).Following the course, the expressions of ICAM-1, VCAM-1 and CD45 were increasingly enhanced, reaching a peak at the 14th day.Conclusion: Increased expression of ICAM-1, VCAM-1 and leukocytes adhering and stacking in retinal capillaries are the very early events in DR. Coherence of expression and distribution of the three further accounts for it is the key point for the onset of DR that Ams mediates leukocytes adhesion and endothelial cell injury.

关键词：细胞间粘附分子-1 血管细胞粘附分子-1 CD45 糖尿病视网膜病变

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寄存器传输级硬件设计信息流建模与安全验证

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西北工业大学学报 2024年第3期42卷 506-513页

作者：秦茂源侯佳滢李家乐唐时博邰瑜西安工业大学计算机科学与工程学院陕西西安710021 西北工业大学网络空间安全学院陕西西安710072

近年来,已有大量研究证明信息流分析能够有效地对设计安全属性与安全行为进行建模。然而,现有的门级抽象层次的信息流分析方法往往受制于算力和验证效力等因素难以应对大规模设计,而RTL抽象层次的信息流分析方法需借助类型系统等形式化... 详细信息

近年来,已有大量研究证明信息流分析能够有效地对设计安全属性与安全行为进行建模。然而,现有的门级抽象层次的信息流分析方法往往受制于算力和验证效力等因素难以应对大规模设计,而RTL抽象层次的信息流分析方法需借助类型系统等形式化语言对硬件设计进行重新描述。因此,提出了一种寄存器传输级硬件设计信息流建模与安全验证方法。该方法在寄存器传输级功能模型的基础上构建附加安全属性的信息流跟踪逻辑模型,从信息流角度建模设计安全行为和安全属性,并利用EDA测试验证工具,以无干扰为策略捕捉违反安全策略的有害信息流,检测硬件设计安全漏洞。以Trust-Hub硬件木马测试集为测试对象的实验结果表明:所提方法能够有效检测设计内潜藏的硬件木马。

关键词：硬件安全信息流安全模型信息流安全验证安全漏洞检测

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AB001. Vision impairment & repairment in diabetes

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Annals of Eye Science 2017年第1期 355-355页

作者： shibo tang Aier School of Ophthalmology Central South UniversityChangshaHunanChina

With the development of global industrialization,urbanization and changes of people’s lifestyle,Diabetes Mellitus,DM has become a serious worldwide health issue.The prevalence of diabetes in China is more than 10%.Due to the huge population base,China has surpassed the U.S.and India,becoming the country with the largest diabetic population in the world.Diabetic retinopathy(DR)is one of the most common complications of DM.The latest epidemiological survey shows that 17.8-29.2%of China’s diabetes patients developed DR,and it has become the leading cause of blindness in adults over the age of 40.Despite the continued emergence of new medicine and treatment in the past ten years,and a large number of global clinical trials have been carried out,we still couldn’t prevent the occurrence and development of DR.Microvascular damage caused by DM has been a top priority in the prevention and treatment of diabetic complications.Chinese government attaches great importance to the prevention and treatment of DR and has included it into China’s plan of the prevention and treatment of blindness.In this presentation,I’m going to focus on the pathogenesis of DR,especially the relationship between immune inflammatory response and DR.Major challenges and solutions in clinical treatment were discussed as well.

关键词： Diabetic retinopathy(DR) retinal microvascular damage Anti-VEGF surgery

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气体在玻璃体视网膜手术中应用和作用的新认识

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中华眼底病杂志 2022年第4期38卷 257-260页

作者：彭绍民唐仕波中南大学爱尔眼科学院长沙410015 爱尔眼科视网膜研究所长沙410015 哈尔滨爱尔眼科医院哈尔滨1500004 广州爱尔眼科医院广州510000

目前视网膜复位手术中眼内可填充的材料主要有无菌空气、长效气体和硅油。无菌空气多用于简单的视网膜脱离复位固定手术后的眼内填充,而长效气体及硅油多用于复杂性视网膜脱离玻璃体切割手术后的眼内填充。近年来随着微创玻璃体切割手... 详细信息

目前视网膜复位手术中眼内可填充的材料主要有无菌空气、长效气体和硅油。无菌空气多用于简单的视网膜脱离复位固定手术后的眼内填充,而长效气体及硅油多用于复杂性视网膜脱离玻璃体切割手术后的眼内填充。近年来随着微创玻璃体切割手术和广角可视系统及围手术期抗血管内皮生长因子药物的应用,眼内填充材料的选择也相应发生了一些变化,硅油的应用明显减少,且膨胀气体的浓度也在降低,无菌空气的应用比例在上升。只要掌握好适应证,选择合适的无菌空气或长效气体,必将减轻社会负担和医生的工作负荷而最终使患者受益。

关键词：空气惰性气体玻璃体视网膜手术外科手术微创性述评

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正确评价后巩膜加固手术对高度近视的防控作用

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中华眼底病杂志 2023年第8期39卷 626-633页

作者：唐仕波肖迎暨南大学附属广州爱尔眼科医院广州510632 爱尔眼科医院集团长沙爱尔眼科医院长沙410035 山东第一医科大学附属省立医院眼科济南250021

高度近视在我国发病率逐年攀升,发病年龄不断提前,目前已成为我国重要的公共卫生问题。在高度近视的治疗中,后巩膜加固手术已有超过60年的临床应用历史。后巩膜加固手术通过在薄弱的后极部球壁表面缝合一定大小的加固材料,使其与后极部... 详细信息

高度近视在我国发病率逐年攀升,发病年龄不断提前,目前已成为我国重要的公共卫生问题。在高度近视的治疗中,后巩膜加固手术已有超过60年的临床应用历史。后巩膜加固手术通过在薄弱的后极部球壁表面缝合一定大小的加固材料,使其与后极部巩膜融合,达到增加局部巩膜厚度和抗张能力、限制眼轴快速增长、减轻高度近视脉络膜视网膜病变的作用。目前后巩膜加固手术尚存在一定争议,在临床仍未得到广泛开展。针对后巩膜加固手术的作用机制、手术方式、应用材料及临床应用现状进行深入分析,可为该手术的进一步规范应用提供依据。

关键词：近视,退行性后巩膜加固手术防控述评

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Macrophages in Human Epiretinal and Vitreal Membranes in Patients with Proliferative Intraocular Disorders

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Eye Science 1996年第1期16卷 28-32页

作者： shibo tang, Rulong Gao, De-zheng WuZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China Zhongshan Ophthalmic Center Sun Yat-sen University of Medical Sciences Guangzhou China.

Purpose: Macrophages are versatile cells and have been known as a cellular component of epiretinal membranes of proliferative intraocular disorders (PID). However, the origin and functions of these cells in the membranes are not yet clear. In the present study we investigated the characterization of macrophages/monocytes in various types of human epiretinal membranes from patients with proliferative vitreortinopathy (PVR) , proliferative diabetic retinopathy (PDR) and ocular perforating injury by means of immunohistochemical techniques. Methods: A total of 49 epiretinal membranes of PID in which 24 were PDR specimens, 17 were PVR and 8 were proliferations after perforating eye injury were studied. Monoclonal antibodies against human macrophages, monocytes, HLA-DR antigen and interleukin-1 (IL-1) were used. The alkaline phosphatase anti-alkaline phosphatase (APAAP) technique was performed.Results: The results showed that 19 out of 24 PDR specimens (79%), 15 out of 17 PVR specimens (88%) and 7 out of 8

关键词： vitreoretinal diseases macrophages cytokine

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基于信息流分析的密码核设计安全验证与漏洞检测

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西北工业大学学报 2022年第1期40卷 76-83页

作者：马艺新唐时博谭静李雪霏胡伟西北工业大学网络空间安全学院陕西西安710072

密码算法核是保障信息机密性和完整性的关键部件。由于密码算法实现的安全性与算法在数学上的安全性是2个完全不同的问题,密码算法核可能隐含设计缺陷和旁路信道等安全隐患。基于功能验证的安全性分析方法严重依赖于测试向量的质量,覆... 详细信息

密码算法核是保障信息机密性和完整性的关键部件。由于密码算法实现的安全性与算法在数学上的安全性是2个完全不同的问题,密码算法核可能隐含设计缺陷和旁路信道等安全隐患。基于功能验证的安全性分析方法严重依赖于测试向量的质量,覆盖率低,难以满足密码算法核这一安全关键部件的安全验证需求。从信息流安全的角度研究密码算法核安全验证与漏洞检测方法。该方法能够对密码算法核中全部逻辑信息流进行精确度量,实现对机密性和完整性等安全属性的形式化验证,可通过捕捉有害信息流动来检测密码算法核设计中潜在的安全隐患。实验结果表明信息流安全验证方法对密码算法核中的设计缺陷和旁路信道导致的敏感信息泄漏有很好的检测效果。

关键词：信息流分析安全验证漏洞检测密码算法核

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