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Effect of high-frequency loading and parathyroid hormone administration on peri-implant bone healing and osseointegration

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International Journal of Oral Science 2018年第1期10卷 50-64页

作者： Aya shibamoto toru Ogawa Joke Duyck Katleen Vandamme Ignace Naert Keiichi Sasaki Division of Advanced Prosthetic Dentistry Tohoku University Graduate School of Dentistry Department of Oral Health Sciences Prosthetic DentistryBIOMAT-BiomaterialsKatholieke Universiteit Leuven

the objective of this study is to examine the effect of low-magnitude, high-frequency(LMHF) loading, and anti-osteoporosis medications such as parathyroid hormone(PtH) and bisphosphonates on peri-implant bone healing in an osteoporosis model, and to assess their combined effects on these processes. thirteen-week-old ovariectomized rats(n = 44) were divided into three groups:PtH, alendronate, and saline. After 3 weeks of drug administration, titanium implants were inserted into the tibiae. Each group was subdivided into two groups: with or without LMHF loading via whole-body vibration(50 Hz at 0.5 g, 15 min per day, 5 days per week). Rats were killed 4 weeks following implantation. Removal torque test, micro-Ct analyses(relative gray(RG) value, water = 0,and implant = 100), and histomorphometric analyses(bone-to-implant contact(BIC) and peri-implant bone formation(bone volume/tissue volume(BV/tV))) were performed. Removal torque values and BIC were significantly differed by loading and drug administration(ANOVA). Post hoc analysis showed that PtH-treated groups were significantly higher than the other drug-treated groups. BV/tV was significantly enhanced by PtH administration. In cortical bone, RG values were significantly increased by *** trabecular bone, however, RG values were significantly increased by PtH administration. these findings suggest that LMHF loading and PtH can act locally and additively on the bone healing process, improving the condition of implant osseointegration.

关键词： WHOLE-BODY VIBRAtION ORAL BISPHOSPHONAtES LOW-MAGNItUDE POStMENOPAUSAL WOMEN MINERAL DENSItY MECHANICAL SIGNALS tItANIUM IMPLANtS DENtAL IMPLANtS tERIPARAtIDE OStEOPOROSIS

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饲料中添加α-硫辛酸和α-生育酚乙酸酯可增强鸡肉的氧化稳定性

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饲料博览 2013年第1期23卷 28-28页

作者： Yasin M Asghar A Anjum F M Butt M S Khan M I Arshad M S Shahid M El-Ghorab A H shibamoto t

肉品质下降是肉发生脂质过氧化反应引起的。饲料中添加抗氧化剂可减少脂质过氧反应化和改善屠宰后肉的氧化稳定性。研究结果表明,给肉鸡饲喂添加α-生育酚醋酸酯(200mg·kg-1)与α-硫辛酸(25、75、150mg·kg-1)可增加肉的氧化稳定性及... 详细信息

肉品质下降是肉发生脂质过氧化反应引起的。饲料中添加抗氧化剂可减少脂质过氧反应化和改善屠宰后肉的氧化稳定性。研究结果表明,给肉鸡饲喂添加α-生育酚醋酸酯(200mg·kg-1)与α-硫辛酸(25、75、150mg·kg-1)可增加肉的氧化稳定性及降低脂肪沉积。随着饲料中添加α-硫辛酸浓度的增加,肉中总酚含量和α-硫辛酸的含量增加。添加α-硫辛酸和α-生育酚乙酸酯,肉中的蛋白质含量没有改变。DPPH和tBA检测的结果表明,饲料中添加α-硫辛酸和α-生育酚乙酸酯,增强了鸡肉的抗氧化活性。给肉鸡饲喂食添加氧化油的饲料(4%),可导致其氧化稳定性降低。

关键词：抗氧化剂肉鸡禽流肉 α-硫辛酸肉品质 α-生育酚

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添加大豆黄酮对肉种鸡产蛋高峰后期产蛋率、抗氧化活性及肝VtG-ⅡmRNA表达变化的影响

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饲料博览 2013年第1期23卷 4-4页

作者： Yasin M Asghar A Anjum F M Butt M S Khan M I Arshad M S Shahid M El-Ghorab A H shibamoto t

大豆黄酮即大豆植物雌激素,是一种强抗氧化剂,具有多种生物活性。研究通过在肉种鸡产蛋后期饲喂大豆苷元来证实大豆黄酮提高产蛋率的作用,并通过相关基因表达的变化和肝脏的抗氧化状态来阐明这个过程的机制。选择460日龄的肉种鸡300只,... 详细信息

大豆黄酮即大豆植物雌激素,是一种强抗氧化剂,具有多种生物活性。研究通过在肉种鸡产蛋后期饲喂大豆苷元来证实大豆黄酮提高产蛋率的作用,并通过相关基因表达的变化和肝脏的抗氧化状态来阐明这个过程的机制。选择460日龄的肉种鸡300只,随机分成3组(每组100只,设10个重复,每个重复10只),分别饲喂基础日粮(对照组,CON)或在基础日粮中添加大豆黄酮5mg·kg-1(低剂量,L)或10mg·kg-1(高剂量,H)。预饲期1周,试验期15d。试验结果表明,添加大豆黄酮的高和低剂量均显著提高产蛋率(P0.05)。血清雌激素表现出剂量依赖性减少,且添加大豆黄酮高剂量组与其他组相比差异显著(P0.05)。大豆黄酮显著降低血清丙二醛含量(P0.05)。实时PCR分析结果表明,大豆黄酮组的母鸡随着产蛋率的增加,肝脏卵黄蛋白原-Ⅱ表达显著下降(P0.05)。结果表明,添加大豆黄酮可通过提高抗氧化能力和不断改变肉鸡肝相关基因的转录来提高产蛋率。

关键词：产蛋率抗氧化基因表达大豆苷元肉种鸡

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the social life of the Japanese language

The social life of the Japanese language

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作者： Shigeko Okamoto and Janet S. shibamoto-Smith

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Plasma copeptin concentration is a predictor of tolvaptan efficacy in patients with hepatic ascites

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Portal Hypertension & Cirrhosis 2023年第3期2卷 109-114页

作者： Fumimasa tomooka Kei Moriya takahiro Kubo Akihiko shibamoto Jyunya Suzuki Satoshi Iwai Soichi takeda Yuki Fujimoto Masahide Enomoto Koji Murata Yuki tsuji Yukihisa Fujinaga Koh Kitagawa Norihisa Nishimura Hiroaki takaya Kosuke Kaji Hideto Kawaratani tadashi Namisaki takemi Akahane Akira Mitoro Hitoshi Yoshiji Department of Gastroenterology and Hepatology Nara Medical UniversityKashiharaJapan Department of Gastroenterology Nara Prefectural General Medical CenterShichijo-NishimachiJapan

Aims:No solid evidence-based opinion was raised regarding predictors of the degree of ascites reduction with *** retrospective cohort study aimed to examine whether serum copeptin concentration is a useful predictor of ***:the study population consisted of 80 patients with liver cirrhosis treated with tolvaptan for hepatic ascites effusions at Nara Medical University Hospital from May 2014 to December ***-three patients who lost>1.5 kg of body weight in the first week after starting tolvaptan were classified as good responders and the remaining 37 as poor *** laboratory parameters were measured immediately before the start of tolvaptan therapy to examine factors associated with predicting its ***:In the univariate analysis,no significant differences with respect to age(67.6 vs.69.8 years,p>0.05),sex,body mass index(24.8 vs.23.7 kg/m^(2),p>0.05),Child-Pugh score(9.4 vs.9.7,p>0.05),and Model for End-stage Liver Disease score(11 vs.12,p>0.05)were found between the two ***,aspartate transferase and alanine transaminase(ALt)levels were significantly lower in the good response group(52.9±56.3 vs.68.8±50.7 U/L,ptin and serum sodium concentrations were significantly higher(57.1±15.0 vs.45.8±16.0 pg/mL,pthe multivariate analysis,serum copeptin concentration and ALt were statistically significant factors(pthe association between the tolvaptan efficacy for refractory ascites and pretreatment serum copeptin concentration showed that a copeptin concentration cutoff of 45.9 pg/mL could predict treatment efficacy with a sensitivity,specificity,and area under the curve of 76.7%,59.5%,and 0.71%,***:Serum copeptin concentration may be a predictor of tolvaptan efficacy for refractory ascites effusion in Japanese patients with liver cirrhosis.

关键词： ascites copeptin decompensated liver cirrhosis diuretics tolvaptan

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Contrast Enhancement of Posterior Mediastinal Ganglioneuromas—Correlation between the Level of Enhancement and Histopathological Features

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Open Journal of Radiology 2014年第1期4卷 123-129页

作者： Yoshiyuki Ozawa Masaki Hara Maho Kato Shigeki Shimizu Yuta shibamoto Departments of Clinical Pathology Nagoya City University Graduate School of Medical Sciences Nagoya Japan Departments of Radiology Nagoya City University Graduate School of Medical Sciences Nagoya Japan

Purpose: Relationship between Ct or MR images and histological findings, especially vascularity, has not been adequately evaluated. the purpose of this study was to investigate correlation between contrast enhancement on Ct and MRI and histological findings in posterior mediastinal ganglioneuromas. Materials and Methods: Contrast-enhanced (CE) Ct (n = 11) and CE MRI (n = 5) of 12 patients with ganglioneuroma were reviewed. the attenuation, signal intensity, and dynamic enhancement pattern of the tumors were evaluated. the vascularity was histologically evaluated by the numbers of vessels. Results: Enhancement on CE-Ct was none, mild, moderate, and high enhancement in 5 (45%), 2 (18%), 3 (27%), and 1 (9%) of the 11 lesions, respectively. Dynamic MRI showed mild, moderate and high enhancement in 3 (60%), 1 (20%) and 1 (20%) cases, respectively. the level of contrast enhancement correlated well only with the number of capillary vessels (r = 0.79, P = 0.0037). Conclusion: the posterior mediastinal ganglioneuromas sometimes show insufficient enhancement particularly on CE-Ct. the level of enhancement might correlate with the amount of capillary vessels.

关键词： Ganglioneuroma Enhancement Ct MRI Mediastinum

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Successful balloon-occluded retrograde transvenous obliteration for bleeding duodenal varices using cyanoacrylate

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World Journal of Gastroenterology 2013年第6期19卷 951-954页

作者： Rintaro Hashimoto Keitaro Sofue Yoshito takeuchi Kentaro shibamoto Yasuaki Arai Department of Diagnostic Radiology National Cancer Center Central Hospital

A 76-year-old woman with hepatitis C cirrhosis presented with tarry stools and *** endoscopy demonstrated bleeding duodenal varices in the second portion of the ***-enhanced computed tomography revealed markedly tortuous varices around the wall in the *** afferent veins appeared to have developed,and the right ovarian vein draining into the inferior vena cava was detected as an efferent ***-occluded retrograde transvenous obliteration (BRtO) of the varices using cyanoacrylate was successfully performed in combination with the temporary occlusion of the portal *** no previous publications have used cyanoacrylate as an embolic agent for BRtO to control bleeding duodenal varices,this strategy can be considered as an alternative procedure to conventional BRtO using ethanolamine oleate when numerous afferent vessels that cannot be embolized are present.

关键词： Bleeding duodenal varices Balloon-occluded retrograde transvenous obliteration Cyanoacrylate Combination therapy temporary portal vein occlusion

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Low-acoustic attenuation and high-mechanical strength silicone rubber lens doped with ZnO nano-powder for medical array probe

Low-acoustic attenuation and high-mechanical strength silico...

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2008 IEEE International Ultrasonics Symposium

作者： Yohachi(John)Yamashita Yasuharu Hosono Noriko Yamamoto Kazuhiro Itsumi Yasuhisa Makita takashi takeuchi Koichi shibamoto Minoru Aoki Hiroyuki Shikata toshiba Research Consulting Corp. KawasakiKanagawa Corporate R &D Center.toshiba Corp.Kawasaki Kanagawa toshiba Medical Systems Corp. OtawaraTochigi

＜正＞Background,Motivation and Objective Silicone（Q）rubber has been the predominant externally focused acoustic lens material applied for the medical array probe application since 1970,because it is safe,has a suit...

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Increases in the number of brain metastases detected at frame-fixed, thin-slice MRI for gamma knife surgery planning

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中国神经肿瘤杂志 2010年第3期8卷 197-197页

作者： Nagai A shibamoto Y Mori Y Hashizume C Hagiwara M Kobayashi t Department of Radiology Nagoya City University Graduate School of Medical Sciences Nagoya A ichi Japan Nagoya Radiosurgery Center Nagoya Kyoritsu Hospital Nagoya Aichi Japan

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DESIGN CRItERIA FOR RAtCHEtING FAtIGUE OF 316FR StEEL UNDER FASt REACtOR CONDItIONS

DESIGN CRITERIA FOR RATCHETING FATIGUE OF 316FR STEEL UNDER ...

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第十八届国际反应堆结构力学大会

作者： Nobuhiro Isobe Masayuki Sukekawa Yasunari Nakayama tomomi Ohtani Shingo Date Yukio takahashi Naoto Kasahara Kyotada Nakamura Hiroshi shibamoto Hideaki Nagashima Kazuhiko Inoue Hitachi Ltd Hitachi Ltd Kawasaki Heavy Industries Ltd Mitsubishi Heavy Industries Ltd Mitsubishi Heavy Industries Ltd Central Research Institute of Electric Power Industry Japan Nuclear Cycle Development Institute Japan Nuclear Cycle Development Institute Japan Atomic Power Company Japan Atomic Power Company Japan Atomic Power Company

＜正＞ 1 INtRODUCtION Feasibility study for the commercialized fast reactor system has been conducting in Japan. In this study, ratcheting fatigue tests were performed and the design criteria taking the accumulated strain by ratcheting into account was discussed in order to improve the structural design methodology for fast reactors. 2 SUMMARY Ratcheting fatigue tests were conducted at 550C. A ratchet-expired cycle was introduced to take the operational condition of fast reactor into account. Fatigue lives decrease with

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