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Investigation of scale efect for the computation of turbulent flow around a circular cylinder

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Acta Mechanica Sinica 2013年第5期29卷 641-648页

作者： lin lin Yan-Ying Wang State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of Technology

In order to investigate the scale effect of turbulent flow around a circular cylinder, two similarity numbers （criteria） based on turbulent kinetic and dissipation rates associ- ated with the fluctuation characteristics of turbulence wake are deduced by analyzing the Reynolds averaged NavierStokes equations （RANS）. The RNG k-s models and finite volume method are used to solve the governing equations and the second-order implicit time and upwind space discretization algorithms are used to discrete the governing equations. A numerical computation of flow parameters around a two-dimensional circular cylinder with Reynolds numbers ranging from 102 to l07 is accomplished and the result indicates that the fluctuation of turbulence flow along the center line in the wake of circular cylinder can never be changed with increasing Reynolds numbers when Re ≥ 3 × 10^6. This conclusion is useful for controlling the scale of numerical calculations and for applying model test data to engineering practice.

关键词： Turbulent flow Flow around circular cylinder Scale effect Dynamic similarity

Discovery of Novel N-Glycoside and Non-Glycoside hSGLT2 Inhibitors for the Treatment of Type 2 Diabetes Mellitus

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Journal of Diabetes Mellitus 2019年第3期9卷 77-104页

作者： Chun-Yi Chang yih Ho Shwu-Jiuan lin Hsuan-Liang Liu Institute of Biochemical and Biomedical Engineering National Taipei University of Technology Taiwan School of Pharmacy Taipei Medical University Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taiwan

Human sodium-glucose cotransporter 2 (hSGLT2) is a membrane protein responsible for glucose reabsorption from the glomerular filtrate in the proximal tubule. Inhibition of hSGLT2 has been regarded as a brand new therapeutic approach for the treatment of type 2 diabetes mellitus (T2DM) due to its non-insulin related characteristics with less side effects. Current commercially available hSGLT2 inhibitors are all C-glycoside inhibitors. Previous studies have reported that N-glycoside inhibitors have better potential to serve as new drugs due to their good metabolic stability. In addition, non-glycoside inhibitors have been shown to exhibit the capability to overcome the existing problems of current glycoside inhibitors, including low tissue permeability, poor stability and short serum half-time. Here, we aimed to discover novel N-glycoside and non-glycoside hSGLT2 inhibitors by a combination of several computational approaches. A ligand-based pharmacophore model was generated, well validated and subsequently utilized as a 3D query to identify novel hSGLT2 inhibitors from National Cancer Institute (NCI) and Traditional Chinese Medicine (TCM) databases. Finally, one N-glycoside (NSC679207) and one non-glycoside (TCM_Piperenol_A) hSGLT2 inhibitors were successfully identified, which were proven to exhibit excellent binding affinities, pharmacokinetic properties and less toxicity than the commercially available hSGLT2 inhibitor, canagliflozin, via molecular docking, ADMET prediction, molecular dynamics (MD) simulations and binding free energy calculations. All together, our results strongly suggest that these two compounds have great potential to serve as novel hSGLT2 inhibitors for the treatment of T2DM and their efficacies may be further examined by a series of in vitro and/or in vivo bioassays.

关键词： Human Sodium-Glucose Cotransports 2 (hSGLT2) Type 2 Diabetes Mellitus (T2DM) Ligand-Based Pharmacophore Model Molecular Docking Molecular Dynamics (MD) Simulations

Eco-friendly physical blowing agent mass loss of bio-based polyurethane rigid foam materials

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International Journal of Minerals,Metallurgy and Materials 2023年第4期30卷 782-789页

作者： Haozhen Wang lin lin Yingshu Liu School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China

Through systematical experiment design, the physical blowing agent(PBA) mass loss of bio-based polyurethane rigid foam(PURF)in the foaming process was measured and calculated in this study, and different eco-friendly PBA mass losses were measured quantitatively for the first time. The core of the proposed method is to add water to replace the difference, and this method has a high fault tolerance rate for different foaming forms of foams. The method was proved to be stable and reliable through the standard deviations σ1and σ2for R1(ratio of the PBA mass loss to the material total mass except the PBA) and R2(ratio of the PBA mass loss to the PBA mass in the material total mass) in parallel experiments. It can be used to measure and calculate the actual PBA mass loss in the foaming process of both bio-based and petroleumbased PURF. The results show that the PBA mass loss in PURF with different PBA systems is controlled by its initial mass content of PBA in PU materials ω. The main way for PBA to dissipate into the air is evaporation/escape along the upper surface of foam. This study further reveals the mechanism of PBA mass loss: the evaporation/escape of PBA along the upper surface of foam is a typical diffusion behavior. Its spread power comes from the difference between the chemical potential of PBA in the interface layer and that in the outside air. For a certain PURF system, R1has approximately linear relationship with the initial mass content of PBA in PU materials ω, which can be expressed by the functional relationship R1= kω, where k is a variable related to PBA’s own attributes.

关键词： polyurethane bio-based polyol eco-friendly physical blowing agent mass loss

Optimal policy for controlling two-server queueing systems with jockeying

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Journal of Systems Engineering and Electronics 2022年第1期33卷 144-155页

作者： lin Bing lin Yuchen BHATNAGAR Rohit School of Business Jiangsu Normal UniversityXuzhou 221116China Wenzheng College Soochow UniversitySuzhou 215104China Nanyang Business School Nanyang Technological UniversityNanyang 639798Singapore

This paper studies the optimal policy for joint control of admission, routing, service, and jockeying in a queueing system consisting of two exponential servers in *** arrive according to a Poisson *** each arrival, an admission/routing decision is made, and the accepted job is routed to one of the two servers with each being associated with a *** each service completion, the servers have an option of serving a job from its own queue, serving a jockeying job from another queue, or staying *** system performance is inclusive of the revenues from accepted jobs, the costs of holding jobs in queues, the service costs and the job jockeying *** maximize the total expected discounted return, we formulate a Markov decision process(MDP) model for this *** value iteration method is employed to characterize the optimal policy as a hedging point *** studies verify the structure of the hedging point policy which is convenient for implementing control actions in practice.

关键词： queueing system jockeying optimal policy Markov decision process(MDP) dynamic programming

Experimental investigation on the distribution uniformity and pressure drop of perforated plate distributors for the innovative spray-type packed bed thermal storage

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Particuology 2022年第2期20卷 60-73页

作者： lin lin Liang Wang Xipeng lin Ningning Xie Haisheng Chen Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Dalian National Laboratory for Clean Energy Chinese Academy of SciencesDalian 116023China National Energy Large Scale Physical Energy Storage Technologies R&D Center of Bijie High-tech Industrial Development Zone Guizhou 551712China Institute of Science and Technology China Three Gorges CorporationBeijing 100038China

As an innovative thermal energy technology,the spray-type packed bed has advantages of high efficiency and low cost.A liquid distributor is the key component for the spray-type packed bed for scattering heat-transfer liquid drops *** this study,the distribution performance and pressure drop of the perforated plate distributors of different orifice diameters were studied *** experimental results indicate that orifice diameter has a greater effect on the distribution performance compared to flow *** an increase in flow rate,the flow pattern through the distributor changes from the uncovered drop to the covered drop and then to the jet *** covered drop pattern shows the best performance with a good distribution and a small pressure drop simultaneously,which is the design and optimization principle of the distributor for a spray-type packed bed.

关键词： Spray-type packed bed Perforated plate distributor Distribution Pressure drop Thermal energy storage

Morphology Optimization in Ternary Organic Solar Cells

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Chinese Journal of Polymer Science 2017年第2期35卷 184-197页

作者： lin zhang 马伟 State Key Laboratory for Mechanical Behavior of Materials Xi 'an Jiaotong University Xi 'an 710049 China

Ternary organic solar cells have drawn great attention because the highest power conversion efficiencies have reached -12%, showing a promising prospect for the future applications. However, most reported ternary solar cells focus on the increase of light absorption and the optimization of energy alignment, but ignore the importance of morphology. Herein, we summarize the morphology optimization on the ternary blends with different structural aspects, such as controlling crystallinity, crystal orientation, domain size, and domain purity. Furthermore, the fundamental mechanism of ternary solar cells which is related to the morphology has been described. The efforts here will provide a guiding role for the morphology optimization on the ternary solar cells in the future.

关键词： Ternary organic solar cells Morphology Crystallization Phase separation

Enhancing Safety in Autonomous Vehicle Navigation:An Optimized Path Planning Approach Leveraging Model Predictive Control

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Computers, Materials & Continua 2024年第9期80卷 3555-3572页

作者： Shih-lin lin Bo-Chen lin Graduate Institute of Vehicle Engineering National Changhua University of EducationChanghua50007TaiwanChina

This paper explores the application of Model Predictive Control(MPC)to enhance safety and efficiency in autonomous vehicle(AV)navigation through optimized path *** evolution of AV technology has progressed rapidly,moving from basic driver-assistance systems(Level 1)to fully autonomous capabilities(Level 5).Central to this advancement are two key functionalities:Lane-Change Maneuvers(LCM)and Adaptive Cruise Control(ACC).In this study,a detailed simulation environment is created to replicate the road network between Nantun andWuri on National Freeway No.1 in *** MPC controller is deployed to optimize vehicle trajectories,ensuring safe and efficient *** onboard sensors,including vehicle cameras and millimeterwave radar,are used to detect and respond to dynamic changes in the surrounding environment,enabling real-time decision-making for LCM and *** simulation resultshighlight the superiority of the MPC-based approach in maintaining safe distances,executing controlled lane changes,and optimizing fuel ***,the MPC controller effectively manages collision avoidance,reduces travel time,and contributes to smoother traffic flow compared to traditional path planning *** findings underscore the potential of MPC to enhance the reliability and safety of autonomous driving in complex traffic *** research will focus on validating these results through real-world testing,addressing computational challenges for real-time implementation,and exploring the adaptability of MPC under various environmental *** study provides a significant step towards achieving safer and more efficient autonomous vehicle navigation,paving the way for broader adoption of MPC in AV systems.

关键词： Autonomous driving model predictive control(MPC) lane change maneuver(LCM) adaptive cruise control(ACC)

Studies on the alcohol exchange reactions of methoxide ditungsten [W(IV)] compound W_2Cl_4(OCH_3)_4(CH_3OH)_2, prepared from (n-Bu_4N)_3W_2Cl_9

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Chinese Journal of Chemistry 1990年第6期8卷 520-528页

作者： HONG Bo JIN, Song-lin yih-Tong KU (GU, Yi-Dong), Department of Chemistry, Fudan University, Shanghai 200433 CHEN, Ming-QinCenter of Analyses and Measurements, Fudan University, Shanghai 200433 Department of Chemistry Fudan University Shanghai 200433 Center of Analyses and Measurements Fudan University Shanghai 200433

(n-Bu_4N)_3W_2Cl_9, prepared from K_3W_2Cl_9, can be readily converted to a series of [W(IV)]cluster compounds,W_3Cl_4(μ-OR)_2(OR')_2(R'OH)_2, including seven known compounds and two newcompounds with R=Me, R＇=i-Pr ... 详细信息

关键词： CI prepared from HONG Bo JIN Song-lin yih-Tong KU Studies on the alcohol exchange reactions of methoxide ditungsten Yi-Dong compound W2Cl4 n-Bu4N CH3OH Fudan University GU Cl IV

Learning capability of the truncated greedy algorithm

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Science China(Information Sciences) 2016年第5期59卷 49-63页

作者： lin XU Shaobo lin Zongben XU Institute for Information and System Sciences Xi'an Jiaotong University College of Mathematics and Information Science Wenzhou University

Pure greedy algorithm(PGA), orthogonal greedy algorithm(OGA) and relaxed greedy algorithm(RGA) are three widely used greedy type algorithms in both nonlinear approximation and supervised *** this paper, we apply another variant of greedy-type algorithm, called the truncated greedy algorithm(TGA)in the realm of supervised learning and study its learning performance. We rigorously prove that TGA is better than PGA in the sense that TGA possesses the faster learning rate than PGA. Furthermore, in some special cases, we also prove that TGA outperforms OGA and RGA. All these theoretical assertions are verified by both toy simulations and real data experiments.

关键词： supervised learning learning theory generalization capability greedy algorithm truncated greedy algorithm